Reviewed, UniProtKB/Swiss-Prot P08432 (DCOR_YEAST)

Names and origin

Protein names

Recommended name:
    Ornithine decarboxylase
      Short name=ODC
    EC=4.1.1.17

Gene names

Name:	SPE1
Synonyms:	ORD1
Ordered Locus Names:	YKL184W

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	L-ornithine = putrescine + CO2.
Cofactor	Pyridoxal phosphate.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
Miscellaneous	Present with 688 molecules/cell in log phase SD medium. Ref.4
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Ontologies

Keywords
Biological process	Polyamine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pantothenate biosynthetic process Inferred from mutant phenotype. Source: SGD putrescine biosynthetic process Inferred from mutant phenotype. Source: SGD
Cellular component	cytoplasm Inferred from direct assay. Source: SGD
Molecular function	ornithine decarboxylase activity Inferred from direct assay. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 466	466	Ornithine decarboxylase		PRO_0000149909
Sites
	Active site	411	1	Proton donor; shared with dimeric partner By similarity
Amino acid modifications
	Modified residue	116	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P08432-1 [UniParc]. Last modified August 1, 1988. Version 1. Checksum: 2EBD7EE8CFAA67CD	FASTA	466	52,285
	10 20 30 40 50 60 MSSTQVGNAL SSSTTTLVDL SNSTVTQKKQ YYKDGETLHN LLLELKNNQD LELLPHEQAH 70 80 90 100 110 120 PKIFQALKAR IGRINNETCD PGEENSFFIC DLGEVKRLFN NWVKELPRIK PFYAVKCNPD 130 140 150 160 170 180 TKVLSLLAEL GVNFDCASKV EIDRVLSMNI SPDRIVYANP CKVASFIRYA ASKNVMKSTF 190 200 210 220 230 240 DNVEELHKIK KFHPESQLLL RIATDDSTAQ CRLSTKYGCE MENVDVLLKA IKELGLNLAG 250 260 270 280 290 300 VSFHVGSGAS DFTSLYKAVR DARTVFDKAA NEYGLPPLKI LDVGGGFQFE SFKESTAVLR 310 320 330 340 350 360 LALEEFFPVG CGVDIIAEPG RYFVATAFTL ASHVIAKRKL SENEAMIYTN DGVYGNMNCI 370 380 390 400 410 420 LFDHQEPHPR TLYHNLEFHY DDFESTTAVL DSINKTRSEY PYKVSIWGPT CDGLDCIAKE 430 440 450 460 YYMKHDVIVG DWFYFPALGA YTSSAATQFN GFEQTADIVY IDSELD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The gene and the primary structure of ornithine decarboxylase from Saccharomyces cerevisiae." Fonzi W.A., Sypherd P.S. J. Biol. Chem. 262:10127-10133(1987) [PubMed: 3038869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene." Wiemann S., Voss H., Schwager C., Rupp T., Stegemann J., Zimmermann J., Grothues D., Sensen C., Erfle H., Hewitt N., Banrevi A., Ansorge W. Yeast 9:1343-1348(1993) [PubMed: 8154185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W. Nature 369:371-378(1994) [PubMed: 8196765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J02777 Genomic DNA. Translation: AAA34829.1. X74151 Genomic DNA. Translation: CAA52254.1. Z28184 Genomic DNA. Translation: CAA82027.1.
PIR	DCBYO. A28437.
RefSeq	NP_012737.1.
3D structure databases
SMR	P08432. Positions 82-463.
ModBase	Search...
Protein-protein interaction databases
STRING	P08432.
Genome annotation databases
Ensembl	YKL184W; YKL184W; YKL184W; Saccharomyces cerevisiae. [Genome view]
GeneID	853651.
KEGG	sce:YKL184W.
NMPDR	fig|4932.3.peg.3714.
Organism-specific databases
CYGD	YKL184w.
SGD	S000001667. SPE1.
Phylogenomic databases
eggNOG	fuNOG06852.
HOGENOM	HBG672375.
OMA	MNCILFD.
OrthoDB	EOG937SX0.
PhylomeDB	P08432.
Enzyme and pathway databases
BRENDA	4.1.1.17. 250.
Gene expression databases
ArrayExpress	P08432.
Genevestigator	P08432.
GermOnline	YKL184W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR009006. Ala_racemase/Decarboxylase_C. IPR000183. De-COase2. IPR002433. Orn_de-COase. [Graphical view]
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PRINTS	PR01179. ODADCRBXLASE. PR01182. ORNDCRBXLASE.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	974563.

Entry information

Entry name

DCOR_YEAST

Accession

Primary (citable) accession number: P08432

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	January 19, 2010
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)