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Protein

U2 small nuclear ribonucleoprotein B''

Gene

SNRPB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A' protein.

GO - Molecular functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125870-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U2 small nuclear ribonucleoprotein B''
Short name:
U2 snRNP B''
Gene namesi
Name:SNRPB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:11155. SNRPB2.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: UniProtKB
  • nucleolus Source: HPA
  • nucleoplasm Source: HPA
  • spliceosomal complex Source: HGNC
  • U2 snRNP Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125870.
PharmGKBiPA35996.

Polymorphism and mutation databases

BioMutaiSNRPB2.
DMDMi134095.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818921 – 225U2 small nuclear ribonucleoprotein B''Add BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei111N6-acetyllysineBy similarity1
Modified residuei151PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP08579.
MaxQBiP08579.
PaxDbiP08579.
PeptideAtlasiP08579.
PRIDEiP08579.
TopDownProteomicsiP08579.

PTM databases

iPTMnetiP08579.
PhosphoSitePlusiP08579.

Expressioni

Gene expression databases

BgeeiENSG00000125870.
CleanExiHS_SNRPB2.
GenevisibleiP08579. HS.

Organism-specific databases

HPAiHPA050814.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Present in a spliceosome complex assembled in vitro, and composed of SNRPB2, HPRP8BP and CRNKL1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GABPB1Q065473EBI-1053651,EBI-618165
GOLGA2Q083793EBI-1053651,EBI-618309
HMBOX1Q6NT763EBI-1053651,EBI-2549423
HOMEZQ8IX15-33EBI-1053651,EBI-10172004
MCM6Q145663EBI-1053651,EBI-374900
MTUS2Q5JR593EBI-1053651,EBI-742948
PNMA1Q8ND905EBI-1053651,EBI-302345
SNRPA1P096612EBI-1053651,EBI-876439
TRIM27P143735EBI-1053651,EBI-719493
ZBTB14O438295EBI-1053651,EBI-10176632

Protein-protein interaction databases

BioGridi112513. 65 interactors.
IntActiP08579. 31 interactors.
MINTiMINT-156501.
STRINGi9606.ENSP00000246071.

Structurei

Secondary structure

1225
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 13Combined sources7
Helixi20 – 32Combined sources13
Beta strandi37 – 41Combined sources5
Turni46 – 50Combined sources5
Beta strandi52 – 58Combined sources7
Helixi59 – 68Combined sources10
Beta strandi80 – 83Combined sources4
Helixi89 – 95Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A9NX-ray2.38B/D1-96[»]
ProteinModelPortaliP08579.
SMRiP08579.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08579.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 86RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini151 – 225RRM 2PROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Belongs to the RRM U1 A/B'' family.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4206. Eukaryota.
ENOG410XPZI. LUCA.
GeneTreeiENSGT00390000007046.
HOGENOMiHOG000217519.
HOVERGENiHBG000895.
KOiK11094.
OMAiMRGTYGD.
OrthoDBiEOG091G0NFU.
PhylomeDBiP08579.
TreeFamiTF313834.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIRPNHTIY INNMNDKIKK EELKRSLYAL FSQFGHVVDI VALKTMKMRG
60 70 80 90 100
QAFVIFKELG SSTNALRQLQ GFPFYGKPMR IQYAKTDSDI ISKMRGTFAD
110 120 130 140 150
KEKKKEKKKA KTVEQTATTT NKKPGQGTPN SANTQGNSTP NPQVPDYPPN
160 170 180 190 200
YILFLNNLPE ETNEMMLSML FNQFPGFKEV RLVPGRHDIA FVEFENDGQA
210 220
GAARDALQGF KITPSHAMKI TYAKK
Length:225
Mass (Da):25,486
Last modified:August 1, 1988 - v1
Checksum:i67C949CC7E14A92A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03548719K → Q in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15841 mRNA. Translation: AAA36796.1.
AK313004 mRNA. Translation: BAG35840.1.
AL034428 Genomic DNA. Translation: CAB38777.2.
CH471133 Genomic DNA. Translation: EAX10284.1.
CH471133 Genomic DNA. Translation: EAX10285.1.
BC018022 mRNA. Translation: AAH18022.1.
BC036737 mRNA. Translation: AAH36737.1.
CCDSiCCDS13123.1.
PIRiA25910.
RefSeqiNP_003083.1. NM_003092.4.
NP_937863.1. NM_198220.2.
UniGeneiHs.280378.

Genome annotation databases

EnsembliENST00000246071; ENSP00000246071; ENSG00000125870.
ENST00000377943; ENSP00000367178; ENSG00000125870.
GeneIDi6629.
KEGGihsa:6629.
UCSCiuc002wph.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15841 mRNA. Translation: AAA36796.1.
AK313004 mRNA. Translation: BAG35840.1.
AL034428 Genomic DNA. Translation: CAB38777.2.
CH471133 Genomic DNA. Translation: EAX10284.1.
CH471133 Genomic DNA. Translation: EAX10285.1.
BC018022 mRNA. Translation: AAH18022.1.
BC036737 mRNA. Translation: AAH36737.1.
CCDSiCCDS13123.1.
PIRiA25910.
RefSeqiNP_003083.1. NM_003092.4.
NP_937863.1. NM_198220.2.
UniGeneiHs.280378.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A9NX-ray2.38B/D1-96[»]
ProteinModelPortaliP08579.
SMRiP08579.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112513. 65 interactors.
IntActiP08579. 31 interactors.
MINTiMINT-156501.
STRINGi9606.ENSP00000246071.

PTM databases

iPTMnetiP08579.
PhosphoSitePlusiP08579.

Polymorphism and mutation databases

BioMutaiSNRPB2.
DMDMi134095.

Proteomic databases

EPDiP08579.
MaxQBiP08579.
PaxDbiP08579.
PeptideAtlasiP08579.
PRIDEiP08579.
TopDownProteomicsiP08579.

Protocols and materials databases

DNASUi6629.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246071; ENSP00000246071; ENSG00000125870.
ENST00000377943; ENSP00000367178; ENSG00000125870.
GeneIDi6629.
KEGGihsa:6629.
UCSCiuc002wph.3. human.

Organism-specific databases

CTDi6629.
GeneCardsiSNRPB2.
HGNCiHGNC:11155. SNRPB2.
HPAiHPA050814.
MIMi603520. gene.
neXtProtiNX_P08579.
OpenTargetsiENSG00000125870.
PharmGKBiPA35996.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4206. Eukaryota.
ENOG410XPZI. LUCA.
GeneTreeiENSGT00390000007046.
HOGENOMiHOG000217519.
HOVERGENiHBG000895.
KOiK11094.
OMAiMRGTYGD.
OrthoDBiEOG091G0NFU.
PhylomeDBiP08579.
TreeFamiTF313834.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125870-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiSNRPB2. human.
EvolutionaryTraceiP08579.
GeneWikiiSNRPB2.
GenomeRNAii6629.
PROiP08579.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125870.
CleanExiHS_SNRPB2.
GenevisibleiP08579. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRU2B_HUMAN
AccessioniPrimary (citable) accession number: P08579
Secondary accession number(s): B2R7J3, D3DW21, Q9UJD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 30, 2016
This is version 179 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Patients with systemic lupus erythematosus produce antibodies which interact with snRNP proteins.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.