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Protein

Sporulation-specific protein 2

Gene

SPS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in middle stages of meiosis. Redundant with SPS22 for the organization of the beta-glucan layer of the spore wall.3 Publications

GO - Biological processi

  • ascospore formation Source: SGD
  • ascospore wall assembly Source: SGD
Complete GO annotation...

Keywords - Biological processi

Meiosis, Sporulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30038-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sporulation-specific protein 2
Gene namesi
Name:SPS2
Ordered Locus Names:YDR522C
ORF Names:D9719.26
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR522C.
SGDiS000002930. SPS2.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • fungal-type cell wall Source: SGD
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 56Sequence analysisAdd BLAST56
ChainiPRO_000003319557 – 475Sporulation-specific protein 2Add BLAST419
PropeptideiPRO_0000277471476 – 502Removed in mature formSequence analysisAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi77N-linked (GlcNAc...)Sequence analysis1
Glycosylationi135N-linked (GlcNAc...)Sequence analysis1
Glycosylationi285N-linked (GlcNAc...)Sequence analysis1
Glycosylationi303N-linked (GlcNAc...)Sequence analysis1
Glycosylationi340N-linked (GlcNAc...)Sequence analysis1
Glycosylationi343N-linked (GlcNAc...)Sequence analysis1
Glycosylationi355N-linked (GlcNAc...)Sequence analysis1
Lipidationi475GPI-anchor amidated asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiP08459.

Interactioni

Protein-protein interaction databases

BioGridi32572. 42 interactors.
DIPiDIP-7764N.
IntActiP08459. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliP08459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPS2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00530000065410.
HOGENOMiHOG000057088.
InParanoidiP08459.
OMAiKMENSAP.
OrthoDBiEOG092C3DSS.

Family and domain databases

Gene3Di3.80.20.20. 1 hit.
InterProiIPR032675. L_dom-like.
IPR000494. Rcpt_L-dom.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIWKTQTFF TSISVIQIVN KETKVSTKKE KDSMLNQLNT ILRFLFLFLQ
60 70 80 90 100
LIKSSAAVEP NGGPNILDHN IMLVNTNATI PKKEQTDFEV ISPTKQTQVD
110 120 130 140 150
EDCKKGLYHI ENAGNLIELQ AKCWKVVGNI EISSNYSGSL IDLGLIREIE
160 170 180 190 200
GDLIIKNNKH IFRIQGYNLE SLGKLELDSL TSFVSLDFPA LKEVETVDWR
210 220 230 240 250
VLPILSSVVI NGNIKKIKNI IISDTALTSI DYFNNVKKVD IFNINNNRFL
260 270 280 290 300
ENLFASLESV TKQLTVHSNA KELELDLSNL HTVENMTIKD VSEIKLAKLS
310 320 330 340 350
SVNSSLEFIE NQFSSLELPL LAKVQGTLGL IDNKNLKKLN FSNATDIQGG
360 370 380 390 400
LMIANNTELA KIDFFPKLRQ IGGAIYFEGS FDKIDLPELK LVKGSAYIKS
410 420 430 440 450
SSEELNCEEF TSPKAGRSII RGGKIECTSG MKSKMLNVDE EGNVLGKQET
460 470 480 490 500
DNDNGKKEKG KNGAKSQGSS KKMENSAPKN IFIDAFKMSV YAVFTVLFSI

IF
Length:502
Mass (Da):55,939
Last modified:October 1, 1996 - v2
Checksum:i11F9EFB11CD4D59C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203P → L in AAA35080 (PubMed:9169867).Curated1
Sequence conflicti210I → S in AAA35080 (PubMed:9169867).Curated1
Sequence conflicti324V → G in AAA35080 (PubMed:9169867).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33057 Genomic DNA. Translation: AAB64962.1.
M13629 Genomic DNA. Translation: AAA35080.1.
BK006938 Genomic DNA. Translation: DAA12352.1.
PIRiS69578.
RefSeqiNP_010810.1. NM_001180830.1.

Genome annotation databases

EnsemblFungiiYDR522C; YDR522C; YDR522C.
GeneIDi852134.
KEGGisce:YDR522C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33057 Genomic DNA. Translation: AAB64962.1.
M13629 Genomic DNA. Translation: AAA35080.1.
BK006938 Genomic DNA. Translation: DAA12352.1.
PIRiS69578.
RefSeqiNP_010810.1. NM_001180830.1.

3D structure databases

ProteinModelPortaliP08459.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32572. 42 interactors.
DIPiDIP-7764N.
IntActiP08459. 3 interactors.

Proteomic databases

PRIDEiP08459.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR522C; YDR522C; YDR522C.
GeneIDi852134.
KEGGisce:YDR522C.

Organism-specific databases

EuPathDBiFungiDB:YDR522C.
SGDiS000002930. SPS2.

Phylogenomic databases

GeneTreeiENSGT00530000065410.
HOGENOMiHOG000057088.
InParanoidiP08459.
OMAiKMENSAP.
OrthoDBiEOG092C3DSS.

Enzyme and pathway databases

BioCyciYEAST:G3O-30038-MONOMER.

Miscellaneous databases

PROiP08459.

Family and domain databases

Gene3Di3.80.20.20. 1 hit.
InterProiIPR032675. L_dom-like.
IPR000494. Rcpt_L-dom.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSPS2_YEAST
AccessioniPrimary (citable) accession number: P08459
Secondary accession number(s): D6VTE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 238 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.