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Protein

Pulmonary surfactant-associated protein A

Gene

Sftpa1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.By similarity

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi215Calcium1
Metal bindingi217Calcium; via carbonyl oxygen1
Metal bindingi234Calcium1
Metal bindingi235Calcium1

GO - Molecular functioni

GO - Biological processi

  • cellular response to mechanical stimulus Source: RGD
  • cellular response to nitric oxide Source: RGD
  • circadian rhythm Source: RGD
  • positive regulation of phagocytosis Source: RGD
  • respiratory gaseous exchange Source: UniProtKB-KW
  • response to epidermal growth factor Source: RGD
  • response to glucocorticoid Source: RGD
  • response to hormone Source: RGD
  • response to hyperoxia Source: RGD
  • response to hypoxia Source: RGD
  • response to interleukin-6 Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to retinoic acid Source: RGD
  • response to vitamin A Source: RGD

Keywordsi

Biological processGaseous exchange
LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-391160 Signal regulatory protein family interactions
R-RNO-5683826 Surfactant metabolism
R-RNO-5686938 Regulation of TLR by endogenous ligand

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein A
Short name:
PSAP
Short name:
PSP-A
Short name:
SP-A
Gene namesi
Name:Sftpa1
Synonyms:Sftp-1, Sftp1, Sftpa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi3665 Sftpa1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001746221 – 248Pulmonary surfactant-associated protein AAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26InterchainPROSITE-ProRule annotation
Modified residuei304-hydroxyproline1 Publication1
Modified residuei334-hydroxyproline1 Publication1
Modified residuei364-hydroxyproline1 Publication1
Modified residuei424-hydroxyproline1 Publication1
Modified residuei544-hydroxyproline1 Publication1
Modified residuei574-hydroxyproline1 Publication1
Modified residuei634-hydroxyproline1 Publication1
Modified residuei674-hydroxyproline1 Publication1
Modified residuei704-hydroxyproline1 Publication1
Modified residuei764-hydroxyproline1 Publication1
Disulfide bondi155 ↔ 246PROSITE-ProRule annotation1 Publication
Glycosylationi207N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi224 ↔ 238PROSITE-ProRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei21Not glycosylated1

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiP08427
PRIDEiP08427

Expressioni

Gene expression databases

BgeeiENSRNOG00000011438
GenevisibleiP08427 RN

Interactioni

Subunit structurei

Oligomeric complex of 6 set of homotrimers.1 Publication

Protein-protein interaction databases

BioGridi246897, 1 interactor
STRINGi10116.ENSRNOP00000039850

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi109 – 127Combined sources19
Beta strandi132 – 134Combined sources3
Beta strandi137 – 146Combined sources10
Helixi148 – 157Combined sources10
Beta strandi160 – 162Combined sources3
Helixi168 – 181Combined sources14
Beta strandi188 – 190Combined sources3
Beta strandi192 – 196Combined sources5
Beta strandi198 – 200Combined sources3
Beta strandi201 – 203Combined sources3
Turni219 – 221Combined sources3
Beta strandi224 – 227Combined sources4
Beta strandi233 – 236Combined sources4
Beta strandi242 – 248Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GIEmodel-A101-248[»]
1R13X-ray2.10A101-248[»]
1R14X-ray2.50A101-248[»]
3PAKX-ray1.90A101-248[»]
3PAQX-ray2.10A101-248[»]
3PARX-ray2.30A101-248[»]
3PBFX-ray1.80A101-248[»]
4WR9X-ray2.30A101-248[»]
4WRCX-ray1.80A101-248[»]
4WREX-ray1.75A101-248[»]
4WRFX-ray1.90A101-248[»]
4WUWX-ray2.40A101-248[»]
4WUXX-ray1.90A101-248[»]
5FFRX-ray2.20A101-248[»]
5FFSX-ray1.80A101-248[»]
5FFTX-ray2.20A101-248[»]
ProteinModelPortaliP08427
SMRiP08427
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08427

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 100Collagen-likeAdd BLAST73
Domaini133 – 248C-type lectinPROSITE-ProRule annotationAdd BLAST116

Sequence similaritiesi

Belongs to the SFTPA family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104102
HOGENOMiHOG000085660
HOVERGENiHBG108270
InParanoidiP08427
KOiK10067
OMAiTWNDKNC
OrthoDBiEOG091G0PU5
PhylomeDBiP08427
TreeFamiTF330481

Family and domain databases

CDDicd03591 CLECT_collectin_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033990 Collectin_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLCSLAFTL FLTVVAGIKC NVTDVCAGSP GIPGAPGNHG LPGRDGRDGV
60 70 80 90 100
KGDPGPPGPM GPPGGMPGLP GRDGLPGAPG APGERGDKGE PGERGLPGFP
110 120 130 140 150
AYLDEELQTE LYEIKHQILQ TMGVLSLQGS MLSVGDKVFS TNGQSVNFDT
160 170 180 190 200
IKEMCTRAGG NIAVPRTPEE NEAIASIAKK YNNYVYLGMI EDQTPGDFHY
210 220 230 240
LDGASVNYTN WYPGEPRGQG KEKCVEMYTD GTWNDRGCLQ YRLAVCEF
Length:248
Mass (Da):26,289
Last modified:October 1, 1996 - v3
Checksum:iCAA0203009E682A5
GO

Sequence cautioni

The sequence AAA41972 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78A → G in AAA41973 (PubMed:2901856).Curated1
Sequence conflicti78A → G in CAA31573 (PubMed:2901856).Curated1
Sequence conflicti78A → G in CAA31574 (PubMed:2901856).Curated1
Sequence conflicti84E → G in AAA41973 (PubMed:2901856).Curated1
Sequence conflicti84E → G in CAA31573 (PubMed:2901856).Curated1
Sequence conflicti84E → G in CAA31574 (PubMed:2901856).Curated1
Sequence conflicti139Missing in AAA41972 (PubMed:3579914).Curated1
Sequence conflicti156T → TF in AAA41972 (PubMed:3579914).Curated1
Sequence conflicti180K → N in CAA31574 (PubMed:2901856).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33201 mRNA Translation: AAA41973.1
X13176 mRNA Translation: CAA31573.1
X13177 mRNA Translation: CAA31574.1
M15754 mRNA Translation: AAA41972.1 Different initiation.
U43092 Genomic DNA Translation: AAA85516.1
BC085353 mRNA Translation: AAH85353.1
PIRiA29299 LNRTPS
RefSeqiNP_001257574.1, NM_001270645.1
NP_001257576.1, NM_001270647.1
NP_059025.2, NM_017329.2
UniGeneiRn.11343

Genome annotation databases

EnsembliENSRNOT00000047870; ENSRNOP00000039850; ENSRNOG00000011438
GeneIDi24773
KEGGirno:24773
UCSCiRGD:3665 rat

Similar proteinsi

Entry informationi

Entry nameiSFTPA_RAT
AccessioniPrimary (citable) accession number: P08427
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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