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P08463

- CKS1_SCHPO

UniProt

P08463 - CKS1_SCHPO

Protein

Cyclin-dependent kinases regulatory subunit

Gene

suc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to the catalytic subunit of the cyclin dependent kinase (cdc2) and is essential for its biological function.

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase activator activity Source: PomBase
    2. protein binding Source: dictyBase
    3. protein complex binding Source: PomBase
    4. zinc ion binding Source: PomBase

    GO - Biological processi

    1. activation of protein kinase activity Source: PomBase
    2. cell cycle Source: UniProtKB-KW
    3. cell division Source: UniProtKB-KW
    4. cyclin catabolic process Source: PomBase
    5. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: PomBase
    6. regulation of mitotic cell cycle Source: PomBase
    7. signal transduction Source: PomBase

    Keywords - Biological processi

    Cell cycle, Cell division

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinases regulatory subunit
    Alternative name(s):
    P13
    Gene namesi
    Name:suc1
    ORF Names:SPBC1734.14c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC1734.14c.

    Subcellular locationi

    GO - Cellular componenti

    1. cyclin-dependent protein kinase holoenzyme complex Source: PomBase
    2. cytosol Source: PomBase
    3. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 113112Cyclin-dependent kinases regulatory subunitPRO_0000206246Add
    BLAST

    Proteomic databases

    PaxDbiP08463.

    Interactioni

    Subunit structurei

    Homodimer (in presence of zinc).

    Protein-protein interaction databases

    BioGridi276571. 6 interactions.
    IntActiP08463. 5 interactions.
    MINTiMINT-4687051.
    STRINGi4896.SPBC1734.14c-1.

    Structurei

    Secondary structure

    1
    113
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi12 – 165
    Turni17 – 215
    Helixi22 – 243
    Beta strandi34 – 429
    Helixi45 – 484
    Helixi53 – 553
    Turni58 – 603
    Beta strandi61 – 633
    Helixi68 – 736
    Beta strandi83 – 853
    Beta strandi94 – 1007

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1PUCX-ray1.95A2-106[»]
    1SCEX-ray2.20A/B/C/D1-112[»]
    ProteinModelPortaliP08463.
    SMRiP08463. Positions 3-105.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP08463.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CKS family.Curated

    Phylogenomic databases

    eggNOGiNOG272189.
    HOGENOMiHOG000157009.
    KOiK02219.
    OMAiHVQLPKA.
    OrthoDBiEOG78D7Z8.
    PhylomeDBiP08463.

    Family and domain databases

    Gene3Di3.30.170.10. 1 hit.
    InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
    [Graphical view]
    PfamiPF01111. CKS. 1 hit.
    [Graphical view]
    PRINTSiPR00296. CYCLINKINASE.
    SMARTiSM01084. CKS. 1 hit.
    [Graphical view]
    SUPFAMiSSF55637. SSF55637. 1 hit.
    PROSITEiPS00944. CKS_1. 1 hit.
    PS00945. CKS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P08463-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKSGVPRLL TASERERLEP FIDQIHYSPR YADDEYEYRH VMLPKAMLKA    50
    IPTDYFNPET GTLRILQEEE WRGLGITQSL GWEMYEVHVP EPHILLFKRE 100
    KDYQMKFSQQ RGG 113
    Length:113
    Mass (Da):13,446
    Last modified:January 23, 2007 - v3
    Checksum:i1CE50666AAD8264F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16032 Genomic DNA. Translation: AAA35346.1.
    CU329671 Genomic DNA. Translation: CAA21308.1.
    PIRiA26722.
    RefSeqiNP_595431.1. NM_001021339.2.

    Genome annotation databases

    EnsemblFungiiSPBC1734.14c.1; SPBC1734.14c.1:pep; SPBC1734.14c.
    GeneIDi2540027.
    KEGGispo:SPBC1734.14c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16032 Genomic DNA. Translation: AAA35346.1 .
    CU329671 Genomic DNA. Translation: CAA21308.1 .
    PIRi A26722.
    RefSeqi NP_595431.1. NM_001021339.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1PUC X-ray 1.95 A 2-106 [» ]
    1SCE X-ray 2.20 A/B/C/D 1-112 [» ]
    ProteinModelPortali P08463.
    SMRi P08463. Positions 3-105.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276571. 6 interactions.
    IntActi P08463. 5 interactions.
    MINTi MINT-4687051.
    STRINGi 4896.SPBC1734.14c-1.

    Proteomic databases

    PaxDbi P08463.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC1734.14c.1 ; SPBC1734.14c.1:pep ; SPBC1734.14c .
    GeneIDi 2540027.
    KEGGi spo:SPBC1734.14c.

    Organism-specific databases

    PomBasei SPBC1734.14c.

    Phylogenomic databases

    eggNOGi NOG272189.
    HOGENOMi HOG000157009.
    KOi K02219.
    OMAi HVQLPKA.
    OrthoDBi EOG78D7Z8.
    PhylomeDBi P08463.

    Miscellaneous databases

    EvolutionaryTracei P08463.
    NextBioi 20801170.

    Family and domain databases

    Gene3Di 3.30.170.10. 1 hit.
    InterProi IPR000789. Cyclin-dep_kinase_reg-sub.
    [Graphical view ]
    Pfami PF01111. CKS. 1 hit.
    [Graphical view ]
    PRINTSi PR00296. CYCLINKINASE.
    SMARTi SM01084. CKS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55637. SSF55637. 1 hit.
    PROSITEi PS00944. CKS_1. 1 hit.
    PS00945. CKS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sucl+ encodes a predicted 13-kilodalton protein that is essential for cell viability and is directly involved in the division cycle of Schizosaccharomyces pombe."
      Hindley J., Phear G., Stein M., Beach D.
      Mol. Cell. Biol. 7:504-511(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. "p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase."
      Brizuela L., Draetta G., Beach D.
      EMBO J. 6:3507-3515(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: ASSOCIATION WITH CDC2.
    4. "The crystal structure of p13suc1, a p34cdc2-interacting cell cycle control protein."
      Endicott J.A., Noble M.E.M., Garman E.F., Brown N., Rasmussen B., Nurse P., Johnson L.N.
      EMBO J. 14:1004-1014(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS), PARTIAL PROTEIN SEQUENCE.
    5. "Crystal structure of the cell cycle-regulatory protein suc1 reveals a beta-hinge conformational switch."
      Bourne Y., Arvai A.S., Bernstein S.L., Watson M.H., Reed S.I., Endicott J.E., Noble M.E.M., Johnson L.N., Tainer J.A.
      Proc. Natl. Acad. Sci. U.S.A. 92:10232-10236(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
    6. "Crystal structure of the yeast cell-cycle control protein, p13suc1, in a strand-exchanged dimer."
      Khazanovich N., Bateman K.S., Chernaia M., Michalak M., James M.N.G.
      Structure 4:299-309(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).

    Entry informationi

    Entry nameiCKS1_SCHPO
    AccessioniPrimary (citable) accession number: P08463
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 128 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3