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Protein

Matrix Gla protein

Gene

Mgp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

GO - Molecular functioni

  • calcium-dependent protein binding Source: RGD
  • calcium ion binding Source: RGD
  • extracellular matrix structural constituent Source: GO_Central

GO - Biological processi

  • branching morphogenesis of an epithelial tube Source: RGD
  • cartilage development Source: UniProtKB-KW
  • cell differentiation Source: UniProtKB-KW
  • lung development Source: RGD
  • ossification Source: RGD
  • protein complex assembly Source: RGD
  • regulation of bone mineralization Source: InterPro
  • response to calcium ion Source: RGD
  • response to glucocorticoid Source: RGD
  • response to hormone Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to nutrient Source: RGD
  • response to organic substance Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix Gla protein
Short name:
MGP
Gene namesi
Name:Mgp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3088. Mgp.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: RGD
  • extracellular matrix Source: RGD
  • extracellular space Source: RGD
  • protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 10384Matrix Gla proteinPRO_0000011116Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 2114-carboxyglutamatePROSITE-ProRule annotationBy similarity
Modified residuei22 – 221Phosphoserine1 Publication
Modified residuei25 – 251Phosphoserine1 Publication
Modified residuei28 – 281Phosphoserine1 Publication
Modified residuei56 – 5614-carboxyglutamatePROSITE-ProRule annotationBy similarity
Modified residuei60 – 6014-carboxyglutamatePROSITE-ProRule annotationBy similarity
Modified residuei67 – 6714-carboxyglutamatePROSITE-ProRule annotationBy similarity
Modified residuei71 – 7114-carboxyglutamatePROSITE-ProRule annotationBy similarity
Disulfide bondi73 ↔ 79PROSITE-ProRule annotation

Post-translational modificationi

Requires vitamin K-dependent gamma-carboxylation for its function.

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Phosphoprotein

Proteomic databases

PaxDbiP08494.
PRIDEiP08494.

PTM databases

iPTMnetiP08494.
PhosphoSiteiP08494.

Interactioni

GO - Molecular functioni

  • calcium-dependent protein binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007577.

Structurei

3D structure databases

ProteinModelPortaliP08494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 9747GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZCH. Eukaryota.
ENOG410Y2RM. LUCA.
HOGENOMiHOG000113581.
HOVERGENiHBG006353.
InParanoidiP08494.
KOiK19481.
PhylomeDBiP08494.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR027118. MGP.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PANTHERiPTHR10109. PTHR10109. 1 hit.
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08494-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLLPLAIL AALAVAALCY ESHESMESYE VSPFTTRRNA NTFISPQQRW
60 70 80 90 100
HAKAQERVRE LNKPAQEINR EACDDYKLCE RYALIYGYNA AYNRYFRQRR

GAK
Length:103
Mass (Da):12,037
Last modified:July 1, 1989 - v2
Checksum:iF93536D35F48A5C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03026 mRNA. Translation: AAA41597.1.
PIRiA39974. GERTM1.
RefSeqiNP_036994.1. NM_012862.1.
UniGeneiRn.2379.

Genome annotation databases

GeneIDi25333.
KEGGirno:25333.
UCSCiRGD:3088. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03026 mRNA. Translation: AAA41597.1.
PIRiA39974. GERTM1.
RefSeqiNP_036994.1. NM_012862.1.
UniGeneiRn.2379.

3D structure databases

ProteinModelPortaliP08494.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007577.

PTM databases

iPTMnetiP08494.
PhosphoSiteiP08494.

Proteomic databases

PaxDbiP08494.
PRIDEiP08494.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25333.
KEGGirno:25333.
UCSCiRGD:3088. rat.

Organism-specific databases

CTDi4256.
RGDi3088. Mgp.

Phylogenomic databases

eggNOGiENOG410IZCH. Eukaryota.
ENOG410Y2RM. LUCA.
HOGENOMiHOG000113581.
HOVERGENiHBG006353.
InParanoidiP08494.
KOiK19481.
PhylomeDBiP08494.

Miscellaneous databases

PROiP08494.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR027118. MGP.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PANTHERiPTHR10109. PTHR10109. 1 hit.
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of matrix Gla protein: implications for substrate recognition by the vitamin K-dependent gamma-carboxylase."
    Price P.A., Fraser J.D., Metz-Virca G.
    Proc. Natl. Acad. Sci. U.S.A. 84:8335-8339(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P) sequences of the vitamin K-dependent matrix Gla protein from shark, lamb, rat, cow, and human."
    Price P.A., Rice J.S., Williamson M.K.
    Protein Sci. 3:822-830(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-22; SER-25 AND SER-28.

Entry informationi

Entry nameiMGP_RAT
AccessioniPrimary (citable) accession number: P08494
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: July 1, 1989
Last modified: July 6, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.