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P08493

- MGP_HUMAN

UniProt

P08493 - MGP_HUMAN

Protein

Matrix Gla protein

Gene

MGP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. extracellular matrix structural constituent Source: ProtInc
    3. structural constituent of bone Source: ProtInc

    GO - Biological processi

    1. cartilage condensation Source: ProtInc
    2. cell differentiation Source: UniProtKB-KW
    3. ossification Source: ProtInc
    4. regulation of bone mineralization Source: InterPro

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Matrix Gla protein
    Short name:
    MGP
    Alternative name(s):
    Cell growth-inhibiting gene 36 protein
    Gene namesi
    Name:MGP
    Synonyms:MGLAP
    ORF Names:GIG36
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:7060. MGP.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. proteinaceous extracellular matrix Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Keutel syndrome (KS) [MIM:245150]: Autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Deafness

    Organism-specific databases

    MIMi245150. phenotype.
    Orphaneti85202. Keutel syndrome.
    PharmGKBiPA30790.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Add
    BLAST
    Chaini20 – 9677Matrix Gla proteinPRO_0000011109Add
    BLAST
    Propeptidei97 – 1037Removed in mature form; probably by carboxypeptidase NPRO_0000011110

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei21 – 2114-carboxyglutamatePROSITE-ProRule annotation
    Modified residuei22 – 221Phosphoserine1 Publication
    Modified residuei25 – 251Phosphoserine1 Publication
    Modified residuei28 – 281Phosphoserine1 Publication
    Modified residuei56 – 5614-carboxyglutamatePROSITE-ProRule annotation
    Modified residuei60 – 6014-carboxyglutamatePROSITE-ProRule annotation
    Modified residuei67 – 6714-carboxyglutamatePROSITE-ProRule annotation
    Modified residuei71 – 7114-carboxyglutamatePROSITE-ProRule annotation
    Disulfide bondi73 ↔ 79PROSITE-ProRule annotation

    Post-translational modificationi

    Requires vitamin K-dependent gamma-carboxylation for its function.

    Keywords - PTMi

    Disulfide bond, Gamma-carboxyglutamic acid, Phosphoprotein

    Proteomic databases

    MaxQBiP08493.
    PaxDbiP08493.
    PeptideAtlasiP08493.
    PRIDEiP08493.

    PTM databases

    PhosphoSiteiP08493.

    Expressioni

    Gene expression databases

    ArrayExpressiP08493.
    BgeeiP08493.
    CleanExiHS_MGP.
    GenevestigatoriP08493.

    Organism-specific databases

    HPAiHPA013949.

    Interactioni

    Protein-protein interaction databases

    BioGridi110412. 1 interaction.
    IntActiP08493. 1 interaction.
    STRINGi9606.ENSP00000228938.

    Structurei

    3D structure databases

    ProteinModelPortaliP08493.
    SMRiP08493. Positions 69-98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 9747GlaPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42431.
    HOGENOMiHOG000113581.
    HOVERGENiHBG006353.
    InParanoidiP08493.
    OMAiFLNRRNA.
    OrthoDBiEOG718KFT.
    PhylomeDBiP08493.
    TreeFamiTF330920.

    Family and domain databases

    InterProiIPR000294. GLA_domain.
    IPR027118. MGP.
    IPR002384. Osteocalcin/MGP.
    [Graphical view]
    PANTHERiPTHR10109. PTHR10109. 1 hit.
    PfamiPF00594. Gla. 1 hit.
    [Graphical view]
    PRINTSiPR00002. GLABONE.
    SMARTiSM00069. GLA. 1 hit.
    [Graphical view]
    SUPFAMiSSF57630. SSF57630. 1 hit.
    PROSITEiPS00011. GLA_1. 1 hit.
    PS50998. GLA_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P08493-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKSLILLAIL AALAVVTLCY ESHESMESYE LNPFINRRNA NTFISPQQRW    50
    RAKVQERIRE RSKPVHELNR EACDDYRLCE RYAMVYGYNA AYNRYFRKRR 100
    GTK 103
    Length:103
    Mass (Da):12,353
    Last modified:November 28, 2006 - v2
    Checksum:i243968D715D54549
    GO
    Isoform 2 (identifier: P08493-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         20-20: Y → YGEWQKEENFGFDIVSVLSLNWHRAQ

    Note: Gene prediction based on EST data.

    Show »
    Length:128
    Mass (Da):15,325
    Checksum:iEC1C9523BC0836E6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201Y → C in AAH93078. (PubMed:15489334)Curated
    Sequence conflicti51 – 511R → G in CAG29354. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti53 – 531K → E.
    Corresponds to variant rs1801716 [ dbSNP | Ensembl ].
    VAR_016177
    Natural varianti102 – 1021T → A.7 Publications
    Corresponds to variant rs4236 [ dbSNP | Ensembl ].
    VAR_016178

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei20 – 201Y → YGEWQKEENFGFDIVSVLSL NWHRAQ in isoform 2. CuratedVSP_046999

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58549 mRNA. Translation: AAB53766.1.
    M55270 Genomic DNA. Translation: AAB53765.1.
    X07362 mRNA. Translation: CAA30287.1.
    X53331 mRNA. Translation: CAA37418.1.
    AY542304 mRNA. Translation: AAT08173.1.
    BT006733 mRNA. Translation: AAP35379.1.
    CR450358 mRNA. Translation: CAG29354.1.
    AK312029 mRNA. Translation: BAG34966.1.
    DQ004248 Genomic DNA. Translation: AAY16978.1.
    AC007655 Genomic DNA. No translation available.
    CH471094 Genomic DNA. Translation: EAW96333.1.
    BC005272 mRNA. Translation: AAH05272.1.
    BC070314 mRNA. Translation: AAH70314.1.
    BC093078 mRNA. Translation: AAH93078.1.
    CCDSiCCDS53752.1. [P08493-2]
    CCDS8669.1. [P08493-1]
    PIRiA35811. GEHUM.
    RefSeqiNP_000891.2. NM_000900.3. [P08493-1]
    NP_001177768.1. NM_001190839.1. [P08493-2]
    UniGeneiHs.365706.

    Genome annotation databases

    EnsembliENST00000228938; ENSP00000228938; ENSG00000111341. [P08493-2]
    ENST00000539261; ENSP00000445907; ENSG00000111341. [P08493-1]
    GeneIDi4256.
    KEGGihsa:4256.
    UCSCiuc001rcn.2. human. [P08493-1]

    Polymorphism databases

    DMDMi118572668.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58549 mRNA. Translation: AAB53766.1 .
    M55270 Genomic DNA. Translation: AAB53765.1 .
    X07362 mRNA. Translation: CAA30287.1 .
    X53331 mRNA. Translation: CAA37418.1 .
    AY542304 mRNA. Translation: AAT08173.1 .
    BT006733 mRNA. Translation: AAP35379.1 .
    CR450358 mRNA. Translation: CAG29354.1 .
    AK312029 mRNA. Translation: BAG34966.1 .
    DQ004248 Genomic DNA. Translation: AAY16978.1 .
    AC007655 Genomic DNA. No translation available.
    CH471094 Genomic DNA. Translation: EAW96333.1 .
    BC005272 mRNA. Translation: AAH05272.1 .
    BC070314 mRNA. Translation: AAH70314.1 .
    BC093078 mRNA. Translation: AAH93078.1 .
    CCDSi CCDS53752.1. [P08493-2 ]
    CCDS8669.1. [P08493-1 ]
    PIRi A35811. GEHUM.
    RefSeqi NP_000891.2. NM_000900.3. [P08493-1 ]
    NP_001177768.1. NM_001190839.1. [P08493-2 ]
    UniGenei Hs.365706.

    3D structure databases

    ProteinModelPortali P08493.
    SMRi P08493. Positions 69-98.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110412. 1 interaction.
    IntActi P08493. 1 interaction.
    STRINGi 9606.ENSP00000228938.

    PTM databases

    PhosphoSitei P08493.

    Polymorphism databases

    DMDMi 118572668.

    Proteomic databases

    MaxQBi P08493.
    PaxDbi P08493.
    PeptideAtlasi P08493.
    PRIDEi P08493.

    Protocols and materials databases

    DNASUi 4256.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000228938 ; ENSP00000228938 ; ENSG00000111341 . [P08493-2 ]
    ENST00000539261 ; ENSP00000445907 ; ENSG00000111341 . [P08493-1 ]
    GeneIDi 4256.
    KEGGi hsa:4256.
    UCSCi uc001rcn.2. human. [P08493-1 ]

    Organism-specific databases

    CTDi 4256.
    GeneCardsi GC12M015034.
    HGNCi HGNC:7060. MGP.
    HPAi HPA013949.
    MIMi 154870. gene.
    245150. phenotype.
    neXtProti NX_P08493.
    Orphaneti 85202. Keutel syndrome.
    PharmGKBi PA30790.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42431.
    HOGENOMi HOG000113581.
    HOVERGENi HBG006353.
    InParanoidi P08493.
    OMAi FLNRRNA.
    OrthoDBi EOG718KFT.
    PhylomeDBi P08493.
    TreeFami TF330920.

    Miscellaneous databases

    ChiTaRSi MGP. human.
    GeneWikii Matrix_gla_protein.
    GenomeRNAii 4256.
    NextBioi 16783.
    PROi P08493.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P08493.
    Bgeei P08493.
    CleanExi HS_MGP.
    Genevestigatori P08493.

    Family and domain databases

    InterProi IPR000294. GLA_domain.
    IPR027118. MGP.
    IPR002384. Osteocalcin/MGP.
    [Graphical view ]
    PANTHERi PTHR10109. PTHR10109. 1 hit.
    Pfami PF00594. Gla. 1 hit.
    [Graphical view ]
    PRINTSi PR00002. GLABONE.
    SMARTi SM00069. GLA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57630. SSF57630. 1 hit.
    PROSITEi PS00011. GLA_1. 1 hit.
    PS50998. GLA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene."
      Cancela M.L., Hsieh C.-L., Francke U., Price P.A.
      J. Biol. Chem. 265:15040-15048(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    2. "The cDNA and derived amino acid sequences for human and bovine matrix Gla protein."
      Kiefer M.C., Bauer D.M., Young D., Hermsen K.M., Masiarz F.K., Barr P.J.
      Nucleic Acids Res. 16:5213-5213(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-102.
    3. "Overexpression of matrix Gla protein mRNA in malignant human breast cells: isolation by differential cDNA hybridization."
      Chen L., O'Bryan J.P., Smith H.S., Liu E.
      Oncogene 5:1391-1395(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-102.
    4. "Identification of a human cell growth inhibition gene."
      Kim J.W.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-102.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-102.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-102.
      Tissue: Cervix.
    8. SeattleSNPs variation discovery resource
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-102.
    9. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-102.
      Tissue: Brain.
    12. "Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P) sequences of the vitamin K-dependent matrix Gla protein from shark, lamb, rat, cow, and human."
      Price P.A., Rice J.S., Williamson M.K.
      Protein Sci. 3:822-830(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-22; SER-25 AND SER-28.
    13. "Carboxyl-terminal proteolytic processing of matrix Gla protein."
      Hale J.E., Williamson M.K., Price P.A.
      J. Biol. Chem. 266:21145-21149(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, PROTEOLYTIC PROCESSING OF C-TERMINAL.
    14. "Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome."
      Munroe P.B., Olgunturk R.O., Fryns J.-P., Van Maldergem L., Ziereisen F., Yuksel B., Gardiner R.M., Chung E.
      Nat. Genet. 21:142-144(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN KEUTEL SYNDROME.

    Entry informationi

    Entry nameiMGP_HUMAN
    AccessioniPrimary (citable) accession number: P08493
    Secondary accession number(s): A0M8W5
    , B2R519, J3KMX7, Q2TU41, Q567P9, Q6ICN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 155 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3