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P08430

- UD16_RAT

UniProt

P08430 - UD16_RAT

Protein

UDP-glucuronosyltransferase 1-6

Gene

Ugt1a6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: RGD
    2. protein complex binding Source: RGD

    GO - Biological processi

    1. 4-chlorobiphenyl metabolic process Source: RGD
    2. cellular response to glucocorticoid stimulus Source: RGD
    3. cellular response to hormone stimulus Source: RGD
    4. liver development Source: RGD
    5. response to lipopolysaccharide Source: RGD
    6. response to organic cyclic compound Source: RGD
    7. response to peptide hormone Source: RGD

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.17. 5301.

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 1-6 (EC:2.4.1.17)
    Short name:
    UDPGT 1-6
    Short name:
    UGT1*6
    Short name:
    UGT1-06
    Short name:
    UGT1.6
    Alternative name(s):
    A1
    P-nitrophenol-specific UDPGT
    UDP-glucuronosyltransferase 1A6
    Short name:
    UGT1A6
    Gene namesi
    Name:Ugt1a6
    Synonyms:Ugt1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620949. Ugt1a6.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. intracellular membrane-bounded organelle Source: RGD
    4. protein complex Source: RGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 529504UDP-glucuronosyltransferase 1-6PRO_0000036019Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi429 – 4291N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP08430.

    Expressioni

    Gene expression databases

    GenevestigatoriP08430.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4580979.

    Structurei

    3D structure databases

    ProteinModelPortaliP08430.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei487 – 50317HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004033.
    KOiK00699.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

    Isoform 1 (identifier: P08430-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MACLLPAARL PAGFLFLVLW GSVLGDKLLV VPQDGSHWLS MKEIVEHLSE    50
    RGHDIVVLVP EVNLLLGESK YYRRKSFPVP YNLEELRTRY RSFGNNHFAA 100
    SSPLMAPLRE YRNNMIVIDM CFFSCQSLLK DSATLSFLRE NQFDALFTDP 150
    AMPCGVILAE YLKLPSIYLF RGFPCSLEHI GQSPSPVSYV PRFYTKFSDH 200
    MTFPQRLANF IANILENYLY HCLYSKYEIL ASDLLKRDVS LPALHQNSLW 250
    LLRYDFVFEY PRPVMPNMIF IGGTNCKKKG NLSQEFEAYV NASGEHGIVV 300
    FSLGSMVSEI PEKKAMEIAE ALGRIPQTLL WRYTGTRPSN LAKNTILVKW 350
    LPQNDLLGHP KARAFITHSG SHGIYEGICN GVPMVMMPLF GDQMDNAKRM 400
    ETRGAGVTLN VLEMTADDLE NALKTVINNK SYKENIMRLS SLHKDRPIEP 450
    LDLAVFWVEY VMRHKGAPHL RPAAHDLTWY QYHSLDVIGF LLAIVLTVVF 500
    IVYKSCAYGC RKCFGGKGRV KKSHKSKTH 529
    Length:529
    Mass (Da):60,132
    Last modified:August 1, 1988 - v1
    Checksum:i144AACD47EDDE04B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02612 mRNA. Translation: AAA42311.1.
    PIRiA24600.
    RefSeqiNP_001034780.1. NM_001039691.2.
    UniGeneiRn.26489.

    Genome annotation databases

    GeneIDi113992.
    KEGGirno:113992.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02612 mRNA. Translation: AAA42311.1 .
    PIRi A24600.
    RefSeqi NP_001034780.1. NM_001039691.2.
    UniGenei Rn.26489.

    3D structure databases

    ProteinModelPortali P08430.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4580979.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Proteomic databases

    PRIDEi P08430.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 113992.
    KEGGi rno:113992.

    Organism-specific databases

    CTDi 54578.
    RGDi 620949. Ugt1a6.

    Phylogenomic databases

    HOVERGENi HBG004033.
    KOi K00699.

    Enzyme and pathway databases

    BRENDAi 2.4.1.17. 5301.

    Miscellaneous databases

    NextBioi 618132.

    Gene expression databases

    Genevestigatori P08430.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase."
      Iyanagi T., Haniu M., Sogawa K., Fujii-Kuriyama Y., Watanabe S., Shively J.E., Anan K.F.
      J. Biol. Chem. 261:15607-15614(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.

    Entry informationi

    Entry nameiUD16_RAT
    AccessioniPrimary (citable) accession number: P08430
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3