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Protein

Cytochrome b-c1 complex subunit 8

Gene

QCR8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR8, together with cytochrome b, binds to ubiquinone.

GO - Molecular functioni

GO - Biological processi

  • aerobic respiration Source: SGD
  • hydrogen ion transmembrane transport Source: GOC
  • mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciYEAST:YJL166W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 8
Alternative name(s):
Complex III subunit 8
Complex III subunit VII
Ubiquinol-cytochrome c reductase complex 11 kDa protein
Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
Gene namesi
Name:QCR8
Ordered Locus Names:YJL166W
ORF Names:J0526
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL166W.
SGDiS000003702. QCR8.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex III Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9494Cytochrome b-c1 complex subunit 8PRO_0000193551Add
BLAST

Proteomic databases

MaxQBiP08525.
PeptideAtlasiP08525.
TopDownProteomicsiP08525.

Interactioni

Subunit structurei

Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

Protein-protein interaction databases

BioGridi33593. 210 interactions.
DIPiDIP-4706N.
IntActiP08525. 2 interactions.
MINTiMINT-572396.

Structurei

Secondary structure

1
94
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi23 – 297Combined sources
Helixi31 – 333Combined sources
Beta strandi36 – 394Combined sources
Turni41 – 444Combined sources
Beta strandi45 – 473Combined sources
Helixi50 – 534Combined sources
Helixi56 – 8025Combined sources
Helixi83 – 853Combined sources
Helixi86 – 938Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30G2-94[»]
1KB9X-ray2.30H2-94[»]
1KYOX-ray2.97H/S2-94[»]
1P84X-ray2.50H2-94[»]
2IBZX-ray2.30G1-94[»]
3CX5X-ray1.90H/S2-94[»]
3CXHX-ray2.50H/S2-94[»]
4PD4X-ray3.04H2-94[»]
ProteinModelPortaliP08525.
SMRiP08525. Positions 2-94.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08525.

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCRQ/QCR8 family.Curated

Phylogenomic databases

HOGENOMiHOG000205681.
InParanoidiP08525.
KOiK00418.
OMAiGSPKQKY.
OrthoDBiEOG7H79FJ.

Family and domain databases

Gene3Di1.20.5.210. 1 hit.
InterProiIPR004205. Cyt_bc1_su8.
[Graphical view]
PANTHERiPTHR12119. PTHR12119. 1 hit.
PfamiPF02939. UcrQ. 1 hit.
[Graphical view]
ProDomiPD331499. UcrQ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81508. SSF81508. 1 hit.

Sequencei

Sequence statusi: Complete.

P08525-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPPSGKTYM GWWGHMGGPK QKGITSYAVS PYAQKPLQGI FHNAVFNSFR
60 70 80 90
RFKSQFLYVL IPAGIYWYWW KNGNEYNEFL YSKAGREELE RVNV
Length:94
Mass (Da):10,975
Last modified:October 1, 1993 - v2
Checksum:i9CB828E495F6ED9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05550 Genomic DNA. Translation: CAA29065.1.
Z49441 Genomic DNA. Translation: CAA89461.1.
AY558554 Genomic DNA. Translation: AAS56880.1.
BK006943 Genomic DNA. Translation: DAA08637.1.
PIRiS48138.
RefSeqiNP_012369.1. NM_001181599.1.

Genome annotation databases

EnsemblFungiiYJL166W; YJL166W; YJL166W.
GeneIDi853273.
KEGGisce:YJL166W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05550 Genomic DNA. Translation: CAA29065.1.
Z49441 Genomic DNA. Translation: CAA89461.1.
AY558554 Genomic DNA. Translation: AAS56880.1.
BK006943 Genomic DNA. Translation: DAA08637.1.
PIRiS48138.
RefSeqiNP_012369.1. NM_001181599.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30G2-94[»]
1KB9X-ray2.30H2-94[»]
1KYOX-ray2.97H/S2-94[»]
1P84X-ray2.50H2-94[»]
2IBZX-ray2.30G1-94[»]
3CX5X-ray1.90H/S2-94[»]
3CXHX-ray2.50H/S2-94[»]
4PD4X-ray3.04H2-94[»]
ProteinModelPortaliP08525.
SMRiP08525. Positions 2-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33593. 210 interactions.
DIPiDIP-4706N.
IntActiP08525. 2 interactions.
MINTiMINT-572396.

Proteomic databases

MaxQBiP08525.
PeptideAtlasiP08525.
TopDownProteomicsiP08525.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL166W; YJL166W; YJL166W.
GeneIDi853273.
KEGGisce:YJL166W.

Organism-specific databases

EuPathDBiFungiDB:YJL166W.
SGDiS000003702. QCR8.

Phylogenomic databases

HOGENOMiHOG000205681.
InParanoidiP08525.
KOiK00418.
OMAiGSPKQKY.
OrthoDBiEOG7H79FJ.

Enzyme and pathway databases

BioCyciYEAST:YJL166W-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP08525.
PROiP08525.

Family and domain databases

Gene3Di1.20.5.210. 1 hit.
InterProiIPR004205. Cyt_bc1_su8.
[Graphical view]
PANTHERiPTHR12119. PTHR12119. 1 hit.
PfamiPF02939. UcrQ. 1 hit.
[Graphical view]
ProDomiPD331499. UcrQ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81508. SSF81508. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the gene encoding the 11-kDa subunit of the ubiquinol-cytochrome-c oxidoreductase in Saccharomyces cerevisiae."
    Maarse A.C., Grivell L.A.
    Eur. J. Biochem. 165:419-425(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE.
  2. "A region of the C-terminal part of the 11-kDa subunit of ubiquinol-cytochrome-c oxidoreductase of the yeast Saccharomyces cerevisiae contributes to the structure of the Qout reaction domain."
    Hemrika W., Berden J.A., Grivell L.A.
    Eur. J. Biochem. 215:601-609(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Structure at 2.3 A resolution of the cytochrome bc1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment."
    Hunte C., Koepke J., Lange C., Rossmanith T., Michel H.
    Structure 8:669-684(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
  8. "Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c."
    Lange C., Hunte C.
    Proc. Natl. Acad. Sci. U.S.A. 99:2800-2805(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.97 ANGSTROMS).

Entry informationi

Entry nameiQCR8_YEAST
AccessioniPrimary (citable) accession number: P08525
Secondary accession number(s): D6VW21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: October 1, 1993
Last modified: June 8, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6140 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.