Reviewed, UniProtKB/Swiss-Prot P08523 (OMP_RAT)

Names and origin

Protein names

Recommended name:
Olfactory marker protein

Alternative name(s):
Olfactory neuronal-specific protein

Gene names

Name:

Omp

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May act as a modulator of the olfactory signal-transduction cascade.
Subunit structure	Interacts with BEX1 and BEX2 By similarity.
Subcellular location	Cytoplasm.
Tissue specificity	Uniquely associated with mature olfactory receptor neurons.
Sequence similarities	Belongs to the olfactory marker protein family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cytoplasm
PTM	Acetylation
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of smell Ref.4 Non-traceable author statement. Source: RGD signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Ref.4 Non-traceable author statement. Source: RGD
Molecular function	peptide binding Ref.4 Inferred from direct assay. Source: RGD protein binding Ref.4 Inferred from direct assay. Source: MGI signal transducer activity Ref.4 Non-traceable author statement. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.3

Chain

2 – 163

162

Olfactory marker protein

PRO_0000058046

Amino acid modifications

Modified residue

2

1

N-acetylalanine

Secondary structure

1

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163

Helix Strand Turn

Details...

Beta strand

4 – 8

5

Helix

19 – 33

15

Turn

36 – 38

3

Beta strand

53 – 56

4

Beta strand

69 – 71

3

Beta strand

73 – 81

9

Turn

89 – 91

3

Beta strand

97 – 99

3

Beta strand

103 – 109

7

Turn

110 – 112

3

Beta strand

113 – 118

6

Helix

119 – 134

16

Beta strand

138 – 144

7

Beta strand

155 – 157

3

Sequences

	Sequence		Length	Mass (Da)
	P08523-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 3E04155D1154199E	FASTA	163	18,853
	10 20 30 40 50 60 MAEDGPQKQQ LDMPLVLDQD LTKQMRLRVE SLKQRGEKKQ DGEKLLRPAE SVYRLDFIQQ 70 80 90 100 110 120 QKLQFDHWNV VLDKPGKVTI TGTSQNWTPD LTNLMTRQLL DPAAIFWRKE DSDAMDWNEA 130 140 150 160 DALEFGERLS DLAKIRKVMY FLITFGEGVE PANLKASVVF NQL

References

[1]	"Molecular cloning and sequencing of a cDNA for olfactory marker protein." Rogers K.E., Dasgupta P., Gubler U., Grillo M., Khew-Goodall Y.S., Margolis F.L. Proc. Natl. Acad. Sci. U.S.A. 84:1704-1708(1987) [PubMed: 3470751] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Olfactory marker protein gene: its structure and olfactory neuron-specific expression in transgenic mice." Danciger E., Mettling C., Vidal M., Morris R., Margolis F.L. Proc. Natl. Acad. Sci. U.S.A. 86:8565-8569(1989) [PubMed: 2701951] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Amino acid sequence of a unique neuronal protein: rat olfactory marker protein." Sydor W., Teitelbaum Z., Blacher R., Sun S., Benz W., Margolis F.L. Arch. Biochem. Biophys. 249:351-362(1986) [PubMed: 3753006] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-163.
[4]	"Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction." Baldisseri D.M., Margolis J.W., Weber D.J., Koo J.H., Margolis F.L. J. Mol. Biol. 319:823-837(2002) [PubMed: 12054873] [Abstract] Cited for: STRUCTURE BY NMR.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M15644 mRNA. Translation: AAA41757.1.
M26926 Unassigned DNA. Translation: AAA03054.1.

IPI

IPI00231790.

PIR

A27450.

RefSeq

NP_036748.1.

UniGene

Rn.9720

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1JYT	NMR	-	A	1-163	[»]
1ZRI	NMR	-	A	1-162	[»]

DisProt

DP00279.

ModBase

Search...

Proteomic databases

PRIDE

P08523.

Genome annotation databases

GeneID

24612.

KEGG

rno:24612.

Organism-specific databases

CTD

24612.

RGD

3231. Omp.

Phylogenomic databases

HOVERGEN

HBG007595.

Gene expression databases

Genevestigator

P08523.

Family and domain databases

InterPro

IPR009103. Olfactory_marker.
[Graphical view]

Gene3D

G3DSA:2.60.120.390. Olfactory_marker. 1 hit.

PANTHER

PTHR15357. Olfactory_marker. 1 hit.

Pfam

PF06554. Olfactory_mark. 1 hit.
[Graphical view]

ProDom

PD022055. Olfactory_marker. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SUPFAM

SSF63697. Olfactory_marker. 1 hit.

ProtoNet

Search...

Other Resources

NextBio

603848.

Entry information

Entry name

OMP_RAT

Accession

Primary (citable) accession number: P08523

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	January 23, 2007
Last modified:	March 2, 2010
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)