UDP-glucuronosyltransferase 2B17 precursor

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P08542 (UDB17_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 104. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
UDP-glucuronosyltransferase 2B17
Short name=UDPGT 2B17
EC=2.4.1.17

Alternative name(s):
17-beta-hydroxysteroid-specific UDPGT
RLUG38
Testosterone, dihydrotestosterone, and beta-estradiol-specific UDPGT
UDP-glucuronosyltransferase 2B5
Short name=UDPGT 2B5
UDPGTr-3

Gene names

Name:	Ugt2b17
Synonyms:	Ugt2b3, Ugt2b5

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B17 is active on testosterone.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Induction	Constitutively expressed.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to ethanol Inferred from expression pattern PubMed 11412396. Source: RGD cellular response to glucocorticoid stimulus Inferred from expression pattern PubMed 10100302. Source: RGD cellular response to growth hormone stimulus Inferred from expression pattern PubMed 10100302. Source: RGD cellular response to testosterone stimulus Inferred from expression pattern PubMed 10100302. Source: RGD response to lipopolysaccharide Inferred from expression pattern PubMed 19356101. Source: RGD
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	glucuronosyltransferase activity Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 23

By similarity

Chain

24 – 530

507

UDP-glucuronosyltransferase 2B17

PRO_0000036027

Regions

Transmembrane

494 – 510

Helical; Potential

Experimental info

Sequence conflict

T → S in CAA68351. Ref.2

Sequence conflict

119

G → E in CAA68351. Ref.2

Sequence conflict

376

S → G in CAA68351. Ref.2

Sequence conflict

424

S → T in CAA68351. Ref.2

Sequence conflict

500

T → S in CAA68351. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P08542 [UniParc].

Last modified February 1, 1991. Version 2.
Checksum: BB633D70DBF8A7E4
Show »

FASTA

530

60,525

        10         20         30         40         50         60 
MPGKWISALL LLQISCCFQS GNCGKVLVWP MEFSHWMNIK TILDELVQRG HEVTVLKPSA 

        70         80         90        100        110        120 
YYVLDPKKSP DLKFETFPTS VSKDELENYF IKLVDVWTYE LQRDTCLSYS PLLQNMIDGF 

       130        140        150        160        170        180 
SDYYLSLCKD TVSNKQLMAK LQESKFDVLL SDPVAACGEL IAEVLHIPFL YSLRFSPGYK 

       190        200        210        220        230        240 
IEKSSGRFIL PPSYVPVILS GMGGPMTFID RVKNMICTLY FDFWFHMFNA KKWDPFYSEI 

       250        260        270        280        290        300 
LGRPTTLAET MGKAEMWLIR SYWDLEFPHP TLPNVDYIGG LQCRPPKPLP KDMEDFVQSS 

       310        320        330        340        350        360 
GEHGVVVFSL GSMVSSMTEE KANAIAWALA QIPQKVLWKF DGKTPATLGP NTRVYKWLPQ 

       370        380        390        400        410        420 
NDLLGHPKTK AFVTHSGANG VYEAIYHGIP MVGIPMFGEQ HDNIAHMVAK GAAVTLNIRT 

       430        440        450        460        470        480 
MSKSDLFNAL KEIINNPFYK KNAVWLSTIH HDQPMKPLDK AVFWIEFVMR HKGAKHLRPL 

       490        500        510        520        530 
GHDLPWYQYH SLDVIGFLLT CSAVIAVLTV KCFLFIYRLF VKKEKKMKNE

« Hide

References

[1]	"Rat liver UDP-glucuronosyltransferase. Identification of cDNAs encoding two enzymes which glucuronidate testosterone, dihydrotestosterone, and beta-estradiol." McKenzie P.I. J. Biol. Chem. 262:9744-9749(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Nucleotide and deduced amino acid sequence of rat liver 17 beta-hydroxysteroid UDP-glucuronosyltransferase." Harding D., Wilson S.M., Jackson M.R., Burchell B., Green M.D., Tephly T.R. Nucleic Acids Res. 15:3936-3936(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M31109 mRNA. Translation: AAA41280.1.
Y00156 mRNA. Translation: CAA68351.1.

IPI

IPI00327626.

PIR

S07390.

RefSeq

NP_695226.2. NM_153314.2.

UniGene

Rn.24945.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2HN3	model	-	@	1-530	[»]

ProteinModelPortal

P08542.

SMR

P08542. Positions 287-447.

ModBase

Search...

Protein family/group databases

CAZy

GT1. Glycosyltransferase Family 1.

Proteomic databases

PaxDb

P08542.

PRIDE

P08542.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

266685.

KEGG

rno:266685.

UCSC

RGD:628623. rat.

Organism-specific databases

CTD

7367.

RGD

628623. Ugt2b5.

Phylogenomic databases

eggNOG

COG1819.

HOVERGEN

HBG004033.

InParanoid

P08542.

K00699.

OrthoDB

EOG4SJ5DW.

Enzyme and pathway databases

BRENDA

2.4.1.17. 5301.

Gene expression databases

ArrayExpress

P08542.

Genevestigator

P08542.

GermOnline

ENSRNOG00000033139. Rattus norvegicus.

Family and domain databases

InterPro

IPR002213. UDP_glucos_trans.
[Graphical view]

PANTHER

PTHR11926. PTHR11926. 1 hit.

Pfam

PF00201. UDPGT. 1 hit.
[Graphical view]

PROSITE

PS00375. UDPGT. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

624488.

Entry information

Entry name

UDB17_RAT

Accession

Primary (citable) accession number: P08542
Secondary accession number(s): P16915

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	February 1, 1991
Last modified:	April 3, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents