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Protein

DsdX permease

Gene

dsdX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable permease for an unknown substrate.1 Publication

GO - Molecular functioni

  • D-serine transmembrane transporter activity Source: EcoCyc
  • gluconate transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • D-serine transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:DSDX-MONOMER.
ECOL316407:JW2362-MONOMER.

Protein family/group databases

TCDBi2.A.8.1.5. the gluconate:h(+) symporter (gntp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
DsdX permease
Gene namesi
Name:dsdX
Synonyms:yfdA, yfdD
Ordered Locus Names:b2365, JW2362
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10250. dsdX.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Topological domaini26 – 28PeriplasmicSequence analysis3
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Topological domaini50 – 56CytoplasmicSequence analysis7
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 105PeriplasmicSequence analysisAdd BLAST28
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 139CytoplasmicSequence analysisAdd BLAST13
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161 – 177PeriplasmicSequence analysisAdd BLAST17
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Topological domaini199 – 223CytoplasmicSequence analysisAdd BLAST25
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 257PeriplasmicSequence analysisAdd BLAST13
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 301CytoplasmicSequence analysisAdd BLAST23
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Topological domaini323 – 342PeriplasmicSequence analysisAdd BLAST20
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Transmembranei364 – 384HelicalSequence analysisAdd BLAST21
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 424CytoplasmicSequence analysisAdd BLAST19
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000619371 – 445DsdX permeaseAdd BLAST445

Proteomic databases

PaxDbiP08555.
PRIDEiP08555.

Interactioni

Protein-protein interaction databases

BioGridi4260554. 2 interactors.
DIPiDIP-9481N.
IntActiP08555. 1 interactor.
MINTiMINT-1235614.
STRINGi511145.b2365.

Structurei

3D structure databases

ProteinModelPortaliP08555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GntP permease family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C6Z. Bacteria.
COG2610. LUCA.
HOGENOMiHOG000237115.
InParanoidiP08555.
KOiK13629.
OMAiMESQIWV.
PhylomeDBiP08555.

Family and domain databases

InterProiIPR003474. Glcn_transporter.
[Graphical view]
PfamiPF02447. GntP_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF002746. Gluconate_transporter. 1 hit.
TIGRFAMsiTIGR00791. gntP. 1 hit.

Sequencei

Sequence statusi: Complete.

P08555-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSQIWVVST LLISIVLIVL TIVKFKFHPF LALLLASFFV GTMMGMGPLD
60 70 80 90 100
MVNAIESGIG GTLGFLAAVI GLGTILGKMM EVSGAAERIG LTLQRCRWLS
110 120 130 140 150
VDVIMVLVGL ICGITLFVEV GVVLLIPLAF SIAKKTNTSL LKLAIPLCTA
160 170 180 190 200
LMAVHCVVPP HPAALYVANK LGADIGSVIV YGLLVGLMAS LIGGPLFLKF
210 220 230 240 250
LGQRLPFKPV PTEFADLKVR DEKTLPSLGA TLFTILLPIA LMLVKTIAEL
260 270 280 290 300
NMARESGLYI LVEFIGNPIT AMFIAVFVAY YVLGIRQHMS MGTMLTHTEN
310 320 330 340 350
GFGSIANILL IIGAGGAFNA ILKSSSLADT LAVILSNMHM HPILLAWLVA
360 370 380 390 400
LILHAAVGSA TVAMMGATAI VAPMLPLYPD ISPEIIAIAI GSGAIGCTIV
410 420 430 440
TDSLFWLVKQ YCGATLNETF KYYTTATFIA SVVALAGTFL LSFII
Length:445
Mass (Da):47,163
Last modified:November 1, 1995 - v2
Checksum:iF88D821090A3F79F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91821 Genomic DNA. Translation: CAA62932.1.
X86379 Genomic DNA. Translation: CAA60138.1.
J01603 Genomic DNA. Translation: AAA87974.1.
U00096 Genomic DNA. Translation: AAC75424.1.
AP009048 Genomic DNA. Translation: BAA16225.1.
M19035 Genomic DNA. No translation available.
X81461 Genomic DNA. Translation: CAA57221.2.
PIRiS54140.
RefSeqiNP_416866.1. NC_000913.3.
WP_000556048.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75424; AAC75424; b2365.
BAA16225; BAA16225; BAA16225.
GeneIDi949103.
KEGGiecj:JW2362.
eco:b2365.
PATRICi32120109. VBIEscCol129921_2463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91821 Genomic DNA. Translation: CAA62932.1.
X86379 Genomic DNA. Translation: CAA60138.1.
J01603 Genomic DNA. Translation: AAA87974.1.
U00096 Genomic DNA. Translation: AAC75424.1.
AP009048 Genomic DNA. Translation: BAA16225.1.
M19035 Genomic DNA. No translation available.
X81461 Genomic DNA. Translation: CAA57221.2.
PIRiS54140.
RefSeqiNP_416866.1. NC_000913.3.
WP_000556048.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP08555.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260554. 2 interactors.
DIPiDIP-9481N.
IntActiP08555. 1 interactor.
MINTiMINT-1235614.
STRINGi511145.b2365.

Protein family/group databases

TCDBi2.A.8.1.5. the gluconate:h(+) symporter (gntp) family.

Proteomic databases

PaxDbiP08555.
PRIDEiP08555.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75424; AAC75424; b2365.
BAA16225; BAA16225; BAA16225.
GeneIDi949103.
KEGGiecj:JW2362.
eco:b2365.
PATRICi32120109. VBIEscCol129921_2463.

Organism-specific databases

EchoBASEiEB0246.
EcoGeneiEG10250. dsdX.

Phylogenomic databases

eggNOGiENOG4105C6Z. Bacteria.
COG2610. LUCA.
HOGENOMiHOG000237115.
InParanoidiP08555.
KOiK13629.
OMAiMESQIWV.
PhylomeDBiP08555.

Enzyme and pathway databases

BioCyciEcoCyc:DSDX-MONOMER.
ECOL316407:JW2362-MONOMER.

Miscellaneous databases

PROiP08555.

Family and domain databases

InterProiIPR003474. Glcn_transporter.
[Graphical view]
PfamiPF02447. GntP_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF002746. Gluconate_transporter. 1 hit.
TIGRFAMsiTIGR00791. gntP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDSDX_ECOLI
AccessioniPrimary (citable) accession number: P08555
Secondary accession number(s): P11693
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

An ORF called dsdC was originally (PubMed:3275618) assigned to the wrong DNA strand and thought to be a D-serine deaminase activator, it was then resequenced by Ref. 2 and still thought to be "dsdC", but this time to function as a D-serine permease. It is PubMed:7592420 that showed that dsdC is another gene and that this sequence should be called dsdX. It should also be noted that the C-terminal part of dsdX (from 338 onward) was also sequenced (PubMed:3029015 and PubMed:1659648) and was thought to be a separate ORF (don't worry, we also had difficulties understanding what happened!).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.