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Protein

Protein-glutamine gamma-glutamyltransferase 2

Gene

TGM2

Organism
Cavia cutleri (Guinea pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Catalytic activityi

A protein-L-glutamine + a protein-L-lysine = a protein with an N6-(gamma-glutamyl)-L-lysine cross-link + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei277PROSITE-ProRule annotation1
Active sitei335PROSITE-ProRule annotation1
Active sitei358PROSITE-ProRule annotation1
Metal bindingi398CalciumBy similarity1
Metal bindingi400CalciumBy similarity1
Metal bindingi446CalciumBy similarity1
Metal bindingi451CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase 2 (EC:2.3.2.13)
Alternative name(s):
Tissue transglutaminase
Transglutaminase C
Short name:
TG(C)
Short name:
TGC
Short name:
TGase C
Transglutaminase-2
Short name:
TGase-2
Gene namesi
Name:TGM2
OrganismiCavia cutleri (Guinea pig)
Taxonomic identifieri10144 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00002137062 – 690Protein-glutamine gamma-glutamyltransferase 2Add BLAST689

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei467N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

PTM databases

iPTMnetiP08587

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

IntActiP08587, 6 interactors
MINTiP08587

Chemistry databases

BindingDBiP08587

Structurei

3D structure databases

ProteinModelPortaliP08587
SMRiP08587
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG004342

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.90.260.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002931 Transglutaminase-like
IPR036985 Transglutaminase-like_sf
IPR023608 Transglutaminase_animal
IPR013808 Transglutaminase_AS
IPR008958 Transglutaminase_C
IPR036238 Transglutaminase_C_sf
IPR001102 Transglutaminase_N
PfamiView protein in Pfam
PF00927 Transglut_C, 2 hits
PF01841 Transglut_core, 1 hit
PF00868 Transglut_N, 1 hit
PIRSFiPIRSF000459 TGM_EBP42, 1 hit
SMARTiView protein in SMART
SM00460 TGc, 1 hit
SUPFAMiSSF49309 SSF49309, 2 hits
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00547 TRANSGLUTAMINASES, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08587-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDLILERC DLQLEVNGRD HRTADLCRER LVLRRGQPFW LTLHFEGRGY
60 70 80 90 100
EAGVDTLTFN AVTGPDPSEE AGTMARFSLS SAVEGGTWSA SAVDQQDSTV
110 120 130 140 150
SLLLSTPADA PIGLYRLSLE ASTGYQGSSF VLGHFILLYN PRCPADAVYM
160 170 180 190 200
DSDQERQEYV LTQQGFIYQG SAKFINGIPW NFGQFEDGIL DICLMLLDTN
210 220 230 240 250
PKFLKNAGQD CSRRSRPVYV GRVVSAMVNC NDDQGVLQGR WDNNYSDGVS
260 270 280 290 300
PMSWIGSVDI LRRWKDYGCQ RVKYGQCWVF AAVACTVLRC LGIPTRVVTN
310 320 330 340 350
FNSAHDQNSN LLIEYFRNES GEIEGNKSEM IWNFHCWVES WMTRPDLEPG
360 370 380 390 400
YEGWQALDPT PQEKSEGTYC CGPVPVRAIK EGHLNVKYDA PFVFAEVNAD
410 420 430 440 450
VVNWIRQKDG SLRKSINHLV VGLKISTKSV GRDEREDITH TYKYPEGSEE
460 470 480 490 500
EREAFVRANH LNKLATKEEA QEETGVAMRI RVGQNMTMGS DFDIFAYITN
510 520 530 540 550
GTAESHECQL LLCARIVSYN GVLGPVCSTN DLLNLTLDPF SENSIPLHIL
560 570 580 590 600
YEKYGDYLTE SNLIKVRGLL IEPAANSYVL AERDIYLENP EIKIRVLGEP
610 620 630 640 650
KQNRKLIAEV SLKNPLPVPL LGCIFTVEGA GLTKDQKSVE VPDPVEAGEQ
660 670 680 690
AKVRVDLLPT EVGLHKLVVN FECDKLKAVK GYRNVIIGPA
Length:690
Mass (Da):77,141
Last modified:January 23, 2007 - v4
Checksum:i047223D38DBEA4A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3AE → EA AA sequence (PubMed:5543674).Curated2
Sequence conflicti292G → A in BAA00068 (Ref. 4) Curated1
Sequence conflicti336 – 354CWVES…GYEGW → SLLGGVVDDQAGPGAWVRGV in BAA00068 (Ref. 4) CuratedAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19646 mRNA Translation: AAA37056.1
D00114 mRNA Translation: BAA00068.1
PIRiA29996

Similar proteinsi

Entry informationi

Entry nameiTGM2_CAVCU
AccessioniPrimary (citable) accession number: P08587
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 127 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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