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P08567

- PLEK_HUMAN

UniProt

P08567 - PLEK_HUMAN

Protein

Pleckstrin

Gene

PLEK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 159 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Major protein kinase C substrate of platelets.

    GO - Molecular functioni

    1. phosphatidylinositol-3,4-bisphosphate binding Source: BHF-UCL
    2. protein binding Source: IntAct
    3. protein homodimerization activity Source: BHF-UCL
    4. protein kinase C binding Source: BHF-UCL

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: BHF-UCL
    2. blood coagulation Source: Reactome
    3. cell projection organization Source: BHF-UCL
    4. cortical actin cytoskeleton organization Source: BHF-UCL
    5. hematopoietic progenitor cell differentiation Source: BHF-UCL
    6. integrin-mediated signaling pathway Source: BHF-UCL
    7. negative regulation of calcium-mediated signaling Source: BHF-UCL
    8. negative regulation of G-protein coupled receptor protein signaling pathway Source: BHF-UCL
    9. negative regulation of inositol phosphate biosynthetic process Source: BHF-UCL
    10. phosphatidylinositol metabolic process Source: BHF-UCL
    11. phospholipase C-inhibiting G-protein coupled receptor signaling pathway Source: BHF-UCL
    12. platelet activation Source: Reactome
    13. platelet aggregation Source: BHF-UCL
    14. platelet degranulation Source: BHF-UCL
    15. positive regulation of actin filament bundle assembly Source: BHF-UCL
    16. positive regulation of actin filament depolymerization Source: BHF-UCL
    17. positive regulation of inositol-polyphosphate 5-phosphatase activity Source: BHF-UCL
    18. positive regulation of integrin activation Source: BHF-UCL
    19. positive regulation of platelet activation Source: BHF-UCL
    20. protein kinase C signaling Source: BHF-UCL
    21. protein secretion by platelet Source: BHF-UCL
    22. regulation of cell diameter Source: BHF-UCL
    23. ruffle organization Source: BHF-UCL
    24. thrombin receptor signaling pathway Source: BHF-UCL
    25. vesicle docking involved in exocytosis Source: BHF-UCL

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pleckstrin
    Alternative name(s):
    Platelet 47 kDa protein
    Short name:
    p47
    Gene namesi
    Name:PLEK
    Synonyms:P47
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:9070. PLEK.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. cytosol Source: Reactome
    3. extracellular region Source: Reactome
    4. membrane Source: UniProtKB
    5. ruffle membrane Source: BHF-UCL

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33400.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350PleckstrinPRO_0000053859Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei64 – 641N6-acetyllysine1 Publication
    Modified residuei113 – 1131Phosphoserine; by PKC1 Publication
    Modified residuei117 – 1171Phosphoserine; by PKC2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP08567.
    PaxDbiP08567.
    PRIDEiP08567.

    2D gel databases

    OGPiP08567.

    PTM databases

    PhosphoSiteiP08567.

    Expressioni

    Gene expression databases

    BgeeiP08567.
    CleanExiHS_PLEK.
    GenevestigatoriP08567.

    Organism-specific databases

    HPAiHPA031838.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    INPP5AQ146424EBI-2565501,EBI-8670520
    SDPRO958104EBI-2565501,EBI-742141

    Protein-protein interaction databases

    BioGridi111357. 1 interaction.
    IntActiP08567. 9 interactions.
    MINTiMINT-8216753.
    STRINGi9606.ENSP00000234313.

    Structurei

    Secondary structure

    1
    350
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 1914
    Beta strandi22 – 298
    Beta strandi32 – 387
    Beta strandi45 – 528
    Beta strandi55 – 584
    Beta strandi65 – 739
    Turni74 – 763
    Beta strandi77 – 826
    Helixi86 – 10318
    Helixi126 – 1338
    Beta strandi135 – 1406
    Beta strandi143 – 1475
    Beta strandi155 – 1573
    Helixi158 – 16710
    Beta strandi168 – 1703
    Helixi174 – 18714
    Beta strandi189 – 1946
    Helixi195 – 2006
    Beta strandi215 – 2184
    Beta strandi220 – 2223
    Beta strandi226 – 2283
    Helixi239 – 2413
    Beta strandi245 – 25410
    Turni256 – 2583
    Beta strandi261 – 2699
    Turni270 – 2734
    Beta strandi274 – 2785
    Beta strandi280 – 2823
    Beta strandi287 – 2915
    Beta strandi296 – 3005
    Beta strandi306 – 3083
    Beta strandi313 – 3186
    Beta strandi324 – 3285
    Helixi332 – 34615

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1PLSNMR-A1-105[»]
    1W4MNMR-A121-223[»]
    1X05NMR-A235-350[»]
    1XX0NMR-A234-350[»]
    1ZM0X-ray2.10A/B240-350[»]
    2CSONMR-A116-229[»]
    2I5CX-ray1.75A/B/C244-347[»]
    2I5FX-ray1.35A244-347[»]
    ProteinModelPortaliP08567.
    SMRiP08567. Positions 1-105, 118-230, 234-350.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP08567.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 10198PH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini136 – 22186DEPPROSITE-ProRule annotationAdd
    BLAST
    Domaini244 – 347104PH 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 2 PH domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG44162.
    HOGENOMiHOG000294078.
    HOVERGENiHBG001361.
    InParanoidiP08567.
    OMAiYYFADSG.
    OrthoDBiEOG74XS6R.
    PhylomeDBiP08567.
    TreeFamiTF332246.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.30.29.30. 2 hits.
    InterProiIPR000591. DEP_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00610. DEP. 1 hit.
    PF00169. PH. 2 hits.
    [Graphical view]
    SMARTiSM00049. DEP. 1 hit.
    SM00233. PH. 2 hits.
    [Graphical view]
    PROSITEiPS50186. DEP. 1 hit.
    PS50003. PH_DOMAIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08567-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPKRIREGY LVKKGSVFNT WKPMWVVLLE DGIEFYKKKS DNSPKGMIPL    50
    KGSTLTSPCQ DFGKRMFVFK ITTTKQQDHF FQAAFLEERD AWVRDIKKAI 100
    KCIEGGQKFA RKSTRRSIRL PETIDLGALY LSMKDTEKGI KELNLEKDKK 150
    IFNHCFTGNC VIDWLVSNQS VRNRQEGLMI ASSLLNEGYL QPAGDMSKSA 200
    VDGTAENPFL DNPDAFYYFP DSGFFCEENS SDDDVILKEE FRGVIIKQGC 250
    LLKQGHRRKN WKVRKFILRE DPAYLHYYDP AGAEDPLGAI HLRGCVVTSV 300
    ESNSNGRKSE EENLFEIITA DEVHYFLQAA TPKERTEWIR AIQMASRTGK 350
    Length:350
    Mass (Da):40,125
    Last modified:January 11, 2011 - v3
    Checksum:i2E292CB18B533261
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti284 – 2841E → G in CAG46876. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51R → W.
    Corresponds to variant rs17035364 [ dbSNP | Ensembl ].
    VAR_027797
    Natural varianti92 – 921W → R.
    VAR_005524
    Natural varianti97 – 971K → N.2 Publications
    Corresponds to variant rs3816281 [ dbSNP | Ensembl ].
    VAR_027798
    Natural varianti108 – 1081K → Q.
    Corresponds to variant rs34515106 [ dbSNP | Ensembl ].
    VAR_056666
    Natural varianti340 – 3401R → K.4 Publications
    Corresponds to variant rs1063479 [ dbSNP | Ensembl ].
    VAR_027799

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07743 mRNA. Translation: CAA30564.1.
    CR542056 mRNA. Translation: CAG46853.1.
    CR542079 mRNA. Translation: CAG46876.1.
    AK313756 mRNA. Translation: BAG36495.1.
    AC015969 Genomic DNA. Translation: AAX93121.1.
    CH471053 Genomic DNA. Translation: EAW99876.1.
    BC018549 mRNA. Translation: AAH18549.1.
    CCDSiCCDS1887.1.
    PIRiS00755.
    RefSeqiNP_002655.2. NM_002664.2.
    UniGeneiHs.468840.

    Genome annotation databases

    EnsembliENST00000234313; ENSP00000234313; ENSG00000115956.
    GeneIDi5341.
    KEGGihsa:5341.
    UCSCiuc002sen.4. human.

    Polymorphism databases

    DMDMi317373523.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07743 mRNA. Translation: CAA30564.1 .
    CR542056 mRNA. Translation: CAG46853.1 .
    CR542079 mRNA. Translation: CAG46876.1 .
    AK313756 mRNA. Translation: BAG36495.1 .
    AC015969 Genomic DNA. Translation: AAX93121.1 .
    CH471053 Genomic DNA. Translation: EAW99876.1 .
    BC018549 mRNA. Translation: AAH18549.1 .
    CCDSi CCDS1887.1.
    PIRi S00755.
    RefSeqi NP_002655.2. NM_002664.2.
    UniGenei Hs.468840.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1PLS NMR - A 1-105 [» ]
    1W4M NMR - A 121-223 [» ]
    1X05 NMR - A 235-350 [» ]
    1XX0 NMR - A 234-350 [» ]
    1ZM0 X-ray 2.10 A/B 240-350 [» ]
    2CSO NMR - A 116-229 [» ]
    2I5C X-ray 1.75 A/B/C 244-347 [» ]
    2I5F X-ray 1.35 A 244-347 [» ]
    ProteinModelPortali P08567.
    SMRi P08567. Positions 1-105, 118-230, 234-350.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111357. 1 interaction.
    IntActi P08567. 9 interactions.
    MINTi MINT-8216753.
    STRINGi 9606.ENSP00000234313.

    PTM databases

    PhosphoSitei P08567.

    Polymorphism databases

    DMDMi 317373523.

    2D gel databases

    OGPi P08567.

    Proteomic databases

    MaxQBi P08567.
    PaxDbi P08567.
    PRIDEi P08567.

    Protocols and materials databases

    DNASUi 5341.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000234313 ; ENSP00000234313 ; ENSG00000115956 .
    GeneIDi 5341.
    KEGGi hsa:5341.
    UCSCi uc002sen.4. human.

    Organism-specific databases

    CTDi 5341.
    GeneCardsi GC02P068504.
    H-InvDB HIX0002122.
    HGNCi HGNC:9070. PLEK.
    HPAi HPA031838.
    MIMi 173570. gene.
    neXtProti NX_P08567.
    PharmGKBi PA33400.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44162.
    HOGENOMi HOG000294078.
    HOVERGENi HBG001361.
    InParanoidi P08567.
    OMAi YYFADSG.
    OrthoDBi EOG74XS6R.
    PhylomeDBi P08567.
    TreeFami TF332246.

    Miscellaneous databases

    EvolutionaryTracei P08567.
    GenomeRNAii 5341.
    NextBioi 20702.
    PROi P08567.
    SOURCEi Search...

    Gene expression databases

    Bgeei P08567.
    CleanExi HS_PLEK.
    Genevestigatori P08567.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.30.29.30. 2 hits.
    InterProi IPR000591. DEP_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00610. DEP. 1 hit.
    PF00169. PH. 2 hits.
    [Graphical view ]
    SMARTi SM00049. DEP. 1 hit.
    SM00233. PH. 2 hits.
    [Graphical view ]
    PROSITEi PS50186. DEP. 1 hit.
    PS50003. PH_DOMAIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of the major protein kinase C substrate of platelets."
      Tyers M., Rachubinski R.A., McCaw M.L., Varrichio A.M., Shorr R.G.L., Haslam R.J., Harley C.B.
      Nature 333:470-473(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASN-97 AND LYS-340.
    2. "Molecular analysis of pleckstrin: the major protein kinase C substrate of platelets."
      Tyers M., Haslam R.J., Rachubinski R.A., Harley C.B.
      J. Cell. Biochem. 40:133-145(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASN-97 AND LYS-340.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-340.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-340.
      Tissue: Lymph.
    8. "Phosphorylation of human pleckstrin on Ser-113 and Ser-117 by protein kinase C."
      Craig K.L., Harley C.B.
      Biochem. J. 314:937-942(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-113 AND SER-117.
    9. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
      Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
      J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: T-cell.
    10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-64, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: STRUCTURE BY NMR OF 1-105.
    13. "Structure and dynamics of the human pleckstrin DEP domain: distinct molecular features of a novel DEP domain subfamily."
      Civera C., Simon B., Stier G., Sattler M., Macias M.J.
      Proteins 58:354-366(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 121-223.
    14. "Solution structure of the DEP domain and of the C-terminal PH domain of human pleckstrin."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 116-350.

    Entry informationi

    Entry nameiPLEK_HUMAN
    AccessioniPrimary (citable) accession number: P08567
    Secondary accession number(s): B2R9E8
    , Q53SU8, Q6FGM8, Q6FGQ1, Q8WV81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 159 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3