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Protein

Low affinity immunoglobulin gamma Fc region receptor III

Gene

Fcgr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor which binds to IgG1, IgG2a and IgG2b (PubMed:17558411). Mediates neutrophil activation by IgG complexes redundantly with Fcgr4 (PubMed:18097064).2 Publications

GO - Molecular functioni

  • IgG binding Source: MGI
  • IgG receptor activity Source: UniProtKB

GO - Biological processi

  • antibody-dependent cellular cytotoxicity Source: MGI
  • antigen processing and presentation of exogenous peptide antigen via MHC class I Source: MGI
  • cell surface receptor signaling pathway Source: MGI
  • mast cell activation Source: MGI
  • neutrophil chemotaxis Source: MGI
  • phagocytosis, engulfment Source: MGI
  • phagocytosis, recognition Source: MGI
  • positive regulation of phagocytosis Source: MGI
  • positive regulation of tumor necrosis factor biosynthetic process Source: MGI
  • positive regulation of type I hypersensitivity Source: MGI
  • positive regulation of type IIa hypersensitivity Source: MGI
  • positive regulation of type III hypersensitivity Source: MGI
  • regulation of immune response Source: MGI
  • serotonin secretion Source: MGI

Keywordsi

Molecular functionIgG-binding protein, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin gamma Fc region receptor III
Short name:
IgG Fc receptor III
Alternative name(s):
Fc-gamma RIII
Short name:
FcRIII
CD_antigen: CD16
Gene namesi
Name:Fcgr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95500. Fcgr3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 215ExtracellularSequence analysisAdd BLAST185
Transmembranei216 – 235HelicalSequence analysisAdd BLAST20
Topological domaini236 – 261CytoplasmicSequence analysisAdd BLAST26

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • external side of plasma membrane Source: MGI
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001515431 – 261Low affinity immunoglobulin gamma Fc region receptor IIIAdd BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 98PROSITE-ProRule annotation
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi137 ↔ 181PROSITE-ProRule annotation
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP08508.
PaxDbiP08508.
PeptideAtlasiP08508.
PRIDEiP08508.

PTM databases

PhosphoSitePlusiP08508.

Expressioni

Gene expression databases

CleanExiMM_FCGR3.

Interactioni

Subunit structurei

Interacts with INPP5D/SHIP1.1 Publication

GO - Molecular functioni

  • IgG binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131938.

Structurei

3D structure databases

ProteinModelPortaliP08508.
SMRiP08508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 110Ig-like C2-type 1Add BLAST78
Domaini116 – 198Ig-like C2-type 2Add BLAST83

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9AP. Eukaryota.
ENOG410YXNK. LUCA.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiP08508.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
PfamiView protein in Pfam
PF13895. Ig_2. 2 hits.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08508-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQNAHSGSQ WLLPPLTILL LFAFADRQSA ALPKAVVKLD PPWIQVLKED
60 70 80 90 100
MVTLMCEGTH NPGNSSTQWF HNGRSIRSQV QASYTFKATV NDSGEYRCQM
110 120 130 140 150
EQTRLSDPVD LGVISDWLLL QTPQRVFLEG ETITLRCHSW RNKLLNRISF
160 170 180 190 200
FHNEKSVRYH HYKSNFSIPK ANHSHSGDYY CKGSLGSTQH QSKPVTITVQ
210 220 230 240 250
DPATTSSISL VWYHTAFSLV MCLLFAVDTG LYFYVRRNLQ TPREYWRKSL
260
SIRKHQAPQD K
Length:261
Mass (Da):30,036
Last modified:August 1, 1988 - v1
Checksum:i757FB83668E41069
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14215 mRNA. Translation: AAA37604.1.
X60929 Genomic DNA. Translation: CAA43266.1.
PIRiS29360.
UniGeneiMm.22119.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14215 mRNA. Translation: AAA37604.1.
X60929 Genomic DNA. Translation: CAA43266.1.
PIRiS29360.
UniGeneiMm.22119.

3D structure databases

ProteinModelPortaliP08508.
SMRiP08508.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131938.

PTM databases

PhosphoSitePlusiP08508.

Proteomic databases

MaxQBiP08508.
PaxDbiP08508.
PeptideAtlasiP08508.
PRIDEiP08508.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95500. Fcgr3.

Phylogenomic databases

eggNOGiENOG410J9AP. Eukaryota.
ENOG410YXNK. LUCA.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiP08508.

Miscellaneous databases

PROiPR:P08508.
SOURCEiSearch...

Gene expression databases

CleanExiMM_FCGR3.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
PfamiView protein in Pfam
PF13895. Ig_2. 2 hits.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiFCGR3_MOUSE
AccessioniPrimary (citable) accession number: P08508
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 10, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.