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P08493

- MGP_HUMAN

UniProt

P08493 - MGP_HUMAN

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Protein

Matrix Gla protein

Gene

MGP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. extracellular matrix structural constituent Source: ProtInc
  3. structural constituent of bone Source: ProtInc

GO - Biological processi

  1. cartilage condensation Source: ProtInc
  2. cell differentiation Source: UniProtKB-KW
  3. ossification Source: ProtInc
  4. regulation of bone mineralization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix Gla protein
Short name:
MGP
Alternative name(s):
Cell growth-inhibiting gene 36 protein
Gene namesi
Name:MGP
Synonyms:MGLAP
ORF Names:GIG36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:7060. MGP.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. proteinaceous extracellular matrix Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Keutel syndrome (KS) [MIM:245150]: Autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Keywords - Diseasei

Deafness

Organism-specific databases

MIMi245150. phenotype.
Orphaneti85202. Keutel syndrome.
PharmGKBiPA30790.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 9677Matrix Gla proteinPRO_0000011109Add
BLAST
Propeptidei97 – 1037Removed in mature form; probably by carboxypeptidase NPRO_0000011110

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 2114-carboxyglutamatePROSITE-ProRule annotation
Modified residuei22 – 221Phosphoserine1 Publication
Modified residuei25 – 251Phosphoserine1 Publication
Modified residuei28 – 281Phosphoserine1 Publication
Modified residuei56 – 5614-carboxyglutamatePROSITE-ProRule annotation
Modified residuei60 – 6014-carboxyglutamatePROSITE-ProRule annotation
Modified residuei67 – 6714-carboxyglutamatePROSITE-ProRule annotation
Modified residuei71 – 7114-carboxyglutamatePROSITE-ProRule annotation
Disulfide bondi73 ↔ 79PROSITE-ProRule annotation

Post-translational modificationi

Requires vitamin K-dependent gamma-carboxylation for its function.

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Phosphoprotein

Proteomic databases

MaxQBiP08493.
PaxDbiP08493.
PeptideAtlasiP08493.
PRIDEiP08493.

PTM databases

PhosphoSiteiP08493.

Expressioni

Gene expression databases

BgeeiP08493.
CleanExiHS_MGP.
GenevestigatoriP08493.

Organism-specific databases

HPAiHPA013949.

Interactioni

Protein-protein interaction databases

BioGridi110412. 1 interaction.
IntActiP08493. 1 interaction.
STRINGi9606.ENSP00000228938.

Structurei

3D structure databases

ProteinModelPortaliP08493.
SMRiP08493. Positions 69-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 9747GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42431.
GeneTreeiENSGT00390000003753.
HOGENOMiHOG000113581.
HOVERGENiHBG006353.
InParanoidiP08493.
OMAiFLNRRNA.
OrthoDBiEOG718KFT.
PhylomeDBiP08493.
TreeFamiTF330920.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR027118. MGP.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PANTHERiPTHR10109. PTHR10109. 1 hit.
PfamiPF00594. Gla. 1 hit.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P08493-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSLILLAIL AALAVVTLCY ESHESMESYE LNPFINRRNA NTFISPQQRW
60 70 80 90 100
RAKVQERIRE RSKPVHELNR EACDDYRLCE RYAMVYGYNA AYNRYFRKRR

GTK
Length:103
Mass (Da):12,353
Last modified:November 28, 2006 - v2
Checksum:i243968D715D54549
GO
Isoform 2 (identifier: P08493-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: Y → YGEWQKEENFGFDIVSVLSLNWHRAQ

Note: Gene prediction based on EST data.

Show »
Length:128
Mass (Da):15,325
Checksum:iEC1C9523BC0836E6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201Y → C in AAH93078. (PubMed:15489334)Curated
Sequence conflicti51 – 511R → G in CAG29354. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531K → E.
Corresponds to variant rs1801716 [ dbSNP | Ensembl ].
VAR_016177
Natural varianti102 – 1021T → A.7 Publications
Corresponds to variant rs4236 [ dbSNP | Ensembl ].
VAR_016178

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei20 – 201Y → YGEWQKEENFGFDIVSVLSL NWHRAQ in isoform 2. CuratedVSP_046999

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M58549 mRNA. Translation: AAB53766.1.
M55270 Genomic DNA. Translation: AAB53765.1.
X07362 mRNA. Translation: CAA30287.1.
X53331 mRNA. Translation: CAA37418.1.
AY542304 mRNA. Translation: AAT08173.1.
BT006733 mRNA. Translation: AAP35379.1.
CR450358 mRNA. Translation: CAG29354.1.
AK312029 mRNA. Translation: BAG34966.1.
DQ004248 Genomic DNA. Translation: AAY16978.1.
AC007655 Genomic DNA. No translation available.
CH471094 Genomic DNA. Translation: EAW96333.1.
BC005272 mRNA. Translation: AAH05272.1.
BC070314 mRNA. Translation: AAH70314.1.
BC093078 mRNA. Translation: AAH93078.1.
CCDSiCCDS53752.1. [P08493-2]
CCDS8669.1. [P08493-1]
PIRiA35811. GEHUM.
RefSeqiNP_000891.2. NM_000900.3. [P08493-1]
NP_001177768.1. NM_001190839.1. [P08493-2]
UniGeneiHs.365706.

Genome annotation databases

EnsembliENST00000228938; ENSP00000228938; ENSG00000111341. [P08493-2]
ENST00000539261; ENSP00000445907; ENSG00000111341. [P08493-1]
GeneIDi4256.
KEGGihsa:4256.
UCSCiuc001rcn.2. human. [P08493-1]

Polymorphism databases

DMDMi118572668.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M58549 mRNA. Translation: AAB53766.1 .
M55270 Genomic DNA. Translation: AAB53765.1 .
X07362 mRNA. Translation: CAA30287.1 .
X53331 mRNA. Translation: CAA37418.1 .
AY542304 mRNA. Translation: AAT08173.1 .
BT006733 mRNA. Translation: AAP35379.1 .
CR450358 mRNA. Translation: CAG29354.1 .
AK312029 mRNA. Translation: BAG34966.1 .
DQ004248 Genomic DNA. Translation: AAY16978.1 .
AC007655 Genomic DNA. No translation available.
CH471094 Genomic DNA. Translation: EAW96333.1 .
BC005272 mRNA. Translation: AAH05272.1 .
BC070314 mRNA. Translation: AAH70314.1 .
BC093078 mRNA. Translation: AAH93078.1 .
CCDSi CCDS53752.1. [P08493-2 ]
CCDS8669.1. [P08493-1 ]
PIRi A35811. GEHUM.
RefSeqi NP_000891.2. NM_000900.3. [P08493-1 ]
NP_001177768.1. NM_001190839.1. [P08493-2 ]
UniGenei Hs.365706.

3D structure databases

ProteinModelPortali P08493.
SMRi P08493. Positions 69-98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110412. 1 interaction.
IntActi P08493. 1 interaction.
STRINGi 9606.ENSP00000228938.

PTM databases

PhosphoSitei P08493.

Polymorphism databases

DMDMi 118572668.

Proteomic databases

MaxQBi P08493.
PaxDbi P08493.
PeptideAtlasi P08493.
PRIDEi P08493.

Protocols and materials databases

DNASUi 4256.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000228938 ; ENSP00000228938 ; ENSG00000111341 . [P08493-2 ]
ENST00000539261 ; ENSP00000445907 ; ENSG00000111341 . [P08493-1 ]
GeneIDi 4256.
KEGGi hsa:4256.
UCSCi uc001rcn.2. human. [P08493-1 ]

Organism-specific databases

CTDi 4256.
GeneCardsi GC12M015034.
HGNCi HGNC:7060. MGP.
HPAi HPA013949.
MIMi 154870. gene.
245150. phenotype.
neXtProti NX_P08493.
Orphaneti 85202. Keutel syndrome.
PharmGKBi PA30790.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42431.
GeneTreei ENSGT00390000003753.
HOGENOMi HOG000113581.
HOVERGENi HBG006353.
InParanoidi P08493.
OMAi FLNRRNA.
OrthoDBi EOG718KFT.
PhylomeDBi P08493.
TreeFami TF330920.

Miscellaneous databases

ChiTaRSi MGP. human.
GeneWikii Matrix_gla_protein.
GenomeRNAii 4256.
NextBioi 16783.
PROi P08493.
SOURCEi Search...

Gene expression databases

Bgeei P08493.
CleanExi HS_MGP.
Genevestigatori P08493.

Family and domain databases

InterProi IPR000294. GLA_domain.
IPR027118. MGP.
IPR002384. Osteocalcin/MGP.
[Graphical view ]
PANTHERi PTHR10109. PTHR10109. 1 hit.
Pfami PF00594. Gla. 1 hit.
[Graphical view ]
PRINTSi PR00002. GLABONE.
SMARTi SM00069. GLA. 1 hit.
[Graphical view ]
SUPFAMi SSF57630. SSF57630. 1 hit.
PROSITEi PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene."
    Cancela M.L., Hsieh C.-L., Francke U., Price P.A.
    J. Biol. Chem. 265:15040-15048(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  2. "The cDNA and derived amino acid sequences for human and bovine matrix Gla protein."
    Kiefer M.C., Bauer D.M., Young D., Hermsen K.M., Masiarz F.K., Barr P.J.
    Nucleic Acids Res. 16:5213-5213(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-102.
  3. "Overexpression of matrix Gla protein mRNA in malignant human breast cells: isolation by differential cDNA hybridization."
    Chen L., O'Bryan J.P., Smith H.S., Liu E.
    Oncogene 5:1391-1395(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-102.
  4. "Identification of a human cell growth inhibition gene."
    Kim J.W.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-102.
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-102.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-102.
    Tissue: Cervix.
  8. SeattleSNPs variation discovery resource
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-102.
  9. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-102.
    Tissue: Brain.
  12. "Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P) sequences of the vitamin K-dependent matrix Gla protein from shark, lamb, rat, cow, and human."
    Price P.A., Rice J.S., Williamson M.K.
    Protein Sci. 3:822-830(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-22; SER-25 AND SER-28.
  13. "Carboxyl-terminal proteolytic processing of matrix Gla protein."
    Hale J.E., Williamson M.K., Price P.A.
    J. Biol. Chem. 266:21145-21149(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, PROTEOLYTIC PROCESSING OF C-TERMINAL.
  14. "Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome."
    Munroe P.B., Olgunturk R.O., Fryns J.-P., Van Maldergem L., Ziereisen F., Yuksel B., Gardiner R.M., Chung E.
    Nat. Genet. 21:142-144(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN KEUTEL SYNDROME.

Entry informationi

Entry nameiMGP_HUMAN
AccessioniPrimary (citable) accession number: P08493
Secondary accession number(s): A0M8W5
, B2R519, J3KMX7, Q2TU41, Q567P9, Q6ICN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 28, 2006
Last modified: October 29, 2014
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3