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Protein

Modification methylase NgoPII

Gene

ngoPIIM

Organism
Neisseria gonorrhoeae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GGCC, causes specific methylation on C-3 on both strands, and protects the DNA from cleavage by the NgoPII endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3609 M.NgoLII

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase NgoPII (EC:2.1.1.37)
Short name:
M.NgoPII
Alternative name(s):
Cytosine-specific methyltransferase NgoPII
Gene namesi
Name:ngoPIIM
Synonyms:dcrM
OrganismiNeisseria gonorrhoeae
Taxonomic identifieri485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000879001 – 330Modification methylase NgoPIIAdd BLAST330

Structurei

3D structure databases

ProteinModelPortaliP08455
SMRiP08455
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 330SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST330

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105DVF Bacteria
COG0270 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS00095 C5_MTASE_2, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

P08455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIISLFSGC GGLDLGFEKA GFEIPAANEY DKTIWATFKA NHPKTHLIEG
60 70 80 90 100
DIRKIKEEDF PEEIDGIIGG PPCQSWSEAG ALRGIDDARG QLFFDYIRIL
110 120 130 140 150
KSKQPKFFLA ENVSGMLANR HNGAVQNLLK MFDGCGYDVT LTMANAKDYG
160 170 180 190 200
VAQERKRVFY IGFRKDLEIK FSFPKGSTVE DKDKITLKDV IWDLQDTAVP
210 220 230 240 250
SAPQNKTNPD AVNNNEYFTG SFSPIFMSRN RVKAWDEQGF TVQASGRQCQ
260 270 280 290 300
LHPQAPKMEK HGANDYRFAA GKETLYRRMT VREVARIQGF PDNFKFIYQN
310 320 330
VNDAYKMIGN AVPVNLAYEI AAAIKKTLER
Length:330
Mass (Da):37,222
Last modified:February 1, 1994 - v2
Checksum:i0A384A98B1EB03E1
GO

Sequence cautioni

The sequence AAA17019 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA30038 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA36888 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06965 Genomic DNA Translation: CAA30038.1 Different initiation.
X52661 Genomic DNA Translation: CAA36888.1 Different initiation.
L14564 Unassigned DNA Translation: AAA17019.1 Different initiation.
PIRiS00920 CTNHP2
RefSeqiWP_003690326.1, NZ_NGQH01000006.1

Similar proteinsi

Entry informationi

Entry nameiMTP2_NEIGO
AccessioniPrimary (citable) accession number: P08455
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health