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P08432

- DCOR_YEAST

UniProt

P08432 - DCOR_YEAST

Protein

Ornithine decarboxylase

Gene

SPE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-ornithine = putrescine + CO2.

    Cofactori

    Pyridoxal phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei411 – 4111Proton donor; shared with dimeric partnerBy similarity

    GO - Molecular functioni

    1. ornithine decarboxylase activity Source: SGD

    GO - Biological processi

    1. pantothenate biosynthetic process Source: SGD
    2. putrescine biosynthetic process Source: SGD
    3. putrescine biosynthetic process from ornithine Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Polyamine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciMetaCyc:YKL184W-MONOMER.
    YEAST:YKL184W-MONOMER.
    UniPathwayiUPA00535; UER00288.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ornithine decarboxylase (EC:4.1.1.17)
    Short name:
    ODC
    Gene namesi
    Name:SPE1
    Synonyms:ORD1
    Ordered Locus Names:YKL184W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKL184w.
    SGDiS000001667. SPE1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 466466Ornithine decarboxylasePRO_0000149909Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei116 – 1161N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PaxDbiP08432.

    Expressioni

    Gene expression databases

    GenevestigatoriP08432.

    Interactioni

    Protein-protein interaction databases

    BioGridi33938. 205 interactions.
    MINTiMINT-4493221.
    STRINGi4932.YKL184W.

    Structurei

    3D structure databases

    ProteinModelPortaliP08432.
    SMRiP08432. Positions 76-463.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0019.
    GeneTreeiENSGT00390000011560.
    HOGENOMiHOG000274133.
    KOiK01581.
    OMAiTIHYVMS.
    OrthoDBiEOG7V76GV.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR002433. Orn_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    PRINTSiPR01179. ODADCRBXLASE.
    PR01182. ORNDCRBXLASE.
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    PROSITEiPS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08432-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSTQVGNAL SSSTTTLVDL SNSTVTQKKQ YYKDGETLHN LLLELKNNQD    50
    LELLPHEQAH PKIFQALKAR IGRINNETCD PGEENSFFIC DLGEVKRLFN 100
    NWVKELPRIK PFYAVKCNPD TKVLSLLAEL GVNFDCASKV EIDRVLSMNI 150
    SPDRIVYANP CKVASFIRYA ASKNVMKSTF DNVEELHKIK KFHPESQLLL 200
    RIATDDSTAQ CRLSTKYGCE MENVDVLLKA IKELGLNLAG VSFHVGSGAS 250
    DFTSLYKAVR DARTVFDKAA NEYGLPPLKI LDVGGGFQFE SFKESTAVLR 300
    LALEEFFPVG CGVDIIAEPG RYFVATAFTL ASHVIAKRKL SENEAMIYTN 350
    DGVYGNMNCI LFDHQEPHPR TLYHNLEFHY DDFESTTAVL DSINKTRSEY 400
    PYKVSIWGPT CDGLDCIAKE YYMKHDVIVG DWFYFPALGA YTSSAATQFN 450
    GFEQTADIVY IDSELD 466
    Length:466
    Mass (Da):52,285
    Last modified:August 1, 1988 - v1
    Checksum:i2EBD7EE8CFAA67CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02777 Genomic DNA. Translation: AAA34829.1.
    X74151 Genomic DNA. Translation: CAA52254.1.
    Z28184 Genomic DNA. Translation: CAA82027.1.
    BK006944 Genomic DNA. Translation: DAA08982.1.
    PIRiA28437. DCBYO.
    RefSeqiNP_012737.1. NM_001179750.1.

    Genome annotation databases

    EnsemblFungiiYKL184W; YKL184W; YKL184W.
    GeneIDi853651.
    KEGGisce:YKL184W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02777 Genomic DNA. Translation: AAA34829.1 .
    X74151 Genomic DNA. Translation: CAA52254.1 .
    Z28184 Genomic DNA. Translation: CAA82027.1 .
    BK006944 Genomic DNA. Translation: DAA08982.1 .
    PIRi A28437. DCBYO.
    RefSeqi NP_012737.1. NM_001179750.1.

    3D structure databases

    ProteinModelPortali P08432.
    SMRi P08432. Positions 76-463.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33938. 205 interactions.
    MINTi MINT-4493221.
    STRINGi 4932.YKL184W.

    Proteomic databases

    PaxDbi P08432.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL184W ; YKL184W ; YKL184W .
    GeneIDi 853651.
    KEGGi sce:YKL184W.

    Organism-specific databases

    CYGDi YKL184w.
    SGDi S000001667. SPE1.

    Phylogenomic databases

    eggNOGi COG0019.
    GeneTreei ENSGT00390000011560.
    HOGENOMi HOG000274133.
    KOi K01581.
    OMAi TIHYVMS.
    OrthoDBi EOG7V76GV.

    Enzyme and pathway databases

    UniPathwayi UPA00535 ; UER00288 .
    BioCyci MetaCyc:YKL184W-MONOMER.
    YEAST:YKL184W-MONOMER.

    Miscellaneous databases

    NextBioi 974563.
    PROi P08432.

    Gene expression databases

    Genevestigatori P08432.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR002433. Orn_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    PRINTSi PR01179. ODADCRBXLASE.
    PR01182. ORNDCRBXLASE.
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    PROSITEi PS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The gene and the primary structure of ornithine decarboxylase from Saccharomyces cerevisiae."
      Fonzi W.A., Sypherd P.S.
      J. Biol. Chem. 262:10127-10133(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene."
      Wiemann S., Voss H., Schwager C., Rupp T., Stegemann J., Zimmermann J., Grothues D., Sensen C., Erfle H., Hewitt N., Banrevi A., Ansorge W.
      Yeast 9:1343-1348(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDCOR_YEAST
    AccessioniPrimary (citable) accession number: P08432
    Secondary accession number(s): D6VX16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 688 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3