Reviewed, UniProtKB/Swiss-Prot P08430 (UD16_RAT)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 1-6
      Short name=UDPGT
      Short name=UGT1*6
    EC=2.4.1.17
Alternative name(s):
    UGT1-06
      Short name=UGT1.6
    UGT1A6
    A1
    P-nitrophenol specific

Gene names

Name:

Ugt1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	bilirubin conjugation Traceable author statement. Source: RGD biphenyl metabolic process Inferred from direct assay. Source: RGD response to drug Inferred from expression pattern. Source: RGD response to ethanol Inferred from expression pattern. Source: RGD response to glucocorticoid stimulus Inferred from expression pattern. Source: RGD response to nutrient Inferred from expression pattern. Source: RGD response to starvation Inferred from expression pattern. Source: RGD
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from direct assay. Source: RGD
Molecular function	glucuronosyltransferase activity Inferred from direct assay. Source: RGD
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: P08430-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 529	504	UDP-glucuronosyltransferase 1-6		PRO_0000036019
Regions
	Transmembrane	487 – 503	17	Potential
Amino acid modifications
	Glycosylation	281	1	N-linked (GlcNAc...) Potential
	Glycosylation	291	1	N-linked (GlcNAc...) Potential
	Glycosylation	429	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 1, 1988. Version 1. Checksum: 144AACD47EDDE04B	FASTA	529	60,132
	10 20 30 40 50 60 MACLLPAARL PAGFLFLVLW GSVLGDKLLV VPQDGSHWLS MKEIVEHLSE RGHDIVVLVP 70 80 90 100 110 120 EVNLLLGESK YYRRKSFPVP YNLEELRTRY RSFGNNHFAA SSPLMAPLRE YRNNMIVIDM 130 140 150 160 170 180 CFFSCQSLLK DSATLSFLRE NQFDALFTDP AMPCGVILAE YLKLPSIYLF RGFPCSLEHI 190 200 210 220 230 240 GQSPSPVSYV PRFYTKFSDH MTFPQRLANF IANILENYLY HCLYSKYEIL ASDLLKRDVS 250 260 270 280 290 300 LPALHQNSLW LLRYDFVFEY PRPVMPNMIF IGGTNCKKKG NLSQEFEAYV NASGEHGIVV 310 320 330 340 350 360 FSLGSMVSEI PEKKAMEIAE ALGRIPQTLL WRYTGTRPSN LAKNTILVKW LPQNDLLGHP 370 380 390 400 410 420 KARAFITHSG SHGIYEGICN GVPMVMMPLF GDQMDNAKRM ETRGAGVTLN VLEMTADDLE 430 440 450 460 470 480 NALKTVINNK SYKENIMRLS SLHKDRPIEP LDLAVFWVEY VMRHKGAPHL RPAAHDLTWY 490 500 510 520 QYHSLDVIGF LLAIVLTVVF IVYKSCAYGC RKCFGGKGRV KKSHKSKTH

References

[1]	"Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase." Iyanagi T., Haniu M., Sogawa K., Fujii-Kuriyama Y., Watanabe S., Shively J.E., Anan K.F. J. Biol. Chem. 261:15607-15614(1986) [PubMed: 3096993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	J02612 mRNA. Translation: AAA42311.1.
IPI	IPI00475707.
PIR	A24600.
RefSeq	NP_001034780.1.
UniGene	Rn.26489
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Genome annotation databases
Ensembl	ENSRNOG00000018740. Rattus norvegicus. [Contig view]
GeneID	113992.
KEGG	rno:113992.
Phylogenomic databases
HOVERGEN	P08430.
Enzyme and pathway databases
BRENDA	2.4.1.17. 248.
Gene expression databases
ArrayExpress	P08430.
GermOnline	ENSRNOG00000018740. Rattus norvegicus.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	618132.

Entry information

Entry name

UD16_RAT

Accession

Primary (citable) accession number: P08430

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	June 16, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)