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P08426

- TRY3_RAT

UniProt

P08426 - TRY3_RAT

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Protein
Cationic trypsin-3
Gene
Try3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641Charge relay system By similarity
Metal bindingi76 – 761Calcium By similarity
Metal bindingi78 – 781Calcium; via carbonyl oxygen By similarity
Metal bindingi81 – 811Calcium; via carbonyl oxygen By similarity
Metal bindingi86 – 861Calcium By similarity
Active sitei108 – 1081Charge relay system By similarity
Sitei195 – 1951Required for specificity By similarity
Active sitei201 – 2011Charge relay system By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiS01.151.

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic trypsin-3 (EC:3.4.21.4)
Alternative name(s):
Cationic trypsin III
Pretrypsinogen III
Gene namesi
Name:Try3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi708437. LOC286911.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515
Add
BLAST
Propeptidei16 – 249Activation peptide
PRO_0000028211
Chaini25 – 247223Cationic trypsin-3
PRO_0000028212Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 161 By similarity
Disulfide bondi49 ↔ 65 By similarity
Disulfide bondi133 ↔ 234 By similarity
Disulfide bondi140 ↔ 207 By similarity
Disulfide bondi172 ↔ 186 By similarity
Disulfide bondi197 ↔ 221 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP08426.
PRIDEiP08426.

PTM databases

PhosphoSiteiP08426.

Expressioni

Gene expression databases

GenevestigatoriP08426.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018042.

Structurei

3D structure databases

ProteinModelPortaliP08426.
SMRiP08426. Positions 25-247.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 245221Peptidase S1
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP08426.
KOiK01312.
PhylomeDBiP08426.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08426-1 [UniParc]FASTAAdd to Basket

« Hide

MKALIFLAFL GAAVALPLDD DDDKIVGGYT CQKNSLPYQV SLNAGYHFCG    50
GSLINSQWVV SAAHCYKSRI QVRLGEHNID VVEGGEQFID AAKIIRHPSY 100
NANTFDNDIM LIKLNSPATL NSRVSTVSLP RSCGSSGTKC LVSGWGNTLS 150
SGTNYPSLLQ CLDAPVLSDS SCKSSYPGKI TSNMFCLGFL EGGKDSCQGD 200
SGGPVVCNGQ LQGVVSWGYG CAQKGKPGVY TKVCNYVNWI QQTVAAN 247
Length:247
Mass (Da):26,269
Last modified:August 1, 1988 - v1
Checksum:iD74892BAA584E4A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16624 mRNA. Translation: AAA41985.1.
PIRiA27547.
RefSeqiNP_775150.1. NM_173127.1.
UniGeneiRn.9817.

Genome annotation databases

GeneIDi286911.
KEGGirno:286911.
UCSCiRGD:708437. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16624 mRNA. Translation: AAA41985.1 .
PIRi A27547.
RefSeqi NP_775150.1. NM_173127.1.
UniGenei Rn.9817.

3D structure databases

ProteinModelPortali P08426.
SMRi P08426. Positions 25-247.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000018042.

Protein family/group databases

MEROPSi S01.151.

PTM databases

PhosphoSitei P08426.

Proteomic databases

PaxDbi P08426.
PRIDEi P08426.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 286911.
KEGGi rno:286911.
UCSCi RGD:708437. rat.

Organism-specific databases

CTDi 5646.
RGDi 708437. LOC286911.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P08426.
KOi K01312.
PhylomeDBi P08426.

Miscellaneous databases

NextBioi 625019.

Gene expression databases

Genevestigatori P08426.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of a cDNA encoding rat cationic trypsinogen."
    Fletcher T.S., Alhadeff M., Craik C.S., Largman C.
    Biochemistry 26:3081-3086(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTRY3_RAT
AccessioniPrimary (citable) accession number: P08426
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 14, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi