Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P08493 (MGP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 152. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Matrix Gla protein

Short name=MGP
Alternative name(s):
Cell growth-inhibiting gene 36 protein
Gene names
Name:MGP
Synonyms:MGLAP
ORF Names:GIG36
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length103 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

Subcellular location

Secreted.

Post-translational modification

Requires vitamin K-dependent gamma-carboxylation for its function.

Involvement in disease

Keutel syndrome (KS) [MIM:245150]: Autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.
Note: The disease is caused by mutations affecting the gene represented in this entry.

Sequence similarities

Belongs to the osteocalcin/matrix Gla protein family.

Contains 1 Gla (gamma-carboxy-glutamate) domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P08493-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P08493-2)

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: Y → YGEWQKEENFGFDIVSVLSLNWHRAQ
Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919
Chain20 – 9677Matrix Gla protein
PRO_0000011109
Propeptide97 – 1037Removed in mature form; probably by carboxypeptidase N
PRO_0000011110

Regions

Domain51 – 9747Gla

Amino acid modifications

Modified residue2114-carboxyglutamate By similarity
Modified residue221Phosphoserine Ref.12
Modified residue251Phosphoserine Ref.12
Modified residue281Phosphoserine Ref.12
Modified residue5614-carboxyglutamate By similarity
Modified residue6014-carboxyglutamate By similarity
Modified residue6714-carboxyglutamate By similarity
Modified residue7114-carboxyglutamate By similarity
Disulfide bond73 ↔ 79 By similarity

Natural variations

Alternative sequence201Y → YGEWQKEENFGFDIVSVLSL NWHRAQ in isoform 2.
VSP_046999
Natural variant531K → E.
Corresponds to variant rs1801716 [ dbSNP | Ensembl ].
VAR_016177
Natural variant1021T → A. Ref.2 Ref.3 Ref.5 Ref.6 Ref.7 Ref.8 Ref.11
Corresponds to variant rs4236 [ dbSNP | Ensembl ].
VAR_016178

Experimental info

Sequence conflict201Y → C in AAH93078. Ref.11
Sequence conflict511R → G in CAG29354. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 28, 2006. Version 2.
Checksum: 243968D715D54549

FASTA10312,353
        10         20         30         40         50         60 
MKSLILLAIL AALAVVTLCY ESHESMESYE LNPFINRRNA NTFISPQQRW RAKVQERIRE 

        70         80         90        100 
RSKPVHELNR EACDDYRLCE RYAMVYGYNA AYNRYFRKRR GTK 

« Hide

Isoform 2 [UniParc].

Checksum: EC1C9523BC0836E6
Show »

FASTA12815,325

References

« Hide 'large scale' references
[1]"Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene."
Cancela M.L., Hsieh C.-L., Francke U., Price P.A.
J. Biol. Chem. 265:15040-15048(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
[2]"The cDNA and derived amino acid sequences for human and bovine matrix Gla protein."
Kiefer M.C., Bauer D.M., Young D., Hermsen K.M., Masiarz F.K., Barr P.J.
Nucleic Acids Res. 16:5213-5213(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-102.
[3]"Overexpression of matrix Gla protein mRNA in malignant human breast cells: isolation by differential cDNA hybridization."
Chen L., O'Bryan J.P., Smith H.S., Liu E.
Oncogene 5:1391-1395(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-102.
[4]"Identification of a human cell growth inhibition gene."
Kim J.W.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-102.
[6]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-102.
[7]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-102.
Tissue: Cervix.
[8]SeattleSNPs variation discovery resource
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-102.
[9]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-102.
Tissue: Brain.
[12]"Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P) sequences of the vitamin K-dependent matrix Gla protein from shark, lamb, rat, cow, and human."
Price P.A., Rice J.S., Williamson M.K.
Protein Sci. 3:822-830(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-22; SER-25 AND SER-28.
[13]"Carboxyl-terminal proteolytic processing of matrix Gla protein."
Hale J.E., Williamson M.K., Price P.A.
J. Biol. Chem. 266:21145-21149(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, PROTEOLYTIC PROCESSING OF C-TERMINAL.
[14]"Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome."
Munroe P.B., Olgunturk R.O., Fryns J.-P., Van Maldergem L., Ziereisen F., Yuksel B., Gardiner R.M., Chung E.
Nat. Genet. 21:142-144(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN KEUTEL SYNDROME.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M58549 mRNA. Translation: AAB53766.1.
M55270 Genomic DNA. Translation: AAB53765.1.
X07362 mRNA. Translation: CAA30287.1.
X53331 mRNA. Translation: CAA37418.1.
AY542304 mRNA. Translation: AAT08173.1.
BT006733 mRNA. Translation: AAP35379.1.
CR450358 mRNA. Translation: CAG29354.1.
AK312029 mRNA. Translation: BAG34966.1.
DQ004248 Genomic DNA. Translation: AAY16978.1.
AC007655 Genomic DNA. No translation available.
CH471094 Genomic DNA. Translation: EAW96333.1.
BC005272 mRNA. Translation: AAH05272.1.
BC070314 mRNA. Translation: AAH70314.1.
BC093078 mRNA. Translation: AAH93078.1.
PIRGEHUM. A35811.
RefSeqNP_000891.2. NM_000900.3.
NP_001177768.1. NM_001190839.1.
UniGeneHs.365706.

3D structure databases

ProteinModelPortalP08493.
SMRP08493. Positions 69-98.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110412. 1 interaction.
IntActP08493. 1 interaction.
STRING9606.ENSP00000228938.

PTM databases

PhosphoSiteP08493.

Polymorphism databases

DMDM118572668.

Proteomic databases

PaxDbP08493.
PeptideAtlasP08493.
PRIDEP08493.

Protocols and materials databases

DNASU4256.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000228938; ENSP00000228938; ENSG00000111341. [P08493-2]
ENST00000539261; ENSP00000445907; ENSG00000111341. [P08493-1]
GeneID4256.
KEGGhsa:4256.
UCSCuc001rcn.2. human. [P08493-1]

Organism-specific databases

CTD4256.
GeneCardsGC12M015034.
HGNCHGNC:7060. MGP.
HPAHPA013949.
MIM154870. gene.
245150. phenotype.
neXtProtNX_P08493.
Orphanet85202. Keutel syndrome.
PharmGKBPA30790.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42431.
HOGENOMHOG000113581.
HOVERGENHBG006353.
InParanoidP08493.
OMAYFRQRRG.
OrthoDBEOG718KFT.
PhylomeDBP08493.
TreeFamTF330920.

Gene expression databases

ArrayExpressP08493.
BgeeP08493.
CleanExHS_MGP.
GenevestigatorP08493.

Family and domain databases

InterProIPR000294. GLA_domain.
IPR027118. MGP.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PANTHERPTHR10109. PTHR10109. 1 hit.
PfamPF00594. Gla. 1 hit.
[Graphical view]
PRINTSPR00002. GLABONE.
SMARTSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMSSF57630. SSF57630. 1 hit.
PROSITEPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMGP. human.
GeneWikiMatrix_gla_protein.
GenomeRNAi4256.
NextBio16783.
PROP08493.
SOURCESearch...

Entry information

Entry nameMGP_HUMAN
AccessionPrimary (citable) accession number: P08493
Secondary accession number(s): A0M8W5 expand/collapse secondary AC list , B2R519, J3KMX7, Q2TU41, Q567P9, Q6ICN5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 28, 2006
Last modified: April 16, 2014
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM