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P08430

- UD16_RAT

UniProt

P08430 - UD16_RAT

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Protein

UDP-glucuronosyltransferase 1-6

Gene

Ugt1a6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: RGD
  2. protein complex binding Source: RGD

GO - Biological processi

  1. 4-chlorobiphenyl metabolic process Source: RGD
  2. cellular response to glucocorticoid stimulus Source: RGD
  3. cellular response to hormone stimulus Source: RGD
  4. liver development Source: RGD
  5. response to lipopolysaccharide Source: RGD
  6. response to organic cyclic compound Source: RGD
  7. response to peptide hormone Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 5301.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-6 (EC:2.4.1.17)
Short name:
UDPGT 1-6
Short name:
UGT1*6
Short name:
UGT1-06
Short name:
UGT1.6
Alternative name(s):
A1
P-nitrophenol-specific UDPGT
UDP-glucuronosyltransferase 1A6
Short name:
UGT1A6
Gene namesi
Name:Ugt1a6
Synonyms:Ugt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620949. Ugt1a6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei487 – 50317HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. intracellular membrane-bounded organelle Source: RGD
  4. protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 529504UDP-glucuronosyltransferase 1-6PRO_0000036019Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi429 – 4291N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP08430.

Expressioni

Gene expression databases

GenevestigatoriP08430.

Interactioni

Protein-protein interaction databases

MINTiMINT-4580979.

Structurei

3D structure databases

ProteinModelPortaliP08430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004033.
InParanoidiP08430.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: P08430-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACLLPAARL PAGFLFLVLW GSVLGDKLLV VPQDGSHWLS MKEIVEHLSE
60 70 80 90 100
RGHDIVVLVP EVNLLLGESK YYRRKSFPVP YNLEELRTRY RSFGNNHFAA
110 120 130 140 150
SSPLMAPLRE YRNNMIVIDM CFFSCQSLLK DSATLSFLRE NQFDALFTDP
160 170 180 190 200
AMPCGVILAE YLKLPSIYLF RGFPCSLEHI GQSPSPVSYV PRFYTKFSDH
210 220 230 240 250
MTFPQRLANF IANILENYLY HCLYSKYEIL ASDLLKRDVS LPALHQNSLW
260 270 280 290 300
LLRYDFVFEY PRPVMPNMIF IGGTNCKKKG NLSQEFEAYV NASGEHGIVV
310 320 330 340 350
FSLGSMVSEI PEKKAMEIAE ALGRIPQTLL WRYTGTRPSN LAKNTILVKW
360 370 380 390 400
LPQNDLLGHP KARAFITHSG SHGIYEGICN GVPMVMMPLF GDQMDNAKRM
410 420 430 440 450
ETRGAGVTLN VLEMTADDLE NALKTVINNK SYKENIMRLS SLHKDRPIEP
460 470 480 490 500
LDLAVFWVEY VMRHKGAPHL RPAAHDLTWY QYHSLDVIGF LLAIVLTVVF
510 520
IVYKSCAYGC RKCFGGKGRV KKSHKSKTH
Length:529
Mass (Da):60,132
Last modified:August 1, 1988 - v1
Checksum:i144AACD47EDDE04B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02612 mRNA. Translation: AAA42311.1.
PIRiA24600.
RefSeqiNP_001034780.1. NM_001039691.2.
UniGeneiRn.26489.

Genome annotation databases

GeneIDi113992.
KEGGirno:113992.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02612 mRNA. Translation: AAA42311.1 .
PIRi A24600.
RefSeqi NP_001034780.1. NM_001039691.2.
UniGenei Rn.26489.

3D structure databases

ProteinModelPortali P08430.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4580979.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEi P08430.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 113992.
KEGGi rno:113992.

Organism-specific databases

CTDi 54578.
RGDi 620949. Ugt1a6.

Phylogenomic databases

HOVERGENi HBG004033.
InParanoidi P08430.
KOi K00699.

Enzyme and pathway databases

BRENDAi 2.4.1.17. 5301.

Miscellaneous databases

NextBioi 618132.

Gene expression databases

Genevestigatori P08430.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase."
    Iyanagi T., Haniu M., Sogawa K., Fujii-Kuriyama Y., Watanabe S., Shively J.E., Anan K.F.
    J. Biol. Chem. 261:15607-15614(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.

Entry informationi

Entry nameiUD16_RAT
AccessioniPrimary (citable) accession number: P08430
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3