Reviewed,
UniProtKB/Swiss-Prot P08432 (DCOR_YEAST)
Last modified
January 19, 2010.
Version 88.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ornithine decarboxylase Short name=ODC EC=4.1.1.17 | ||||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||||
| Taxonomic identifier | 4932 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 466 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | L-ornithine = putrescine + CO2. |
| Cofactor | Pyridoxal phosphate. |
| Pathway | |
| Miscellaneous | Present with 688 molecules/cell in log phase SD medium. Ref.4 |
| Sequence similarities | Belongs to the Orn/Lys/Arg decarboxylase class-II family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Polyamine biosynthesis |
| Ligand | Pyridoxal phosphate |
| Molecular function | Decarboxylase Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | pantothenate biosynthetic process Inferred from mutant phenotype. Source: SGD putrescine biosynthetic processInferred from mutant phenotype. Source: SGD |
| Cellular component | cytoplasm Inferred from direct assay. Source: SGD |
| Molecular function | ornithine decarboxylase activity Inferred from direct assay. Source: SGD |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 466 | 466 | Ornithine decarboxylase | PRO_0000149909 | |||||
Sites | |||||||||
| Active site | 411 | 1 | Proton donor; shared with dimeric partner By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 116 | 1 | N6-(pyridoxal phosphate)lysine By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The gene and the primary structure of ornithine decarboxylase from Saccharomyces cerevisiae." Fonzi W.A., Sypherd P.S. J. Biol. Chem. 262:10127-10133(1987) [PubMed: 3038869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene." Wiemann S., Voss H., Schwager C., Rupp T., Stegemann J., Zimmermann J., Grothues D., Sensen C., Erfle H., Hewitt N., Banrevi A., Ansorge W. Yeast 9:1343-1348(1993) [PubMed: 8154185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. Mewes H.-W.Nature 369:371-378(1994) [PubMed: 8196765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [4] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | J02777 Genomic DNA. Translation: AAA34829.1. X74151 Genomic DNA. Translation: CAA52254.1. Z28184 Genomic DNA. Translation: CAA82027.1. |
| PIR | DCBYO. A28437. |
| RefSeq | NP_012737.1. |
3D structure databases | |
| SMR | P08432. Positions 82-463. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P08432. |
Genome annotation databases | |
| Ensembl | YKL184W; YKL184W; YKL184W; Saccharomyces cerevisiae. [Genome view] |
| GeneID | 853651. |
| KEGG | sce:YKL184W. |
| NMPDR | fig|4932.3.peg.3714. |
Organism-specific databases | |
| CYGD | YKL184w. |
| SGD | S000001667. SPE1. |
Phylogenomic databases | |
| eggNOG | fuNOG06852. |
| HOGENOM | HBG672375. |
| OMA | MNCILFD. |
| OrthoDB | EOG937SX0. |
| PhylomeDB | P08432. |
Enzyme and pathway databases | |
| BRENDA | 4.1.1.17. 250. |
Gene expression databases | |
| ArrayExpress | P08432. |
| Genevestigator | P08432. |
| GermOnline | YKL184W. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR009006. Ala_racemase/Decarboxylase_C. IPR000183. De-COase2. IPR002433. Orn_de-COase. [Graphical view] |
| Pfam | PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view] |
| PRINTS | PR01179. ODADCRBXLASE. PR01182. ORNDCRBXLASE. |
| PROSITE | PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 974563. |
Entry information
| Entry name | DCOR_YEAST | ||||||||
| Accession | Primary (citable) accession number: P08432 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome XI Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names |

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