Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DsdX permease

Gene

dsdX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable permease for an unknown substrate.1 Publication

GO - Molecular functioni

  • D-serine transmembrane transporter activity Source: EcoCyc
  • gluconate transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • D-serine transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:DSDX-MONOMER.
ECOL316407:JW2362-MONOMER.

Protein family/group databases

TCDBi2.A.8.1.5. the gluconate:h(+) symporter (gntp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
DsdX permease
Gene namesi
Name:dsdX
Synonyms:yfdA, yfdD
Ordered Locus Names:b2365, JW2362
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10250. dsdX.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44CytoplasmicSequence analysis
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST
Topological domaini26 – 283PeriplasmicSequence analysis
Transmembranei29 – 4921HelicalSequence analysisAdd
BLAST
Topological domaini50 – 567CytoplasmicSequence analysis
Transmembranei57 – 7721HelicalSequence analysisAdd
BLAST
Topological domaini78 – 10528PeriplasmicSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Topological domaini127 – 13913CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence analysisAdd
BLAST
Topological domaini161 – 17717PeriplasmicSequence analysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence analysisAdd
BLAST
Topological domaini199 – 22325CytoplasmicSequence analysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence analysisAdd
BLAST
Topological domaini245 – 25713PeriplasmicSequence analysisAdd
BLAST
Transmembranei258 – 27821HelicalSequence analysisAdd
BLAST
Topological domaini279 – 30123CytoplasmicSequence analysisAdd
BLAST
Transmembranei302 – 32221HelicalSequence analysisAdd
BLAST
Topological domaini323 – 34220PeriplasmicSequence analysisAdd
BLAST
Transmembranei343 – 36321HelicalSequence analysisAdd
BLAST
Transmembranei364 – 38421HelicalSequence analysisAdd
BLAST
Transmembranei385 – 40521HelicalSequence analysisAdd
BLAST
Topological domaini406 – 42419CytoplasmicSequence analysisAdd
BLAST
Transmembranei425 – 44521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445DsdX permeasePRO_0000061937Add
BLAST

Proteomic databases

PaxDbiP08555.
PRIDEiP08555.

Interactioni

Protein-protein interaction databases

BioGridi4260554. 2 interactions.
DIPiDIP-9481N.
IntActiP08555. 1 interaction.
MINTiMINT-1235614.
STRINGi511145.b2365.

Structurei

3D structure databases

ProteinModelPortaliP08555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GntP permease family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C6Z. Bacteria.
COG2610. LUCA.
HOGENOMiHOG000237115.
InParanoidiP08555.
KOiK13629.
OMAiMESQIWV.
PhylomeDBiP08555.

Family and domain databases

InterProiIPR003474. Glcn_transporter.
[Graphical view]
PfamiPF02447. GntP_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF002746. Gluconate_transporter. 1 hit.
TIGRFAMsiTIGR00791. gntP. 1 hit.

Sequencei

Sequence statusi: Complete.

P08555-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSQIWVVST LLISIVLIVL TIVKFKFHPF LALLLASFFV GTMMGMGPLD
60 70 80 90 100
MVNAIESGIG GTLGFLAAVI GLGTILGKMM EVSGAAERIG LTLQRCRWLS
110 120 130 140 150
VDVIMVLVGL ICGITLFVEV GVVLLIPLAF SIAKKTNTSL LKLAIPLCTA
160 170 180 190 200
LMAVHCVVPP HPAALYVANK LGADIGSVIV YGLLVGLMAS LIGGPLFLKF
210 220 230 240 250
LGQRLPFKPV PTEFADLKVR DEKTLPSLGA TLFTILLPIA LMLVKTIAEL
260 270 280 290 300
NMARESGLYI LVEFIGNPIT AMFIAVFVAY YVLGIRQHMS MGTMLTHTEN
310 320 330 340 350
GFGSIANILL IIGAGGAFNA ILKSSSLADT LAVILSNMHM HPILLAWLVA
360 370 380 390 400
LILHAAVGSA TVAMMGATAI VAPMLPLYPD ISPEIIAIAI GSGAIGCTIV
410 420 430 440
TDSLFWLVKQ YCGATLNETF KYYTTATFIA SVVALAGTFL LSFII
Length:445
Mass (Da):47,163
Last modified:November 1, 1995 - v2
Checksum:iF88D821090A3F79F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91821 Genomic DNA. Translation: CAA62932.1.
X86379 Genomic DNA. Translation: CAA60138.1.
J01603 Genomic DNA. Translation: AAA87974.1.
U00096 Genomic DNA. Translation: AAC75424.1.
AP009048 Genomic DNA. Translation: BAA16225.1.
M19035 Genomic DNA. No translation available.
X81461 Genomic DNA. Translation: CAA57221.2.
PIRiS54140.
RefSeqiNP_416866.1. NC_000913.3.
WP_000556048.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75424; AAC75424; b2365.
BAA16225; BAA16225; BAA16225.
GeneIDi949103.
KEGGiecj:JW2362.
eco:b2365.
PATRICi32120109. VBIEscCol129921_2463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91821 Genomic DNA. Translation: CAA62932.1.
X86379 Genomic DNA. Translation: CAA60138.1.
J01603 Genomic DNA. Translation: AAA87974.1.
U00096 Genomic DNA. Translation: AAC75424.1.
AP009048 Genomic DNA. Translation: BAA16225.1.
M19035 Genomic DNA. No translation available.
X81461 Genomic DNA. Translation: CAA57221.2.
PIRiS54140.
RefSeqiNP_416866.1. NC_000913.3.
WP_000556048.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP08555.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260554. 2 interactions.
DIPiDIP-9481N.
IntActiP08555. 1 interaction.
MINTiMINT-1235614.
STRINGi511145.b2365.

Protein family/group databases

TCDBi2.A.8.1.5. the gluconate:h(+) symporter (gntp) family.

Proteomic databases

PaxDbiP08555.
PRIDEiP08555.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75424; AAC75424; b2365.
BAA16225; BAA16225; BAA16225.
GeneIDi949103.
KEGGiecj:JW2362.
eco:b2365.
PATRICi32120109. VBIEscCol129921_2463.

Organism-specific databases

EchoBASEiEB0246.
EcoGeneiEG10250. dsdX.

Phylogenomic databases

eggNOGiENOG4105C6Z. Bacteria.
COG2610. LUCA.
HOGENOMiHOG000237115.
InParanoidiP08555.
KOiK13629.
OMAiMESQIWV.
PhylomeDBiP08555.

Enzyme and pathway databases

BioCyciEcoCyc:DSDX-MONOMER.
ECOL316407:JW2362-MONOMER.

Miscellaneous databases

PROiP08555.

Family and domain databases

InterProiIPR003474. Glcn_transporter.
[Graphical view]
PfamiPF02447. GntP_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF002746. Gluconate_transporter. 1 hit.
TIGRFAMsiTIGR00791. gntP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDSDX_ECOLI
AccessioniPrimary (citable) accession number: P08555
Secondary accession number(s): P11693
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

An ORF called dsdC was originally (PubMed:3275618) assigned to the wrong DNA strand and thought to be a D-serine deaminase activator, it was then resequenced by Ref. 2 and still thought to be "dsdC", but this time to function as a D-serine permease. It is PubMed:7592420 that showed that dsdC is another gene and that this sequence should be called dsdX. It should also be noted that the C-terminal part of dsdX (from 338 onward) was also sequenced (PubMed:3029015 and PubMed:1659648) and was thought to be a separate ORF (don't worry, we also had difficulties understanding what happened!).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.