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P08508 (FCGR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low affinity immunoglobulin gamma Fc region receptor III

Short name=IgG Fc receptor III
Alternative name(s):
Fc-gamma RIII
Short name=FcRIII
CD_antigen=CD16
Gene names
Name:Fcgr3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor.

Subunit structure

Interacts with INPP5D/SHIP1. Ref.4

Subcellular location

Cell membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
Transmembrane helix
   LigandIgG-binding protein
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processFc-gamma receptor signaling pathway

Inferred from mutant phenotype PubMed 9743367PubMed 9834201. Source: GOC

antibody-dependent cellular cytotoxicity

Inferred from mutant phenotype PubMed 8769481PubMed 9743367. Source: MGI

antigen processing and presentation of exogenous peptide antigen via MHC class I

Inferred from mutant phenotype PubMed 11911824. Source: MGI

cell surface receptor signaling pathway

Inferred from mutant phenotype PubMed 8769481. Source: MGI

mast cell activation

Inferred from direct assay PubMed 8552190. Source: MGI

neutrophil chemotaxis

Inferred from mutant phenotype PubMed 11420040. Source: MGI

phagocytosis, engulfment

Inferred from mutant phenotype PubMed 8769481PubMed 9743367PubMed 9834201. Source: MGI

phagocytosis, recognition

Inferred from mutant phenotype PubMed 8769481PubMed 9743367PubMed 9834201. Source: MGI

positive regulation of phagocytosis

Inferred from mutant phenotype PubMed 8769481PubMed 9743367PubMed 9834201. Source: MGI

positive regulation of tumor necrosis factor biosynthetic process

Inferred from mutant phenotype PubMed 10229794. Source: MGI

positive regulation of type I hypersensitivity

Inferred from direct assay PubMed 8552190. Source: MGI

positive regulation of type III hypersensitivity

Inferred from mutant phenotype PubMed 8769481. Source: MGI

positive regulation of type IIa hypersensitivity

Inferred from mutant phenotype PubMed 11911824PubMed 9834201. Source: MGI

regulation of immune response

Inferred from mutant phenotype PubMed 11911824. Source: MGI

serotonin secretion

Inferred from direct assay PubMed 8552190. Source: MGI

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionIgG binding

Inferred from mutant phenotype PubMed 9743367PubMed 9834201. Source: MGI

IgG receptor activity

Inferred from mutant phenotype PubMed 9743367PubMed 9834201. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 261231Low affinity immunoglobulin gamma Fc region receptor III
PRO_0000015154

Regions

Topological domain31 – 215185Extracellular Potential
Transmembrane216 – 23520Helical; Potential
Topological domain236 – 26126Cytoplasmic Potential
Domain33 – 11078Ig-like C2-type 1
Domain116 – 19883Ig-like C2-type 2

Amino acid modifications

Glycosylation641N-linked (GlcNAc...) Potential
Glycosylation911N-linked (GlcNAc...) Potential
Glycosylation1651N-linked (GlcNAc...) Potential
Glycosylation1721N-linked (GlcNAc...) Potential
Disulfide bond56 ↔ 98 By similarity
Disulfide bond137 ↔ 181 By similarity

Sequences

Sequence LengthMass (Da)Tools
P08508 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: 757FB83668E41069

FASTA26130,036
        10         20         30         40         50         60 
MFQNAHSGSQ WLLPPLTILL LFAFADRQSA ALPKAVVKLD PPWIQVLKED MVTLMCEGTH 

        70         80         90        100        110        120 
NPGNSSTQWF HNGRSIRSQV QASYTFKATV NDSGEYRCQM EQTRLSDPVD LGVISDWLLL 

       130        140        150        160        170        180 
QTPQRVFLEG ETITLRCHSW RNKLLNRISF FHNEKSVRYH HYKSNFSIPK ANHSHSGDYY 

       190        200        210        220        230        240 
CKGSLGSTQH QSKPVTITVQ DPATTSSISL VWYHTAFSLV MCLLFAVDTG LYFYVRRNLQ 

       250        260 
TPREYWRKSL SIRKHQAPQD K 

« Hide

References

[1]"Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors."
Ravetch J.V., Luster A.D., Weinshank R., Kochan J., Pavlovec A., Portnoy D.A., Hulmes J., Pan Y.-C.E., Unkeless J.C.
Science 234:718-725(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Soares H.J., Onken M.D., Kulczycki A. Jr.
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE OF 1-29.
Strain: BALB/c.
Tissue: Liver.
[3]"PU.1 and an HLH family member contribute to the myeloid-specific transcription of the Fc gamma RIIIA promoter."
Feinman R., Qiu W.Q., Pearse R.N., Nikolajczyk B.S., Sen R., Sheffery M., Ravetch J.V.
EMBO J. 13:3852-3860(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 1-22.
[4]"SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells."
Galandrini R., Tassi I., Mattia G., Lenti L., Piccoli M., Frati L., Santoni A.
Blood 100:4581-4589(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH INPP5D.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M14215 mRNA. Translation: AAA37604.1.
X60929 Genomic DNA. Translation: CAA43266.1.
PIRS29360.
UniGeneMm.22119.

3D structure databases

ProteinModelPortalP08508.
SMRP08508. Positions 31-203.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP08508.

Proteomic databases

PaxDbP08508.
PRIDEP08508.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:95500. Fcgr3.

Phylogenomic databases

eggNOGNOG25177.
HOGENOMHOG000251632.
HOVERGENHBG051602.
InParanoidP08508.

Gene expression databases

CleanExMM_FCGR3.
GenevestigatorP08508.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTSM00409. IG. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

PROP08508.
SOURCESearch...

Entry information

Entry nameFCGR3_MOUSE
AccessionPrimary (citable) accession number: P08508
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: June 11, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot