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Protein

C4b-binding protein

Gene

C4bpa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement pathway, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
C4b-binding protein
Short name:
C4bp
Gene namesi
Name:C4bpa
Synonyms:C4bp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88229. C4bp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 56Add BLAST56
ChainiPRO_000000588957 – 469C4b-binding proteinAdd BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 103PROSITE-ProRule annotation
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi88 ↔ 115PROSITE-ProRule annotation
Disulfide bondi120 ↔ 160PROSITE-ProRule annotation
Disulfide bondi146 ↔ 176PROSITE-ProRule annotation
Disulfide bondi181 ↔ 223PROSITE-ProRule annotation
Disulfide bondi209 ↔ 240PROSITE-ProRule annotation
Glycosylationi227N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi245 ↔ 287PROSITE-ProRule annotation
Disulfide bondi273 ↔ 299PROSITE-ProRule annotation
Glycosylationi275N-linked (GlcNAc...)1 Publication1
Glycosylationi292N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi303 ↔ 343PROSITE-ProRule annotation
Disulfide bondi329 ↔ 355PROSITE-ProRule annotation
Disulfide bondi359 ↔ 400PROSITE-ProRule annotation
Glycosylationi366N-linked (GlcNAc...)Sequence analysis1
Glycosylationi381N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi386 ↔ 413PROSITE-ProRule annotation
Glycosylationi428N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP08607.
PaxDbiP08607.
PeptideAtlasiP08607.
PRIDEiP08607.

PTM databases

iPTMnetiP08607.
PhosphoSitePlusiP08607.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026405.
CleanExiMM_C4BP.
ExpressionAtlasiP08607. baseline and differential.
GenevisibleiP08607. MM.

Interactioni

Subunit structurei

Homoheptamer; not covalently linked. Mouse lacks the beta chain of C4BP.

Binary interactionsi

WithEntry#Exp.IntActNotes
BMPR2Q138733EBI-527325,EBI-527196From a different organism.

Protein-protein interaction databases

IntActiP08607. 2 interactors.
MINTiMINT-4089542.
STRINGi10090.ENSMUSP00000027657.

Structurei

3D structure databases

ProteinModelPortaliP08607.
SMRiP08607.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 117Sushi 1PROSITE-ProRule annotationAdd BLAST61
Domaini118 – 178Sushi 2PROSITE-ProRule annotationAdd BLAST61
Domaini179 – 242Sushi 3PROSITE-ProRule annotationAdd BLAST64
Domaini243 – 301Sushi 4PROSITE-ProRule annotationAdd BLAST59
Domaini302 – 357Sushi 5PROSITE-ProRule annotationAdd BLAST56
Domaini358 – 415Sushi 6PROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Contains 6 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

GeneTreeiENSGT00760000118803.
HOGENOMiHOG000015324.
HOVERGENiHBG004657.
InParanoidiP08607.
KOiK04002.
OMAiPKCEWEF.
OrthoDBiEOG091G0BW2.
TreeFamiTF334137.

Family and domain databases

CDDicd00033. CCP. 6 hits.
InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 6 hits.
[Graphical view]
SMARTiSM00032. CCP. 6 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 6 hits.
PROSITEiPS50923. SUSHI. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCAKQQQTLL PTRAAHGRLH RNRDAVAWPF STLCRVSGPT LFQMTFTAAL
60 70 80 90 100
WVAVFGKCGP PPAIPNALPA SDVNRTDFES HTTLKYECLP GYGRGISRMM
110 120 130 140 150
VYCKPSGEWE ISVSCAKKHC RNPGYLDNGY VNGETITFGS QIEFSCQEGF
160 170 180 190 200
ILVGSSTSSC EVRGKGVAWS NPFPECVIVK CGPPPDISNG KHSGTEDFYP
210 220 230 240 250
YNHGISYTCD PGFRLVGSPF IGCTVVNKTV PVWSSSPPTC EKIICSQPNI
260 270 280 290 300
LHGVIVSGYK ATYTHRDSVR LACLNGTVLR GRHVIECQGN GNWSSLPTCE
310 320 330 340 350
FDCDLPPAIV NGYYTSMVYS KITLVTYECD KGYRLVGKAI ISCSFSKWKG
360 370 380 390 400
TAPQCKALCQ KPEVGNGTLS DEKDQYVESE NVTIQCDSGF AMLGSQSISC
410 420 430 440 450
SESGTWYPEV PRCEQEASED LKPALTGNKT MQYVPNSHDV KMALEIYKLT
460
LEVELLQLQI QKEKHTEAH
Length:469
Mass (Da):51,524
Last modified:July 27, 2011 - v3
Checksum:i14266B31430F7107
GO

Sequence cautioni

The sequence AAA37312 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17122 mRNA. Translation: AAA37312.1. Different initiation.
AK149468 mRNA. Translation: BAE28899.1.
AK149477 mRNA. Translation: BAE28904.1.
CH466520 Genomic DNA. Translation: EDL39738.1.
BC012257 mRNA. Translation: AAH12257.1.
CCDSiCCDS35700.1.
PIRiA27117. NBMSC4.
RefSeqiNP_031602.3. NM_007576.3.
XP_011246208.1. XM_011247906.2.
UniGeneiMm.306720.

Genome annotation databases

EnsembliENSMUST00000027657; ENSMUSP00000027657; ENSMUSG00000026405.
GeneIDi12269.
KEGGimmu:12269.
UCSCiuc007cmc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17122 mRNA. Translation: AAA37312.1. Different initiation.
AK149468 mRNA. Translation: BAE28899.1.
AK149477 mRNA. Translation: BAE28904.1.
CH466520 Genomic DNA. Translation: EDL39738.1.
BC012257 mRNA. Translation: AAH12257.1.
CCDSiCCDS35700.1.
PIRiA27117. NBMSC4.
RefSeqiNP_031602.3. NM_007576.3.
XP_011246208.1. XM_011247906.2.
UniGeneiMm.306720.

3D structure databases

ProteinModelPortaliP08607.
SMRiP08607.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP08607. 2 interactors.
MINTiMINT-4089542.
STRINGi10090.ENSMUSP00000027657.

PTM databases

iPTMnetiP08607.
PhosphoSitePlusiP08607.

Proteomic databases

MaxQBiP08607.
PaxDbiP08607.
PeptideAtlasiP08607.
PRIDEiP08607.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027657; ENSMUSP00000027657; ENSMUSG00000026405.
GeneIDi12269.
KEGGimmu:12269.
UCSCiuc007cmc.1. mouse.

Organism-specific databases

CTDi12269.
MGIiMGI:88229. C4bp.

Phylogenomic databases

GeneTreeiENSGT00760000118803.
HOGENOMiHOG000015324.
HOVERGENiHBG004657.
InParanoidiP08607.
KOiK04002.
OMAiPKCEWEF.
OrthoDBiEOG091G0BW2.
TreeFamiTF334137.

Miscellaneous databases

PROiP08607.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026405.
CleanExiMM_C4BP.
ExpressionAtlasiP08607. baseline and differential.
GenevisibleiP08607. MM.

Family and domain databases

CDDicd00033. CCP. 6 hits.
InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 6 hits.
[Graphical view]
SMARTiSM00032. CCP. 6 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 6 hits.
PROSITEiPS50923. SUSHI. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC4BPA_MOUSE
AccessioniPrimary (citable) accession number: P08607
Secondary accession number(s): Q91X48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-44 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.