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Protein

Tachykinin-3

Gene

Tac3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function (By similarity).By similarity

GO - Biological processi

  • neuropeptide signaling pathway Source: UniProtKB-KW
  • positive regulation of blood pressure Source: RGD
  • response to morphine Source: RGD
  • tachykinin receptor signaling pathway Source: InterPro

Keywordsi

Molecular functionNeuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Tachykinin-3
Cleaved into the following chain:
Neurokinin-B
Short name:
NKB
Alternative name(s):
Neuromedin-K
Gene namesi
Name:Tac3
Synonyms:Nknb, Tac2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3809 Tac3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000003357121 – 79Add BLAST59
PeptideiPRO_000003357282 – 91Neurokinin-B10
PropeptideiPRO_000003357395 – 116Add BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91Methionine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP08435
PRIDEiP08435

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005679

Structurei

3D structure databases

SMRiP08435
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2QH Eukaryota
ENOG4111D7S LUCA
HOGENOMiHOG000154597
HOVERGENiHBG016587
InParanoidiP08435
KOiK05240
PhylomeDBiP08435

Family and domain databases

InterProiView protein in InterPro
IPR003635 Neurokinin-B/TAC3
IPR013055 Tachy_Neuro_lke_CS
PANTHERiPTHR15536 PTHR15536, 1 hit
PfamiView protein in Pfam
PF03823 Neurokinin_B, 1 hit
PIRSFiPIRSF001843 Neurokinin, 1 hit
PRINTSiPR01828 NEUROKININB
PROSITEiView protein in PROSITE
PS00267 TACHYKININ, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08435-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSAMLFAAV LALSLAWTFG AACEEPQEQG GRLSKDSDLS LLPPPLLRRL
60 70 80 90 100
YDSRSISLEG LLKVLSKASV GPKETSLPQK RDMHDFFVGL MGKRNSQPDT
110
PADVVEENTP SFGVLK
Length:116
Mass (Da):12,660
Last modified:August 1, 1988 - v1
Checksum:iC73EC67F2BAF8C8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16410 mRNA Translation: AAA41711.1
PIRiA43779
RefSeqiNP_062035.1, NM_019162.2
UniGeneiRn.9708

Genome annotation databases

GeneIDi29191
KEGGirno:29191

Similar proteinsi

Entry informationi

Entry nameiTKNK_RAT
AccessioniPrimary (citable) accession number: P08435
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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