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P08430 (UD16_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 1-6
Short name=UDPGT 1-6
Short name=UGT1*6
Short name=UGT1-06
Short name=UGT1.6
EC=2.4.1.17
Alternative name(s):
A1
P-nitrophenol-specific UDPGT
UGT1A6
Gene names
Name:Ugt1
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.
Isoform 1 (identifier: P08430-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 529504UDP-glucuronosyltransferase 1-6
PRO_0000036019

Regions

Transmembrane487 – 50317Helical; Potential

Amino acid modifications

Glycosylation2811N-linked (GlcNAc...) Potential
Glycosylation2911N-linked (GlcNAc...) Potential
Glycosylation4291N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: 144AACD47EDDE04B

FASTA52960,132
        10         20         30         40         50         60 
MACLLPAARL PAGFLFLVLW GSVLGDKLLV VPQDGSHWLS MKEIVEHLSE RGHDIVVLVP 

        70         80         90        100        110        120 
EVNLLLGESK YYRRKSFPVP YNLEELRTRY RSFGNNHFAA SSPLMAPLRE YRNNMIVIDM 

       130        140        150        160        170        180 
CFFSCQSLLK DSATLSFLRE NQFDALFTDP AMPCGVILAE YLKLPSIYLF RGFPCSLEHI 

       190        200        210        220        230        240 
GQSPSPVSYV PRFYTKFSDH MTFPQRLANF IANILENYLY HCLYSKYEIL ASDLLKRDVS 

       250        260        270        280        290        300 
LPALHQNSLW LLRYDFVFEY PRPVMPNMIF IGGTNCKKKG NLSQEFEAYV NASGEHGIVV 

       310        320        330        340        350        360 
FSLGSMVSEI PEKKAMEIAE ALGRIPQTLL WRYTGTRPSN LAKNTILVKW LPQNDLLGHP 

       370        380        390        400        410        420 
KARAFITHSG SHGIYEGICN GVPMVMMPLF GDQMDNAKRM ETRGAGVTLN VLEMTADDLE 

       430        440        450        460        470        480 
NALKTVINNK SYKENIMRLS SLHKDRPIEP LDLAVFWVEY VMRHKGAPHL RPAAHDLTWY 

       490        500        510        520 
QYHSLDVIGF LLAIVLTVVF IVYKSCAYGC RKCFGGKGRV KKSHKSKTH

« Hide

References

[1]"Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase."
Iyanagi T., Haniu M., Sogawa K., Fujii-Kuriyama Y., Watanabe S., Shively J.E., Anan K.F.
J. Biol. Chem. 261:15607-15614(1986) [PubMed: 3096993] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		J02612 mRNA. Translation: AAA42311.1.
IPIIPI00475707.
PIRA24600.
RefSeqNP_001034780.1. NM_001039691.2.
UniGeneRn.26489.

3D structure databases

ProteinModelPortalP08430.
ModBaseSearch...

Protein-protein interaction databases

STRINGP08430.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEP08430.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID113992.
KEGGrno:113992.
UCSCNM_057105. rat.

Organism-specific databases

CTD54578.

Phylogenomic databases

eggNOGroNOG10010.
HOVERGENHBG004033.

Enzyme and pathway databases

BRENDA2.4.1.17. 5301.

Gene expression databases

ArrayExpressP08430.
GenevestigatorP08430.
GermOnlineENSRNOG00000018740. Rattus norvegicus.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
KOK00699.
PANTHERPTHR11926. UDP_glucos_trans. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio618132.

Entry information

Entry nameUD16_RAT
AccessionPrimary (citable) accession number: P08430
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 16, 2011
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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