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Protein

Olfactory marker protein

Gene

Omp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a modulator of the olfactory signal-transduction cascade.

GO - Molecular functioni

  • peptide binding Source: RGD
  • signal transducer activity Source: RGD

GO - Biological processi

  • sensory perception of smell Source: RGD
Complete GO annotation...

Keywords - Biological processi

Olfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory marker protein
Alternative name(s):
Olfactory neuronal-specific protein
Gene namesi
Name:Omp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3231. Omp.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 163162Olfactory marker proteinPRO_0000058046Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP08523.

2D gel databases

World-2DPAGE0004:P08523.

Expressioni

Tissue specificityi

Uniquely associated with mature olfactory receptor neurons.

Interactioni

Subunit structurei

Interacts with BEX1 and BEX2.By similarity

Protein-protein interaction databases

BioGridi246751. 1 interaction.

Structurei

Secondary structure

1
163
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 85Combined sources
Helixi19 – 3315Combined sources
Turni36 – 383Combined sources
Beta strandi53 – 564Combined sources
Beta strandi59 – 624Combined sources
Beta strandi69 – 713Combined sources
Beta strandi73 – 819Combined sources
Turni89 – 913Combined sources
Beta strandi97 – 993Combined sources
Beta strandi103 – 1097Combined sources
Turni110 – 1123Combined sources
Beta strandi113 – 1186Combined sources
Helixi119 – 13416Combined sources
Beta strandi138 – 1447Combined sources
Beta strandi155 – 1573Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JYTNMR-A1-163[»]
1ZRINMR-A1-163[»]
DisProtiDP00279.
ProteinModelPortaliP08523.
SMRiP08523. Positions 1-163.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08523.

Family & Domainsi

Sequence similaritiesi

Belongs to the olfactory marker protein family.Curated

Phylogenomic databases

HOVERGENiHBG007595.
InParanoidiP08523.
PhylomeDBiP08523.

Family and domain databases

Gene3Di2.60.120.390. 1 hit.
InterProiIPR009103. Olfactory_marker.
[Graphical view]
PANTHERiPTHR15357. PTHR15357. 1 hit.
PfamiPF06554. Olfactory_mark. 1 hit.
[Graphical view]
ProDomiPD022055. Olfactory_marker. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF63697. SSF63697. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08523-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDGPQKQQ LDMPLVLDQD LTKQMRLRVE SLKQRGEKKQ DGEKLLRPAE
60 70 80 90 100
SVYRLDFIQQ QKLQFDHWNV VLDKPGKVTI TGTSQNWTPD LTNLMTRQLL
110 120 130 140 150
DPAAIFWRKE DSDAMDWNEA DALEFGERLS DLAKIRKVMY FLITFGEGVE
160
PANLKASVVF NQL
Length:163
Mass (Da):18,853
Last modified:January 23, 2007 - v2
Checksum:i3E04155D1154199E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15644 mRNA. Translation: AAA41757.1.
M26926 Unassigned DNA. Translation: AAA03054.1.
PIRiA27450.
RefSeqiNP_036748.1. NM_012616.1.
UniGeneiRn.9720.

Genome annotation databases

GeneIDi24612.
KEGGirno:24612.
UCSCiRGD:3231. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15644 mRNA. Translation: AAA41757.1.
M26926 Unassigned DNA. Translation: AAA03054.1.
PIRiA27450.
RefSeqiNP_036748.1. NM_012616.1.
UniGeneiRn.9720.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JYTNMR-A1-163[»]
1ZRINMR-A1-163[»]
DisProtiDP00279.
ProteinModelPortaliP08523.
SMRiP08523. Positions 1-163.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246751. 1 interaction.

2D gel databases

World-2DPAGE0004:P08523.

Proteomic databases

PRIDEiP08523.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24612.
KEGGirno:24612.
UCSCiRGD:3231. rat.

Organism-specific databases

CTDi4975.
RGDi3231. Omp.

Phylogenomic databases

HOVERGENiHBG007595.
InParanoidiP08523.
PhylomeDBiP08523.

Miscellaneous databases

EvolutionaryTraceiP08523.
PROiP08523.

Family and domain databases

Gene3Di2.60.120.390. 1 hit.
InterProiIPR009103. Olfactory_marker.
[Graphical view]
PANTHERiPTHR15357. PTHR15357. 1 hit.
PfamiPF06554. Olfactory_mark. 1 hit.
[Graphical view]
ProDomiPD022055. Olfactory_marker. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF63697. SSF63697. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Olfactory marker protein gene: its structure and olfactory neuron-specific expression in transgenic mice."
    Danciger E., Mettling C., Vidal M., Morris R., Margolis F.L.
    Proc. Natl. Acad. Sci. U.S.A. 86:8565-8569(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Amino acid sequence of a unique neuronal protein: rat olfactory marker protein."
    Sydor W., Teitelbaum Z., Blacher R., Sun S., Benz W., Margolis F.L.
    Arch. Biochem. Biophys. 249:351-362(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-163, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2.
  4. "Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction."
    Baldisseri D.M., Margolis J.W., Weber D.J., Koo J.H., Margolis F.L.
    J. Mol. Biol. 319:823-837(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiOMP_RAT
AccessioniPrimary (citable) accession number: P08523
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.