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Protein

Galactose-1-phosphate uridylyltransferase

Gene

GAL7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose.By similarity
UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit. Zinc binding seems to play a structural role.By similarity

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54ZincPROSITE-ProRule annotation1
Metal bindingi57ZincPROSITE-ProRule annotation1
Binding sitei63UDP-alpha-D-glucose; via amide nitrogenBy similarity1
Metal bindingi124ZincPROSITE-ProRule annotation1
Binding sitei169UDP-alpha-D-glucose; shared with dimeric partnerBy similarity1
Metal bindingi180ZincPROSITE-ProRule annotation1
Active sitei182Tele-UMP-histidine intermediatePROSITE-ProRule annotation1
Binding sitei184UDP-alpha-D-glucoseBy similarity1
Metal bindingi198IronBy similarity1
Metal bindingi297IronBy similarity1
Metal bindingi314IronBy similarity1
Metal bindingi316IronBy similarity1

GO - Molecular functioni

GO - Biological processi

  • galactose catabolic process via UDP-galactose Source: SGD

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCarbohydrate metabolism, Galactose metabolism
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:YBR018C-MONOMER.
ReactomeiR-SCE-70370. Galactose catabolism.
UniPathwayiUPA00214.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-1-phosphate uridylyltransferase (EC:2.7.7.12By similarity)
Short name:
Gal-1-P uridylyltransferase
Alternative name(s):
UDP-glucose--hexose-1-phosphate uridylyltransferase
Gene namesi
Name:GAL7
Ordered Locus Names:YBR018C
ORF Names:YBR0226
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR018C.
SGDiS000000222. GAL7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001698932 – 366Galactose-1-phosphate uridylyltransferaseAdd BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP08431.
PRIDEiP08431.

PTM databases

iPTMnetiP08431.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi32721. 119 interactors.
DIPiDIP-5357N.
IntActiP08431. 4 interactors.
MINTiMINT-504266.
STRINGi4932.YBR018C.

Structurei

3D structure databases

ProteinModelPortaliP08431.
SMRiP08431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni79 – 80UDP-alpha-D-glucose bindingBy similarity2
Regioni329 – 332UDP-alpha-D-glucose bindingBy similarity4
Regioni334 – 335UDP-alpha-D-glucose bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000016188.
HOGENOMiHOG000230490.
InParanoidiP08431.
KOiK00965.
OMAiHAIYYPP.
OrthoDBiEOG092C2FWQ.

Family and domain databases

Gene3Di3.30.428.10. 2 hits.
InterProiView protein in InterPro
IPR001937. GalP_UDPtransf1.
IPR019779. GalP_UDPtransf1_His-AS.
IPR005850. GalP_Utransf_C.
IPR005849. GalP_Utransf_N.
IPR011146. HIT-like.
PANTHERiPTHR11943. PTHR11943. 1 hit.
PfamiView protein in Pfam
PF02744. GalP_UDP_tr_C. 1 hit.
PF01087. GalP_UDP_transf. 1 hit.
PIRSFiPIRSF000808. GalT. 1 hit.
SUPFAMiSSF54197. SSF54197. 2 hits.
TIGRFAMsiTIGR00209. galT_1. 1 hit.
PROSITEiView protein in PROSITE
PS00117. GAL_P_UDP_TRANSF_I. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAEEFDFSS HSHRRYNPLT DSWILVSPHR AKRPWLGQQE AAYKPTAPLY
60 70 80 90 100
DPKCYLCPGN KRATGNLNPR YESTYIFPND YAAVRLDQPI LPQNDSNEDN
110 120 130 140 150
LKNRLLKVQS VRGNCFVICF SPNHNLTIPQ MKQSDLVHIV NSWQALTDDL
160 170 180 190 200
SREARENHKP FKYVQIFENK GTAMGCSNLH PHGQAWCLES IPSEVSQELK
210 220 230 240 250
SFDKYKREHN TDLFADYVKL ESREKSRVVV ENESFIVVVP YWAIWPFETL
260 270 280 290 300
VISKKKLASI SQFNQMVKED LASILKQLTI KYDNLFETSF PYSMGIHQAP
310 320 330 340 350
LNATGDELSN SWFHMHFYPP LLRSATVRKF LVGFELLGEP QRDLTSEQAA
360
EKLRNLDGQI HYLQRL
Length:366
Mass (Da):42,385
Last modified:January 23, 2007 - v4
Checksum:i960F75532D2621DC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11H → Y in AAA34628 (PubMed:6715281).Curated1
Sequence conflicti58P → H in AAA34628 (PubMed:6715281).Curated1
Sequence conflicti85 – 86RL → S in AAA34627 (PubMed:2851900).Curated2
Sequence conflicti267V → A in AAA34627 (PubMed:2851900).Curated1
Sequence conflicti345T → I in AAA34627 (PubMed:2851900).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81324 Genomic DNA. Translation: CAA57105.1.
M12348 Genomic DNA. Translation: AAA34627.1.
X00215 Genomic DNA. Translation: CAA25039.1.
Z35887 Genomic DNA. Translation: CAA84960.1.
K01752 Genomic DNA. Translation: AAA34628.1.
BK006936 Genomic DNA. Translation: DAA07140.1.
PIRiS45873. XNBYUG.
RefSeqiNP_009574.1. NM_001178366.1.

Genome annotation databases

EnsemblFungiiYBR018C; YBR018C; YBR018C.
GeneIDi852306.
KEGGisce:YBR018C.

Similar proteinsi

Entry informationi

Entry nameiGAL7_YEAST
AccessioniPrimary (citable) accession number: P08431
Secondary accession number(s): D6VQ20, P04398
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 162 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names