Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P08426

- TRY3_RAT

UniProt

P08426 - TRY3_RAT

Protein

Cationic trypsin-3

Gene

Try3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei64 – 641Charge relay systemBy similarity
    Metal bindingi76 – 761CalciumBy similarity
    Metal bindingi78 – 781Calcium; via carbonyl oxygenBy similarity
    Metal bindingi81 – 811Calcium; via carbonyl oxygenBy similarity
    Metal bindingi86 – 861CalciumBy similarity
    Active sitei108 – 1081Charge relay systemBy similarity
    Sitei195 – 1951Required for specificityBy similarity
    Active sitei201 – 2011Charge relay systemBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. digestion Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Digestion

    Keywords - Ligandi

    Calcium, Metal-binding

    Protein family/group databases

    MEROPSiS01.151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cationic trypsin-3 (EC:3.4.21.4)
    Alternative name(s):
    Cationic trypsin III
    Pretrypsinogen III
    Gene namesi
    Name:Try3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi708437. LOC286911.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Add
    BLAST
    Propeptidei16 – 249Activation peptidePRO_0000028211
    Chaini25 – 247223Cationic trypsin-3PRO_0000028212Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 161PROSITE-ProRule annotation
    Disulfide bondi49 ↔ 65PROSITE-ProRule annotation
    Disulfide bondi133 ↔ 234PROSITE-ProRule annotation
    Disulfide bondi140 ↔ 207PROSITE-ProRule annotation
    Disulfide bondi172 ↔ 186PROSITE-ProRule annotation
    Disulfide bondi197 ↔ 221PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    PaxDbiP08426.
    PRIDEiP08426.

    PTM databases

    PhosphoSiteiP08426.

    Expressioni

    Gene expression databases

    GenevestigatoriP08426.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000018042.

    Structurei

    3D structure databases

    ProteinModelPortaliP08426.
    SMRiP08426. Positions 25-247.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 245221Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP08426.
    KOiK01312.
    PhylomeDBiP08426.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P08426-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKALIFLAFL GAAVALPLDD DDDKIVGGYT CQKNSLPYQV SLNAGYHFCG    50
    GSLINSQWVV SAAHCYKSRI QVRLGEHNID VVEGGEQFID AAKIIRHPSY 100
    NANTFDNDIM LIKLNSPATL NSRVSTVSLP RSCGSSGTKC LVSGWGNTLS 150
    SGTNYPSLLQ CLDAPVLSDS SCKSSYPGKI TSNMFCLGFL EGGKDSCQGD 200
    SGGPVVCNGQ LQGVVSWGYG CAQKGKPGVY TKVCNYVNWI QQTVAAN 247
    Length:247
    Mass (Da):26,269
    Last modified:August 1, 1988 - v1
    Checksum:iD74892BAA584E4A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16624 mRNA. Translation: AAA41985.1.
    PIRiA27547.
    RefSeqiNP_775150.1. NM_173127.1.
    UniGeneiRn.9817.

    Genome annotation databases

    GeneIDi286911.
    KEGGirno:286911.
    UCSCiRGD:708437. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16624 mRNA. Translation: AAA41985.1 .
    PIRi A27547.
    RefSeqi NP_775150.1. NM_173127.1.
    UniGenei Rn.9817.

    3D structure databases

    ProteinModelPortali P08426.
    SMRi P08426. Positions 25-247.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000018042.

    Protein family/group databases

    MEROPSi S01.151.

    PTM databases

    PhosphoSitei P08426.

    Proteomic databases

    PaxDbi P08426.
    PRIDEi P08426.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 286911.
    KEGGi rno:286911.
    UCSCi RGD:708437. rat.

    Organism-specific databases

    CTDi 5646.
    RGDi 708437. LOC286911.

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P08426.
    KOi K01312.
    PhylomeDBi P08426.

    Miscellaneous databases

    NextBioi 625019.

    Gene expression databases

    Genevestigatori P08426.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a cDNA encoding rat cationic trypsinogen."
      Fletcher T.S., Alhadeff M., Craik C.S., Largman C.
      Biochemistry 26:3081-3086(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiTRY3_RAT
    AccessioniPrimary (citable) accession number: P08426
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3