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Protein

Nidogen-1

Gene

Nid1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Nidogen-1
Short name:
NID-1
Alternative name(s):
Entactin
Gene namesi
Name:Nid1
Synonyms:Nid
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3178. Nid1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000055634‹1 – ›324Nidogen-1Add BLAST›324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei200SulfotyrosineSequence analysis1
Modified residuei205SulfotyrosineSequence analysis1
Disulfide bondi299 ↔ 312PROSITE-ProRule annotation
Disulfide bondi306 ↔ 321PROSITE-ProRule annotation

Post-translational modificationi

N- and O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

PaxDbiP08460.
PeptideAtlasiP08460.
PRIDEiP08460.

Interactioni

Subunit structurei

Interacts with FBLN1 and LGALS3BP. Interacts with PLXDC1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Plxdc1Q91ZV72EBI-8280787,EBI-8280807From Mus musculus.

Protein-protein interaction databases

IntActiP08460. 1 interactor.
MINTiMINT-1892021.
STRINGi10116.ENSRNOP00000003349.

Structurei

3D structure databases

ProteinModelPortaliP08460.
SMRiP08460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 178NIDOPROSITE-ProRule annotationAdd BLAST163
Domaini295 – ›324EGF-likePROSITE-ProRule annotationAdd BLAST›30

Keywords - Domaini

EGF-like domain

Phylogenomic databases

eggNOGiKOG1214. Eukaryota.
ENOG410XR8N. LUCA.
HOGENOMiHOG000072712.
InParanoidiP08460.
PhylomeDBiP08460.

Family and domain databases

InterProiView protein in InterPro
IPR003886. NIDO_dom.
PfamiView protein in Pfam
PF06119. NIDO. 1 hit.
SMARTiView protein in SMART
SM00539. NIDO. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 1 hit.
PS51220. NIDO. 1 hit.

Sequencei

Sequence statusi: Fragment.

P08460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EFHPGTFPPS FGSVAPFLAD LDTTDGLGNV YYREDLSPFI IQMAAEYVQR
60 70 80 90 100
GFPEVSFQPT SVVVVTWESM APYGGPSGSL VEEGKRNTFQ AVLASSNSSS
110 120 130 140 150
YAIFLYPDDG LQFFTTFSKK DENQVPAVVG FSKGLEGFLW KSNGAYNIFA
160 170 180 190 200
NDRESIENLA KSSNAGHQGV WVFEIGSPAT AKGVVPADVN LDVDDDGADY
210 220 230 240 250
EDEDYDLQTS HLGLEDVATQ PFPSHSPRRG YPDPHNVPRT LAPSYEATER
260 270 280 290 300
PHGIPTERTK SFQLPVERFP QKHPQVIDVD EVEETGVVFS YNTGSQQTCA
310 320
NNRHQCSVHA ECRDYATGFC CRCV
Length:324
Mass (Da):35,661
Last modified:May 1, 1992 - v2
Checksum:iCBDEAD3337019027
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei3241

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15797 mRNA. Translation: AAA41120.1. Sequence problems.
AJ224450 mRNA. Translation: CAA11963.1.
PIRiS14828.
UniGeneiRn.105658.

Genome annotation databases

UCSCiRGD:3178. rat.

Similar proteinsi

Entry informationi

Entry nameiNID1_RAT
AccessioniPrimary (citable) accession number: P08460
Secondary accession number(s): Q712L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 1, 1992
Last modified: August 30, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome