P08611 (TKN_KASSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Kassinin
Organism	Kassina senegalensis (Senegal running frog)
Taxonomic identifier	8415 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Neobatrachia › Microhyloidea › Hyperoliidae › Kassina

Protein attributes

Sequence length	12 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Subcellular location	Secreted.
Tissue specificity	Expressed by the skin glands.
Sequence similarities	Belongs to the tachykinin family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Amphibian defense peptide Neuropeptide
PTM	Amidation
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological_process	defense response Inferred from electronic annotation. Source: UniProtKB-KW neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW synaptic transmission Inferred from electronic annotation. Source: InterPro tachykinin receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Peptide

1 – 12

12

Kassinin

PRO_0000044397

Amino acid modifications

Modified residue

12

1

Methionine amide Ref.1

Secondary structure

1

.

.

.

12

Helix Strand Turn

Details...

Helix

4 – 11

8

Sequences

	Sequence		Length	Mass (Da)
	P08611 [UniParc]. Last modified August 1, 1988. Version 1. Checksum: 91757AB89DD6DAB5	FASTA	12	1,336
	10 DVPKSDQFVG LM

References

[1]	"Amino acid composition and sequence of kassinin, a tachykinin dodecapeptide from the skin of the African frog Kassina senegalensis." Anastasi A., Montecucchi P.C., Erspamer V., Visser J. Experientia 33:857-858(1977) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Skin secretion.
+	Additional computationally mapped references.

Cross-references

Sequence databases

PIR

S07206.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1MYU	NMR	-	A	1-12	[»]

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR002040. Neurokinin/Substance-P.
IPR013055. Tachy_Neuro_lke_CS.
[Graphical view]

Pfam

PF02202. Tachykinin. 1 hit.
[Graphical view]

PROSITE

PS00267. TACHYKININ. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P08611.

Entry information

Entry name

TKN_KASSE

Accession

Primary (citable) accession number: P08611

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program