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P08567

- PLEK_HUMAN

UniProt

P08567 - PLEK_HUMAN

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Protein

Pleckstrin

Gene

PLEK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Major protein kinase C substrate of platelets.

GO - Molecular functioni

  1. phosphatidylinositol-3,4-bisphosphate binding Source: BHF-UCL
  2. protein homodimerization activity Source: BHF-UCL
  3. protein kinase C binding Source: BHF-UCL

GO - Biological processi

  1. actin cytoskeleton reorganization Source: BHF-UCL
  2. blood coagulation Source: Reactome
  3. cell projection organization Source: BHF-UCL
  4. cortical actin cytoskeleton organization Source: BHF-UCL
  5. hematopoietic progenitor cell differentiation Source: BHF-UCL
  6. integrin-mediated signaling pathway Source: BHF-UCL
  7. negative regulation of calcium-mediated signaling Source: BHF-UCL
  8. negative regulation of G-protein coupled receptor protein signaling pathway Source: BHF-UCL
  9. negative regulation of inositol phosphate biosynthetic process Source: BHF-UCL
  10. phosphatidylinositol metabolic process Source: BHF-UCL
  11. phospholipase C-inhibiting G-protein coupled receptor signaling pathway Source: BHF-UCL
  12. platelet activation Source: Reactome
  13. platelet aggregation Source: UniProtKB
  14. platelet degranulation Source: BHF-UCL
  15. positive regulation of actin filament bundle assembly Source: BHF-UCL
  16. positive regulation of actin filament depolymerization Source: BHF-UCL
  17. positive regulation of inositol-polyphosphate 5-phosphatase activity Source: BHF-UCL
  18. positive regulation of integrin activation Source: BHF-UCL
  19. positive regulation of platelet activation Source: BHF-UCL
  20. protein kinase C signaling Source: BHF-UCL
  21. protein secretion by platelet Source: BHF-UCL
  22. regulation of cell diameter Source: BHF-UCL
  23. ruffle organization Source: BHF-UCL
  24. thrombin receptor signaling pathway Source: BHF-UCL
  25. vesicle docking involved in exocytosis Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin
Alternative name(s):
Platelet 47 kDa protein
Short name:
p47
Gene namesi
Name:PLEK
Synonyms:P47
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:9070. PLEK.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. cytosol Source: Reactome
  3. extracellular region Source: Reactome
  4. membrane Source: UniProtKB
  5. ruffle membrane Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33400.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350PleckstrinPRO_0000053859Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641N6-acetyllysine1 Publication
Modified residuei113 – 1131Phosphoserine; by PKC1 Publication
Modified residuei117 – 1171Phosphoserine; by PKC2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP08567.
PaxDbiP08567.
PRIDEiP08567.

2D gel databases

OGPiP08567.

PTM databases

PhosphoSiteiP08567.

Expressioni

Gene expression databases

BgeeiP08567.
CleanExiHS_PLEK.
GenevestigatoriP08567.

Organism-specific databases

HPAiHPA031838.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
INPP5AQ146424EBI-2565501,EBI-8670520
SDPRO958104EBI-2565501,EBI-742141

Protein-protein interaction databases

BioGridi111357. 1 interaction.
IntActiP08567. 9 interactions.
MINTiMINT-8216753.
STRINGi9606.ENSP00000234313.

Structurei

Secondary structure

1
350
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 1914
Beta strandi22 – 298
Beta strandi32 – 387
Beta strandi45 – 528
Beta strandi55 – 584
Beta strandi65 – 739
Turni74 – 763
Beta strandi77 – 826
Helixi86 – 10318
Helixi126 – 1338
Beta strandi135 – 1406
Beta strandi143 – 1475
Beta strandi155 – 1573
Helixi158 – 16710
Beta strandi168 – 1703
Helixi174 – 18714
Beta strandi189 – 1946
Helixi195 – 2006
Beta strandi215 – 2184
Beta strandi220 – 2223
Beta strandi226 – 2283
Helixi239 – 2413
Beta strandi245 – 25410
Turni256 – 2583
Beta strandi261 – 2699
Turni270 – 2734
Beta strandi274 – 2785
Beta strandi280 – 2823
Beta strandi287 – 2915
Beta strandi296 – 3005
Beta strandi306 – 3083
Beta strandi313 – 3186
Beta strandi324 – 3285
Helixi332 – 34615

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PLSNMR-A1-105[»]
1W4MNMR-A121-223[»]
1X05NMR-A235-350[»]
1XX0NMR-A234-350[»]
1ZM0X-ray2.10A/B240-350[»]
2CSONMR-A116-229[»]
2I5CX-ray1.75A/B/C244-347[»]
2I5FX-ray1.35A244-347[»]
ProteinModelPortaliP08567.
SMRiP08567. Positions 1-105, 118-230, 234-350.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08567.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 10198PH 1PROSITE-ProRule annotationAdd
BLAST
Domaini136 – 22186DEPPROSITE-ProRule annotationAdd
BLAST
Domaini244 – 347104PH 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG44162.
GeneTreeiENSGT00390000006543.
HOGENOMiHOG000294078.
HOVERGENiHBG001361.
InParanoidiP08567.
OMAiYYFADSG.
OrthoDBiEOG74XS6R.
PhylomeDBiP08567.
TreeFamiTF332246.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR000591. DEP_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00169. PH. 2 hits.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
PROSITEiPS50186. DEP. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08567-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPKRIREGY LVKKGSVFNT WKPMWVVLLE DGIEFYKKKS DNSPKGMIPL
60 70 80 90 100
KGSTLTSPCQ DFGKRMFVFK ITTTKQQDHF FQAAFLEERD AWVRDIKKAI
110 120 130 140 150
KCIEGGQKFA RKSTRRSIRL PETIDLGALY LSMKDTEKGI KELNLEKDKK
160 170 180 190 200
IFNHCFTGNC VIDWLVSNQS VRNRQEGLMI ASSLLNEGYL QPAGDMSKSA
210 220 230 240 250
VDGTAENPFL DNPDAFYYFP DSGFFCEENS SDDDVILKEE FRGVIIKQGC
260 270 280 290 300
LLKQGHRRKN WKVRKFILRE DPAYLHYYDP AGAEDPLGAI HLRGCVVTSV
310 320 330 340 350
ESNSNGRKSE EENLFEIITA DEVHYFLQAA TPKERTEWIR AIQMASRTGK
Length:350
Mass (Da):40,125
Last modified:January 11, 2011 - v3
Checksum:i2E292CB18B533261
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti284 – 2841E → G in CAG46876. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51R → W.
Corresponds to variant rs17035364 [ dbSNP | Ensembl ].
VAR_027797
Natural varianti92 – 921W → R.
VAR_005524
Natural varianti97 – 971K → N.2 Publications
Corresponds to variant rs3816281 [ dbSNP | Ensembl ].
VAR_027798
Natural varianti108 – 1081K → Q.
Corresponds to variant rs34515106 [ dbSNP | Ensembl ].
VAR_056666
Natural varianti340 – 3401R → K.4 Publications
Corresponds to variant rs1063479 [ dbSNP | Ensembl ].
VAR_027799

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07743 mRNA. Translation: CAA30564.1.
CR542056 mRNA. Translation: CAG46853.1.
CR542079 mRNA. Translation: CAG46876.1.
AK313756 mRNA. Translation: BAG36495.1.
AC015969 Genomic DNA. Translation: AAX93121.1.
CH471053 Genomic DNA. Translation: EAW99876.1.
BC018549 mRNA. Translation: AAH18549.1.
CCDSiCCDS1887.1.
PIRiS00755.
RefSeqiNP_002655.2. NM_002664.2.
UniGeneiHs.468840.

Genome annotation databases

EnsembliENST00000234313; ENSP00000234313; ENSG00000115956.
GeneIDi5341.
KEGGihsa:5341.
UCSCiuc002sen.4. human.

Polymorphism databases

DMDMi317373523.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07743 mRNA. Translation: CAA30564.1 .
CR542056 mRNA. Translation: CAG46853.1 .
CR542079 mRNA. Translation: CAG46876.1 .
AK313756 mRNA. Translation: BAG36495.1 .
AC015969 Genomic DNA. Translation: AAX93121.1 .
CH471053 Genomic DNA. Translation: EAW99876.1 .
BC018549 mRNA. Translation: AAH18549.1 .
CCDSi CCDS1887.1.
PIRi S00755.
RefSeqi NP_002655.2. NM_002664.2.
UniGenei Hs.468840.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1PLS NMR - A 1-105 [» ]
1W4M NMR - A 121-223 [» ]
1X05 NMR - A 235-350 [» ]
1XX0 NMR - A 234-350 [» ]
1ZM0 X-ray 2.10 A/B 240-350 [» ]
2CSO NMR - A 116-229 [» ]
2I5C X-ray 1.75 A/B/C 244-347 [» ]
2I5F X-ray 1.35 A 244-347 [» ]
ProteinModelPortali P08567.
SMRi P08567. Positions 1-105, 118-230, 234-350.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111357. 1 interaction.
IntActi P08567. 9 interactions.
MINTi MINT-8216753.
STRINGi 9606.ENSP00000234313.

PTM databases

PhosphoSitei P08567.

Polymorphism databases

DMDMi 317373523.

2D gel databases

OGPi P08567.

Proteomic databases

MaxQBi P08567.
PaxDbi P08567.
PRIDEi P08567.

Protocols and materials databases

DNASUi 5341.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000234313 ; ENSP00000234313 ; ENSG00000115956 .
GeneIDi 5341.
KEGGi hsa:5341.
UCSCi uc002sen.4. human.

Organism-specific databases

CTDi 5341.
GeneCardsi GC02P068504.
H-InvDB HIX0002122.
HGNCi HGNC:9070. PLEK.
HPAi HPA031838.
MIMi 173570. gene.
neXtProti NX_P08567.
PharmGKBi PA33400.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44162.
GeneTreei ENSGT00390000006543.
HOGENOMi HOG000294078.
HOVERGENi HBG001361.
InParanoidi P08567.
OMAi YYFADSG.
OrthoDBi EOG74XS6R.
PhylomeDBi P08567.
TreeFami TF332246.

Miscellaneous databases

EvolutionaryTracei P08567.
GenomeRNAii 5341.
NextBioi 20702.
PROi P08567.
SOURCEi Search...

Gene expression databases

Bgeei P08567.
CleanExi HS_PLEK.
Genevestigatori P08567.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.30.29.30. 2 hits.
InterProi IPR000591. DEP_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00610. DEP. 1 hit.
PF00169. PH. 2 hits.
[Graphical view ]
SMARTi SM00049. DEP. 1 hit.
SM00233. PH. 2 hits.
[Graphical view ]
PROSITEi PS50186. DEP. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of the major protein kinase C substrate of platelets."
    Tyers M., Rachubinski R.A., McCaw M.L., Varrichio A.M., Shorr R.G.L., Haslam R.J., Harley C.B.
    Nature 333:470-473(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASN-97 AND LYS-340.
  2. "Molecular analysis of pleckstrin: the major protein kinase C substrate of platelets."
    Tyers M., Haslam R.J., Rachubinski R.A., Harley C.B.
    J. Cell. Biochem. 40:133-145(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASN-97 AND LYS-340.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-340.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-340.
    Tissue: Lymph.
  8. "Phosphorylation of human pleckstrin on Ser-113 and Ser-117 by protein kinase C."
    Craig K.L., Harley C.B.
    Biochem. J. 314:937-942(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-113 AND SER-117.
  9. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
    Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
    J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: T-cell.
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-64, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: STRUCTURE BY NMR OF 1-105.
  13. "Structure and dynamics of the human pleckstrin DEP domain: distinct molecular features of a novel DEP domain subfamily."
    Civera C., Simon B., Stier G., Sattler M., Macias M.J.
    Proteins 58:354-366(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 121-223.
  14. "Solution structure of the DEP domain and of the C-terminal PH domain of human pleckstrin."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 116-350.

Entry informationi

Entry nameiPLEK_HUMAN
AccessioniPrimary (citable) accession number: P08567
Secondary accession number(s): B2R9E8
, Q53SU8, Q6FGM8, Q6FGQ1, Q8WV81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 160 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3