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Protein

Cyclin-dependent kinases regulatory subunit

Gene

suc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the catalytic subunit of the cyclin dependent kinase (cdc2) and is essential for its biological function.

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase activator activity Source: PomBase
  • histone binding Source: GO_Central
  • protein kinase binding Source: GO_Central
  • ubiquitin binding Source: GO_Central
  • zinc ion binding Source: PomBase

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit
Alternative name(s):
P13
Gene namesi
Name:suc1
ORF Names:SPBC1734.14c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.14c
PomBaseiSPBC1734.14c suc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002062462 – 113Cyclin-dependent kinases regulatory subunitAdd BLAST112

Proteomic databases

PaxDbiP08463
PRIDEiP08463

Interactioni

Subunit structurei

Homodimer (in presence of zinc).

GO - Molecular functioni

Protein-protein interaction databases

BioGridi276571, 8 interactors
IntActiP08463, 5 interactors
STRINGi4896.SPBC1734.14c.1

Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi12 – 16Combined sources5
Turni17 – 21Combined sources5
Helixi22 – 24Combined sources3
Beta strandi34 – 42Combined sources9
Helixi45 – 48Combined sources4
Helixi53 – 55Combined sources3
Turni58 – 60Combined sources3
Beta strandi61 – 63Combined sources3
Helixi68 – 73Combined sources6
Beta strandi83 – 85Combined sources3
Beta strandi94 – 100Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PUCX-ray1.95A2-106[»]
1SCEX-ray2.20A/B/C/D1-112[»]
ProteinModelPortaliP08463
SMRiP08463
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08463

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.Curated

Phylogenomic databases

HOGENOMiHOG000157009
InParanoidiP08463
KOiK02219
OMAiIHYSSRY
OrthoDBiEOG092C5VM2
PhylomeDBiP08463

Family and domain databases

Gene3Di3.30.170.10, 1 hit
InterProiView protein in InterPro
IPR000789 Cyclin-dep_kinase_reg-sub
IPR036858 Cyclin-dep_kinase_reg-sub_sf
PfamiView protein in Pfam
PF01111 CKS, 1 hit
PRINTSiPR00296 CYCLINKINASE
SMARTiView protein in SMART
SM01084 CKS, 1 hit
SUPFAMiSSF55637 SSF55637, 1 hit
PROSITEiView protein in PROSITE
PS00944 CKS_1, 1 hit
PS00945 CKS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSGVPRLL TASERERLEP FIDQIHYSPR YADDEYEYRH VMLPKAMLKA
60 70 80 90 100
IPTDYFNPET GTLRILQEEE WRGLGITQSL GWEMYEVHVP EPHILLFKRE
110
KDYQMKFSQQ RGG
Length:113
Mass (Da):13,446
Last modified:January 23, 2007 - v3
Checksum:i1CE50666AAD8264F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16032 Genomic DNA Translation: AAA35346.1
CU329671 Genomic DNA Translation: CAA21308.1
PIRiA26722
RefSeqiNP_595431.1, NM_001021339.2

Genome annotation databases

EnsemblFungiiSPBC1734.14c.1; SPBC1734.14c.1:pep; SPBC1734.14c
GeneIDi2540027
KEGGispo:SPBC1734.14c

Similar proteinsi

Entry informationi

Entry nameiCKS1_SCHPO
AccessioniPrimary (citable) accession number: P08463
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health