P08508 (FCGR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Low affinity immunoglobulin gamma Fc region receptor III
Short name=IgG Fc receptor III

Alternative name(s):
Fc-gamma RIII
Short name=FcRIII
CD_antigen=CD16

Gene names

Name:

Fcgr3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor.
Subunit structure	Interacts with INPP5D/SHIP1. Ref.4
Subcellular location	Cell membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Ligand	IgG-binding protein
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	antibody-dependent cellular cytotoxicity Inferred from mutant phenotype PubMed 8769481PubMed 9743367. Source: MGI antigen processing and presentation of exogenous peptide antigen via MHC class I Inferred from mutant phenotype PubMed 11911824. Source: MGI mast cell activation Inferred from direct assay PubMed 8552190. Source: MGI neutrophil chemotaxis Inferred from mutant phenotype PubMed 11420040. Source: MGI phagocytosis, engulfment Inferred from mutant phenotype PubMed 8769481PubMed 9743367PubMed 9834201. Source: MGI phagocytosis, recognition Inferred from mutant phenotype PubMed 8769481PubMed 9743367PubMed 9834201. Source: MGI positive regulation of phagocytosis Inferred from mutant phenotype PubMed 8769481PubMed 9743367PubMed 9834201. Source: MGI positive regulation of tumor necrosis factor biosynthetic process Inferred from mutant phenotype PubMed 10229794. Source: MGI positive regulation of type I hypersensitivity Inferred from direct assay PubMed 8552190. Source: MGI positive regulation of type III hypersensitivity Inferred from mutant phenotype PubMed 8769481. Source: MGI positive regulation of type IIa hypersensitivity Inferred from mutant phenotype PubMed 11911824PubMed 9834201. Source: MGI serotonin secretion Inferred from direct assay PubMed 8552190. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	IgG binding Inferred from mutant phenotype PubMed 9743367PubMed 9834201. Source: MGI IgG receptor activity Inferred from mutant phenotype PubMed 9743367PubMed 9834201. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 261	231	Low affinity immunoglobulin gamma Fc region receptor III		PRO_0000015154
Regions
	Topological domain	31 – 215	185	Extracellular Potential
	Transmembrane	216 – 235	20	Helical; Potential
	Topological domain	236 – 261	26	Cytoplasmic Potential
	Domain	33 – 110	78	Ig-like C2-type 1
	Domain	116 – 198	83	Ig-like C2-type 2
Amino acid modifications
	Glycosylation	64	1	N-linked (GlcNAc...) Potential
	Glycosylation	91	1	N-linked (GlcNAc...) Potential
	Glycosylation	165	1	N-linked (GlcNAc...) Potential
	Glycosylation	172	1	N-linked (GlcNAc...) Potential
	Disulfide bond	56 ↔ 98		By similarity
	Disulfide bond	137 ↔ 181		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P08508 [UniParc]. Last modified August 1, 1988. Version 1. Checksum: 757FB83668E41069	FASTA	261	30,036
	10 20 30 40 50 60 MFQNAHSGSQ WLLPPLTILL LFAFADRQSA ALPKAVVKLD PPWIQVLKED MVTLMCEGTH 70 80 90 100 110 120 NPGNSSTQWF HNGRSIRSQV QASYTFKATV NDSGEYRCQM EQTRLSDPVD LGVISDWLLL 130 140 150 160 170 180 QTPQRVFLEG ETITLRCHSW RNKLLNRISF FHNEKSVRYH HYKSNFSIPK ANHSHSGDYY 190 200 210 220 230 240 CKGSLGSTQH QSKPVTITVQ DPATTSSISL VWYHTAFSLV MCLLFAVDTG LYFYVRRNLQ 250 260 TPREYWRKSL SIRKHQAPQD K

References

[1]	"Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors." Ravetch J.V., Luster A.D., Weinshank R., Kochan J., Pavlovec A., Portnoy D.A., Hulmes J., Pan Y.-C.E., Unkeless J.C. Science 234:718-725(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Soares H.J., Onken M.D., Kulczycki A. Jr. Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 1-29. Strain: BALB/c. Tissue: Liver.
[3]	"PU.1 and an HLH family member contribute to the myeloid-specific transcription of the Fc gamma RIIIA promoter." Feinman R., Qiu W.Q., Pearse R.N., Nikolajczyk B.S., Sen R., Sheffery M., Ravetch J.V. EMBO J. 13:3852-3860(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 1-22.
[4]	"SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells." Galandrini R., Tassi I., Mattia G., Lenti L., Piccoli M., Frati L., Santoni A. Blood 100:4581-4589(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH INPP5D.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M14215 mRNA. Translation: AAA37604.1. X60929 Genomic DNA. Translation: CAA43266.1.
IPI	IPI00133707.
PIR	S29360.
UniGene	Mm.22119.
3D structure databases
ProteinModelPortal	P08508.
SMR	P08508. Positions 31-203.
ModBase	Search...
PTM databases
PhosphoSite	P08508.
Proteomic databases
PaxDb	P08508.
PRIDE	P08508.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:95500. Fcgr3.
Phylogenomic databases
eggNOG	NOG25177.
HOGENOM	HOG000251632.
HOVERGEN	HBG051602.
InParanoid	P08508.
OrthoDB	EOG4ZS94D.
Gene expression databases
CleanEx	MM_FCGR3.
Genevestigator	P08508.
GermOnline	ENSMUSG00000059498. Mus musculus.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. [Graphical view]
SMART	SM00409. IG. 2 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. 2 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

FCGR3_MOUSE

Accession

Primary (citable) accession number: P08508

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	May 1, 2013
This is version 120 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program