Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P08587

- TGM2_CAVCU

UniProt

P08587 - TGM2_CAVCU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein-glutamine gamma-glutamyltransferase 2

Gene

TGM2

Organism
Cavia cutleri (Guinea pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei277 – 2771PROSITE-ProRule annotation
Active sitei335 – 3351PROSITE-ProRule annotation
Active sitei358 – 3581PROSITE-ProRule annotation
Metal bindingi398 – 3981CalciumBy similarity
Metal bindingi400 – 4001CalciumBy similarity
Metal bindingi446 – 4461CalciumBy similarity
Metal bindingi451 – 4511CalciumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC
  3. transaminase activity Source: MGI

GO - Biological processi

  1. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase 2 (EC:2.3.2.13)
Alternative name(s):
Tissue transglutaminase
Transglutaminase C
Short name:
TG(C)
Short name:
TGC
Short name:
TGase C
Transglutaminase-2
Short name:
TGase-2
Gene namesi
Name:TGM2
OrganismiCavia cutleri (Guinea pig)
Taxonomic identifieri10144 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 690689Protein-glutamine gamma-glutamyltransferase 2PRO_0000213706Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei467 – 4671N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

IntActiP08587. 6 interactions.
MINTiMINT-1522105.

Structurei

3D structure databases

ProteinModelPortaliP08587.
SMRiP08587. Positions 15-690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG004342.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08587-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEDLILERC DLQLEVNGRD HRTADLCRER LVLRRGQPFW LTLHFEGRGY
60 70 80 90 100
EAGVDTLTFN AVTGPDPSEE AGTMARFSLS SAVEGGTWSA SAVDQQDSTV
110 120 130 140 150
SLLLSTPADA PIGLYRLSLE ASTGYQGSSF VLGHFILLYN PRCPADAVYM
160 170 180 190 200
DSDQERQEYV LTQQGFIYQG SAKFINGIPW NFGQFEDGIL DICLMLLDTN
210 220 230 240 250
PKFLKNAGQD CSRRSRPVYV GRVVSAMVNC NDDQGVLQGR WDNNYSDGVS
260 270 280 290 300
PMSWIGSVDI LRRWKDYGCQ RVKYGQCWVF AAVACTVLRC LGIPTRVVTN
310 320 330 340 350
FNSAHDQNSN LLIEYFRNES GEIEGNKSEM IWNFHCWVES WMTRPDLEPG
360 370 380 390 400
YEGWQALDPT PQEKSEGTYC CGPVPVRAIK EGHLNVKYDA PFVFAEVNAD
410 420 430 440 450
VVNWIRQKDG SLRKSINHLV VGLKISTKSV GRDEREDITH TYKYPEGSEE
460 470 480 490 500
EREAFVRANH LNKLATKEEA QEETGVAMRI RVGQNMTMGS DFDIFAYITN
510 520 530 540 550
GTAESHECQL LLCARIVSYN GVLGPVCSTN DLLNLTLDPF SENSIPLHIL
560 570 580 590 600
YEKYGDYLTE SNLIKVRGLL IEPAANSYVL AERDIYLENP EIKIRVLGEP
610 620 630 640 650
KQNRKLIAEV SLKNPLPVPL LGCIFTVEGA GLTKDQKSVE VPDPVEAGEQ
660 670 680 690
AKVRVDLLPT EVGLHKLVVN FECDKLKAVK GYRNVIIGPA
Length:690
Mass (Da):77,141
Last modified:January 23, 2007 - v4
Checksum:i047223D38DBEA4A4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 32AE → EA AA sequence (PubMed:5543674)Curated
Sequence conflicti292 – 2921G → A in BAA00068. 1 PublicationCurated
Sequence conflicti336 – 35419CWVES…GYEGW → SLLGGVVDDQAGPGAWVRGV in BAA00068. 1 PublicationCuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19646 mRNA. Translation: AAA37056.1.
D00114 mRNA. Translation: BAA00068.1.
PIRiA29996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19646 mRNA. Translation: AAA37056.1 .
D00114 mRNA. Translation: BAA00068.1 .
PIRi A29996.

3D structure databases

ProteinModelPortali P08587.
SMRi P08587. Positions 15-690.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P08587. 6 interactions.
MINTi MINT-1522105.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004342.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amino acid sequence of guinea pig liver transglutaminase from its cDNA sequence."
    Ikura K., Nasu T.-A., Yokota H., Tsuchiya Y., Sasaki R., Chiba H.
    Biochemistry 27:2898-2905(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Structural properties of guinea pig liver transglutaminase."
    Connellan J.M., Chung S.I., Whetzel N.K., Bradley L.M., Folk J.E.
    J. Biol. Chem. 246:1093-1098(1971) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-5.
    Tissue: Liver.
  3. "Determination of amino- and carboxyl-terminal sequences of guinea pig liver transglutaminase: evidence for amino-terminal processing."
    Ikura K., Yokota H., Sasaki R., Chiba H.
    Biochemistry 28:2344-2348(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-8 AND 684-690, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Liver.
  4. "Cloning of cDNA coding for guinea pig liver transglutaminase."
    Ikura K., Nasu T.-A., Yokota H., Sasaki R., Chiba H.
    Agric. Biol. Chem. 51:957-961(1987)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 189-632.
    Tissue: Liver.

Entry informationi

Entry nameiTGM2_CAVCU
AccessioniPrimary (citable) accession number: P08587
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 110 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3