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P08508

- FCGR3_MOUSE

UniProt

P08508 - FCGR3_MOUSE

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Protein

Low affinity immunoglobulin gamma Fc region receptor III

Gene

Fcgr3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor.

GO - Molecular functioni

  1. IgG binding Source: MGI
  2. IgG receptor activity Source: MGI

GO - Biological processi

  1. antibody-dependent cellular cytotoxicity Source: MGI
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: MGI
  3. cell surface receptor signaling pathway Source: MGI
  4. Fc-gamma receptor signaling pathway Source: GOC
  5. mast cell activation Source: MGI
  6. neutrophil chemotaxis Source: MGI
  7. phagocytosis, engulfment Source: MGI
  8. phagocytosis, recognition Source: MGI
  9. positive regulation of phagocytosis Source: MGI
  10. positive regulation of tumor necrosis factor biosynthetic process Source: MGI
  11. positive regulation of type I hypersensitivity Source: MGI
  12. positive regulation of type IIa hypersensitivity Source: MGI
  13. positive regulation of type III hypersensitivity Source: MGI
  14. regulation of immune response Source: MGI
  15. serotonin secretion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgG-binding protein

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin gamma Fc region receptor III
Short name:
IgG Fc receptor III
Alternative name(s):
Fc-gamma RIII
Short name:
FcRIII
CD_antigen: CD16
Gene namesi
Name:Fcgr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:95500. Fcgr3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 215185ExtracellularSequence AnalysisAdd
BLAST
Transmembranei216 – 23520HelicalSequence AnalysisAdd
BLAST
Topological domaini236 – 26126CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 261231Low affinity immunoglobulin gamma Fc region receptor IIIPRO_0000015154Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 98PROSITE-ProRule annotation
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi137 ↔ 181PROSITE-ProRule annotation
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP08508.
PRIDEiP08508.

PTM databases

PhosphoSiteiP08508.

Expressioni

Gene expression databases

CleanExiMM_FCGR3.
GenevestigatoriP08508.

Interactioni

Subunit structurei

Interacts with INPP5D/SHIP1.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP08508.
SMRiP08508. Positions 31-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 11078Ig-like C2-type 1Add
BLAST
Domaini116 – 19883Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG25177.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiP08508.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08508-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFQNAHSGSQ WLLPPLTILL LFAFADRQSA ALPKAVVKLD PPWIQVLKED
60 70 80 90 100
MVTLMCEGTH NPGNSSTQWF HNGRSIRSQV QASYTFKATV NDSGEYRCQM
110 120 130 140 150
EQTRLSDPVD LGVISDWLLL QTPQRVFLEG ETITLRCHSW RNKLLNRISF
160 170 180 190 200
FHNEKSVRYH HYKSNFSIPK ANHSHSGDYY CKGSLGSTQH QSKPVTITVQ
210 220 230 240 250
DPATTSSISL VWYHTAFSLV MCLLFAVDTG LYFYVRRNLQ TPREYWRKSL
260
SIRKHQAPQD K
Length:261
Mass (Da):30,036
Last modified:August 1, 1988 - v1
Checksum:i757FB83668E41069
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14215 mRNA. Translation: AAA37604.1.
X60929 Genomic DNA. Translation: CAA43266.1.
PIRiS29360.
UniGeneiMm.22119.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14215 mRNA. Translation: AAA37604.1 .
X60929 Genomic DNA. Translation: CAA43266.1 .
PIRi S29360.
UniGenei Mm.22119.

3D structure databases

ProteinModelPortali P08508.
SMRi P08508. Positions 31-203.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P08508.

Proteomic databases

PaxDbi P08508.
PRIDEi P08508.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:95500. Fcgr3.

Phylogenomic databases

eggNOGi NOG25177.
HOGENOMi HOG000251632.
HOVERGENi HBG051602.
InParanoidi P08508.

Miscellaneous databases

PROi P08508.
SOURCEi Search...

Gene expression databases

CleanExi MM_FCGR3.
Genevestigatori P08508.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors."
    Ravetch J.V., Luster A.D., Weinshank R., Kochan J., Pavlovec A., Portnoy D.A., Hulmes J., Pan Y.-C.E., Unkeless J.C.
    Science 234:718-725(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Soares H.J., Onken M.D., Kulczycki A. Jr.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 1-29.
    Strain: BALB/c.
    Tissue: Liver.
  3. "PU.1 and an HLH family member contribute to the myeloid-specific transcription of the Fc gamma RIIIA promoter."
    Feinman R., Qiu W.Q., Pearse R.N., Nikolajczyk B.S., Sen R., Sheffery M., Ravetch J.V.
    EMBO J. 13:3852-3860(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-22.
  4. "SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells."
    Galandrini R., Tassi I., Mattia G., Lenti L., Piccoli M., Frati L., Santoni A.
    Blood 100:4581-4589(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INPP5D.

Entry informationi

Entry nameiFCGR3_MOUSE
AccessioniPrimary (citable) accession number: P08508
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: October 29, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3