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P08541

- UD2B2_RAT

UniProt

P08541 - UD2B2_RAT

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Protein

UDP-glucuronosyltransferase 2B2

Gene

Ugt2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B2 acts on various endogenous steroids, especially etiocholanolone and androsterone.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 5301.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B2 (EC:2.4.1.17)
Short name:
UDPGT 2B2
Alternative name(s):
3-hydroxyandrogen-specific UDPGT
RLUG23
UDPGTr-4
Gene namesi
Name:Ugt2b
Synonyms:Ugt2b2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3936. Ugt2b.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 530507UDP-glucuronosyltransferase 2B2PRO_0000036026Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Autoacylation in vitro.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP08541.
PRIDEiP08541.

Expressioni

Inductioni

Constitutively expressed.

Gene expression databases

GenevestigatoriP08541.

Interactioni

Protein-protein interaction databases

IntActiP08541. 1 interaction.
MINTiMINT-4564702.
STRINGi10116.ENSRNOP00000034723.

Structurei

3D structure databases

ProteinModelPortaliP08541.
SMRiP08541. Positions 286-447.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei494 – 51017HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP08541.
PhylomeDBiP08541.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08541-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRKWISALF LLQISYCFKS GHCGKVLVWP MDFSHWMNIK IILDELVQRG
60 70 80 90 100
HEVTVLKPSA YFFLDPKKSS DLKFEIFSTS ISKDELQNHF IKLLDVWTYE
110 120 130 140 150
LPRDTCLSYS PILQNLVYEF SYFYLSICKD AVSNKQLMTK LQESKFDVLF
160 170 180 190 200
ADPVASCGDL IAELLHIPFL YSLSFSPGHK LEKSIGKFIL PPSYVPVILS
210 220 230 240 250
GLAGKMTFID RVKNMICMLY FDFWFERLRH KEWDTFYSEI LGRPTTVDET
260 270 280 290 300
MSKVEIWLIR SYWDLKFPHP TLPNVDYIGG LHCKPAKPLP KDMEEFVQSS
310 320 330 340 350
GEHGVVVFSL GSMVSNMTEE KANAIAWALA QIPQKVLWKF DGKTPATLGP
360 370 380 390 400
NTRVYKWLPQ NDLLGHPKTK AFVTHGGANG LYEAIYHGIP MIGIPLFGDQ
410 420 430 440 450
PDNIAHMVAK GAAVSLNIRT MSKLDFLSAL EEVIDNPFYK KNVMLLSTIH
460 470 480 490 500
HDQPMKPLDR AVFWIEFIMR HKGAKHLRPL GHNLPWYQYH SLDVIGFLLT
510 520 530
CFAVIAALTV KCLLFMYRFF VKKEKKMKNE
Length:530
Mass (Da):60,986
Last modified:August 1, 1988 - v1
Checksum:iF2FFF3E23E2D75B2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591D → E in CAA27198. (PubMed:3003696)Curated
Sequence conflicti286 – 2861A → S in CAA27198. (PubMed:3003696)Curated
Sequence conflicti351 – 3511N → I in CAA27198. (PubMed:3003696)Curated
Sequence conflicti363 – 3631L → I in CAA27198. (PubMed:3003696)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02589 Genomic DNA. Translation: AAA42314.1.
M74439 Genomic DNA. No translation available.
X03478 mRNA. Translation: CAA27198.1.
PIRiA40467.
UniGeneiRn.2521.

Genome annotation databases

UCSCiRGD:3936. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02589 Genomic DNA. Translation: AAA42314.1 .
M74439 Genomic DNA. No translation available.
X03478 mRNA. Translation: CAA27198.1 .
PIRi A40467.
UniGenei Rn.2521.

3D structure databases

ProteinModelPortali P08541.
SMRi P08541. Positions 286-447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P08541. 1 interaction.
MINTi MINT-4564702.
STRINGi 10116.ENSRNOP00000034723.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Proteomic databases

PaxDbi P08541.
PRIDEi P08541.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:3936. rat.

Organism-specific databases

RGDi 3936. Ugt2b.

Phylogenomic databases

eggNOGi COG1819.
HOGENOMi HOG000220831.
HOVERGENi HBG004033.
InParanoidi P08541.
PhylomeDBi P08541.

Enzyme and pathway databases

BRENDAi 2.4.1.17. 5301.

Gene expression databases

Genevestigatori P08541.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rat liver UDP-glucuronosyltransferase. cDNA sequence and expression of a form glucuronidating 3-hydroxyandrogens."
    McKenzie P.I.
    J. Biol. Chem. 261:14112-14117(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  2. "Isolation, sequence, and developmental expression of rat UGT2B2: the gene encoding a constitutive UDP glucuronosyltransferase that metabolizes etiocholanolone and androsterone."
    Haque S.J., Peterson D.D., Nebert D.W., McKenzie P.I.
    DNA Cell Biol. 10:515-524(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The full length coding sequence of rat liver androsterone UDP-glucuronyltransferase cDNA and comparison with other members of this gene family."
    Jackson M.R., Burchell B.
    Nucleic Acids Res. 14:779-795(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-530.
    Tissue: Liver.
  4. "Acyl-CoA binding and acylation of UDP-glucuronosyltransferase isoforms of rat liver: their effect on enzyme activity."
    Yamashita A., Watanabe M., Tonegawa T., Sugiura T., Waku K.
    Biochem. J. 312:301-308(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-44, LIPID-BINDING.

Entry informationi

Entry nameiUD2B2_RAT
AccessioniPrimary (citable) accession number: P08541
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3