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P08587 (TGM2_CAVCU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein-glutamine gamma-glutamyltransferase 2

EC=2.3.2.13
Alternative name(s):
Tissue transglutaminase
Transglutaminase C
Short name=TG(C)
Short name=TGC
Short name=TGase C
Transglutaminase-2
Short name=TGase-2
Gene names
Name:TGM2
OrganismCavia cutleri (Guinea pig)
Taxonomic identifier10144 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length690 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Catalytic activity

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Subunit structure

Monomer.

Sequence similarities

Belongs to the transglutaminase superfamily. Transglutaminase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2 Ref.3
Chain2 – 690689Protein-glutamine gamma-glutamyltransferase 2
PRO_0000213706

Sites

Active site2771 By similarity
Active site3351 By similarity
Active site3581 By similarity
Metal binding3981Calcium By similarity
Metal binding4001Calcium By similarity
Metal binding4461Calcium By similarity
Metal binding4511Calcium By similarity

Amino acid modifications

Modified residue21N-acetylalanine Ref.3
Modified residue4671N6-acetyllysine By similarity

Experimental info

Sequence conflict2 – 32AE → EA AA sequence Ref.2
Sequence conflict2921G → A in BAA00068. Ref.4
Sequence conflict336 – 35419CWVES…GYEGW → SLLGGVVDDQAGPGAWVRGV in BAA00068. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P08587 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 047223D38DBEA4A4

FASTA69077,141
        10         20         30         40         50         60 
MAEDLILERC DLQLEVNGRD HRTADLCRER LVLRRGQPFW LTLHFEGRGY EAGVDTLTFN 

        70         80         90        100        110        120 
AVTGPDPSEE AGTMARFSLS SAVEGGTWSA SAVDQQDSTV SLLLSTPADA PIGLYRLSLE 

       130        140        150        160        170        180 
ASTGYQGSSF VLGHFILLYN PRCPADAVYM DSDQERQEYV LTQQGFIYQG SAKFINGIPW 

       190        200        210        220        230        240 
NFGQFEDGIL DICLMLLDTN PKFLKNAGQD CSRRSRPVYV GRVVSAMVNC NDDQGVLQGR 

       250        260        270        280        290        300 
WDNNYSDGVS PMSWIGSVDI LRRWKDYGCQ RVKYGQCWVF AAVACTVLRC LGIPTRVVTN 

       310        320        330        340        350        360 
FNSAHDQNSN LLIEYFRNES GEIEGNKSEM IWNFHCWVES WMTRPDLEPG YEGWQALDPT 

       370        380        390        400        410        420 
PQEKSEGTYC CGPVPVRAIK EGHLNVKYDA PFVFAEVNAD VVNWIRQKDG SLRKSINHLV 

       430        440        450        460        470        480 
VGLKISTKSV GRDEREDITH TYKYPEGSEE EREAFVRANH LNKLATKEEA QEETGVAMRI 

       490        500        510        520        530        540 
RVGQNMTMGS DFDIFAYITN GTAESHECQL LLCARIVSYN GVLGPVCSTN DLLNLTLDPF 

       550        560        570        580        590        600 
SENSIPLHIL YEKYGDYLTE SNLIKVRGLL IEPAANSYVL AERDIYLENP EIKIRVLGEP 

       610        620        630        640        650        660 
KQNRKLIAEV SLKNPLPVPL LGCIFTVEGA GLTKDQKSVE VPDPVEAGEQ AKVRVDLLPT 

       670        680        690 
EVGLHKLVVN FECDKLKAVK GYRNVIIGPA 

« Hide

References

[1]"Amino acid sequence of guinea pig liver transglutaminase from its cDNA sequence."
Ikura K., Nasu T.-A., Yokota H., Tsuchiya Y., Sasaki R., Chiba H.
Biochemistry 27:2898-2905(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Structural properties of guinea pig liver transglutaminase."
Connellan J.M., Chung S.I., Whetzel N.K., Bradley L.M., Folk J.E.
J. Biol. Chem. 246:1093-1098(1971) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-5.
Tissue: Liver.
[3]"Determination of amino- and carboxyl-terminal sequences of guinea pig liver transglutaminase: evidence for amino-terminal processing."
Ikura K., Yokota H., Sasaki R., Chiba H.
Biochemistry 28:2344-2348(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-8 AND 684-690, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Liver.
[4]"Cloning of cDNA coding for guinea pig liver transglutaminase."
Ikura K., Nasu T.-A., Yokota H., Sasaki R., Chiba H.
Agric. Biol. Chem. 51:957-961(1987)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 189-632.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M19646 mRNA. Translation: AAA37056.1.
D00114 mRNA. Translation: BAA00068.1.
PIRA29996.

3D structure databases

ProteinModelPortalP08587.
SMRP08587. Positions 15-690.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP08587. 6 interactions.
MINTMINT-1522105.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG004342.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERPTHR11590. PTHR11590. 1 hit.
PfamPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFPIRSF000459. TGM_EBP42. 1 hit.
SMARTSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTGM2_CAVCU
AccessionPrimary (citable) accession number: P08587
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 107 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families