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Protein

Uperolein

Gene
N/A
Organism
Uperoleia rugosa (Wrinkled toadlet)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

GO - Biological processi

Keywordsi

Molecular functionAmphibian defense peptide, Neuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Uperolein
OrganismiUperoleia rugosa (Wrinkled toadlet)
Taxonomic identifieri8368 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaMyobatrachoideaMyobatrachidaeMyobatrachinaeUperoleia

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000444141 – 11UperoleinAdd BLAST11

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Pyrrolidone carboxylic acid1 Publication1
Modified residuei11Methionine amide1 Publication1

Keywords - PTMi

Amidation, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Expressed by the skin glands.

Structurei

Secondary structure

111
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 7Combined sources4
Turni8 – 10Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GFRNMR-A1-11[»]
SMRiP08612.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08612.

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR013055. Tachy_Neuro_lke_CS.
IPR008215. Tachykinin_dom.
PfamiView protein in Pfam
PF02202. Tachykinin. 1 hit.
PROSITEiView protein in PROSITE
PS00267. TACHYKININ. 1 hit.

Sequencei

Sequence statusi: Complete.

Length:11
Mass (Da):1,252
Last modified:February 1, 1994 - v2
Checksum:i32867C3E59CDD457
GO

Similar proteinsi

Entry informationi

Entry nameiTKN1_UPERU
AccessioniPrimary (citable) accession number: P08612
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 1, 1994
Last modified: April 12, 2017
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families