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Protein

Sensor protein CreC

Gene

creC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane-associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB.2 Publications

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • phosphorelay sensor kinase activity Source: EcoCyc

GO - Biological processi

  • peptidyl-histidine phosphorylation Source: EcoCyc
  • phosphorelay signal transduction system Source: EcoCyc
  • response to nutrient Source: EcoCyc

Keywordsi

Molecular functionKinase, Transferase
Biological processTwo-component regulatory system
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:CREC-MONOMER
BRENDAi2.7.13.3 2026

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein CreC (EC:2.7.13.3)
Gene namesi
Name:creC
Synonyms:phoM
Ordered Locus Names:b4399, JW4362
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10730 creC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6PeriplasmicSequence analysis6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 146CytoplasmicSequence analysisAdd BLAST119
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 183PeriplasmicSequence analysisAdd BLAST16
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 474CytoplasmicSequence analysisAdd BLAST270

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000747421 – 474Sensor protein CreCAdd BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei265Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP08401
PRIDEiP08401

PTM databases

iPTMnetiP08401

Interactioni

Protein-protein interaction databases

BioGridi4261905, 10 interactors
DIPiDIP-9319N
IntActiP08401, 5 interactors
STRINGi316385.ECDH10B_4557

Structurei

3D structure databases

ProteinModelPortaliP08401
SMRiP08401
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini205 – 255HAMPPROSITE-ProRule annotationAdd BLAST51
Domaini262 – 473Histidine kinasePROSITE-ProRule annotationAdd BLAST212

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EB3 Bacteria
COG0642 LUCA
HOGENOMiHOG000211121
InParanoidiP08401
KOiK07641
OMAiRWNDVYL
PhylomeDBiP08401

Family and domain databases

CDDicd06225 HAMP, 1 hit
cd00075 HATPase_c, 1 hit
cd00082 HisKA, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003660 HAMP_dom
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR029151 Sensor-like_sf
IPR004358 Sig_transdc_His_kin-like_C
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00304 HAMP, 1 hit
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SUPFAMiSSF103190 SSF103190, 1 hit
SSF47384 SSF47384, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50885 HAMP, 1 hit
PS50109 HIS_KIN, 1 hit

Sequencei

Sequence statusi: Complete.

P08401-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIGMRLLLG YFLLVAVAAW FVLAIFVKEV KPGVRRATEG TLIDTATLLA
60 70 80 90 100
ELARPDLLSG DPTHGQLAQA FNQLQHRPFR ANIGGINKVR NEYHVYMTDA
110 120 130 140 150
QGKVLFDSAN KAVGQDYSRW NDVWLTLRGQ YGARSTLQNP ADPESSVMYV
160 170 180 190 200
AAPIMDGSRL IGVLSVGKPN AAMAPVIKRS ERRILWASAI LLGIALVIGA
210 220 230 240 250
GMVWWINRSI ARLTRYADSV TDNKPVPLPD LGSSELRKLA QALESMRVKL
260 270 280 290 300
EGKNYIEQYV YALTHELKSP LAAIRGAAEI LREGPPPEVV ARFTDNILTQ
310 320 330 340 350
NARMQALVET LLRQARLENR QEVVLTAVDV AALFRRVSEA RTVQLAEKKI
360 370 380 390 400
TLHVTPTEVN VAAEPALLEQ ALGNLLDNAI DFTPESGCIT LSAEVDQEHV
410 420 430 440 450
TLKVLDTGSG IPDYALSRIF ERFYSLPRAN GQKSSGLGLA FVSEVARLFN
460 470
GEVTLRNVQE GGVLASLRLH RHFT
Length:474
Mass (Da):52,176
Last modified:July 19, 2003 - v2
Checksum:i9CEB8CCE406E3163
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77R → P in AAA24375 (PubMed:3531171).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13608 Genomic DNA Translation: AAA24375.1
U14003 Genomic DNA Translation: AAA97295.1
U00096 Genomic DNA Translation: AAC77352.1
AP009048 Genomic DNA Translation: BAE78388.1
Y00538 Genomic DNA Translation: CAA68601.1
PIRiS56623 RGECFM
RefSeqiNP_418816.1, NC_000913.3
WP_001219559.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77352; AAC77352; b4399
BAE78388; BAE78388; BAE78388
GeneIDi948609
KEGGiecj:JW4362
eco:b4399
PATRICifig|511145.12.peg.4548

Entry informationi

Entry nameiCREC_ECOLI
AccessioniPrimary (citable) accession number: P08401
Secondary accession number(s): Q2M5R8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: July 19, 2003
Last modified: March 28, 2018
This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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