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P08542

- UDB17_RAT

UniProt

P08542 - UDB17_RAT

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Protein

UDP-glucuronosyltransferase 2B17

Gene

Ugt2b17

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B17 is active on testosterone.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: RGD

GO - Biological processi

  1. cellular response to ethanol Source: RGD
  2. cellular response to glucocorticoid stimulus Source: RGD
  3. cellular response to growth hormone stimulus Source: RGD
  4. cellular response to testosterone stimulus Source: RGD
  5. response to lipopolysaccharide Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 5301.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B17 (EC:2.4.1.17)
Short name:
UDPGT 2B17
Alternative name(s):
17-beta-hydroxysteroid-specific UDPGT
RLUG38
Testosterone, dihydrotestosterone, and beta-estradiol-specific UDPGT
UDP-glucuronosyltransferase 2B5
Short name:
UDPGT 2B5
UDPGTr-3
Gene namesi
Name:Ugt2b17
Synonyms:Ugt2b3, Ugt2b5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi628623. Ugt2b5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei494 – 51017HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 530507UDP-glucuronosyltransferase 2B17PRO_0000036027Add
BLAST

Proteomic databases

PaxDbiP08542.
PRIDEiP08542.

Expressioni

Inductioni

Constitutively expressed.

Gene expression databases

GenevestigatoriP08542.

Interactioni

Protein-protein interaction databases

MINTiMINT-4571383.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HN3model-@1-530[»]
ProteinModelPortaliP08542.
SMRiP08542. Positions 287-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
HOVERGENiHBG004033.
InParanoidiP08542.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08542-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGKWISALL LLQISCCFQS GNCGKVLVWP MEFSHWMNIK TILDELVQRG
60 70 80 90 100
HEVTVLKPSA YYVLDPKKSP DLKFETFPTS VSKDELENYF IKLVDVWTYE
110 120 130 140 150
LQRDTCLSYS PLLQNMIDGF SDYYLSLCKD TVSNKQLMAK LQESKFDVLL
160 170 180 190 200
SDPVAACGEL IAEVLHIPFL YSLRFSPGYK IEKSSGRFIL PPSYVPVILS
210 220 230 240 250
GMGGPMTFID RVKNMICTLY FDFWFHMFNA KKWDPFYSEI LGRPTTLAET
260 270 280 290 300
MGKAEMWLIR SYWDLEFPHP TLPNVDYIGG LQCRPPKPLP KDMEDFVQSS
310 320 330 340 350
GEHGVVVFSL GSMVSSMTEE KANAIAWALA QIPQKVLWKF DGKTPATLGP
360 370 380 390 400
NTRVYKWLPQ NDLLGHPKTK AFVTHSGANG VYEAIYHGIP MVGIPMFGEQ
410 420 430 440 450
HDNIAHMVAK GAAVTLNIRT MSKSDLFNAL KEIINNPFYK KNAVWLSTIH
460 470 480 490 500
HDQPMKPLDK AVFWIEFVMR HKGAKHLRPL GHDLPWYQYH SLDVIGFLLT
510 520 530
CSAVIAVLTV KCFLFIYRLF VKKEKKMKNE
Length:530
Mass (Da):60,525
Last modified:February 1, 1991 - v2
Checksum:iBB633D70DBF8A7E4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541T → S in CAA68351. (PubMed:3108864)Curated
Sequence conflicti119 – 1191G → E in CAA68351. (PubMed:3108864)Curated
Sequence conflicti376 – 3761S → G in CAA68351. (PubMed:3108864)Curated
Sequence conflicti424 – 4241S → T in CAA68351. (PubMed:3108864)Curated
Sequence conflicti500 – 5001T → S in CAA68351. (PubMed:3108864)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31109 mRNA. Translation: AAA41280.1.
Y00156 mRNA. Translation: CAA68351.1.
PIRiS07390.
RefSeqiNP_695226.2. NM_153314.2.
UniGeneiRn.24945.

Genome annotation databases

GeneIDi266685.
KEGGirno:266685.
UCSCiRGD:628623. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31109 mRNA. Translation: AAA41280.1 .
Y00156 mRNA. Translation: CAA68351.1 .
PIRi S07390.
RefSeqi NP_695226.2. NM_153314.2.
UniGenei Rn.24945.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HN3 model - @ 1-530 [» ]
ProteinModelPortali P08542.
SMRi P08542. Positions 287-447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4571383.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Proteomic databases

PaxDbi P08542.
PRIDEi P08542.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 266685.
KEGGi rno:266685.
UCSCi RGD:628623. rat.

Organism-specific databases

CTDi 7367.
RGDi 628623. Ugt2b5.

Phylogenomic databases

eggNOGi COG1819.
HOVERGENi HBG004033.
InParanoidi P08542.
KOi K00699.

Enzyme and pathway databases

BRENDAi 2.4.1.17. 5301.

Miscellaneous databases

NextBioi 624488.

Gene expression databases

Genevestigatori P08542.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rat liver UDP-glucuronosyltransferase. Identification of cDNAs encoding two enzymes which glucuronidate testosterone, dihydrotestosterone, and beta-estradiol."
    McKenzie P.I.
    J. Biol. Chem. 262:9744-9749(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Nucleotide and deduced amino acid sequence of rat liver 17 beta-hydroxysteroid UDP-glucuronosyltransferase."
    Harding D., Wilson S.M., Jackson M.R., Burchell B., Green M.D., Tephly T.R.
    Nucleic Acids Res. 15:3936-3936(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiUDB17_RAT
AccessioniPrimary (citable) accession number: P08542
Secondary accession number(s): P16915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 1, 1991
Last modified: October 29, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3