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P08508

- FCGR3_MOUSE

UniProt

P08508 - FCGR3_MOUSE

Protein

Low affinity immunoglobulin gamma Fc region receptor III

Gene

Fcgr3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
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    Functioni

    Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor.

    GO - Molecular functioni

    1. IgG binding Source: MGI
    2. IgG receptor activity Source: MGI

    GO - Biological processi

    1. antibody-dependent cellular cytotoxicity Source: MGI
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: MGI
    3. cell surface receptor signaling pathway Source: MGI
    4. Fc-gamma receptor signaling pathway Source: GOC
    5. mast cell activation Source: MGI
    6. neutrophil chemotaxis Source: MGI
    7. phagocytosis, engulfment Source: MGI
    8. phagocytosis, recognition Source: MGI
    9. positive regulation of phagocytosis Source: MGI
    10. positive regulation of tumor necrosis factor biosynthetic process Source: MGI
    11. positive regulation of type I hypersensitivity Source: MGI
    12. positive regulation of type IIa hypersensitivity Source: MGI
    13. positive regulation of type III hypersensitivity Source: MGI
    14. regulation of immune response Source: MGI
    15. serotonin secretion Source: MGI

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    IgG-binding protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low affinity immunoglobulin gamma Fc region receptor III
    Short name:
    IgG Fc receptor III
    Alternative name(s):
    Fc-gamma RIII
    Short name:
    FcRIII
    CD_antigen: CD16
    Gene namesi
    Name:Fcgr3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:95500. Fcgr3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 261231Low affinity immunoglobulin gamma Fc region receptor IIIPRO_0000015154Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 98PROSITE-ProRule annotation
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi137 ↔ 181PROSITE-ProRule annotation
    Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP08508.
    PRIDEiP08508.

    PTM databases

    PhosphoSiteiP08508.

    Expressioni

    Gene expression databases

    CleanExiMM_FCGR3.
    GenevestigatoriP08508.

    Interactioni

    Subunit structurei

    Interacts with INPP5D/SHIP1.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP08508.
    SMRiP08508. Positions 31-203.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 215185ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini236 – 26126CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei216 – 23520HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 11078Ig-like C2-type 1Add
    BLAST
    Domaini116 – 19883Ig-like C2-type 2Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG25177.
    HOGENOMiHOG000251632.
    HOVERGENiHBG051602.
    InParanoidiP08508.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P08508-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFQNAHSGSQ WLLPPLTILL LFAFADRQSA ALPKAVVKLD PPWIQVLKED    50
    MVTLMCEGTH NPGNSSTQWF HNGRSIRSQV QASYTFKATV NDSGEYRCQM 100
    EQTRLSDPVD LGVISDWLLL QTPQRVFLEG ETITLRCHSW RNKLLNRISF 150
    FHNEKSVRYH HYKSNFSIPK ANHSHSGDYY CKGSLGSTQH QSKPVTITVQ 200
    DPATTSSISL VWYHTAFSLV MCLLFAVDTG LYFYVRRNLQ TPREYWRKSL 250
    SIRKHQAPQD K 261
    Length:261
    Mass (Da):30,036
    Last modified:August 1, 1988 - v1
    Checksum:i757FB83668E41069
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14215 mRNA. Translation: AAA37604.1.
    X60929 Genomic DNA. Translation: CAA43266.1.
    PIRiS29360.
    UniGeneiMm.22119.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14215 mRNA. Translation: AAA37604.1 .
    X60929 Genomic DNA. Translation: CAA43266.1 .
    PIRi S29360.
    UniGenei Mm.22119.

    3D structure databases

    ProteinModelPortali P08508.
    SMRi P08508. Positions 31-203.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P08508.

    Proteomic databases

    PaxDbi P08508.
    PRIDEi P08508.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:95500. Fcgr3.

    Phylogenomic databases

    eggNOGi NOG25177.
    HOGENOMi HOG000251632.
    HOVERGENi HBG051602.
    InParanoidi P08508.

    Miscellaneous databases

    PROi P08508.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_FCGR3.
    Genevestigatori P08508.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors."
      Ravetch J.V., Luster A.D., Weinshank R., Kochan J., Pavlovec A., Portnoy D.A., Hulmes J., Pan Y.-C.E., Unkeless J.C.
      Science 234:718-725(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Soares H.J., Onken M.D., Kulczycki A. Jr.
      Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 1-29.
      Strain: BALB/c.
      Tissue: Liver.
    3. "PU.1 and an HLH family member contribute to the myeloid-specific transcription of the Fc gamma RIIIA promoter."
      Feinman R., Qiu W.Q., Pearse R.N., Nikolajczyk B.S., Sen R., Sheffery M., Ravetch J.V.
      EMBO J. 13:3852-3860(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-22.
    4. "SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells."
      Galandrini R., Tassi I., Mattia G., Lenti L., Piccoli M., Frati L., Santoni A.
      Blood 100:4581-4589(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH INPP5D.

    Entry informationi

    Entry nameiFCGR3_MOUSE
    AccessioniPrimary (citable) accession number: P08508
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3