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P08463 (CKS1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinases regulatory subunit
Alternative name(s):
P13
Gene names
Name:suc1
ORF Names:SPBC1734.14c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length113 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to the catalytic subunit of the cyclin dependent kinase (cdc2) and is essential for its biological function.

Subunit structure

Homodimer (in presence of zinc).

Sequence similarities

Belongs to the CKS family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 113112Cyclin-dependent kinases regulatory subunit
PRO_0000206246

Secondary structure

.................... 113
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P08463 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 1CE50666AAD8264F

FASTA11313,446
        10         20         30         40         50         60 
MSKSGVPRLL TASERERLEP FIDQIHYSPR YADDEYEYRH VMLPKAMLKA IPTDYFNPET 

        70         80         90        100        110 
GTLRILQEEE WRGLGITQSL GWEMYEVHVP EPHILLFKRE KDYQMKFSQQ RGG 

« Hide

References

« Hide 'large scale' references
[1]"Sucl+ encodes a predicted 13-kilodalton protein that is essential for cell viability and is directly involved in the division cycle of Schizosaccharomyces pombe."
Hindley J., Phear G., Stein M., Beach D.
Mol. Cell. Biol. 7:504-511(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase."
Brizuela L., Draetta G., Beach D.
EMBO J. 6:3507-3515(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: ASSOCIATION WITH CDC2.
[4]"The crystal structure of p13suc1, a p34cdc2-interacting cell cycle control protein."
Endicott J.A., Noble M.E.M., Garman E.F., Brown N., Rasmussen B., Nurse P., Johnson L.N.
EMBO J. 14:1004-1014(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS), PARTIAL PROTEIN SEQUENCE.
[5]"Crystal structure of the cell cycle-regulatory protein suc1 reveals a beta-hinge conformational switch."
Bourne Y., Arvai A.S., Bernstein S.L., Watson M.H., Reed S.I., Endicott J.E., Noble M.E.M., Johnson L.N., Tainer J.A.
Proc. Natl. Acad. Sci. U.S.A. 92:10232-10236(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
[6]"Crystal structure of the yeast cell-cycle control protein, p13suc1, in a strand-exchanged dimer."
Khazanovich N., Bateman K.S., Chernaia M., Michalak M., James M.N.G.
Structure 4:299-309(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M16032 Genomic DNA. Translation: AAA35346.1.
CU329671 Genomic DNA. Translation: CAA21308.1.
PIRA26722.
RefSeqNP_595431.1. NM_001021339.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1PUCX-ray1.95A2-106[»]
1SCEX-ray2.20A/B/C/D1-106[»]
ProteinModelPortalP08463.
SMRP08463. Positions 3-105.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid276571. 6 interactions.
IntActP08463. 5 interactions.
MINTMINT-4687051.
STRING4896.SPBC1734.14c-1.

Proteomic databases

PaxDbP08463.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC1734.14c.1; SPBC1734.14c.1:pep; SPBC1734.14c.
GeneID2540027.
KEGGspo:SPBC1734.14c.

Organism-specific databases

PomBaseSPBC1734.14c.

Phylogenomic databases

eggNOGNOG272189.
HOGENOMHOG000157009.
KOK02219.
OMAHVQLPKA.
OrthoDBEOG78D7Z8.
PhylomeDBP08463.

Family and domain databases

Gene3D3.30.170.10. 1 hit.
InterProIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamPF01111. CKS. 1 hit.
[Graphical view]
PRINTSPR00296. CYCLINKINASE.
SMARTSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMSSF55637. SSF55637. 1 hit.
PROSITEPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP08463.
NextBio20801170.

Entry information

Entry nameCKS1_SCHPO
AccessionPrimary (citable) accession number: P08463
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references