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Protein

Cytochrome b-c1 complex subunit 8

Gene

QCR8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR8, together with cytochrome b, binds to ubiquinone.

Miscellaneous

Present with 6140 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • aerobic respiration Source: SGD
  • mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciYEAST:YJL166W-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 8
Alternative name(s):
Complex III subunit 8
Complex III subunit VII
Ubiquinol-cytochrome c reductase complex 11 kDa protein
Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
Gene namesi
Name:QCR8
Ordered Locus Names:YJL166W
ORF Names:J0526
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL166W
SGDiS000003702 QCR8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001935511 – 94Cytochrome b-c1 complex subunit 8Add BLAST94

Proteomic databases

MaxQBiP08525
PaxDbiP08525
PRIDEiP08525
TopDownProteomicsiP08525

Interactioni

Subunit structurei

Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

Protein-protein interaction databases

BioGridi33593, 312 interactors
DIPiDIP-4706N
IntActiP08525, 3 interactors
STRINGi4932.YJL166W

Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 29Combined sources7
Helixi31 – 33Combined sources3
Beta strandi36 – 39Combined sources4
Turni41 – 44Combined sources4
Beta strandi45 – 47Combined sources3
Helixi50 – 53Combined sources4
Helixi56 – 80Combined sources25
Helixi83 – 85Combined sources3
Helixi86 – 93Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30G2-94[»]
1KB9X-ray2.30H2-94[»]
1KYOX-ray2.97H/S2-94[»]
1P84X-ray2.50H2-94[»]
2IBZX-ray2.30G1-94[»]
3CX5X-ray1.90H/S2-94[»]
3CXHX-ray2.50H/S2-94[»]
4PD4X-ray3.04H2-94[»]
ProteinModelPortaliP08525
SMRiP08525
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08525

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCRQ/QCR8 family.Curated

Phylogenomic databases

HOGENOMiHOG000205681
InParanoidiP08525
KOiK00418
OMAiRHQVLYV
OrthoDBiEOG092C5SBP

Family and domain databases

Gene3Di1.20.5.210, 1 hit
InterProiView protein in InterPro
IPR004205 Cyt_bc1_su8
IPR036642 Cyt_bc1_su8_sf
PANTHERiPTHR12119 PTHR12119, 1 hit
PfamiView protein in Pfam
PF02939 UcrQ, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD331499 UcrQ, 1 hit
SUPFAMiSSF81508 SSF81508, 1 hit

Sequencei

Sequence statusi: Complete.

P08525-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPPSGKTYM GWWGHMGGPK QKGITSYAVS PYAQKPLQGI FHNAVFNSFR
60 70 80 90
RFKSQFLYVL IPAGIYWYWW KNGNEYNEFL YSKAGREELE RVNV
Length:94
Mass (Da):10,975
Last modified:October 1, 1993 - v2
Checksum:i9CB828E495F6ED9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05550 Genomic DNA Translation: CAA29065.1
Z49441 Genomic DNA Translation: CAA89461.1
AY558554 Genomic DNA Translation: AAS56880.1
BK006943 Genomic DNA Translation: DAA08637.1
PIRiS48138
RefSeqiNP_012369.1, NM_001181599.1

Genome annotation databases

EnsemblFungiiYJL166W; YJL166W; YJL166W
GeneIDi853273
KEGGisce:YJL166W

Similar proteinsi

Entry informationi

Entry nameiQCR8_YEAST
AccessioniPrimary (citable) accession number: P08525
Secondary accession number(s): D6VW21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
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Main funding by: National Institutes of Health