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Protein

CDP-diacylglycerol--serine O-phosphatidyltransferase

Gene

CHO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

CDP-diacylglycerol + L-serine = CMP + (3-sn-phosphatidyl)-L-serine.

Pathwayi: phosphatidylethanolamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphatidylethanolamine from CDP-diacylglycerol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. CDP-diacylglycerol--serine O-phosphatidyltransferase (CHO1)
  2. Phosphatidylserine decarboxylase proenzyme 2 (PSD2), Phosphatidylserine decarboxylase proenzyme 1, mitochondrial (PSD1)
This subpathway is part of the pathway phosphatidylethanolamine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from CDP-diacylglycerol, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

  • CDP-diacylglycerol-serine O-phosphatidyltransferase activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciYEAST:YER026C-MONOMER
UniPathwayiUPA00558; UER00615

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--serine O-phosphatidyltransferase (EC:2.7.8.8)
Alternative name(s):
Phosphatidylserine synthase
Gene namesi
Name:CHO1
Synonyms:PSS, PSS1
Ordered Locus Names:YER026C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER026C
SGDiS000000828 CHO1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000568012 – 276CDP-diacylglycerol--serine O-phosphatidyltransferaseAdd BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Modified residuei46PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP08456
PRIDEiP08456

PTM databases

CarbonylDBiP08456
iPTMnetiP08456

Interactioni

Protein-protein interaction databases

BioGridi36761, 49 interactors
DIPiDIP-5331N
IntActiP08456, 8 interactors
MINTiP08456
STRINGi4932.YER026C

Structurei

3D structure databases

ProteinModelPortaliP08456
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000229371
InParanoidiP08456
KOiK17103
OMAiCGMISKS
OrthoDBiEOG092C3PEV

Family and domain databases

InterProiView protein in InterPro
IPR004533 CDP-diaglyc--ser_O-PTrfase
IPR016271 CDP-diaglyc--ser_O-PTrfase_fun
IPR000462 CDP-OH_P_trans
PfamiView protein in Pfam
PF01066 CDP-OH_P_transf, 1 hit
PIRSFiPIRSF000852 Phosphatidylserine_synth_fun, 1 hit
TIGRFAMsiTIGR00473 pssA, 1 hit
PROSITEiView protein in PROSITE
PS00379 CDP_ALCOHOL_P_TRANSF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVESDEDFAP QEFPHTDTDV IVNEHRDEND GYASDEVGGT LSRRASSIFS
60 70 80 90 100
INTTPLAPPN ATDIQKFTSD EHHFSMMRNL HMADYITMLN GFSGFYSIVS
110 120 130 140 150
CLRFTLTGKP HYVQRAHFFI LLGMCFDFLD GRVARLRNRS SLMGQELDSL
160 170 180 190 200
ADLVSFGVAP AAIAFAIGFQ TTFDVMILSF FVLCGLARLA RFNVTVAQLP
210 220 230 240 250
KDSSTGKSKY FEGLPMPTTL ALVLGMAYCV RKGLIFDNIP FGIFREDQIL
260 270
EFHPIILVFF IHGCGMISKS LKIPKP
Length:276
Mass (Da):30,805
Last modified:January 23, 2007 - v3
Checksum:iE52B1FC836B67D24
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123G → A in BAA00121 (PubMed:2830250).Curated1
Sequence conflicti191R → T in BAA00121 (PubMed:2830250).Curated1
Sequence conflicti276P → A in BAA00121 (PubMed:2830250).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05944 Genomic DNA Translation: CAA29376.1
D00171 Genomic DNA Translation: BAA00121.1
U18778 Genomic DNA Translation: AAB64559.1
BK006939 Genomic DNA Translation: DAA07679.1
PIRiS00080
RefSeqiNP_010943.3, NM_001178917.3

Genome annotation databases

EnsemblFungiiYER026C; YER026C; YER026C
GeneIDi856748
KEGGisce:YER026C

Similar proteinsi

Entry informationi

Entry nameiPSS_YEAST
AccessioniPrimary (citable) accession number: P08456
Secondary accession number(s): D3DLS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 171 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health