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P08611

- TKN_KASSE

UniProt

P08611 - TKN_KASSE

Protein

Kassinin

Gene
N/A
Organism
Kassina senegalensis (Senegal running frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

    GO - Biological processi

    1. defense response Source: UniProtKB-KW
    2. neuropeptide signaling pathway Source: UniProtKB-KW
    3. synaptic transmission Source: InterPro
    4. tachykinin receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Amphibian defense peptide, Neuropeptide

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kassinin
    OrganismiKassina senegalensis (Senegal running frog)
    Taxonomic identifieri8415 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaMicrohyloideaHyperoliidaeKassina

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 1212KassininPRO_0000044397Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei12 – 121Methionine amide1 Publication

    Keywords - PTMi

    Amidation

    Expressioni

    Tissue specificityi

    Expressed by the skin glands.

    Structurei

    Secondary structure

    1
    12
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 118

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1MYUNMR-A1-12[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP08611.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tachykinin family.Curated

    Family and domain databases

    InterProiIPR002040. Neurokinin/Substance-P.
    IPR013055. Tachy_Neuro_lke_CS.
    [Graphical view]
    PfamiPF02202. Tachykinin. 1 hit.
    [Graphical view]
    PROSITEiPS00267. TACHYKININ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08611-1 [UniParc]FASTAAdd to Basket

    « Hide

    DVPKSDQFVG LM                                            12
    Length:12
    Mass (Da):1,336
    Last modified:August 1, 1988 - v1
    Checksum:i91757AB89DD6DAB5
    GO

    Sequence databases

    PIRiS07206.

    Cross-referencesi

    Sequence databases

    PIRi S07206.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1MYU NMR - A 1-12 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P08611.

    Family and domain databases

    InterProi IPR002040. Neurokinin/Substance-P.
    IPR013055. Tachy_Neuro_lke_CS.
    [Graphical view ]
    Pfami PF02202. Tachykinin. 1 hit.
    [Graphical view ]
    PROSITEi PS00267. TACHYKININ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Amino acid composition and sequence of kassinin, a tachykinin dodecapeptide from the skin of the African frog Kassina senegalensis."
      Anastasi A., Montecucchi P.C., Erspamer V., Visser J.
      Experientia 33:857-858(1977) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Skin secretion.

    Entry informationi

    Entry nameiTKN_KASSE
    AccessioniPrimary (citable) accession number: P08611
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3