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P08542 (UDB17_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2B17

Short name=UDPGT 2B17
EC=2.4.1.17
Alternative name(s):
17-beta-hydroxysteroid-specific UDPGT
RLUG38
Testosterone, dihydrotestosterone, and beta-estradiol-specific UDPGT
UDP-glucuronosyltransferase 2B5
Short name=UDPGT 2B5
UDPGTr-3
Gene names
Name:Ugt2b17
Synonyms:Ugt2b3, Ugt2b5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B17 is active on testosterone.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Induction

Constitutively expressed.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 530507UDP-glucuronosyltransferase 2B17
PRO_0000036027

Regions

Transmembrane494 – 51017Helical; Potential

Experimental info

Sequence conflict541T → S in CAA68351. Ref.2
Sequence conflict1191G → E in CAA68351. Ref.2
Sequence conflict3761S → G in CAA68351. Ref.2
Sequence conflict4241S → T in CAA68351. Ref.2
Sequence conflict5001T → S in CAA68351. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P08542 [UniParc].

Last modified February 1, 1991. Version 2.
Checksum: BB633D70DBF8A7E4

FASTA53060,525
        10         20         30         40         50         60 
MPGKWISALL LLQISCCFQS GNCGKVLVWP MEFSHWMNIK TILDELVQRG HEVTVLKPSA 

        70         80         90        100        110        120 
YYVLDPKKSP DLKFETFPTS VSKDELENYF IKLVDVWTYE LQRDTCLSYS PLLQNMIDGF 

       130        140        150        160        170        180 
SDYYLSLCKD TVSNKQLMAK LQESKFDVLL SDPVAACGEL IAEVLHIPFL YSLRFSPGYK 

       190        200        210        220        230        240 
IEKSSGRFIL PPSYVPVILS GMGGPMTFID RVKNMICTLY FDFWFHMFNA KKWDPFYSEI 

       250        260        270        280        290        300 
LGRPTTLAET MGKAEMWLIR SYWDLEFPHP TLPNVDYIGG LQCRPPKPLP KDMEDFVQSS 

       310        320        330        340        350        360 
GEHGVVVFSL GSMVSSMTEE KANAIAWALA QIPQKVLWKF DGKTPATLGP NTRVYKWLPQ 

       370        380        390        400        410        420 
NDLLGHPKTK AFVTHSGANG VYEAIYHGIP MVGIPMFGEQ HDNIAHMVAK GAAVTLNIRT 

       430        440        450        460        470        480 
MSKSDLFNAL KEIINNPFYK KNAVWLSTIH HDQPMKPLDK AVFWIEFVMR HKGAKHLRPL 

       490        500        510        520        530 
GHDLPWYQYH SLDVIGFLLT CSAVIAVLTV KCFLFIYRLF VKKEKKMKNE 

« Hide

References

[1]"Rat liver UDP-glucuronosyltransferase. Identification of cDNAs encoding two enzymes which glucuronidate testosterone, dihydrotestosterone, and beta-estradiol."
McKenzie P.I.
J. Biol. Chem. 262:9744-9749(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Nucleotide and deduced amino acid sequence of rat liver 17 beta-hydroxysteroid UDP-glucuronosyltransferase."
Harding D., Wilson S.M., Jackson M.R., Burchell B., Green M.D., Tephly T.R.
Nucleic Acids Res. 15:3936-3936(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M31109 mRNA. Translation: AAA41280.1.
Y00156 mRNA. Translation: CAA68351.1.
PIRS07390.
RefSeqNP_695226.2. NM_153314.2.
UniGeneRn.24945.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2HN3model-@1-530[»]
ProteinModelPortalP08542.
SMRP08542. Positions 287-447.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4571383.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Proteomic databases

PaxDbP08542.
PRIDEP08542.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID266685.
KEGGrno:266685.
UCSCRGD:628623. rat.

Organism-specific databases

CTD7367.
RGD628623. Ugt2b5.

Phylogenomic databases

eggNOGCOG1819.
HOVERGENHBG004033.
InParanoidP08542.
KOK00699.

Enzyme and pathway databases

BRENDA2.4.1.17. 5301.

Gene expression databases

GenevestigatorP08542.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio624488.

Entry information

Entry nameUDB17_RAT
AccessionPrimary (citable) accession number: P08542
Secondary accession number(s): P16915
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 1, 1991
Last modified: February 19, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references