Reviewed,
UniProtKB/Swiss-Prot P08523 (OMP_RAT)
Last modified
March 2, 2010.
Version 73.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Olfactory marker protein Alternative name(s): Olfactory neuronal-specific protein | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 163 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May act as a modulator of the olfactory signal-transduction cascade. |
| Subunit structure | Interacts with BEX1 and BEX2 By similarity. |
| Subcellular location | |
| Tissue specificity | Uniquely associated with mature olfactory receptor neurons. |
| Sequence similarities | Belongs to the olfactory marker protein family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Olfaction Sensory transduction |
| Cellular component | Cytoplasm |
| PTM | Acetylation |
| Technical term | 3D-structure Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of smell Ref.4Non-traceable author statement. Source: RGD signal transductionInferred from electronic annotation. Source: InterPro |
| Cellular component | cytosol Ref.4 Non-traceable author statement. Source: RGD |
| Molecular function | peptide binding Ref.4 Inferred from direct assay. Source: RGD protein binding Ref.4Inferred from direct assay. Source: MGI signal transducer activity Ref.4Non-traceable author statement. Source: RGD |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.3 | |||||||||||||||||||||||||||||||
| Chain | 2 – 163 | 162 | Olfactory marker protein | PRO_0000058046 | ||||||||||||||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||||||||||||||
| Modified residue | 2 | 1 | N-acetylalanine | |||||||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||||||
| Beta strand | 4 – 8 | 5 | ||||||||||||||||||||||||||||||||
| Helix | 19 – 33 | 15 | ||||||||||||||||||||||||||||||||
| Turn | 36 – 38 | 3 | ||||||||||||||||||||||||||||||||
| Beta strand | 53 – 56 | 4 | ||||||||||||||||||||||||||||||||
| Beta strand | 69 – 71 | 3 | ||||||||||||||||||||||||||||||||
| Beta strand | 73 – 81 | 9 | ||||||||||||||||||||||||||||||||
| Turn | 89 – 91 | 3 | ||||||||||||||||||||||||||||||||
| Beta strand | 97 – 99 | 3 | ||||||||||||||||||||||||||||||||
| Beta strand | 103 – 109 | 7 | ||||||||||||||||||||||||||||||||
| Turn | 110 – 112 | 3 | ||||||||||||||||||||||||||||||||
| Beta strand | 113 – 118 | 6 | ||||||||||||||||||||||||||||||||
| Helix | 119 – 134 | 16 | ||||||||||||||||||||||||||||||||
| Beta strand | 138 – 144 | 7 | ||||||||||||||||||||||||||||||||
| Beta strand | 155 – 157 | 3 | ||||||||||||||||||||||||||||||||
Sequences
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References
| [1] | "Molecular cloning and sequencing of a cDNA for olfactory marker protein." Rogers K.E., Dasgupta P., Gubler U., Grillo M., Khew-Goodall Y.S., Margolis F.L. Proc. Natl. Acad. Sci. U.S.A. 84:1704-1708(1987) [PubMed: 3470751] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Olfactory marker protein gene: its structure and olfactory neuron-specific expression in transgenic mice." Danciger E., Mettling C., Vidal M., Morris R., Margolis F.L. Proc. Natl. Acad. Sci. U.S.A. 86:8565-8569(1989) [PubMed: 2701951] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. |
| [3] | "Amino acid sequence of a unique neuronal protein: rat olfactory marker protein." Sydor W., Teitelbaum Z., Blacher R., Sun S., Benz W., Margolis F.L. Arch. Biochem. Biophys. 249:351-362(1986) [PubMed: 3753006] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-163. |
| [4] | "Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction." Baldisseri D.M., Margolis J.W., Weber D.J., Koo J.H., Margolis F.L. J. Mol. Biol. 319:823-837(2002) [PubMed: 12054873] [Abstract] Cited for: STRUCTURE BY NMR. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | M15644 mRNA. Translation: AAA41757.1. M26926 Unassigned DNA. Translation: AAA03054.1. | ||||||||||||||||||
| IPI | IPI00231790. | ||||||||||||||||||
| PIR | A27450. | ||||||||||||||||||
| RefSeq | NP_036748.1. | ||||||||||||||||||
| UniGene | Rn.9720 | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||||||||
| DisProt | DP00279. | ||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | P08523. | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| GeneID | 24612. | ||||||||||||||||||
| KEGG | rno:24612. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CTD | 24612. | ||||||||||||||||||
| RGD | 3231. Omp. | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| HOVERGEN | HBG007595. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| Genevestigator | P08523. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR009103. Olfactory_marker. [Graphical view] | ||||||||||||||||||
| Gene3D | G3DSA:2.60.120.390. Olfactory_marker. 1 hit. | ||||||||||||||||||
| PANTHER | PTHR15357. Olfactory_marker. 1 hit. | ||||||||||||||||||
| Pfam | PF06554. Olfactory_mark. 1 hit. [Graphical view] | ||||||||||||||||||
| ProDom | PD022055. Olfactory_marker. 1 hit. [Graphical view] [Entries sharing at least one domain] | ||||||||||||||||||
| SUPFAM | SSF63697. Olfactory_marker. 1 hit. | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other Resources | |||||||||||||||||||
| NextBio | 603848. | ||||||||||||||||||
Entry information
| Entry name | OMP_RAT | ||||||||
| Accession | Primary (citable) accession number: P08523 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


