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Protein

60S acidic ribosomal protein P1

Gene

RpLP1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the elongation step of protein synthesis.

GO - Molecular functioni

  • protein kinase activator activity Source: GO_Central
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • cytoplasmic translation Source: FlyBase
  • positive regulation of protein kinase activity Source: GO_Central
  • translational elongation Source: InterPro

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S acidic ribosomal protein P1
Alternative name(s):
Acidic ribosomal protein RPA2
RP21C
Gene namesi
Name:RpLP1
Synonyms:M(2)21C, rp21C, RPA2, RpP2
ORF Names:CG4087
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0002593. RpLP1.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: FlyBase
  • cytosolic ribosome Source: FlyBase
  • ribosome Source: FlyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001576921 – 11260S acidic ribosomal protein P1Add BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei99Phosphoserine1 Publication1
Modified residuei102Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP08570.
PRIDEiP08570.

PTM databases

iPTMnetiP08570.

Expressioni

Gene expression databases

BgeeiFBgn0002593.
ExpressionAtlasiP08570. differential.
GenevisibleiP08570. DM.

Interactioni

Subunit structurei

P1 and P2 exist as dimers at the large ribosomal subunit.

Protein-protein interaction databases

BioGridi59470. 45 interactors.
DIPiDIP-18310N.
IntActiP08570. 11 interactors.
MINTiMINT-332892.
STRINGi7227.FBpp0304265.

Structurei

3D structure databases

ProteinModelPortaliP08570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1762. Eukaryota.
COG2058. LUCA.
InParanoidiP08570.
KOiK02942.
OMAiQELLCTY.
OrthoDBiEOG091G17EU.
PhylomeDBiP08570.

Family and domain databases

HAMAPiMF_01478. Ribosomal_L12_arch. 1 hit.
InterProiView protein in InterPro
IPR027534. Ribosomal_L12.

Sequencei

Sequence statusi: Complete.

P08570-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKAELACV YASLILVDDD VAVTGEKINT ILKAANVEVE PYWPGLFAKA
60 70 80 90 100
LEGINVKDLI TNIGSGVGAA PAGGAAPAAA AAAPAAESKK EEKKKEEESD
110
QSDDDMGFGL FD
Length:112
Mass (Da):11,513
Last modified:February 1, 1996 - v2
Checksum:i2EA9CA3E884A7CCF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9C → S in CAA68557 (PubMed:3122177).Curated1
Sequence conflicti53G → A in CAA68557 (PubMed:3122177).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00504 mRNA. Translation: CAA68557.1.
S62170 mRNA. Translation: AAB26902.1.
AE014134 Genomic DNA. Translation: AAF51499.1.
AY069125 mRNA. Translation: AAL39270.1.
PIRiS00659. R5FF2E.
RefSeqiNP_001259822.1. NM_001272893.1.
NP_476630.1. NM_057282.4.
UniGeneiDm.2270.

Genome annotation databases

EnsemblMetazoaiFBtr0078056; FBpp0077716; FBgn0002593.
FBtr0331932; FBpp0304265; FBgn0002593.
GeneIDi33214.
KEGGidme:Dmel_CG4087.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRLA1_DROME
AccessioniPrimary (citable) accession number: P08570
Secondary accession number(s): Q9VPP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 1, 1996
Last modified: July 5, 2017
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families