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Protein

Chymotrypsin-like elastase family member 2A

Gene

CELA2A

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts upon elastin.

Catalytic activityi

Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa. Hydrolyzes elastin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73Charge relay system1
Active sitei121Charge relay system1
Active sitei216Charge relay system1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiR-SSC-6809371 Formation of the cornified envelope

Protein family/group databases

MEROPSiS01.155

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-like elastase family member 2A (EC:3.4.21.71)
Alternative name(s):
Elastase-2
Elastase-2A
Gene namesi
Name:CELA2A
Synonyms:ELA2, ELA2A
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2407

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
PropeptideiPRO_000002768917 – 28Activation peptideAdd BLAST12
ChainiPRO_000002769029 – 269Chymotrypsin-like elastase family member 2AAdd BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 74PROSITE-ProRule annotation1 Publication
Disulfide bondi155 ↔ 222PROSITE-ProRule annotation1 Publication
Disulfide bondi186 ↔ 202PROSITE-ProRule annotation1 Publication
Disulfide bondi212 ↔ 243PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP08419
PRIDEiP08419

Expressioni

Tissue specificityi

Pancreas.

Gene expression databases

BgeeiENSSSCG00000003459
GenevisibleiP08419 SS

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000003756

Chemistry databases

BindingDBiP08419

Structurei

Secondary structure

1269
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi43 – 50Combined sources8
Beta strandi53 – 64Combined sources12
Beta strandi67 – 70Combined sources4
Helixi72 – 74Combined sources3
Beta strandi81 – 86Combined sources6
Beta strandi88 – 92Combined sources5
Beta strandi98 – 107Combined sources10
Helixi116 – 118Combined sources3
Beta strandi123 – 129Combined sources7
Beta strandi154 – 160Combined sources7
Beta strandi174 – 181Combined sources8
Helixi183 – 186Combined sources4
Turni189 – 192Combined sources4
Helixi193 – 195Combined sources3
Beta strandi200 – 203Combined sources4
Beta strandi206 – 210Combined sources5
Beta strandi219 – 223Combined sources5
Beta strandi229 – 237Combined sources9
Beta strandi242 – 244Combined sources3
Beta strandi250 – 254Combined sources5
Helixi255 – 257Combined sources3
Helixi259 – 268Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BRUX-ray2.30P29-269[»]
ProteinModelPortaliP08419
SMRiP08419
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08419

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 267Peptidase S1PROSITE-ProRule annotationAdd BLAST239

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
InParanoidiP08419
KOiK01346
OMAiKIQLGCL
OrthoDBiEOG091G0DF7
TreeFamiTF330455

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08419-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRALLLSTL VAGALSCGLP ANLPQLPRVV GGEDARPNSW PWQVSLQYDS
60 70 80 90 100
SGQWRHTCGG TLVDQSWVLT AAHCISSSRT YRVVLGRHSL STNEPGSLAV
110 120 130 140 150
KVSKLVVHQD WNSNQLSNGN DIALLKLASP VSLTDKIQLG CLPAAGTILP
160 170 180 190 200
NNYVCYVTGW GRLQTNGASP DILQQGQLLV VDYATCSKPG WWGSTVKTNM
210 220 230 240 250
ICAGGDGIIS SCNGDSGGPL NCQGANGQWQ VHGIVSFGSS LGCNYYHKPS
260
VFTRVSNYID WINSVIANN
Length:269
Mass (Da):28,699
Last modified:August 1, 1988 - v1
Checksum:iBAC6FE69AF4DDE56
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10L → S in BAA00166 (PubMed:2834346).Curated1
Sequence conflicti118N → K in BAA00166 (PubMed:2834346).Curated1
Sequence conflicti132S → Y in BAA00166 (PubMed:2834346).Curated1
Sequence conflicti172I → V in BAA00166 (PubMed:2834346).Curated1
Sequence conflicti202C → V in BAA00166 (PubMed:2834346).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16651 mRNA Translation: AAA31027.1
D00237 mRNA Translation: BAA00166.1
PIRiA26823
RefSeqiNP_999274.1, NM_214109.1
UniGeneiSsc.316

Genome annotation databases

EnsembliENSSSCT00000003844; ENSSSCP00000003756; ENSSSCG00000003459
GeneIDi397197
KEGGissc:397197

Similar proteinsi

Entry informationi

Entry nameiCEL2A_PIG
AccessioniPrimary (citable) accession number: P08419
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: February 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome