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Protein

LINE-1 reverse transcriptase homolog

Gene
N/A
Organism
Nycticebus coucang (Slow loris)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi599 – 5991Magnesium; catalyticPROSITE-ProRule annotation
Metal bindingi701 – 7011Magnesium; catalyticPROSITE-ProRule annotation
Metal bindingi702 – 7021Magnesium; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed DNA polymerase, Transferase

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
LINE-1 reverse transcriptase homolog (EC:2.7.7.49)
OrganismiNycticebus coucang (Slow loris)
Taxonomic identifieri9470 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLorisiformesLorisidaeNycticebus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12601260LINE-1 reverse transcriptase homologPRO_0000084427Add
BLAST

Proteomic databases

PRIDEiP08548.

Structurei

3D structure databases

ProteinModelPortaliP08548.
SMRiP08548. Positions 2-236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini497 – 772276Reverse transcriptasePROSITE-ProRule annotationAdd
BLAST
Domaini1242 – 126019DUF1725Add
BLAST

Sequence similaritiesi

Contains 1 DUF1725 domain.Curated
Contains 1 reverse transcriptase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG006270.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR013544. DUF1725.
IPR005135. Endo/exonuclease/phosphatase.
IPR000477. RT_dom.
[Graphical view]
PfamiPF08333. DUF1725. 1 hit.
PF03372. Exo_endo_phos. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 1 hit.
PROSITEiPS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TGLSKGLSIF SINVNGLNCP LKRHRLADWI QKLKPDICCI QESHLTLKDK
60 70 80 90 100
YRLKVKGWSS IFQANGKQKK AGIAILFADA IGFKPTKIRK DKDGHFIFVK
110 120 130 140 150
GNTQYDEISI INIYAPNHNA PQFIRETLTD MSNLISSTSI VVGDFNTPLA
160 170 180 190 200
VLDRSSKKKL SKEILDLNST IQHLDLTDIY RTFHPNKTEY TFFSSAHGTY
210 220 230 240 250
SKIDHILGHK SNLSKFKKIE IIPCIFSDHH GIKVELNNNR NLHTHTKTWK
260 270 280 290 300
LNNLMLKDTW VIDEIKKEIT KFLEQNNNQD TNYQNLWDTA KAVLRGKFIA
310 320 330 340 350
LQAFLKKTER EEVNNLMGHL KQLEKEEHSN PKPSRRKEIT KIRAELNEIE
360 370 380 390 400
NKRIIQQINK SKSWFFEKIN KIDKPLANLT RKKRVKSLIS SIRNGNDEIT
410 420 430 440 450
TDPSEIQKIL NEYYKKLYSH KYENLKEIDQ YLEACHLPRL SQKEVEMLNR
460 470 480 490 500
PISSSEIAST IQNLPKKKSP GPDGFTSEFY QTFKEELVPI LLNLFQNIEK
510 520 530 540 550
EGILPNTFYE ANITLIPKPG KDPTRKENYR PISLMNIDAK ILNKILTNRI
560 570 580 590 600
QQHIKKIIHH DQVGFIPGSQ GWFNIRKSIN VIQHINKLKN KDHMILSIDA
610 620 630 640 650
EKAFDNIQHP FMIRTLKKIG IEGTFLKLIE AIYSKPTANI ILNGVKLKSF
660 670 680 690 700
PLRSGTRQGC PLSPLLFNIV MEVLAIAIRE EKAIKGIHIG SEEIKLSLFA
710 720 730 740 750
DDMIVYLENT RDSTTKLLEV IKEYSNVSGY KINTHKSVAF IYTNNNQAEK
760 770 780 790 800
TVKDSIPFTV VPKKMKYLGV YLTKDVKDLY KENYETLRKE IAEDVNKWKN
810 820 830 840 850
IPCSWLGRIN IVKMSILPKA IYNFNAIPIK APLSYFKDLE KIILHFIWNQ
860 870 880 890 900
KKPQIAKTLL SNKNKAGGIT LPDLRLYYKS IVIKTAWYWH KNREVDVWNR
910 920 930 940 950
IENQEMDPAT YHYLIFDKPI KNIQWGKDSL FNKWCWVNWL AICRRLKLDP
960 970 980 990 1000
HLSPLTKIDS HWIKDLNLRH ETIKILEESA GKTLEGISLG EYFMRRTPQA
1010 1020 1030 1040 1050
IEAVSKIHYW DLIKLKSFCT AKNIVSKASR QPSEWEKIFA GYTSDKGLIT
1060 1070 1080 1090 1100
RIHRELKHIN KKRTRDPISG WARDLKRNFS KEDRHTIYKH MKKSSSSLII
1110 1120 1130 1140 1150
REMQIKTTLR YHLTPVRVAH ITKSPNQRCW RGCGGKGTLL HCWWECPLIR
1160 1170 1180 1190 1200
SFWKDVWRIL RDLKIDLPFD PIIPLLGLYP EDQKSQYNKD ICTRMFIAAQ
1210 1220 1230 1240 1250
FIIAKSWKKP KCPSTHEWTS KLWYMYTMEY YAALKKDGDF TSFMFTWMEL
1260
EHILLSKVSQ
Length:1,260
Mass (Da):147,043
Last modified:August 1, 1988 - v1
Checksum:i7A6803DF471F7253
GO

Sequence databases

PIRiB25313. GNLRL1.

Cross-referencesi

Sequence databases

PIRiB25313. GNLRL1.

3D structure databases

ProteinModelPortaliP08548.
SMRiP08548. Positions 2-236.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP08548.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006270.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR013544. DUF1725.
IPR005135. Endo/exonuclease/phosphatase.
IPR000477. RT_dom.
[Graphical view]
PfamiPF08333. DUF1725. 1 hit.
PF03372. Exo_endo_phos. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 1 hit.
PROSITEiPS50878. RT_POL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "L1 family of repetitive DNA sequences in primates may be derived from a sequence encoding a reverse transcriptase-related protein."
    Hattori M., Kuhara S., Takenaka O., Sakaki Y.
    Nature 321:625-628(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiLIN1_NYCCO
AccessioniPrimary (citable) accession number: P08548
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: October 14, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This sequence was constructed from an alignment of six sequences, determined by these authors but not shown, belonging to the LINE-1 family.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.