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P08456 (PSS_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 142. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CDP-diacylglycerol--serine O-phosphatidyltransferase

EC=2.7.8.8
Alternative name(s):
Phosphatidylserine synthase
Gene names
Name:CHO1
Synonyms:PSS, PSS1
Ordered Locus Names:YER026C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself1EBI-14055,EBI-14055
AGP1P253761EBI-14055,EBI-2357
ALG11P539541EBI-14055,EBI-2497
ARF1P110761EBI-14055,EBI-2816
BAP2P380841EBI-14055,EBI-3414
BSD2P383561EBI-14055,EBI-3783
CAN1P048171EBI-14055,EBI-3993
CAX4P532231EBI-14055,EBI-23136
CBR1P386261EBI-14055,EBI-2048224
CCW12Q121271EBI-14055,EBI-5303
CHO2P053741EBI-14055,EBI-2049142
CNE1P278251EBI-14055,EBI-3987
COS1P538221EBI-14055,EBI-4959
COS4P435421EBI-14055,EBI-2050225
CPR4P253341EBI-14055,EBI-5468
CPT1P178981EBI-14055,EBI-2050738
CSG2P352061EBI-14055,EBI-2051140
DAL5P153651EBI-14055,EBI-5527
DCW1P360911EBI-14055,EBI-2052781
DFG5Q050311EBI-14055,EBI-27512
DIP5P533881EBI-14055,EBI-5904
ELO1P395401EBI-14055,EBI-2049096
EPT1P221401EBI-14055,EBI-6494
ERG11P106141EBI-14055,EBI-5127
ERG24P324621EBI-14055,EBI-6502
ERG25P530451EBI-14055,EBI-6506
ERG26P531991EBI-14055,EBI-6514
ERG28P400301EBI-14055,EBI-22518
ERG3P323531EBI-14055,EBI-6554
ERG4P253401EBI-14055,EBI-6558
ERG5P547811EBI-14055,EBI-6563
ERJ5P436131EBI-14055,EBI-23020
ERP1Q053591EBI-14055,EBI-6581
ERP4Q124501EBI-14055,EBI-6598
ERP5P388191EBI-14055,EBI-6603
ERP6P531981EBI-14055,EBI-2058104
ERV25P548371EBI-14055,EBI-6642
ERV29P533371EBI-14055,EBI-23662
ERV41Q046511EBI-14055,EBI-27850
ESBP6P539181EBI-14055,EBI-28895
FCY2P170641EBI-14055,EBI-2047850
FET3P389931EBI-14055,EBI-6876
GAA1P390121EBI-14055,EBI-7252
GAP1P191451EBI-14055,EBI-7314
GNP1P488131EBI-14055,EBI-7758
GOT1Q035541EBI-14055,EBI-2057821
GPI13Q078301EBI-14055,EBI-32339
GPT2P361481EBI-14055,EBI-26471
GTT1P405821EBI-14055,EBI-7941
GUP1P531541EBI-14055,EBI-7994
ILM1P471551EBI-14055,EBI-2051644
KRE27P405401EBI-14055,EBI-24977
LAC1P284961EBI-14055,EBI-26585
MCD4P360511EBI-14055,EBI-2070979
MSC7P386941EBI-14055,EBI-24511
NDC1P325001EBI-14055,EBI-11950
NSG1P388371EBI-14055,EBI-24733
OLE1P211471EBI-14055,EBI-2098
ORM2Q061441EBI-14055,EBI-34916
OST1P415431EBI-14055,EBI-12651
PHO84P252971EBI-14055,EBI-13320
PHO86P469561EBI-14055,EBI-13337
PHO88P382641EBI-14055,EBI-13350
PIS1P061971EBI-14055,EBI-13458
PKR1Q038801EBI-14055,EBI-27252
PMP2P409751EBI-14055,EBI-2043041
PMP3P872841EBI-14055,EBI-13555
POM33Q121641EBI-14055,EBI-30000
PRM8P531741EBI-14055,EBI-6200
QDR2P404741EBI-14055,EBI-25203
RTN1Q049471EBI-14055,EBI-38020
SAC1P323681EBI-14055,EBI-16210
SCS7Q035291EBI-14055,EBI-16747
SEC4P075601EBI-14055,EBI-16858
SEC61P329151EBI-14055,EBI-16400
SEC63P149061EBI-14055,EBI-16636
SEY1Q992871EBI-14055,EBI-37523
SHR3Q027741EBI-14055,EBI-17099
SLC1P333331EBI-14055,EBI-13494
SOP4P395431EBI-14055,EBI-26193
SPC1P469651EBI-14055,EBI-17823
SPC2Q049691EBI-14055,EBI-27827
SPF1P399861EBI-14055,EBI-3128
SSH1P383531EBI-14055,EBI-18175
STE24P471541EBI-14055,EBI-18298
SUR2P389921EBI-14055,EBI-18574
SWP1Q027951EBI-14055,EBI-12666
TRM1P15565-11EBI-14055,EBI-1009955From a different organism.
VHS3Q084381EBI-14055,EBI-30482
VMA21P418061EBI-14055,EBI-20323
VPS66Q065081EBI-14055,EBI-36961
VRG4P401071EBI-14055,EBI-7764
WBP1P337671EBI-14055,EBI-12658
YDC1Q028961EBI-14055,EBI-22203
YHR146WP388451EBI-14055,EBI-24770
YNL190WP538721EBI-14055,EBI-29075
YOP1Q124021EBI-14055,EBI-37092
YPC1P382981EBI-14055,EBI-2103141
YPS3Q123031EBI-14055,EBI-27104
YVH1Q022561EBI-14055,EBI-14322

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 276275CDP-diacylglycerol--serine O-phosphatidyltransferase
PRO_0000056801

Regions

Transmembrane82 – 10221Helical; Potential
Transmembrane163 – 18321Helical; Potential
Transmembrane210 – 23021Helical; Potential
Transmembrane248 – 26821Helical; Potential

Amino acid modifications

Modified residue41Phosphoserine Ref.5 Ref.6 Ref.7
Modified residue341Phosphoserine Ref.5 Ref.6 Ref.7
Modified residue421Phosphoserine Ref.5 Ref.7
Modified residue461Phosphoserine Ref.5 Ref.7
Modified residue471Phosphoserine Ref.5 Ref.7
Modified residue501Phosphoserine Ref.5 Ref.7

Experimental info

Sequence conflict1231G → A in BAA00121. Ref.2
Sequence conflict1911R → T in BAA00121. Ref.2
Sequence conflict2761P → A in BAA00121. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P08456 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: E52B1FC836B67D24

FASTA27630,805
        10         20         30         40         50         60 
MVESDEDFAP QEFPHTDTDV IVNEHRDEND GYASDEVGGT LSRRASSIFS INTTPLAPPN 

        70         80         90        100        110        120 
ATDIQKFTSD EHHFSMMRNL HMADYITMLN GFSGFYSIVS CLRFTLTGKP HYVQRAHFFI 

       130        140        150        160        170        180 
LLGMCFDFLD GRVARLRNRS SLMGQELDSL ADLVSFGVAP AAIAFAIGFQ TTFDVMILSF 

       190        200        210        220        230        240 
FVLCGLARLA RFNVTVAQLP KDSSTGKSKY FEGLPMPTTL ALVLGMAYCV RKGLIFDNIP 

       250        260        270 
FGIFREDQIL EFHPIILVFF IHGCGMISKS LKIPKP 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence and characterization of the yeast PSS gene encoding phosphatidylserine synthase."
Nikawa J., Tsukagoschi Y., Kodaki T., Yamashita S.
Eur. J. Biochem. 167:7-12(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Primary structure and product characterization of the Saccharomyces cerevisiae CHO1 gene that encodes phosphatidylserine synthase."
Kiyono K., Miura K., Kushima Y., Hikiji T., Fukushima M., Shibuya I., Ohta A.
J. Biochem. 102:1089-1100(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-15.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-34; SER-42; SER-46; SER-47 AND SER-50, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[6]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 AND SER-34, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-34; SER-42; SER-46; SER-47 AND SER-50, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X05944 Genomic DNA. Translation: CAA29376.1.
D00171 Genomic DNA. Translation: BAA00121.1.
U18778 Genomic DNA. Translation: AAB64559.1.
BK006939 Genomic DNA. Translation: DAA07679.1.
PIRS00080.
RefSeqNP_010943.3. NM_001178917.3.

3D structure databases

ProteinModelPortalP08456.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36761. 39 interactions.
DIPDIP-5331N.
IntActP08456. 7 interactions.
MINTMINT-521670.
STRING4932.YER026C.

Proteomic databases

PaxDbP08456.
PeptideAtlasP08456.

Protocols and materials databases

DNASU856748.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER026C; YER026C; YER026C.
GeneID856748.
KEGGsce:YER026C.

Organism-specific databases

SGDS000000828. CHO1.

Phylogenomic databases

eggNOGCOG1183.
HOGENOMHOG000229371.
KOK17103.
OMAFNISANK.
OrthoDBEOG7W15FB.

Enzyme and pathway databases

BioCycYEAST:YER026C-MONOMER.
BRENDA2.7.8.8. 984.
UniPathwayUPA00558; UER00615.

Gene expression databases

GenevestigatorP08456.

Family and domain databases

InterProIPR004533. CDP-diaglyc--ser_O-PTrfase.
IPR016271. CDP-diaglyc--ser_O-PTrfase_fun.
IPR000462. CDP-OH_P_trans.
[Graphical view]
PfamPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFPIRSF000852. Phosphatidylserine_synth_fun. 1 hit.
TIGRFAMsTIGR00473. pssA. 1 hit.
PROSITEPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982893.

Entry information

Entry namePSS_YEAST
AccessionPrimary (citable) accession number: P08456
Secondary accession number(s): D3DLS5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways