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Protein

Glycoprotein UL18

Gene

H301

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the protection against host NK cell cytotoxicity by interacting with and modulating the activity of the host inhibitory leukocyte Ig-like receptor 1/LILRB1, which is expressed on monocytes, dendritic cells, as well as subsets of T and NK cells. UL18 exerts an inhibitory effect on LIR-1+ NK cells, while it stimulates LIR-1- NK cell. These modulations prevent lysis of the infected cells by NK cells.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity, Modulation of host NK-cell activity by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein UL18
Gene namesi
Name:H301
Synonyms:UL18
OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri10360 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008992 Componenti: Genome
  • UP000008991 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei321 – 342HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host membrane, Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003745219 – 368Glycoprotein UL18Add BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi66N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi74N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi95N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi123N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi127N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi150N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi167N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi177N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi193N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi240N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi282N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi291N-linked (GlcNAc...); by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with host LILRB1.1 Publication

Protein-protein interaction databases

DIPiDIP-46164N.

Structurei

Secondary structure

1368
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 35Combined sources14
Beta strandi37 – 45Combined sources9
Beta strandi48 – 58Combined sources11
Beta strandi60 – 62Combined sources3
Beta strandi64 – 67Combined sources4
Helixi71 – 78Combined sources8
Helixi82 – 108Combined sources27
Beta strandi115 – 124Combined sources10
Beta strandi130 – 139Combined sources10
Beta strandi142 – 147Combined sources6
Turni159 – 161Combined sources3
Helixi163 – 167Combined sources5
Helixi168 – 176Combined sources9
Helixi181 – 191Combined sources11
Helixi193 – 204Combined sources12
Beta strandi212 – 221Combined sources10
Beta strandi224 – 237Combined sources14
Beta strandi240 – 248Combined sources9
Beta strandi269 – 278Combined sources10
Beta strandi281 – 288Combined sources8
Beta strandi293 – 299Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D2UX-ray2.21A/E21-301[»]
ProteinModelPortaliP08560.
SMRiP08560.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08560.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 114Alpha-1-likeAdd BLAST96
Regioni115 – 208Alpha-2-likeAdd BLAST94
Regioni209 – 303Alpha-3-likeAdd BLAST95

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTMWCLTLF VLWMLRVVGM HVLRYGYTGI FDDTSHMTLT VVGIFDGQHF
60 70 80 90 100
FTYHVNSSDK ASSRANGTIS WMANVSAAYP TYLDGERAKG DLIFNQTEQN
110 120 130 140 150
LLELEIALGY RSQSVLTWTH ECNTTENGSF VAGYEGFGWD GETLMELKDN
160 170 180 190 200
LTLWTGPNYE ISWLKQNKTY IDGKIKNISE GDTTIQRNYL KGNCTQWSVI
210 220 230 240 250
YSGFQPPVTH PVVKGGVRNQ NDNRAEAFCT SYGFFPGEIN ITFIHYGDKV
260 270 280 290 300
PEDSEPQCNP LLPTLDGTFH QGCYVAIFCN QNYTCRVTHG NWTVEIPISV
310 320 330 340 350
TSPDDSSSGE VPDHPTANKR YNTMTISSVL LALLLCALLF AFLHYFTTLK
360
QYLRNLAFAW RYRKVRSS
Length:368
Mass (Da):41,735
Last modified:August 1, 1988 - v1
Checksum:i48AE7EFB4DDCCB4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00293 Genomic DNA. Translation: CAA68399.1.
X17403 Genomic DNA. Translation: CAA35417.1.
BK000394 Genomic DNA. Translation: DAA00121.1.
PIRiS09781. HLBECM.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00293 Genomic DNA. Translation: CAA68399.1.
X17403 Genomic DNA. Translation: CAA35417.1.
BK000394 Genomic DNA. Translation: DAA00121.1.
PIRiS09781. HLBECM.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D2UX-ray2.21A/E21-301[»]
ProteinModelPortaliP08560.
SMRiP08560.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46164N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP08560.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUL18_HCMVA
AccessioniPrimary (citable) accession number: P08560
Secondary accession number(s): Q7M6R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 30, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.