SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P08463

- CKS1_SCHPO

UniProt

P08463 - CKS1_SCHPO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cyclin-dependent kinases regulatory subunit

Gene
suc1, SPBC1734.14c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to the catalytic subunit of the cyclin dependent kinase (cdc2) and is essential for its biological function.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase activator activity Source: PomBase
  2. protein binding Source: dictyBase
  3. protein complex binding Source: PomBase
  4. zinc ion binding Source: PomBase

GO - Biological processi

  1. activation of protein kinase activity Source: PomBase
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. cyclin catabolic process Source: PomBase
  5. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: PomBase
  6. regulation of mitotic cell cycle Source: PomBase
  7. signal transduction Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit
Alternative name(s):
P13
Gene namesi
Name:suc1
ORF Names:SPBC1734.14c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC1734.14c.

Subcellular locationi

GO - Cellular componenti

  1. cyclin-dependent protein kinase holoenzyme complex Source: PomBase
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 113112Cyclin-dependent kinases regulatory subunitPRO_0000206246Add
BLAST

Proteomic databases

PaxDbiP08463.

Interactioni

Subunit structurei

Homodimer (in presence of zinc).

Protein-protein interaction databases

BioGridi276571. 6 interactions.
IntActiP08463. 5 interactions.
MINTiMINT-4687051.
STRINGi4896.SPBC1734.14c-1.

Structurei

Secondary structure

1
113
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi12 – 165
Turni17 – 215
Helixi22 – 243
Beta strandi34 – 429
Helixi45 – 484
Helixi53 – 553
Turni58 – 603
Beta strandi61 – 633
Helixi68 – 736
Beta strandi83 – 853
Beta strandi94 – 1007

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PUCX-ray1.95A2-106[»]
1SCEX-ray2.20A/B/C/D1-112[»]
ProteinModelPortaliP08463.
SMRiP08463. Positions 3-105.

Miscellaneous databases

EvolutionaryTraceiP08463.

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.

Phylogenomic databases

eggNOGiNOG272189.
HOGENOMiHOG000157009.
KOiK02219.
OMAiHVQLPKA.
OrthoDBiEOG78D7Z8.
PhylomeDBiP08463.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08463-1 [UniParc]FASTAAdd to Basket

« Hide

MSKSGVPRLL TASERERLEP FIDQIHYSPR YADDEYEYRH VMLPKAMLKA    50
IPTDYFNPET GTLRILQEEE WRGLGITQSL GWEMYEVHVP EPHILLFKRE 100
KDYQMKFSQQ RGG 113
Length:113
Mass (Da):13,446
Last modified:January 23, 2007 - v3
Checksum:i1CE50666AAD8264F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16032 Genomic DNA. Translation: AAA35346.1.
CU329671 Genomic DNA. Translation: CAA21308.1.
PIRiA26722.
RefSeqiNP_595431.1. NM_001021339.2.

Genome annotation databases

EnsemblFungiiSPBC1734.14c.1; SPBC1734.14c.1:pep; SPBC1734.14c.
GeneIDi2540027.
KEGGispo:SPBC1734.14c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16032 Genomic DNA. Translation: AAA35346.1 .
CU329671 Genomic DNA. Translation: CAA21308.1 .
PIRi A26722.
RefSeqi NP_595431.1. NM_001021339.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1PUC X-ray 1.95 A 2-106 [» ]
1SCE X-ray 2.20 A/B/C/D 1-112 [» ]
ProteinModelPortali P08463.
SMRi P08463. Positions 3-105.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276571. 6 interactions.
IntActi P08463. 5 interactions.
MINTi MINT-4687051.
STRINGi 4896.SPBC1734.14c-1.

Proteomic databases

PaxDbi P08463.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC1734.14c.1 ; SPBC1734.14c.1:pep ; SPBC1734.14c .
GeneIDi 2540027.
KEGGi spo:SPBC1734.14c.

Organism-specific databases

PomBasei SPBC1734.14c.

Phylogenomic databases

eggNOGi NOG272189.
HOGENOMi HOG000157009.
KOi K02219.
OMAi HVQLPKA.
OrthoDBi EOG78D7Z8.
PhylomeDBi P08463.

Miscellaneous databases

EvolutionaryTracei P08463.
NextBioi 20801170.

Family and domain databases

Gene3Di 3.30.170.10. 1 hit.
InterProi IPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view ]
Pfami PF01111. CKS. 1 hit.
[Graphical view ]
PRINTSi PR00296. CYCLINKINASE.
SMARTi SM01084. CKS. 1 hit.
[Graphical view ]
SUPFAMi SSF55637. SSF55637. 1 hit.
PROSITEi PS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sucl+ encodes a predicted 13-kilodalton protein that is essential for cell viability and is directly involved in the division cycle of Schizosaccharomyces pombe."
    Hindley J., Phear G., Stein M., Beach D.
    Mol. Cell. Biol. 7:504-511(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase."
    Brizuela L., Draetta G., Beach D.
    EMBO J. 6:3507-3515(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION WITH CDC2.
  4. "The crystal structure of p13suc1, a p34cdc2-interacting cell cycle control protein."
    Endicott J.A., Noble M.E.M., Garman E.F., Brown N., Rasmussen B., Nurse P., Johnson L.N.
    EMBO J. 14:1004-1014(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS), PARTIAL PROTEIN SEQUENCE.
  5. "Crystal structure of the cell cycle-regulatory protein suc1 reveals a beta-hinge conformational switch."
    Bourne Y., Arvai A.S., Bernstein S.L., Watson M.H., Reed S.I., Endicott J.E., Noble M.E.M., Johnson L.N., Tainer J.A.
    Proc. Natl. Acad. Sci. U.S.A. 92:10232-10236(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
  6. "Crystal structure of the yeast cell-cycle control protein, p13suc1, in a strand-exchanged dimer."
    Khazanovich N., Bateman K.S., Chernaia M., Michalak M., James M.N.G.
    Structure 4:299-309(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).

Entry informationi

Entry nameiCKS1_SCHPO
AccessioniPrimary (citable) accession number: P08463
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi