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Protein

C4b-binding protein

Gene

C4bpa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component.

Caution

It is uncertain whether Met-1 or Met-44 is the initiator.Curated

GO - Biological processi

Keywordsi

Biological processComplement pathway, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
C4b-binding protein
Short name:
C4bp
Gene namesi
Name:C4bpa
Synonyms:C4bp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88229 C4bp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 56Add BLAST56
ChainiPRO_000000588957 – 469C4b-binding proteinAdd BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 103PROSITE-ProRule annotation
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi88 ↔ 115PROSITE-ProRule annotation
Disulfide bondi120 ↔ 160PROSITE-ProRule annotation
Disulfide bondi146 ↔ 176PROSITE-ProRule annotation
Disulfide bondi181 ↔ 223PROSITE-ProRule annotation
Disulfide bondi209 ↔ 240PROSITE-ProRule annotation
Glycosylationi227N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi245 ↔ 287PROSITE-ProRule annotation
Disulfide bondi273 ↔ 299PROSITE-ProRule annotation
Glycosylationi275N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi303 ↔ 343PROSITE-ProRule annotation
Disulfide bondi329 ↔ 355PROSITE-ProRule annotation
Disulfide bondi359 ↔ 400PROSITE-ProRule annotation
Glycosylationi366N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi386 ↔ 413PROSITE-ProRule annotation
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP08607
PaxDbiP08607
PeptideAtlasiP08607
PRIDEiP08607

PTM databases

GlyConnecti814
iPTMnetiP08607
PhosphoSitePlusiP08607

Expressioni

Gene expression databases

BgeeiENSMUSG00000026405
CleanExiMM_C4BP
ExpressionAtlasiP08607 baseline and differential
GenevisibleiP08607 MM

Interactioni

Subunit structurei

Homoheptamer; not covalently linked. Mouse lacks the beta chain of C4BP.

Binary interactionsi

WithEntry#Exp.IntActNotes
BMPR2Q138733EBI-527325,EBI-527196From Homo sapiens.

Protein-protein interaction databases

IntActiP08607, 2 interactors
MINTiP08607
STRINGi10090.ENSMUSP00000027657

Structurei

3D structure databases

ProteinModelPortaliP08607
SMRiP08607
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 117Sushi 1PROSITE-ProRule annotationAdd BLAST61
Domaini118 – 178Sushi 2PROSITE-ProRule annotationAdd BLAST61
Domaini179 – 242Sushi 3PROSITE-ProRule annotationAdd BLAST64
Domaini243 – 301Sushi 4PROSITE-ProRule annotationAdd BLAST59
Domaini302 – 357Sushi 5PROSITE-ProRule annotationAdd BLAST56
Domaini358 – 415Sushi 6PROSITE-ProRule annotationAdd BLAST58

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

GeneTreeiENSGT00910000143999
HOGENOMiHOG000015324
HOVERGENiHBG004657
InParanoidiP08607
KOiK04002
OMAiLKYTCRP
OrthoDBiEOG091G0BW2
TreeFamiTF334137

Family and domain databases

CDDicd00033 CCP, 6 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 6 hits
SMARTiView protein in SMART
SM00032 CCP, 6 hits
SUPFAMiSSF57535 SSF57535, 6 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCAKQQQTLL PTRAAHGRLH RNRDAVAWPF STLCRVSGPT LFQMTFTAAL
60 70 80 90 100
WVAVFGKCGP PPAIPNALPA SDVNRTDFES HTTLKYECLP GYGRGISRMM
110 120 130 140 150
VYCKPSGEWE ISVSCAKKHC RNPGYLDNGY VNGETITFGS QIEFSCQEGF
160 170 180 190 200
ILVGSSTSSC EVRGKGVAWS NPFPECVIVK CGPPPDISNG KHSGTEDFYP
210 220 230 240 250
YNHGISYTCD PGFRLVGSPF IGCTVVNKTV PVWSSSPPTC EKIICSQPNI
260 270 280 290 300
LHGVIVSGYK ATYTHRDSVR LACLNGTVLR GRHVIECQGN GNWSSLPTCE
310 320 330 340 350
FDCDLPPAIV NGYYTSMVYS KITLVTYECD KGYRLVGKAI ISCSFSKWKG
360 370 380 390 400
TAPQCKALCQ KPEVGNGTLS DEKDQYVESE NVTIQCDSGF AMLGSQSISC
410 420 430 440 450
SESGTWYPEV PRCEQEASED LKPALTGNKT MQYVPNSHDV KMALEIYKLT
460
LEVELLQLQI QKEKHTEAH
Length:469
Mass (Da):51,524
Last modified:July 27, 2011 - v3
Checksum:i14266B31430F7107
GO

Sequence cautioni

The sequence AAA37312 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17122 mRNA Translation: AAA37312.1 Different initiation.
AK149468 mRNA Translation: BAE28899.1
AK149477 mRNA Translation: BAE28904.1
CH466520 Genomic DNA Translation: EDL39738.1
BC012257 mRNA Translation: AAH12257.1
CCDSiCCDS35700.1
PIRiA27117 NBMSC4
RefSeqiNP_031602.3, NM_007576.3
XP_011246208.1, XM_011247906.2
UniGeneiMm.306720

Genome annotation databases

EnsembliENSMUST00000027657; ENSMUSP00000027657; ENSMUSG00000026405
GeneIDi12269
KEGGimmu:12269
UCSCiuc007cmc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiC4BPA_MOUSE
AccessioniPrimary (citable) accession number: P08607
Secondary accession number(s): Q91X48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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