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P08510

- KCNAS_DROME

UniProt

P08510 - KCNAS_DROME

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Protein
Potassium voltage-gated channel protein Shaker
Gene
Sh, mns, CG12348
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Voltage-dependent potassium channel involved in regulation of sleep need or efficiency. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.1 Publication

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome
  2. voltage-gated cation channel activity Source: FlyBase
  3. voltage-gated potassium channel activity Source: FlyBase

GO - Biological processi

  1. action potential Source: FlyBase
  2. axon extension Source: FlyBase
  3. behavioral response to ether Source: FlyBase
  4. courtship behavior Source: FlyBase
  5. detection of visible light Source: FlyBase
  6. flight behavior Source: FlyBase
  7. larval locomotory behavior Source: FlyBase
  8. learning or memory Source: FlyBase
  9. mating behavior, sex discrimination Source: FlyBase
  10. potassium ion transport Source: FlyBase
  11. proboscis extension reflex Source: FlyBase
  12. protein homooligomerization Source: InterPro
  13. regulation of circadian sleep/wake cycle, sleep Source: FlyBase
  14. regulation of synaptic activity Source: FlyBase
  15. sensory perception of taste Source: FlyBase
  16. sleep Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_180793. Voltage gated Potassium channels.

Protein family/group databases

TCDBi1.A.1.2.6. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel protein Shaker
Alternative name(s):
Protein minisleep
Gene namesi
Name:Sh
Synonyms:mns
ORF Names:CG12348
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003380. Sh.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 227227Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei228 – 24619Helical; Name=Segment S1
Add
BLAST
Topological domaini247 – 27832Extracellular Reviewed prediction
Add
BLAST
Transmembranei279 – 30022Helical; Name=Segment S2
Add
BLAST
Topological domaini301 – 31111Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei312 – 33221Helical; Name=Segment S3
Add
BLAST
Topological domaini333 – 36028Extracellular Reviewed prediction
Add
BLAST
Transmembranei361 – 38020Helical; Voltage-sensor; Name=Segment S4
Add
BLAST
Topological domaini381 – 39515Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei396 – 41520Helical; Name=Segment S5
Add
BLAST
Transmembranei457 – 47822Helical; Name=Segment S6
Add
BLAST
Topological domaini479 – 616138Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: FlyBase
  2. voltage-gated potassium channel complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Reduced sleep. Flies sleep for one-third of the wild-type amount. They perform normally in a number of tasks, have preserved sleep homeostasis, but are not impaired by sleep deprivation. They also have a reduced lifespan.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi248 – 2481T → I in mns; flies display reduced sleep. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 655655Potassium voltage-gated channel protein Shaker
PRO_0000053963Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi259 – 2591N-linked (GlcNAc...)1 Publication
Glycosylationi263 – 2631N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP08510.

Expressioni

Gene expression databases

BgeeiP08510.

Interactioni

Subunit structurei

The voltage-dependent potassium channel is a heterotetramer of potassium channel proteins By similarity.

Protein-protein interaction databases

BioGridi59101. 10 interactions.
IntActiP08510. 5 interactions.
MINTiMINT-317832.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi380 – 39415

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HO2NMR-A378-397[»]
1HO7NMR-A378-397[»]
DisProtiDP00267.
ProteinModelPortaliP08510.
SMRiP08510. Positions 96-489.

Miscellaneous databases

EvolutionaryTraceiP08510.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi442 – 4476Selectivity filter

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 5339Gln-rich
Add
BLAST
Compositional biasi558 – 61962Gln-rich
Add
BLAST
Compositional biasi625 – 6306Poly-Ala

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00740000115291.
InParanoidiP08510.
KOiK05318.
OMAiCVSADAN.
OrthoDBiEOG7M0NRD.
PhylomeDBiP08510.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. Align

Isoform E (identifier: P08510-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAVAGLYGL GEDRQHRKKQ QQQQQHQKEQ LEQKEEQKKI AERKLQLREQ    50
QLQRNSLDGY GSLPKLSSQD EEGGAGHGFG GGPQHFEPIP HDHDFCERVV 100
INVSGLRFET QLRTLNQFPD TLLGDPARRL RYFDPLRNEY FFDRSRPSFD 150
AILYYYQSGG RLRRPVNVPL DVFSEEIKFY ELGDQAINKF REDEGFIKEE 200
ERPLPDNEKQ RKVWLLFEYP ESSQAARVVA IISVFVILLS IVIFCLETLP 250
EFKHYKVFNT TTNGTKIEED EVPDITDPFF LIETLCIIWF TFELTVRFLA 300
CPNKLNFCRD VMNVIDIIAI IPYFITLATV VAEEEDTLNL PKAPVSPQDK 350
SSNQAMSLAI LRVIRLVRVF RIFKLSRHSK GLQILGRTLK ASMRELGLLI 400
FFLFIGVVLF SSAVYFAEAG SENSFFKSIP DAFWWAVVTM TTVGYGDMTP 450
VGVWGKIVGS LCAIAGVLTI ALPVPVIVSN FNYFYHRETD QEEMQSQNFN 500
HVTSCPYLPG TLGQHMKKSS LSESSSDMMD LDDGVESTPG LTETHPGRSA 550
VAPFLGAQQQ QQQPVASSLS MSIDKQLQHP LQQLTQTQLY QQQQQQQQQQ 600
QNGFKQQQQQ TQQQLQQQQS HTINASAAAA TSGSGSSGLT MRHNNALAVS 650
IETDV 655
Length:655
Mass (Da):74,193
Last modified:April 4, 2006 - v3
Checksum:i5833E3052C9D19B3
GO
Isoform Alpha (identifier: P08510-2) [UniParc]FASTAAdd to Basket

Also known as: B, Adult

The sequence of this isoform differs from the canonical sequence as follows:
     453-463: VWGKIVGSLCA → FWGKIVGSLCV
     506-655: PYLPGTLGQH...ALAVSIETDV → SYLPGALGQH...AMAVSIETDV

Show »
Length:616
Mass (Da):70,281
Checksum:iB6453435442CB513
GO
Isoform Beta (identifier: P08510-3) [UniParc]FASTAAdd to Basket

Also known as: C, I, J, Late population

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MAAVAGLYGL...LQRNSLDGYG → MTMWQSGGMG...SGSNERNLNQ

Show »
Length:643
Mass (Da):72,501
Checksum:iE1F358B5555496D2
GO
Isoform Delta (identifier: P08510-5) [UniParc]FASTAAdd to Basket

Also known as: Larval, A, H

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MAAVAGLYGL...LQRNSLDGYG → MAHITTTHGSLSQATR
     349-349: D → V
     350-655: Missing.

Show »
Length:304
Mass (Da):34,946
Checksum:i05898ADD605604B5
GO
Isoform Epsilon (identifier: P08510-6) [UniParc]FASTAAdd to Basket

Also known as: Larval, F

The sequence of this isoform differs from the canonical sequence as follows:
     349-349: D → V
     350-655: Missing.

Show »
Length:349
Mass (Da):40,493
Checksum:iB509504C2D3EE550
GO
Isoform D (identifier: P08510-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MAAVAGLYGL...LQRNSLDGYG → MAHITTTHGSLSQATR
     453-463: VWGKIVGSLCA → FWGKIVGSLCV
     506-655: PYLPGTLGQH...ALAVSIETDV → SYLPGALGQH...AMAVSIETDV

Note: No experimental confirmation available.

Show »
Length:571
Mass (Da):64,734
Checksum:i7CFF19956D54D599
GO
Isoform N (identifier: P08510-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-655: VVLFSSAVYF...ALAVSIETDV → KFHTVNKKKK...IKTTTKDTYI

Note: No experimental confirmation available.

Show »
Length:505
Mass (Da):58,751
Checksum:i5F0D4BCB5FA4F23D
GO
Isoform L (identifier: P08510-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MAAVAGLYGL...LQRNSLDGYG → MTMWQSGGMG...SGSNERNLNQ
     512-512: L → LV

Note: No experimental confirmation available.

Show »
Length:644
Mass (Da):72,600
Checksum:iA9B6FD52794B82C3
GO

Sequence cautioni

The sequence AAA70217.1 differs from that shown. Reason: Frameshift at several positions.

RNA editingi

Partially edited.4 Publications

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti178 – 1781K → E in RNA edited version.
Natural varianti178 – 1781K → G in RNA edited version.
Natural varianti178 – 1781K → R in RNA edited version.
Natural varianti360 – 3601I → M in RNA edited version.
Natural varianti464 – 4641I → V in RNA edited version.
Natural varianti489 – 4891T → A in RNA edited version.
Natural varianti491 – 4911Q → R in RNA edited version.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6161MAAVA…LDGYG → MTMWQSGGMGGHGSQNNPWM KLMGIVHKERRHTENVQSQS GSNERNLNQ in isoform Beta and isoform L.
VSP_000954Add
BLAST
Alternative sequencei1 – 6161MAAVA…LDGYG → MAHITTTHGSLSQATR in isoform Delta and isoform D.
VSP_000956Add
BLAST
Alternative sequencei349 – 3491D → V in isoform Delta and isoform Epsilon.
VSP_000957
Alternative sequencei350 – 655306Missing in isoform Delta and isoform Epsilon.
VSP_000958Add
BLAST
Alternative sequencei407 – 655249VVLFS…IETDV → KFHTVNKKKKNNIPHLLIDL RVLFKQHQKQKRNTAKRLRP SRQTYPRYPAPSKDIFSTTS HCPKVLIHILTVNRSKTTYN YSGIVQRSRIKTTTKDTYI in isoform N.
VSP_054719Add
BLAST
Alternative sequencei453 – 46311VWGKIVGSLCA → FWGKIVGSLCV in isoform Alpha and isoform D.
VSP_017889Add
BLAST
Alternative sequencei506 – 655150PYLPG…IETDV → SYLPGALGQHLKKSSLSESS SDIMDLDDGIDATTPGLTDH TGRHMVPFLRTQQSFEKQQL QLQLQLQQQSQSPHGQQMTQ QQQLGQNGLRSTNSLQLRHN NAMAVSIETDV in isoform Alpha and isoform D.
VSP_000959Add
BLAST
Alternative sequencei512 – 5121L → LV in isoform L.
VSP_054720

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti563 – 5631Q → QQ in CAA29917. 1 Publication
Sequence conflicti583 – 5842QL → HV in CAA29917. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17211 mRNA. Translation: AAA28417.1.
X06184 mRNA. Translation: CAA29549.1.
X07131 mRNA. Translation: CAA30143.1.
X07132 mRNA. Translation: CAA30144.1.
X07133 mRNA. Translation: CAA30145.1.
X07134 mRNA. Translation: CAA30146.1.
X06742 mRNA. Translation: CAA29917.1.
AE014298 Genomic DNA. Translation: AAF48785.3.
AE014298 Genomic DNA. Translation: AAF48786.3.
AE014298 Genomic DNA. Translation: AAF48790.2.
AE014298 Genomic DNA. Translation: AAN09451.1.
AE014298 Genomic DNA. Translation: AAN09452.1.
AE014298 Genomic DNA. Translation: AAS65395.2.
AE014298 Genomic DNA. Translation: AAS65396.1.
AE014298 Genomic DNA. Translation: ADV37750.1.
AE014298 Genomic DNA. Translation: AFH07440.1.
AE014298 Genomic DNA. Translation: AGB95507.1.
AY118398 mRNA. Translation: AAM48427.1.
BT050432 mRNA. Translation: ACJ13139.1.
M17155 mRNA. Translation: AAA70217.1. Frameshift.
X78908 Genomic DNA. Translation: CAA55519.1.
PIRiA27159.
JH0193.
S00480.
S02284.
RefSeqiNP_001162788.1. NM_001169317.1. [P08510-5]
NP_001188668.1. NM_001201739.1. [P08510-3]
NP_001245727.1. NM_001258798.1. [P08510-9]
NP_001259665.1. NM_001272736.1. [P08510-8]
NP_523393.3. NM_078669.5. [P08510-2]
NP_728120.1. NM_167592.4. [P08510-7]
NP_728122.1. NM_167594.3. [P08510-3]
NP_728123.1. NM_167595.4. [P08510-1]
NP_728124.1. NM_167596.4. [P08510-5]
NP_996497.1. NM_206774.2. [P08510-6]
NP_996498.2. NM_206775.4. [P08510-3]
UniGeneiDm.7088.

Genome annotation databases

EnsemblMetazoaiFBtr0089657; FBpp0088599; FBgn0003380. [P08510-1]
FBtr0089660; FBpp0088602; FBgn0003380. [P08510-7]
FBtr0089661; FBpp0088603; FBgn0003380. [P08510-3]
FBtr0302902; FBpp0292033; FBgn0003380. [P08510-3]
FBtr0302903; FBpp0292034; FBgn0003380. [P08510-3]
FBtr0308200; FBpp0300520; FBgn0003380. [P08510-9]
FBtr0332300; FBpp0304579; FBgn0003380. [P08510-8]
GeneIDi32780.
KEGGidme:Dmel_CG12348.

Keywords - Coding sequence diversityi

Alternative splicing, RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17211 mRNA. Translation: AAA28417.1 .
X06184 mRNA. Translation: CAA29549.1 .
X07131 mRNA. Translation: CAA30143.1 .
X07132 mRNA. Translation: CAA30144.1 .
X07133 mRNA. Translation: CAA30145.1 .
X07134 mRNA. Translation: CAA30146.1 .
X06742 mRNA. Translation: CAA29917.1 .
AE014298 Genomic DNA. Translation: AAF48785.3 .
AE014298 Genomic DNA. Translation: AAF48786.3 .
AE014298 Genomic DNA. Translation: AAF48790.2 .
AE014298 Genomic DNA. Translation: AAN09451.1 .
AE014298 Genomic DNA. Translation: AAN09452.1 .
AE014298 Genomic DNA. Translation: AAS65395.2 .
AE014298 Genomic DNA. Translation: AAS65396.1 .
AE014298 Genomic DNA. Translation: ADV37750.1 .
AE014298 Genomic DNA. Translation: AFH07440.1 .
AE014298 Genomic DNA. Translation: AGB95507.1 .
AY118398 mRNA. Translation: AAM48427.1 .
BT050432 mRNA. Translation: ACJ13139.1 .
M17155 mRNA. Translation: AAA70217.1 . Frameshift.
X78908 Genomic DNA. Translation: CAA55519.1 .
PIRi A27159.
JH0193.
S00480.
S02284.
RefSeqi NP_001162788.1. NM_001169317.1. [P08510-5 ]
NP_001188668.1. NM_001201739.1. [P08510-3 ]
NP_001245727.1. NM_001258798.1. [P08510-9 ]
NP_001259665.1. NM_001272736.1. [P08510-8 ]
NP_523393.3. NM_078669.5. [P08510-2 ]
NP_728120.1. NM_167592.4. [P08510-7 ]
NP_728122.1. NM_167594.3. [P08510-3 ]
NP_728123.1. NM_167595.4. [P08510-1 ]
NP_728124.1. NM_167596.4. [P08510-5 ]
NP_996497.1. NM_206774.2. [P08510-6 ]
NP_996498.2. NM_206775.4. [P08510-3 ]
UniGenei Dm.7088.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1HO2 NMR - A 378-397 [» ]
1HO7 NMR - A 378-397 [» ]
DisProti DP00267.
ProteinModelPortali P08510.
SMRi P08510. Positions 96-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 59101. 10 interactions.
IntActi P08510. 5 interactions.
MINTi MINT-317832.

Protein family/group databases

TCDBi 1.A.1.2.6. the voltage-gated ion channel (vic) superfamily.

Proteomic databases

PaxDbi P08510.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0089657 ; FBpp0088599 ; FBgn0003380 . [P08510-1 ]
FBtr0089660 ; FBpp0088602 ; FBgn0003380 . [P08510-7 ]
FBtr0089661 ; FBpp0088603 ; FBgn0003380 . [P08510-3 ]
FBtr0302902 ; FBpp0292033 ; FBgn0003380 . [P08510-3 ]
FBtr0302903 ; FBpp0292034 ; FBgn0003380 . [P08510-3 ]
FBtr0308200 ; FBpp0300520 ; FBgn0003380 . [P08510-9 ]
FBtr0332300 ; FBpp0304579 ; FBgn0003380 . [P08510-8 ]
GeneIDi 32780.
KEGGi dme:Dmel_CG12348.

Organism-specific databases

CTDi 32780.
FlyBasei FBgn0003380. Sh.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00740000115291.
InParanoidi P08510.
KOi K05318.
OMAi CVSADAN.
OrthoDBi EOG7M0NRD.
PhylomeDBi P08510.

Enzyme and pathway databases

Reactomei REACT_180793. Voltage gated Potassium channels.

Miscellaneous databases

ChiTaRSi Sh. drosophila.
EvolutionaryTracei P08510.
GenomeRNAii 32780.
NextBioi 780331.

Gene expression databases

Bgeei P08510.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila."
    Tempel B.L., Papazian D.M., Schwarz T.L., Jan Y.N., Jan L.Y.
    Science 237:770-775(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), RNA EDITING OF POSITIONS 464; 489 AND 491.
  2. "Molecular organization of the maternal effect region of the Shaker complex of Drosophila: characterization of an I(A) channel transcript with homology to vertebrate Na(+) channel."
    Baumann A., Krah-Jentgens I., Mueller R., Mueller-Holtkamp F., Seidel R., Kecskemethy N., Casal J., Ferrus A., Pongs O.
    EMBO J. 6:3419-3429(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DELTA).
    Strain: Canton-S and Oregon-R.
  3. "Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila."
    Pongs O., Kecskemethy N., Mueller R., Krah-Jentgens I., Baumann A., Kiltz H.H., Canal I., Llamazares S., Ferrus A.
    EMBO J. 7:1087-1096(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA; BETA; DELTA AND EPSILON), RNA EDITING OF POSITIONS 464; 489 AND 491.
    Strain: Canton-S.
    Tissue: Larva.
  4. "Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila."
    Schwarz T.L., Tempel B.L., Papazian D.M., Jan Y.N., Jan L.Y.
    Nature 331:137-142(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA; BETA AND E).
  5. Erratum
    Schwarz T.L., Tempel B.L., Papazian D.M., Jan Y.N., Jan L.Y.
    Nature 332:740-740(1988)
  6. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  7. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D), RNA EDITING OF POSITION 360.
    Strain: Berkeley.
    Tissue: Embryo.
  9. Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.
    Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D).
    Strain: Berkeley.
  10. "Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel."
    Kamb A., Iverson L.E., Tanouye M.A.
    Cell 50:405-413(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-257 (ISOFORM BETA).
    Tissue: Larva.
  11. "Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversity."
    Kamb A., Tseng-Crank J., Tanouye M.A.
    Neuron 1:421-430(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 450-534.
    Strain: H4.
  12. "Nervous system targets of RNA editing identified by comparative genomics."
    Hoopengardner B., Bhalla T., Staber C., Reenan R.
    Science 301:832-836(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA EDITING.
  13. Cited for: FUNCTION, DISRUPTION PHENOTYPE, MUTAGENESIS OF THR-248.
  14. "Identification of N-glycosylated proteins from the central nervous system of Drosophila melanogaster."
    Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L., Panin V.
    Glycobiology 17:1388-1403(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-259 AND ASN-263, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Oregon-R.
    Tissue: Head.
  15. "Three-dimensional structure of the S4-S5 segment of the Shaker potassium channel."
    Ohlenschlaeger O., Hojo H., Ramachandran R., Goerlach M., Haris P.I.
    Biophys. J. 82:2995-3002(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 378-397.

Entry informationi

Entry nameiKCNAS_DROME
AccessioniPrimary (citable) accession number: P08510
Secondary accession number(s): A4V4Q2
, B6IDJ2, M9MSC0, M9NEM4, M9PF21, P08511, P08512, P08513, Q24277, Q24521, Q7KUW5, Q8IQY9, Q8MT41, Q9VWZ5, Q9VWZ9, Q9VX00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: April 4, 2006
Last modified: September 3, 2014
This is version 169 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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