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P08541

- UD2B2_RAT

UniProt

P08541 - UD2B2_RAT

Protein

UDP-glucuronosyltransferase 2B2

Gene

Ugt2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B2 acts on various endogenous steroids, especially etiocholanolone and androsterone.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: RGD

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.17. 5301.

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2B2 (EC:2.4.1.17)
    Short name:
    UDPGT 2B2
    Alternative name(s):
    3-hydroxyandrogen-specific UDPGT
    RLUG23
    UDPGTr-4
    Gene namesi
    Name:Ugt2b
    Synonyms:Ugt2b2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3936. Ugt2b.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 530507UDP-glucuronosyltransferase 2B2PRO_0000036026Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Autoacylation in vitro.

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP08541.
    PRIDEiP08541.

    Expressioni

    Inductioni

    Constitutively expressed.

    Gene expression databases

    GenevestigatoriP08541.

    Interactioni

    Protein-protein interaction databases

    IntActiP08541. 1 interaction.
    MINTiMINT-4564702.
    STRINGi10116.ENSRNOP00000034723.

    Structurei

    3D structure databases

    ProteinModelPortaliP08541.
    SMRiP08541. Positions 286-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei494 – 51017HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    HOGENOMiHOG000220831.
    HOVERGENiHBG004033.
    PhylomeDBiP08541.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P08541-1 [UniParc]FASTAAdd to Basket

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    MPRKWISALF LLQISYCFKS GHCGKVLVWP MDFSHWMNIK IILDELVQRG    50
    HEVTVLKPSA YFFLDPKKSS DLKFEIFSTS ISKDELQNHF IKLLDVWTYE 100
    LPRDTCLSYS PILQNLVYEF SYFYLSICKD AVSNKQLMTK LQESKFDVLF 150
    ADPVASCGDL IAELLHIPFL YSLSFSPGHK LEKSIGKFIL PPSYVPVILS 200
    GLAGKMTFID RVKNMICMLY FDFWFERLRH KEWDTFYSEI LGRPTTVDET 250
    MSKVEIWLIR SYWDLKFPHP TLPNVDYIGG LHCKPAKPLP KDMEEFVQSS 300
    GEHGVVVFSL GSMVSNMTEE KANAIAWALA QIPQKVLWKF DGKTPATLGP 350
    NTRVYKWLPQ NDLLGHPKTK AFVTHGGANG LYEAIYHGIP MIGIPLFGDQ 400
    PDNIAHMVAK GAAVSLNIRT MSKLDFLSAL EEVIDNPFYK KNVMLLSTIH 450
    HDQPMKPLDR AVFWIEFIMR HKGAKHLRPL GHNLPWYQYH SLDVIGFLLT 500
    CFAVIAALTV KCLLFMYRFF VKKEKKMKNE 530
    Length:530
    Mass (Da):60,986
    Last modified:August 1, 1988 - v1
    Checksum:iF2FFF3E23E2D75B2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti159 – 1591D → E in CAA27198. (PubMed:3003696)Curated
    Sequence conflicti286 – 2861A → S in CAA27198. (PubMed:3003696)Curated
    Sequence conflicti351 – 3511N → I in CAA27198. (PubMed:3003696)Curated
    Sequence conflicti363 – 3631L → I in CAA27198. (PubMed:3003696)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02589 Genomic DNA. Translation: AAA42314.1.
    M74439 Genomic DNA. No translation available.
    X03478 mRNA. Translation: CAA27198.1.
    PIRiA40467.
    UniGeneiRn.2521.

    Genome annotation databases

    UCSCiRGD:3936. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02589 Genomic DNA. Translation: AAA42314.1 .
    M74439 Genomic DNA. No translation available.
    X03478 mRNA. Translation: CAA27198.1 .
    PIRi A40467.
    UniGenei Rn.2521.

    3D structure databases

    ProteinModelPortali P08541.
    SMRi P08541. Positions 286-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P08541. 1 interaction.
    MINTi MINT-4564702.
    STRINGi 10116.ENSRNOP00000034723.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Proteomic databases

    PaxDbi P08541.
    PRIDEi P08541.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:3936. rat.

    Organism-specific databases

    RGDi 3936. Ugt2b.

    Phylogenomic databases

    eggNOGi COG1819.
    HOGENOMi HOG000220831.
    HOVERGENi HBG004033.
    PhylomeDBi P08541.

    Enzyme and pathway databases

    BRENDAi 2.4.1.17. 5301.

    Gene expression databases

    Genevestigatori P08541.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rat liver UDP-glucuronosyltransferase. cDNA sequence and expression of a form glucuronidating 3-hydroxyandrogens."
      McKenzie P.I.
      J. Biol. Chem. 261:14112-14117(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.
    2. "Isolation, sequence, and developmental expression of rat UGT2B2: the gene encoding a constitutive UDP glucuronosyltransferase that metabolizes etiocholanolone and androsterone."
      Haque S.J., Peterson D.D., Nebert D.W., McKenzie P.I.
      DNA Cell Biol. 10:515-524(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The full length coding sequence of rat liver androsterone UDP-glucuronyltransferase cDNA and comparison with other members of this gene family."
      Jackson M.R., Burchell B.
      Nucleic Acids Res. 14:779-795(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-530.
      Tissue: Liver.
    4. "Acyl-CoA binding and acylation of UDP-glucuronosyltransferase isoforms of rat liver: their effect on enzyme activity."
      Yamashita A., Watanabe M., Tonegawa T., Sugiura T., Waku K.
      Biochem. J. 312:301-308(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-44, LIPID-BINDING.

    Entry informationi

    Entry nameiUD2B2_RAT
    AccessioniPrimary (citable) accession number: P08541
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3