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Protein

Tachykinin-3

Gene

Tac3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function (By similarity).By similarity

GO - Biological processi

  • neuropeptide signaling pathway Source: UniProtKB-KW
  • positive regulation of blood pressure Source: RGD
  • response to morphine Source: RGD
  • tachykinin receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Tachykinin-3
Cleaved into the following chain:
Neurokinin-B
Short name:
NKB
Alternative name(s):
Neuromedin-K
Gene namesi
Name:Tac3
Synonyms:Nknb, Tac2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3809. Tac3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Propeptidei21 – 7959PRO_0000033571Add
BLAST
Peptidei82 – 9110Neurokinin-BPRO_0000033572
Propeptidei95 – 11622PRO_0000033573Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei91 – 911Methionine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP08435.
PRIDEiP08435.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005679.

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2QH. Eukaryota.
ENOG4111D7S. LUCA.
HOGENOMiHOG000154597.
HOVERGENiHBG016587.
InParanoidiP08435.
KOiK05240.
PhylomeDBiP08435.

Family and domain databases

InterProiIPR003635. Neurokinin-B/TAC3.
IPR013055. Tachy_Neuro_lke_CS.
[Graphical view]
PANTHERiPTHR15536. PTHR15536. 1 hit.
PfamiPF03823. Neurokinin_B. 1 hit.
[Graphical view]
PIRSFiPIRSF001843. Neurokinin. 1 hit.
PRINTSiPR01828. NEUROKININB.
PROSITEiPS00267. TACHYKININ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08435-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSAMLFAAV LALSLAWTFG AACEEPQEQG GRLSKDSDLS LLPPPLLRRL
60 70 80 90 100
YDSRSISLEG LLKVLSKASV GPKETSLPQK RDMHDFFVGL MGKRNSQPDT
110
PADVVEENTP SFGVLK
Length:116
Mass (Da):12,660
Last modified:August 1, 1988 - v1
Checksum:iC73EC67F2BAF8C8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16410 mRNA. Translation: AAA41711.1.
PIRiA43779.
RefSeqiNP_062035.1. NM_019162.2.
UniGeneiRn.9708.

Genome annotation databases

GeneIDi29191.
KEGGirno:29191.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16410 mRNA. Translation: AAA41711.1.
PIRiA43779.
RefSeqiNP_062035.1. NM_019162.2.
UniGeneiRn.9708.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005679.

Proteomic databases

PaxDbiP08435.
PRIDEiP08435.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29191.
KEGGirno:29191.

Organism-specific databases

CTDi6866.
RGDi3809. Tac3.

Phylogenomic databases

eggNOGiENOG410J2QH. Eukaryota.
ENOG4111D7S. LUCA.
HOGENOMiHOG000154597.
HOVERGENiHBG016587.
InParanoidiP08435.
KOiK05240.
PhylomeDBiP08435.

Miscellaneous databases

NextBioi608319.
PROiP08435.

Family and domain databases

InterProiIPR003635. Neurokinin-B/TAC3.
IPR013055. Tachy_Neuro_lke_CS.
[Graphical view]
PANTHERiPTHR15536. PTHR15536. 1 hit.
PfamiPF03823. Neurokinin_B. 1 hit.
[Graphical view]
PIRSFiPIRSF001843. Neurokinin. 1 hit.
PRINTSiPR01828. NEUROKININB.
PROSITEiPS00267. TACHYKININ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A cDNA encoding the precursor of the rat neuropeptide, neurokinin B."
    Bonner T.I., Affolter H.-U., Young A.C., Young W.S. III
    Brain Res. 388:243-249(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTKNK_RAT
AccessioniPrimary (citable) accession number: P08435
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 11, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.