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P08426

- TRY3_RAT

UniProt

P08426 - TRY3_RAT

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Protein

Cationic trypsin-3

Gene

Try3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactori

Ca2+By similarityNote: Binds 1 Ca(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641Charge relay systemBy similarity
Metal bindingi76 – 761CalciumBy similarity
Metal bindingi78 – 781Calcium; via carbonyl oxygenBy similarity
Metal bindingi81 – 811Calcium; via carbonyl oxygenBy similarity
Metal bindingi86 – 861CalciumBy similarity
Active sitei108 – 1081Charge relay systemBy similarity
Sitei195 – 1951Required for specificityBy similarity
Active sitei201 – 2011Charge relay systemBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiS01.151.

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic trypsin-3 (EC:3.4.21.4)
Alternative name(s):
Cationic trypsin III
Pretrypsinogen III
Gene namesi
Name:Try3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi708437. LOC286911.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Add
BLAST
Propeptidei16 – 249Activation peptidePRO_0000028211
Chaini25 – 247223Cationic trypsin-3PRO_0000028212Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 161PROSITE-ProRule annotation
Disulfide bondi49 ↔ 65PROSITE-ProRule annotation
Disulfide bondi133 ↔ 234PROSITE-ProRule annotation
Disulfide bondi140 ↔ 207PROSITE-ProRule annotation
Disulfide bondi172 ↔ 186PROSITE-ProRule annotation
Disulfide bondi197 ↔ 221PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP08426.
PRIDEiP08426.

PTM databases

PhosphoSiteiP08426.

Expressioni

Gene expression databases

GenevestigatoriP08426.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018042.

Structurei

3D structure databases

ProteinModelPortaliP08426.
SMRiP08426. Positions 25-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 245221Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP08426.
KOiK01312.
PhylomeDBiP08426.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08426-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKALIFLAFL GAAVALPLDD DDDKIVGGYT CQKNSLPYQV SLNAGYHFCG
60 70 80 90 100
GSLINSQWVV SAAHCYKSRI QVRLGEHNID VVEGGEQFID AAKIIRHPSY
110 120 130 140 150
NANTFDNDIM LIKLNSPATL NSRVSTVSLP RSCGSSGTKC LVSGWGNTLS
160 170 180 190 200
SGTNYPSLLQ CLDAPVLSDS SCKSSYPGKI TSNMFCLGFL EGGKDSCQGD
210 220 230 240
SGGPVVCNGQ LQGVVSWGYG CAQKGKPGVY TKVCNYVNWI QQTVAAN
Length:247
Mass (Da):26,269
Last modified:August 1, 1988 - v1
Checksum:iD74892BAA584E4A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16624 mRNA. Translation: AAA41985.1.
PIRiA27547.
RefSeqiNP_775150.1. NM_173127.1.
UniGeneiRn.9817.

Genome annotation databases

GeneIDi286911.
KEGGirno:286911.
UCSCiRGD:708437. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16624 mRNA. Translation: AAA41985.1 .
PIRi A27547.
RefSeqi NP_775150.1. NM_173127.1.
UniGenei Rn.9817.

3D structure databases

ProteinModelPortali P08426.
SMRi P08426. Positions 25-247.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000018042.

Protein family/group databases

MEROPSi S01.151.

PTM databases

PhosphoSitei P08426.

Proteomic databases

PaxDbi P08426.
PRIDEi P08426.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 286911.
KEGGi rno:286911.
UCSCi RGD:708437. rat.

Organism-specific databases

CTDi 5646.
RGDi 708437. LOC286911.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P08426.
KOi K01312.
PhylomeDBi P08426.

Miscellaneous databases

NextBioi 625019.

Gene expression databases

Genevestigatori P08426.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of a cDNA encoding rat cationic trypsinogen."
    Fletcher T.S., Alhadeff M., Craik C.S., Largman C.
    Biochemistry 26:3081-3086(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTRY3_RAT
AccessioniPrimary (citable) accession number: P08426
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 26, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3