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P08542

- UDB17_RAT

UniProt

P08542 - UDB17_RAT

Protein

UDP-glucuronosyltransferase 2B17

Gene

Ugt2b17

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B17 is active on testosterone.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: RGD

    GO - Biological processi

    1. cellular response to ethanol Source: RGD
    2. cellular response to glucocorticoid stimulus Source: RGD
    3. cellular response to growth hormone stimulus Source: RGD
    4. cellular response to testosterone stimulus Source: RGD
    5. response to lipopolysaccharide Source: RGD

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.17. 5301.

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2B17 (EC:2.4.1.17)
    Short name:
    UDPGT 2B17
    Alternative name(s):
    17-beta-hydroxysteroid-specific UDPGT
    RLUG38
    Testosterone, dihydrotestosterone, and beta-estradiol-specific UDPGT
    UDP-glucuronosyltransferase 2B5
    Short name:
    UDPGT 2B5
    UDPGTr-3
    Gene namesi
    Name:Ugt2b17
    Synonyms:Ugt2b3, Ugt2b5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi628623. Ugt2b5.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 530507UDP-glucuronosyltransferase 2B17PRO_0000036027Add
    BLAST

    Proteomic databases

    PaxDbiP08542.
    PRIDEiP08542.

    Expressioni

    Inductioni

    Constitutively expressed.

    Gene expression databases

    GenevestigatoriP08542.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4571383.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2HN3model-@1-530[»]
    ProteinModelPortaliP08542.
    SMRiP08542. Positions 287-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei494 – 51017HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    HOVERGENiHBG004033.
    InParanoidiP08542.
    KOiK00699.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P08542-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGKWISALL LLQISCCFQS GNCGKVLVWP MEFSHWMNIK TILDELVQRG    50
    HEVTVLKPSA YYVLDPKKSP DLKFETFPTS VSKDELENYF IKLVDVWTYE 100
    LQRDTCLSYS PLLQNMIDGF SDYYLSLCKD TVSNKQLMAK LQESKFDVLL 150
    SDPVAACGEL IAEVLHIPFL YSLRFSPGYK IEKSSGRFIL PPSYVPVILS 200
    GMGGPMTFID RVKNMICTLY FDFWFHMFNA KKWDPFYSEI LGRPTTLAET 250
    MGKAEMWLIR SYWDLEFPHP TLPNVDYIGG LQCRPPKPLP KDMEDFVQSS 300
    GEHGVVVFSL GSMVSSMTEE KANAIAWALA QIPQKVLWKF DGKTPATLGP 350
    NTRVYKWLPQ NDLLGHPKTK AFVTHSGANG VYEAIYHGIP MVGIPMFGEQ 400
    HDNIAHMVAK GAAVTLNIRT MSKSDLFNAL KEIINNPFYK KNAVWLSTIH 450
    HDQPMKPLDK AVFWIEFVMR HKGAKHLRPL GHDLPWYQYH SLDVIGFLLT 500
    CSAVIAVLTV KCFLFIYRLF VKKEKKMKNE 530
    Length:530
    Mass (Da):60,525
    Last modified:February 1, 1991 - v2
    Checksum:iBB633D70DBF8A7E4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 541T → S in CAA68351. (PubMed:3108864)Curated
    Sequence conflicti119 – 1191G → E in CAA68351. (PubMed:3108864)Curated
    Sequence conflicti376 – 3761S → G in CAA68351. (PubMed:3108864)Curated
    Sequence conflicti424 – 4241S → T in CAA68351. (PubMed:3108864)Curated
    Sequence conflicti500 – 5001T → S in CAA68351. (PubMed:3108864)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31109 mRNA. Translation: AAA41280.1.
    Y00156 mRNA. Translation: CAA68351.1.
    PIRiS07390.
    RefSeqiNP_695226.2. NM_153314.2.
    UniGeneiRn.24945.

    Genome annotation databases

    GeneIDi266685.
    KEGGirno:266685.
    UCSCiRGD:628623. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31109 mRNA. Translation: AAA41280.1 .
    Y00156 mRNA. Translation: CAA68351.1 .
    PIRi S07390.
    RefSeqi NP_695226.2. NM_153314.2.
    UniGenei Rn.24945.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2HN3 model - @ 1-530 [» ]
    ProteinModelPortali P08542.
    SMRi P08542. Positions 287-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4571383.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Proteomic databases

    PaxDbi P08542.
    PRIDEi P08542.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 266685.
    KEGGi rno:266685.
    UCSCi RGD:628623. rat.

    Organism-specific databases

    CTDi 7367.
    RGDi 628623. Ugt2b5.

    Phylogenomic databases

    eggNOGi COG1819.
    HOVERGENi HBG004033.
    InParanoidi P08542.
    KOi K00699.

    Enzyme and pathway databases

    BRENDAi 2.4.1.17. 5301.

    Miscellaneous databases

    NextBioi 624488.

    Gene expression databases

    Genevestigatori P08542.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rat liver UDP-glucuronosyltransferase. Identification of cDNAs encoding two enzymes which glucuronidate testosterone, dihydrotestosterone, and beta-estradiol."
      McKenzie P.I.
      J. Biol. Chem. 262:9744-9749(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Nucleotide and deduced amino acid sequence of rat liver 17 beta-hydroxysteroid UDP-glucuronosyltransferase."
      Harding D., Wilson S.M., Jackson M.R., Burchell B., Green M.D., Tephly T.R.
      Nucleic Acids Res. 15:3936-3936(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiUDB17_RAT
    AccessioniPrimary (citable) accession number: P08542
    Secondary accession number(s): P16915
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3