UniProtKB - P08460 (NID1_RAT)
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Protein
Nidogen-1
Gene
Nid1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.
GO - Molecular functioni
- collagen binding Source: RGD
- extracellular matrix binding Source: RGD
- laminin-1 binding Source: RGD
- laminin binding Source: RGD
- proteoglycan binding Source: RGD
GO - Biological processi
- cell-matrix adhesion Source: RGD
- extracellular matrix organization Source: RGD
- glomerular basement membrane development Source: RGD
- positive regulation of cell-substrate adhesion Source: RGD
Keywordsi
Biological process | Cell adhesion |
Names & Taxonomyi
Protein namesi | Recommended name: Nidogen-1Short name: NID-1 Alternative name(s): Entactin |
Gene namesi | Name:Nid1 Synonyms:Nid |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3178. Nid1. |
Subcellular locationi
Keywords - Cellular componenti
Basement membrane, Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000055634 | ‹1 – ›324 | Nidogen-1Add BLAST | ›324 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 97 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 200 | SulfotyrosineSequence analysis | 1 | |
Modified residuei | 205 | SulfotyrosineSequence analysis | 1 | |
Disulfide bondi | 299 ↔ 312 | PROSITE-ProRule annotation | ||
Disulfide bondi | 306 ↔ 321 | PROSITE-ProRule annotation |
Post-translational modificationi
N- and O-glycosylated.
Keywords - PTMi
Disulfide bond, Glycoprotein, SulfationProteomic databases
PaxDbi | P08460. |
PeptideAtlasi | P08460. |
PRIDEi | P08460. |
Interactioni
Subunit structurei
Interacts with FBLN1 and LGALS3BP. Interacts with PLXDC1 (By similarity).By similarity
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Plxdc1 | Q91ZV7 | 2 | EBI-8280787,EBI-8280807 | From Mus musculus. |
GO - Molecular functioni
- collagen binding Source: RGD
- laminin-1 binding Source: RGD
- laminin binding Source: RGD
- proteoglycan binding Source: RGD
Protein-protein interaction databases
IntActi | P08460. 1 interactor. |
MINTi | P08460. |
STRINGi | 10116.ENSRNOP00000003349. |
Structurei
3D structure databases
ProteinModelPortali | P08460. |
SMRi | P08460. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 178 | NIDOPROSITE-ProRule annotationAdd BLAST | 163 | |
Domaini | 295 – ›324 | EGF-likePROSITE-ProRule annotationAdd BLAST | ›30 |
Keywords - Domaini
EGF-like domainPhylogenomic databases
eggNOGi | KOG1214. Eukaryota. ENOG410XR8N. LUCA. |
HOGENOMi | HOG000072712. |
InParanoidi | P08460. |
PhylomeDBi | P08460. |
Family and domain databases
InterProi | View protein in InterPro IPR003886. NIDO_dom. |
Pfami | View protein in Pfam PF06119. NIDO. 1 hit. |
SMARTi | View protein in SMART SM00539. NIDO. 1 hit. |
PROSITEi | View protein in PROSITE PS00010. ASX_HYDROXYL. 1 hit. PS51220. NIDO. 1 hit. |
i Sequence
Sequence statusi: Fragment.
P08460-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
EFHPGTFPPS FGSVAPFLAD LDTTDGLGNV YYREDLSPFI IQMAAEYVQR
60 70 80 90 100
GFPEVSFQPT SVVVVTWESM APYGGPSGSL VEEGKRNTFQ AVLASSNSSS
110 120 130 140 150
YAIFLYPDDG LQFFTTFSKK DENQVPAVVG FSKGLEGFLW KSNGAYNIFA
160 170 180 190 200
NDRESIENLA KSSNAGHQGV WVFEIGSPAT AKGVVPADVN LDVDDDGADY
210 220 230 240 250
EDEDYDLQTS HLGLEDVATQ PFPSHSPRRG YPDPHNVPRT LAPSYEATER
260 270 280 290 300
PHGIPTERTK SFQLPVERFP QKHPQVIDVD EVEETGVVFS YNTGSQQTCA
310 320
NNRHQCSVHA ECRDYATGFC CRCV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 | ||
Non-terminal residuei | 324 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15797 mRNA. Translation: AAA41120.1. Sequence problems. AJ224450 mRNA. Translation: CAA11963.1. |
PIRi | S14828. |
UniGenei | Rn.105658. |
Genome annotation databases
UCSCi | RGD:3178. rat. |
Similar proteinsi
Entry informationi
Entry namei | NID1_RAT | |
Accessioni | P08460Primary (citable) accession number: P08460 Secondary accession number(s): Q712L9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | May 1, 1992 | |
Last modified: | February 28, 2018 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |