Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cyclin-dependent kinases regulatory subunit

Gene

suc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the catalytic subunit of the cyclin dependent kinase (cdc2) and is essential for its biological function.

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase activator activity Source: PomBase
  • histone binding Source: GO_Central
  • protein complex binding Source: PomBase
  • protein kinase binding Source: GO_Central
  • ubiquitin binding Source: GO_Central
  • zinc ion binding Source: PomBase

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit
Alternative name(s):
P13
Gene namesi
Name:suc1
ORF Names:SPBC1734.14c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.14c.
PomBaseiSPBC1734.14c. suc1.

Subcellular locationi

GO - Cellular componenti

  • cyclin-dependent protein kinase holoenzyme complex Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • SCF ubiquitin ligase complex Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002062462 – 113Cyclin-dependent kinases regulatory subunitAdd BLAST112

Proteomic databases

PRIDEiP08463.

Interactioni

Subunit structurei

Homodimer (in presence of zinc).

GO - Molecular functioni

  • histone binding Source: GO_Central
  • protein complex binding Source: PomBase
  • protein kinase binding Source: GO_Central
  • ubiquitin binding Source: GO_Central

Protein-protein interaction databases

BioGridi276571. 8 interactors.
IntActiP08463. 5 interactors.
MINTiMINT-4687051.

Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi12 – 16Combined sources5
Turni17 – 21Combined sources5
Helixi22 – 24Combined sources3
Beta strandi34 – 42Combined sources9
Helixi45 – 48Combined sources4
Helixi53 – 55Combined sources3
Turni58 – 60Combined sources3
Beta strandi61 – 63Combined sources3
Helixi68 – 73Combined sources6
Beta strandi83 – 85Combined sources3
Beta strandi94 – 100Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PUCX-ray1.95A2-106[»]
1SCEX-ray2.20A/B/C/D1-112[»]
ProteinModelPortaliP08463.
SMRiP08463.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08463.

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.Curated

Phylogenomic databases

HOGENOMiHOG000157009.
InParanoidiP08463.
KOiK02219.
OMAiQDMIHYS.
OrthoDBiEOG092C5VM2.
PhylomeDBiP08463.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSGVPRLL TASERERLEP FIDQIHYSPR YADDEYEYRH VMLPKAMLKA
60 70 80 90 100
IPTDYFNPET GTLRILQEEE WRGLGITQSL GWEMYEVHVP EPHILLFKRE
110
KDYQMKFSQQ RGG
Length:113
Mass (Da):13,446
Last modified:January 23, 2007 - v3
Checksum:i1CE50666AAD8264F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16032 Genomic DNA. Translation: AAA35346.1.
CU329671 Genomic DNA. Translation: CAA21308.1.
PIRiA26722.
RefSeqiNP_595431.1. NM_001021339.2.

Genome annotation databases

EnsemblFungiiSPBC1734.14c.1; SPBC1734.14c.1:pep; SPBC1734.14c.
GeneIDi2540027.
KEGGispo:SPBC1734.14c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16032 Genomic DNA. Translation: AAA35346.1.
CU329671 Genomic DNA. Translation: CAA21308.1.
PIRiA26722.
RefSeqiNP_595431.1. NM_001021339.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PUCX-ray1.95A2-106[»]
1SCEX-ray2.20A/B/C/D1-112[»]
ProteinModelPortaliP08463.
SMRiP08463.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276571. 8 interactors.
IntActiP08463. 5 interactors.
MINTiMINT-4687051.

Proteomic databases

PRIDEiP08463.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1734.14c.1; SPBC1734.14c.1:pep; SPBC1734.14c.
GeneIDi2540027.
KEGGispo:SPBC1734.14c.

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.14c.
PomBaseiSPBC1734.14c. suc1.

Phylogenomic databases

HOGENOMiHOG000157009.
InParanoidiP08463.
KOiK02219.
OMAiQDMIHYS.
OrthoDBiEOG092C5VM2.
PhylomeDBiP08463.

Miscellaneous databases

EvolutionaryTraceiP08463.
PROiP08463.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCKS1_SCHPO
AccessioniPrimary (citable) accession number: P08463
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.