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Protein

Glycoprotein UL18

Gene

H301

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the protection against host NK cell cytotoxicity by interacting with and modulating the activity of the host inhibitory leukocyte Ig-like receptor 1/LILRB1, which is expressed on monocytes, dendritic cells, as well as subsets of T and NK cells. UL18 exerts an inhibitory effect on LIR-1+ NK cells, while it stimulates LIR-1- NK cell. These modulations prevent lysis of the infected cells by NK cells.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity, Modulation of host NK-cell activity by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein UL18
Gene namesi
Name:H301
Synonyms:UL18
OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri10360 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008992 Componenti: Genome
  • UP000008991 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei321 – 34222HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host membrane, Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 368350Glycoprotein UL18PRO_0000037452Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi66 – 661N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi74 – 741N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi95 – 951N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi123 – 1231N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi127 – 1271N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi150 – 1501N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi167 – 1671N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi177 – 1771N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi193 – 1931N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi240 – 2401N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi282 – 2821N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi291 – 2911N-linked (GlcNAc...); by hostSequence analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with host LILRB1.1 Publication

Protein-protein interaction databases

DIPiDIP-46164N.

Structurei

Secondary structure

1
368
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 3514Combined sources
Beta strandi37 – 459Combined sources
Beta strandi48 – 5811Combined sources
Beta strandi60 – 623Combined sources
Beta strandi64 – 674Combined sources
Helixi71 – 788Combined sources
Helixi82 – 10827Combined sources
Beta strandi115 – 12410Combined sources
Beta strandi130 – 13910Combined sources
Beta strandi142 – 1476Combined sources
Turni159 – 1613Combined sources
Helixi163 – 1675Combined sources
Helixi168 – 1769Combined sources
Helixi181 – 19111Combined sources
Helixi193 – 20412Combined sources
Beta strandi212 – 22110Combined sources
Beta strandi224 – 23714Combined sources
Beta strandi240 – 2489Combined sources
Beta strandi269 – 27810Combined sources
Beta strandi281 – 2888Combined sources
Beta strandi293 – 2997Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3D2UX-ray2.21A/E21-301[»]
ProteinModelPortaliP08560.
SMRiP08560. Positions 21-301.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08560.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 11496Alpha-1-likeAdd
BLAST
Regioni115 – 20894Alpha-2-likeAdd
BLAST
Regioni209 – 30395Alpha-3-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTMWCLTLF VLWMLRVVGM HVLRYGYTGI FDDTSHMTLT VVGIFDGQHF
60 70 80 90 100
FTYHVNSSDK ASSRANGTIS WMANVSAAYP TYLDGERAKG DLIFNQTEQN
110 120 130 140 150
LLELEIALGY RSQSVLTWTH ECNTTENGSF VAGYEGFGWD GETLMELKDN
160 170 180 190 200
LTLWTGPNYE ISWLKQNKTY IDGKIKNISE GDTTIQRNYL KGNCTQWSVI
210 220 230 240 250
YSGFQPPVTH PVVKGGVRNQ NDNRAEAFCT SYGFFPGEIN ITFIHYGDKV
260 270 280 290 300
PEDSEPQCNP LLPTLDGTFH QGCYVAIFCN QNYTCRVTHG NWTVEIPISV
310 320 330 340 350
TSPDDSSSGE VPDHPTANKR YNTMTISSVL LALLLCALLF AFLHYFTTLK
360
QYLRNLAFAW RYRKVRSS
Length:368
Mass (Da):41,735
Last modified:August 1, 1988 - v1
Checksum:i48AE7EFB4DDCCB4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00293 Genomic DNA. Translation: CAA68399.1.
X17403 Genomic DNA. Translation: CAA35417.1.
BK000394 Genomic DNA. Translation: DAA00121.1.
PIRiS09781. HLBECM.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00293 Genomic DNA. Translation: CAA68399.1.
X17403 Genomic DNA. Translation: CAA35417.1.
BK000394 Genomic DNA. Translation: DAA00121.1.
PIRiS09781. HLBECM.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3D2UX-ray2.21A/E21-301[»]
ProteinModelPortaliP08560.
SMRiP08560. Positions 21-301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46164N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP08560.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens."
    Beck S., Barrell B.G.
    Nature 331:269-272(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169."
    Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.
    Curr. Top. Microbiol. Immunol. 154:125-169(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome."
    Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S.
    J. Gen. Virol. 84:17-28(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
  4. "The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18."
    Chapman T.L., Heikeman A.P., Bjorkman P.J.
    Immunity 11:603-613(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HOST LILRB1.
  5. "Human cytomegalovirus UL18 utilizes US6 for evading the NK and T-cell responses."
    Kim Y., Park B., Cho S., Shin J., Cho K., Jun Y., Ahn K.
    PLoS Pathog. 4:E1000123-E1000123(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Structure of UL18, a peptide-binding viral MHC mimic, bound to a host inhibitory receptor."
    Yang Z., Bjorkman P.J.
    Proc. Natl. Acad. Sci. U.S.A. 105:10095-10100(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.21 ANGSTROMS) OF 21-301.

Entry informationi

Entry nameiUL18_HCMVA
AccessioniPrimary (citable) accession number: P08560
Secondary accession number(s): Q7M6R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 11, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.