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Protein

Matrix Gla protein

Gene

Mgp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

GO - Molecular functioni

  • calcium ion binding Source: RGD
  • extracellular matrix structural constituent Source: GO_Central

GO - Biological processi

  • branching morphogenesis of an epithelial tube Source: RGD
  • cartilage development Source: UniProtKB-KW
  • cell differentiation Source: UniProtKB-KW
  • lung development Source: RGD
  • ossification Source: RGD
  • regulation of bone mineralization Source: InterPro
  • response to calcium ion Source: RGD
  • response to glucocorticoid Source: RGD
  • response to hormone Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to nutrient Source: RGD
  • response to organic substance Source: RGD

Keywordsi

Molecular functionDevelopmental protein
Biological processChondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix Gla protein
Short name:
MGP
Gene namesi
Name:Mgp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3088 Mgp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000001111620 – 103Matrix Gla proteinAdd BLAST84

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei214-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei22Phosphoserine1 Publication1
Modified residuei25Phosphoserine1 Publication1
Modified residuei28Phosphoserine1 Publication1
Modified residuei564-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei604-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei674-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei714-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Disulfide bondi73 ↔ 79PROSITE-ProRule annotation

Post-translational modificationi

Requires vitamin K-dependent gamma-carboxylation for its function.

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Phosphoprotein

Proteomic databases

PaxDbiP08494
PRIDEiP08494

PTM databases

iPTMnetiP08494
PhosphoSitePlusiP08494

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007577

Structurei

3D structure databases

ProteinModelPortaliP08494
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 97GlaPROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZCH Eukaryota
ENOG410Y2RM LUCA
HOGENOMiHOG000113581
HOVERGENiHBG006353
InParanoidiP08494
KOiK19481
PhylomeDBiP08494

Family and domain databases

InterProiView protein in InterPro
IPR035972 GLA-like_dom_SF
IPR000294 GLA_domain
IPR027118 MGP
IPR002384 Osteocalcin/MGP
PANTHERiPTHR10109 PTHR10109, 1 hit
PRINTSiPR00002 GLABONE
SMARTiView protein in SMART
SM00069 GLA, 1 hit
SUPFAMiSSF57630 SSF57630, 1 hit
PROSITEiView protein in PROSITE
PS00011 GLA_1, 1 hit
PS50998 GLA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08494-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLLPLAIL AALAVAALCY ESHESMESYE VSPFTTRRNA NTFISPQQRW
60 70 80 90 100
HAKAQERVRE LNKPAQEINR EACDDYKLCE RYALIYGYNA AYNRYFRQRR

GAK
Length:103
Mass (Da):12,037
Last modified:July 1, 1989 - v2
Checksum:iF93536D35F48A5C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03026 mRNA Translation: AAA41597.1
PIRiA39974 GERTM1
RefSeqiNP_036994.1, NM_012862.1
UniGeneiRn.2379

Genome annotation databases

GeneIDi25333
KEGGirno:25333
UCSCiRGD:3088 rat

Similar proteinsi

Entry informationi

Entry nameiMGP_RAT
AccessioniPrimary (citable) accession number: P08494
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: July 1, 1989
Last modified: May 23, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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