##gff-version 3 P08588 UniProtKB Chain 1 477 . . . ID=PRO_0000069118;Note=Beta-1 adrenergic receptor P08588 UniProtKB Topological domain 1 55 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250 P08588 UniProtKB Transmembrane 56 84 . . . Note=Helical%3B Name%3D1;Ontology_term=ECO:0000250;evidence=ECO:0000250 P08588 UniProtKB Topological domain 85 93 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250 P08588 UniProtKB Transmembrane 94 120 . . . Note=Helical%3B Name%3D2;Ontology_term=ECO:0000250;evidence=ECO:0000250 P08588 UniProtKB Topological domain 121 132 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250 P08588 UniProtKB Transmembrane 133 154 . . . Note=Helical%3B Name%3D3;Ontology_term=ECO:0000250;evidence=ECO:0000250 P08588 UniProtKB Topological domain 155 172 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250 P08588 UniProtKB Transmembrane 173 196 . . . Note=Helical%3B Name%3D4;Ontology_term=ECO:0000250;evidence=ECO:0000250 P08588 UniProtKB Topological domain 197 222 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250 P08588 UniProtKB Transmembrane 223 248 . . . Note=Helical%3B Name%3D5;Ontology_term=ECO:0000250;evidence=ECO:0000250 P08588 UniProtKB Topological domain 249 319 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250 P08588 UniProtKB Transmembrane 320 349 . . . Note=Helical%3B Name%3D6;Ontology_term=ECO:0000250;evidence=ECO:0000250 P08588 UniProtKB Topological domain 350 354 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250 P08588 UniProtKB Transmembrane 355 377 . . . Note=Helical%3B Name%3D7;Ontology_term=ECO:0000250;evidence=ECO:0000250 P08588 UniProtKB Topological domain 378 477 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250 P08588 UniProtKB Region 269 307 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P08588 UniProtKB Region 403 477 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P08588 UniProtKB Motif 474 477 . . . Note=PDZ-Binding P08588 UniProtKB Compositional bias 270 294 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P08588 UniProtKB Modified residue 312 312 . . . Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000255;evidence=ECO:0000255 P08588 UniProtKB Modified residue 412 412 . . . Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000255;evidence=ECO:0000255 P08588 UniProtKB Modified residue 428 428 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P18090 P08588 UniProtKB Lipidation 392 392 . . . Note=S-palmitoyl cysteine;Ontology_term=ECO:0000250;evidence=ECO:0000250 P08588 UniProtKB Glycosylation 15 15 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000305;evidence=ECO:0000305 P08588 UniProtKB Disulfide bond 131 216 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00521 P08588 UniProtKB Disulfide bond 209 215 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00521 P08588 UniProtKB Natural variant 26 26 . . . ID=VAR_055909;Note=A->V;Dbxref=dbSNP:rs34844626 P08588 UniProtKB Natural variant 29 29 . . . ID=VAR_055910;Note=A->T;Dbxref=dbSNP:rs35720093 P08588 UniProtKB Natural variant 31 31 . . . ID=VAR_055911;Note=R->Q;Dbxref=dbSNP:rs35230616 P08588 UniProtKB Natural variant 49 49 . . . ID=VAR_009879;Note=Correlated with low mean resting heart rate and decreased mortality risk in patients with congestive heart failure. S->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10477438,ECO:0000269|PubMed:11052857,ECO:0000269|PubMed:11854867,ECO:0000269|Ref.3;Dbxref=dbSNP:rs1801252,PMID:10477438,PMID:11052857,PMID:11854867 P08588 UniProtKB Natural variant 187 187 . . . ID=VAR_082587;Note=Found in individuals with short sleep%3B results in decreased adenylate cyclase-activating adrenergic receptor signaling%3B decreased protein stability. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31473062;Dbxref=dbSNP:rs776439595,PMID:31473062 P08588 UniProtKB Natural variant 389 389 . . . ID=VAR_009880;Note=Increased beta1-adrenergic receptor activity%3B increased basal activity and increased coupling to heterotrimeric G protein Gs that stimulates the adenylyl cyclase. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10212248;Dbxref=dbSNP:rs1801253,PMID:10212248 P08588 UniProtKB Natural variant 399 399 . . . ID=VAR_055912;Note=R->H;Dbxref=dbSNP:rs36052953 P08588 UniProtKB Natural variant 405 405 . . . ID=VAR_055913;Note=H->Y;Dbxref=dbSNP:rs35705839 P08588 UniProtKB Mutagenesis 474 474 . . . Note=Loss of interaction with GOPC. E->A%2CD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358775;Dbxref=PMID:15358775 P08588 UniProtKB Mutagenesis 474 474 . . . Note=Loss of interaction with GOPC%3B when associated with A-477. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358775;Dbxref=PMID:15358775 P08588 UniProtKB Mutagenesis 475 475 . . . Note=Loss of interaction with GOPC. Loss of interaction with RAPGEF2. Abolishes agonist-induced Ras activation. S->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12391161,ECO:0000269|PubMed:15358775;Dbxref=PMID:12391161,PMID:15358775 P08588 UniProtKB Mutagenesis 475 475 . . . Note=Loss of interaction with RAPGEF2. S->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12391161,ECO:0000269|PubMed:15358775;Dbxref=PMID:12391161,PMID:15358775 P08588 UniProtKB Mutagenesis 475 475 . . . Note=Partial loss of interaction with GOPC. S->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12391161,ECO:0000269|PubMed:15358775;Dbxref=PMID:12391161,PMID:15358775 P08588 UniProtKB Mutagenesis 476 476 . . . Note=Partial loss of interaction with GOPC. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358775;Dbxref=PMID:15358775 P08588 UniProtKB Mutagenesis 477 477 . . . Note=Loss of interaction with GOPC. V->A%2CF%2CL%2CI%2CM;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12391161,ECO:0000269|PubMed:15358775;Dbxref=PMID:12391161,PMID:15358775 P08588 UniProtKB Mutagenesis 477 477 . . . Note=Loss of interaction with RAPGEF2. Abolishes agonist-induced Ras activation. V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12391161,ECO:0000269|PubMed:15358775;Dbxref=PMID:12391161,PMID:15358775 P08588 UniProtKB Helix 54 85 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BVQ P08588 UniProtKB Helix 87 89 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BVQ P08588 UniProtKB Helix 92 110 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BVQ P08588 UniProtKB Helix 112 121 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BVQ P08588 UniProtKB Helix 127 161 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BVQ P08588 UniProtKB Helix 163 169 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BVQ P08588 UniProtKB Helix 172 195 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BVQ P08588 UniProtKB Turn 196 199 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BVQ P08588 UniProtKB Helix 204 210 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BVQ P08588 UniProtKB Helix 213 215 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LSQ P08588 UniProtKB Helix 222 232 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BVQ P08588 UniProtKB Helix 234 253 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BVQ P08588 UniProtKB Helix 316 349 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BVQ P08588 UniProtKB Helix 351 353 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BVQ P08588 UniProtKB Helix 356 377 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BVQ P08588 UniProtKB Helix 381 391 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BVQ