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P08456

- PSS_YEAST

UniProt

P08456 - PSS_YEAST

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Protein
CDP-diacylglycerol--serine O-phosphatidyltransferase
Gene
CHO1, PSS, PSS1, YER026C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

CDP-diacylglycerol + L-serine = CMP + (3-sn-phosphatidyl)-L-serine.

Pathwayi

GO - Molecular functioni

  1. CDP-diacylglycerol-serine O-phosphatidyltransferase activity Source: SGD

GO - Biological processi

  1. phosphatidylethanolamine biosynthetic process Source: UniProtKB-UniPathway
  2. phosphatidylserine biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciYEAST:YER026C-MONOMER.
BRENDAi2.7.8.8. 984.
UniPathwayiUPA00558; UER00615.

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--serine O-phosphatidyltransferase (EC:2.7.8.8)
Alternative name(s):
Phosphatidylserine synthase
Gene namesi
Name:CHO1
Synonyms:PSS, PSS1
Ordered Locus Names:YER026C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

SGDiS000000828. CHO1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei82 – 10221Helical; Reviewed prediction
Add
BLAST
Transmembranei163 – 18321Helical; Reviewed prediction
Add
BLAST
Transmembranei210 – 23021Helical; Reviewed prediction
Add
BLAST
Transmembranei248 – 26821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: SGD
  2. mitochondrial outer membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 276275CDP-diacylglycerol--serine O-phosphatidyltransferase
PRO_0000056801Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41Phosphoserine3 Publications
Modified residuei34 – 341Phosphoserine3 Publications
Modified residuei42 – 421Phosphoserine2 Publications
Modified residuei46 – 461Phosphoserine2 Publications
Modified residuei47 – 471Phosphoserine2 Publications
Modified residuei50 – 501Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP08456.
PeptideAtlasiP08456.

Expressioni

Gene expression databases

GenevestigatoriP08456.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself1EBI-14055,EBI-14055
AGP1P253761EBI-14055,EBI-2357
ALG11P539541EBI-14055,EBI-2497
ARF1P110761EBI-14055,EBI-2816
BAP2P380841EBI-14055,EBI-3414
BSD2P383561EBI-14055,EBI-3783
CAN1P048171EBI-14055,EBI-3993
CAX4P532231EBI-14055,EBI-23136
CBR1P386261EBI-14055,EBI-2048224
CCW12Q121271EBI-14055,EBI-5303
CHO2P053741EBI-14055,EBI-2049142
CNE1P278251EBI-14055,EBI-3987
COS1P538221EBI-14055,EBI-4959
COS4P435421EBI-14055,EBI-2050225
CPR4P253341EBI-14055,EBI-5468
CPT1P178981EBI-14055,EBI-2050738
CSG2P352061EBI-14055,EBI-2051140
DAL5P153651EBI-14055,EBI-5527
DCW1P360911EBI-14055,EBI-2052781
DFG5Q050311EBI-14055,EBI-27512
DIP5P533881EBI-14055,EBI-5904
ELO1P395401EBI-14055,EBI-2049096
EPT1P221401EBI-14055,EBI-6494
ERG11P106141EBI-14055,EBI-5127
ERG24P324621EBI-14055,EBI-6502
ERG25P530451EBI-14055,EBI-6506
ERG26P531991EBI-14055,EBI-6514
ERG28P400301EBI-14055,EBI-22518
ERG3P323531EBI-14055,EBI-6554
ERG4P253401EBI-14055,EBI-6558
ERG5P547811EBI-14055,EBI-6563
ERJ5P436131EBI-14055,EBI-23020
ERP1Q053591EBI-14055,EBI-6581
ERP4Q124501EBI-14055,EBI-6598
ERP5P388191EBI-14055,EBI-6603
ERP6P531981EBI-14055,EBI-2058104
ERV25P548371EBI-14055,EBI-6642
ERV29P533371EBI-14055,EBI-23662
ERV41Q046511EBI-14055,EBI-27850
ESBP6P539181EBI-14055,EBI-28895
FCY2P170641EBI-14055,EBI-2047850
FET3P389931EBI-14055,EBI-6876
GAA1P390121EBI-14055,EBI-7252
GAP1P191451EBI-14055,EBI-7314
GNP1P488131EBI-14055,EBI-7758
GOT1Q035541EBI-14055,EBI-2057821
GPI13Q078301EBI-14055,EBI-32339
GPT2P361481EBI-14055,EBI-26471
GTT1P405821EBI-14055,EBI-7941
GUP1P531541EBI-14055,EBI-7994
ILM1P471551EBI-14055,EBI-2051644
KRE27P405401EBI-14055,EBI-24977
LAC1P284961EBI-14055,EBI-26585
MCD4P360511EBI-14055,EBI-2070979
MSC7P386941EBI-14055,EBI-24511
NDC1P325001EBI-14055,EBI-11950
NSG1P388371EBI-14055,EBI-24733
OLE1P211471EBI-14055,EBI-2098
ORM2Q061441EBI-14055,EBI-34916
OST1P415431EBI-14055,EBI-12651
PHO84P252971EBI-14055,EBI-13320
PHO86P469561EBI-14055,EBI-13337
PHO88P382641EBI-14055,EBI-13350
PIS1P061971EBI-14055,EBI-13458
PKR1Q038801EBI-14055,EBI-27252
PMP2P409751EBI-14055,EBI-2043041
PMP3P872841EBI-14055,EBI-13555
POM33Q121641EBI-14055,EBI-30000
PRM8P531741EBI-14055,EBI-6200
QDR2P404741EBI-14055,EBI-25203
RTN1Q049471EBI-14055,EBI-38020
SAC1P323681EBI-14055,EBI-16210
SCS7Q035291EBI-14055,EBI-16747
SEC4P075601EBI-14055,EBI-16858
SEC61P329151EBI-14055,EBI-16400
SEC63P149061EBI-14055,EBI-16636
SEY1Q992871EBI-14055,EBI-37523
SHR3Q027741EBI-14055,EBI-17099
SLC1P333331EBI-14055,EBI-13494
SOP4P395431EBI-14055,EBI-26193
SPC1P469651EBI-14055,EBI-17823
SPC2Q049691EBI-14055,EBI-27827
SPF1P399861EBI-14055,EBI-3128
SSH1P383531EBI-14055,EBI-18175
STE24P471541EBI-14055,EBI-18298
SUR2P389921EBI-14055,EBI-18574
SWP1Q027951EBI-14055,EBI-12666
TRM1P15565-11EBI-14055,EBI-1009955From a different organism.
VHS3Q084381EBI-14055,EBI-30482
VMA21P418061EBI-14055,EBI-20323
VPS66Q065081EBI-14055,EBI-36961
VRG4P401071EBI-14055,EBI-7764
WBP1P337671EBI-14055,EBI-12658
YDC1Q028961EBI-14055,EBI-22203
YHR146WP388451EBI-14055,EBI-24770
YNL190WP538721EBI-14055,EBI-29075
YOP1Q124021EBI-14055,EBI-37092
YPC1P382981EBI-14055,EBI-2103141
YPS3Q123031EBI-14055,EBI-27104
YVH1Q022561EBI-14055,EBI-14322

Protein-protein interaction databases

BioGridi36761. 39 interactions.
DIPiDIP-5331N.
IntActiP08456. 7 interactions.
MINTiMINT-521670.
STRINGi4932.YER026C.

Structurei

3D structure databases

ProteinModelPortaliP08456.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1183.
HOGENOMiHOG000229371.
KOiK17103.
OMAiFNISANK.
OrthoDBiEOG7W15FB.

Family and domain databases

InterProiIPR004533. CDP-diaglyc--ser_O-PTrfase.
IPR016271. CDP-diaglyc--ser_O-PTrfase_fun.
IPR000462. CDP-OH_P_trans.
[Graphical view]
PfamiPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF000852. Phosphatidylserine_synth_fun. 1 hit.
TIGRFAMsiTIGR00473. pssA. 1 hit.
PROSITEiPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08456-1 [UniParc]FASTAAdd to Basket

« Hide

MVESDEDFAP QEFPHTDTDV IVNEHRDEND GYASDEVGGT LSRRASSIFS    50
INTTPLAPPN ATDIQKFTSD EHHFSMMRNL HMADYITMLN GFSGFYSIVS 100
CLRFTLTGKP HYVQRAHFFI LLGMCFDFLD GRVARLRNRS SLMGQELDSL 150
ADLVSFGVAP AAIAFAIGFQ TTFDVMILSF FVLCGLARLA RFNVTVAQLP 200
KDSSTGKSKY FEGLPMPTTL ALVLGMAYCV RKGLIFDNIP FGIFREDQIL 250
EFHPIILVFF IHGCGMISKS LKIPKP 276
Length:276
Mass (Da):30,805
Last modified:January 23, 2007 - v3
Checksum:iE52B1FC836B67D24
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1231G → A in BAA00121. 1 Publication
Sequence conflicti191 – 1911R → T in BAA00121. 1 Publication
Sequence conflicti276 – 2761P → A in BAA00121. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X05944 Genomic DNA. Translation: CAA29376.1.
D00171 Genomic DNA. Translation: BAA00121.1.
U18778 Genomic DNA. Translation: AAB64559.1.
BK006939 Genomic DNA. Translation: DAA07679.1.
PIRiS00080.
RefSeqiNP_010943.3. NM_001178917.3.

Genome annotation databases

EnsemblFungiiYER026C; YER026C; YER026C.
GeneIDi856748.
KEGGisce:YER026C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X05944 Genomic DNA. Translation: CAA29376.1 .
D00171 Genomic DNA. Translation: BAA00121.1 .
U18778 Genomic DNA. Translation: AAB64559.1 .
BK006939 Genomic DNA. Translation: DAA07679.1 .
PIRi S00080.
RefSeqi NP_010943.3. NM_001178917.3.

3D structure databases

ProteinModelPortali P08456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36761. 39 interactions.
DIPi DIP-5331N.
IntActi P08456. 7 interactions.
MINTi MINT-521670.
STRINGi 4932.YER026C.

Proteomic databases

PaxDbi P08456.
PeptideAtlasi P08456.

Protocols and materials databases

DNASUi 856748.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER026C ; YER026C ; YER026C .
GeneIDi 856748.
KEGGi sce:YER026C.

Organism-specific databases

SGDi S000000828. CHO1.

Phylogenomic databases

eggNOGi COG1183.
HOGENOMi HOG000229371.
KOi K17103.
OMAi FNISANK.
OrthoDBi EOG7W15FB.

Enzyme and pathway databases

UniPathwayi UPA00558 ; UER00615 .
BioCyci YEAST:YER026C-MONOMER.
BRENDAi 2.7.8.8. 984.

Miscellaneous databases

NextBioi 982893.

Gene expression databases

Genevestigatori P08456.

Family and domain databases

InterProi IPR004533. CDP-diaglyc--ser_O-PTrfase.
IPR016271. CDP-diaglyc--ser_O-PTrfase_fun.
IPR000462. CDP-OH_P_trans.
[Graphical view ]
Pfami PF01066. CDP-OH_P_transf. 1 hit.
[Graphical view ]
PIRSFi PIRSF000852. Phosphatidylserine_synth_fun. 1 hit.
TIGRFAMsi TIGR00473. pssA. 1 hit.
PROSITEi PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and characterization of the yeast PSS gene encoding phosphatidylserine synthase."
    Nikawa J., Tsukagoschi Y., Kodaki T., Yamashita S.
    Eur. J. Biochem. 167:7-12(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Primary structure and product characterization of the Saccharomyces cerevisiae CHO1 gene that encodes phosphatidylserine synthase."
    Kiyono K., Miura K., Kushima Y., Hikiji T., Fukushima M., Shibuya I., Ohta A.
    J. Biochem. 102:1089-1100(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-15.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-34; SER-42; SER-46; SER-47 AND SER-50, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 AND SER-34, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-34; SER-42; SER-46; SER-47 AND SER-50, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPSS_YEAST
AccessioniPrimary (citable) accession number: P08456
Secondary accession number(s): D3DLS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

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