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Protein

Melanotransferrin

Gene

MELTF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi78Iron 1PROSITE-ProRule annotation1
Metal bindingi107Iron 1PROSITE-ProRule annotation1
Binding sitei132Carbonate 1PROSITE-ProRule annotation1
Binding sitei136Carbonate 1PROSITE-ProRule annotation1
Binding sitei138Carbonate 1; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei139Carbonate 1; via amide nitrogenPROSITE-ProRule annotation1
Metal bindingi210Iron 1PROSITE-ProRule annotation1
Metal bindingi279Iron 1PROSITE-ProRule annotation1
Metal bindingi421Iron 2PROSITE-ProRule annotation1
Metal bindingi451Iron 2PROSITE-ProRule annotation1
Metal bindingi556Iron 2PROSITE-ProRule annotation1
Metal bindingi625Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

  • iron ion binding Source: UniProtKB

GO - Biological processi

  • cellular protein metabolic process Source: Reactome
  • iron ion homeostasis Source: UniProtKB-KW
  • iron ion import Source: UniProtKB
  • negative regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
  • positive regulation of extracellular matrix disassembly Source: UniProtKB
  • positive regulation of plasminogen activation Source: UniProtKB
  • post-translational protein modification Source: Reactome

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiS60.973

Names & Taxonomyi

Protein namesi
Recommended name:
MelanotransferrinImported
Alternative name(s):
Melanoma-associated antigen p97
CD_antigen: CD228
Gene namesi
Name:MELTFImported
Synonyms:MAP97, MFI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163975.11
HGNCiHGNC:7037 MELTF
MIMi155750 gene
neXtProtiNX_P08582

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4241
OpenTargetsiENSG00000163975
PharmGKBiPA30774

Polymorphism and mutation databases

BioMutaiMFI2
DMDMi338817914

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000003573920 – 709MelanotransferrinSequence analysisAdd BLAST690
PropeptideiPRO_0000035740710 – 738Removed in mature formSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 63PROSITE-ProRule annotation
Disulfide bondi36 ↔ 54PROSITE-ProRule annotation
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi130 ↔ 216PROSITE-ProRule annotation
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi172 ↔ 189PROSITE-ProRule annotation
Disulfide bondi186 ↔ 199PROSITE-ProRule annotation
Disulfide bondi257 ↔ 271PROSITE-ProRule annotation
Modified residuei462Phosphoserine; by FAM20C1 Publication1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi709GPI-anchor amidated cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

EPDiP08582
MaxQBiP08582
PaxDbiP08582
PeptideAtlasiP08582
PRIDEiP08582

PTM databases

iPTMnetiP08582
PhosphoSitePlusiP08582

Expressioni

Tissue specificityi

Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts.

Gene expression databases

BgeeiENSG00000163975
CleanExiHS_MFI2
ExpressionAtlasiP08582 baseline and differential
GenevisibleiP08582 HS

Organism-specific databases

HPAiHPA004880

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110399, 5 interactors
IntActiP08582, 6 interactors
MINTiP08582
STRINGi9606.ENSP00000296350

Structurei

3D structure databases

ProteinModelPortaliP08582
SMRiP08582
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 357Transferrin-like 1PROSITE-ProRule annotationAdd BLAST335
Domaini366 – 706Transferrin-like 2PROSITE-ProRule annotationAdd BLAST341

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 30Antigenic epitopeAdd BLAST11

Sequence similaritiesi

Belongs to the transferrin family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEAI Eukaryota
ENOG410XQ36 LUCA
GeneTreeiENSGT00390000001619
HOGENOMiHOG000043759
HOVERGENiHBG000055
InParanoidiP08582
KOiK06569
OMAiGRNKCVG
OrthoDBiEOG091G0242
PhylomeDBiP08582
TreeFamiTF324013

Family and domain databases

InterProiView protein in InterPro
IPR016357 Transferrin
IPR001156 Transferrin-like_dom
IPR018195 Transferrin_Fe_BS
PfamiView protein in Pfam
PF00405 Transferrin, 2 hits
PIRSFiPIRSF002549 Transferrin, 1 hit
PRINTSiPR00422 TRANSFERRIN
SMARTiView protein in SMART
SM00094 TR_FER, 2 hits
PROSITEiView protein in PROSITE
PS00205 TRANSFERRIN_LIKE_1, 2 hits
PS00206 TRANSFERRIN_LIKE_2, 2 hits
PS00207 TRANSFERRIN_LIKE_3, 2 hits
PS51408 TRANSFERRIN_LIKE_4, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P08582-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGPSGALWL LLALRTVLGG MEVRWCATSD PEQHKCGNMS EAFREAGIQP
60 70 80 90 100
SLLCVRGTSA DHCVQLIAAQ EADAITLDGG AIYEAGKEHG LKPVVGEVYD
110 120 130 140 150
QEVGTSYYAV AVVRRSSHVT IDTLKGVKSC HTGINRTVGW NVPVGYLVES
160 170 180 190 200
GRLSVMGCDV LKAVSDYFGG SCVPGAGETS YSESLCRLCR GDSSGEGVCD
210 220 230 240 250
KSPLERYYDY SGAFRCLAEG AGDVAFVKHS TVLENTDGKT LPSWGQALLS
260 270 280 290 300
QDFELLCRDG SRADVTEWRQ CHLARVPAHA VVVRADTDGG LIFRLLNEGQ
310 320 330 340 350
RLFSHEGSSF QMFSSEAYGQ KDLLFKDSTS ELVPIATQTY EAWLGHEYLH
360 370 380 390 400
AMKGLLCDPN RLPPYLRWCV LSTPEIQKCG DMAVAFRRQR LKPEIQCVSA
410 420 430 440 450
KSPQHCMERI QAEQVDAVTL SGEDIYTAGK TYGLVPAAGE HYAPEDSSNS
460 470 480 490 500
YYVVAVVRRD SSHAFTLDEL RGKRSCHAGF GSPAGWDVPV GALIQRGFIR
510 520 530 540 550
PKDCDVLTAV SEFFNASCVP VNNPKNYPSS LCALCVGDEQ GRNKCVGNSQ
560 570 580 590 600
ERYYGYRGAF RCLVENAGDV AFVRHTTVFD NTNGHNSEPW AAELRSEDYE
610 620 630 640 650
LLCPNGARAE VSQFAACNLA QIPPHAVMVR PDTNIFTVYG LLDKAQDLFG
660 670 680 690 700
DDHNKNGFKM FDSSNYHGQD LLFKDATVRA VPVGEKTTYR GWLGLDYVAA
710 720 730
LEGMSSQQCS GAAAPAPGAP LLPLLLPALA ARLLPPAL
Length:738
Mass (Da):80,215
Last modified:June 28, 2011 - v2
Checksum:iB0F08B708D2A0A0F
GO
Isoform 2 (identifier: P08582-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-302: GKTLPSWGQA...FRLLNEGQRL → ESPSRRQTWT...KRAKSRDMLG
     303-738: Missing.

Note: No experimental confirmation available.
Show »
Length:302
Mass (Da):32,723
Checksum:i0D51C8347D9EBD8F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti431T → K in AAA59992 (PubMed:2419904).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020413294R → W. Corresponds to variant dbSNP:rs2276790Ensembl.1
Natural variantiVAR_057304559A → T. Corresponds to variant dbSNP:rs17129219Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006557238 – 302GKTLP…EGQRL → ESPSRRQTWTRSEEEEGECP AHEEARRTMRSSAGQAWKWA PVHRPQDESDKGEFGKRAKS RDMLG in isoform 2. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_006558303 – 738Missing in isoform 2. 1 PublicationAdd BLAST436

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12154 mRNA Translation: AAA59992.1
AC068302 Genomic DNA No translation available.
BC001875 mRNA Translation: AAH01875.1
BC002623 mRNA Translation: AAH02623.1
BC007550 mRNA Translation: AAH07550.1
BC071910 mRNA Translation: AAH71910.1
CCDSiCCDS3325.1 [P08582-1]
CCDS3326.1 [P08582-2]
PIRiA23814 TFHUM
RefSeqiNP_005920.2, NM_005929.5 [P08582-1]
NP_201573.1, NM_033316.3 [P08582-2]
UniGeneiHs.184727

Genome annotation databases

EnsembliENST00000296350; ENSP00000296350; ENSG00000163975 [P08582-1]
ENST00000296351; ENSP00000296351; ENSG00000163975 [P08582-2]
GeneIDi4241
KEGGihsa:4241
UCSCiuc003fxk.5 human [P08582-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRFM_HUMAN
AccessioniPrimary (citable) accession number: P08582
Secondary accession number(s): Q9BQE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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