Reviewed,
UniProtKB/Swiss-Prot P08543 (RIR1_HHV11)
Last modified
September 22, 2009.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ribonucleoside-diphosphate reductase large subunit Short name=R1 EC=1.17.4.1 Alternative name(s): Ribonucleotide reductase large subunit Ribonucleotide reductase 136 kDa subunit ICP6 | ||
| Gene names |
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| Organism | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) | ||
| Taxonomic identifier | 10299 [NCBI] | ||
| Taxonomic lineage | Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus | ||
| Virus host | Homo sapiens (Human) [TaxID: 9606] |
Protein attributes
| Sequence length | 1137 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. The N-terminal region confers antiapoptotic activity in differenciated cells such as neurons and is important for viral reactivation to increase neural survivability By similarity. |
| Catalytic activity | 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. |
| Pathway | |
| Subunit structure | Heterodimer of a large subunit UL39 and a small subunit UL40. |
| Domain | Contains an alpha-crystallin domain homologous to small heat-shock proteins By similarity. |
| Sequence similarities | Belongs to the ribonucleoside diphosphate reductase large chain family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA replication Host-virus interaction |
| Developmental stage | Early protein |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Oxidoreductase |
| Technical term | Allosteric enzyme Complete proteome Virus reference strain |
| Gene Ontology (GO) | |
| Biological process | DNA replication Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | ribonucleoside-diphosphate reductase complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ribonucleoside-diphosphate reductase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1137 | 1137 | Ribonucleoside-diphosphate reductase large subunit | PRO_0000187236 | |||||
Regions | |||||||||
| Region | 287 – 393 | 107 | alpha-crystallin domain By similarity | ||||||
| Compositional bias | 150 – 154 | 5 | Poly-Pro | ||||||
| Compositional bias | 190 – 239 | 50 | Asp/Ser-rich | ||||||
Sites | |||||||||
| Active site | 582 | 1 | Hydrogen atom transfer By similarity | ||||||
| Active site | 791 | 1 | Proton acceptor By similarity | ||||||
| Active site | 793 | 1 | Proton acceptor By similarity | ||||||
| Active site | 795 | 1 | Proton acceptor By similarity | ||||||
| Active site | 808 | 1 | Hydrogen atom transfer By similarity | ||||||
| Active site | 1111 | 1 | Electron transfer By similarity | ||||||
| Active site | 1112 | 1 | Electron transfer By similarity | ||||||
| Site | 1132 | 1 | Interacts with thioredoxin/glutaredoxin By similarity | ||||||
| Site | 1135 | 1 | Interacts with thioredoxin/glutaredoxin By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 70 | 1 | N → S in strain: Nonneuroinvasive mutant HF10, 17 syn+ and Isolate pYN1. | ||||||
| Natural variant | 1133 | 1 | M → T in strain: Nonneuroinvasive mutant HF10. | ||||||
Experimental info | |||||||||
| Sequence conflict | 1034 | 1 | A → P in AAA45805. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed: 2839594] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "Structural features of ribonucleotide reductase." Nikas I., McLauchlan J., Davison A.J., Taylor W.R., Clements J.B. Proteins 1:376-384(1986) [PubMed: 2835765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Isolate pYN1. |
| [3] | "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus." Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y. Microbes Infect. 9:142-149(2007) [PubMed: 17218138] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nonneuroinvasive mutant HF10. |
| [4] | "Herpes simplex virus type 1 bacterial artificial chromosome." Cunningham C., Davison A.J. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 17 syn+. |
Cross-references
Sequence databases | |
|---|---|
| X14112 Genomic DNA. Translation: CAA32314.1. M18410 Genomic DNA. Translation: AAA45805.1. DQ889502 Genomic DNA. Translation: ABI63501.1. FJ593289 Genomic DNA. Translation: ACM62262.1. | |
| PIR | WMBEB1. A26536. |
| RefSeq | NP_044641.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2703361. |
Family and domain databases | |
| InterPro | IPR013346. NrdE_NrdA. IPR013509. Ribncl_Rdtase_lsu_N. IPR000788. Ribncl_red_lg_C. [Graphical view] |
| PANTHER | PTHR11573. Ribncl_red_lg_C. 1 hit. |
| Pfam | PF02867. Ribonuc_red_lgC. 1 hit. PF00317. Ribonuc_red_lgN. 1 hit. [Graphical view] |
| PRINTS | PR01183. RIBORDTASEM1. |
| TIGRFAMs | TIGR02506. NrdE_NrdA. 1 hit. |
| PROSITE | PS00089. RIBORED_LARGE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RIR1_HHV11 | ||||||||
| Accession | Primary (citable) accession number: P08543 Secondary accession number(s): B9VQG7, Q09I94 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Virus (Virus annotation project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


