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P08459 (SPS2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sporulation-specific protein 2
Gene names
Name:SPS2
Ordered Locus Names:YDR522C
ORF Names:D9719.26
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in middle stages of meiosis. Redundant with SPS22 for the organization of the beta-glucan layer of the spore wall. Ref.4 Ref.5 Ref.7

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor Potential.

Miscellaneous

Present with 238 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the SPS2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 5656 Potential
Chain57 – 475419Sporulation-specific protein 2
PRO_0000033195
Propeptide476 – 50227Removed in mature form Potential
PRO_0000277471

Amino acid modifications

Lipidation4751GPI-anchor amidated asparagine Potential
Glycosylation771N-linked (GlcNAc...) Potential
Glycosylation1351N-linked (GlcNAc...) Potential
Glycosylation2851N-linked (GlcNAc...) Potential
Glycosylation3031N-linked (GlcNAc...) Potential
Glycosylation3401N-linked (GlcNAc...) Potential
Glycosylation3431N-linked (GlcNAc...) Potential
Glycosylation3551N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2031P → L in AAA35080. Ref.1
Sequence conflict2101I → S in AAA35080. Ref.1
Sequence conflict3241V → G in AAA35080. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P08459 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 11F9EFB11CD4D59C

FASTA50255,939
        10         20         30         40         50         60 
MPIWKTQTFF TSISVIQIVN KETKVSTKKE KDSMLNQLNT ILRFLFLFLQ LIKSSAAVEP 

        70         80         90        100        110        120 
NGGPNILDHN IMLVNTNATI PKKEQTDFEV ISPTKQTQVD EDCKKGLYHI ENAGNLIELQ 

       130        140        150        160        170        180 
AKCWKVVGNI EISSNYSGSL IDLGLIREIE GDLIIKNNKH IFRIQGYNLE SLGKLELDSL 

       190        200        210        220        230        240 
TSFVSLDFPA LKEVETVDWR VLPILSSVVI NGNIKKIKNI IISDTALTSI DYFNNVKKVD 

       250        260        270        280        290        300 
IFNINNNRFL ENLFASLESV TKQLTVHSNA KELELDLSNL HTVENMTIKD VSEIKLAKLS 

       310        320        330        340        350        360 
SVNSSLEFIE NQFSSLELPL LAKVQGTLGL IDNKNLKKLN FSNATDIQGG LMIANNTELA 

       370        380        390        400        410        420 
KIDFFPKLRQ IGGAIYFEGS FDKIDLPELK LVKGSAYIKS SSEELNCEEF TSPKAGRSII 

       430        440        450        460        470        480 
RGGKIECTSG MKSKMLNVDE EGNVLGKQET DNDNGKKEKG KNGAKSQGSS KKMENSAPKN 

       490        500 
IFIDAFKMSV YAVFTVLFSI IF 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Characterization and mutational analysis of a cluster of three genes expressed preferentially during sporulation of Saccharomyces cerevisiae."
Percival-Smith A., Segall J.
Mol. Cell. Biol. 6:2443-2451(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-502.
[4]"Increased copy number of the 5' end of the SPS2 gene inhibits sporulation of Saccharomyces cerevisiae."
Percival-Smith A., Segall J.
Mol. Cell. Biol. 7:2484-2490(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Stimulation of later functions of the yeast meiotic protein kinase Ime2p by the IDS2 gene product."
Sia R.A., Mitchell A.P.
Mol. Cell. Biol. 15:5279-5287(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Morphogenetic pathway of spore wall assembly in Saccharomyces cerevisiae."
Coluccio A., Bogengruber E., Conrad M.N., Dresser M.E., Briza P., Neiman A.M.
Eukaryot. Cell 3:1464-1475(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U33057 Genomic DNA. Translation: AAB64962.1.
M13629 Genomic DNA. Translation: AAA35080.1.
BK006938 Genomic DNA. Translation: DAA12352.1.
PIRS69578.
RefSeqNP_010810.1. NM_001180830.1.

3D structure databases

ProteinModelPortalP08459.
SMRP08459. Positions 216-248.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid32572. 42 interactions.
DIPDIP-7764N.
IntActP08459. 3 interactions.
STRING4932.YDR522C.

Proteomic databases

PaxDbP08459.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDR522C; YDR522C; YDR522C.
GeneID852134.
KEGGsce:YDR522C.

Organism-specific databases

CYGDYDR522c.
SGDS000002930. SPS2.

Phylogenomic databases

eggNOGNOG309463.
GeneTreeENSGT00530000065410.
HOGENOMHOG000057088.
OMAGLMIANN.
OrthoDBEOG75XGWQ.

Enzyme and pathway databases

BioCycYEAST:G3O-30038-MONOMER.

Gene expression databases

GenevestigatorP08459.

Family and domain databases

ProtoNetSearch...

Other

NextBio970537.

Entry information

Entry nameSPS2_YEAST
AccessionPrimary (citable) accession number: P08459
Secondary accession number(s): D6VTE2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IV

Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families