Reviewed, UniProtKB/Swiss-Prot P08390 (USG_ECOLI)

Names and origin

Protein names

Recommended name:
    USG-1 protein

Gene names

Name:	usg
Ordered Locus Names:	b2319, JW2316

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the aspartate-semialdehyde dehydrogenase family.

Ontologies

Keywords
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	amino acid biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro NADP or NADPH binding Inferred from electronic annotation. Source: InterPro aspartate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
def	P0A6K3	1	EBI-548921,EBI-548913

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	USG-1 protein		PRO_0000141402

Sequences

	Sequence		Length	Mass (Da)
	P08390-1 [UniParc]. Last modified August 1, 1988. Version 1. Checksum: DF399045C50AE3C5	FASTA	337	36,364
	10 20 30 40 50 60 MSEGWNIAVL GATGAVGEAL LETLAERQFP VGEIYALARN ESAGEQLRFG GKTITVQDAA 70 80 90 100 110 120 EFDWTQAQLA FFVAGKEATA AWVEEATNSG CLVIDSSGLF ALEPDVPLVV PEVNPFVLTD 130 140 150 160 170 180 YRNRNVIAVP DSLTSQLLAA LKPLIDQGGL SRISVTSLIS ASAQGKKAVD ALAGQSAKLL 190 200 210 220 230 240 NGIPIDEEDF FGRQLAFNML PLLPDSEGSV REERRIVDEV RKILQDEGLM ISASVVQAPV 250 260 270 280 290 300 FYGHAQMVNF EALRPLAAEE ARDAFVQGED IVLSEENEFP TQVGDASGTP HLSVGCVRND 310 320 330 YGMPEQVQFW SVADNVRFGG ALMAVKIAEK LVQEYLY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural features of the hisT operon of Escherichia coli K-12." Arps P.J., Marvel C.C., Rubin B.C., Tolan D.A., Penhoet E.E., Winkler M.E. Nucleic Acids Res. 13:5297-5315(1985) [PubMed: 2991861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features." Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T. , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T. DNA Res. 4:91-113(1997) [PubMed: 9205837] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Structural analysis of the Escherichia coli K-12 hisT operon by using a kanamycin resistance cassette." Arps P.J., Winkler M.E. J. Bacteriol. 169:1061-1070(1987) [PubMed: 3029016] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-13 AND 329-337. Strain: K12.
[6]	"Divergent transcription of pdxB and homology between the pdxB and serA gene products in Escherichia coli K-12." Schoenlein P.V., Roa B.B., Winkler M.E. J. Bacteriol. 171:6084-6092(1989) [PubMed: 2681152] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-27. Strain: K12.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X02743 Genomic DNA. Translation: CAA26521.1. U00096 Genomic DNA. Translation: AAC75379.1. AP009048 Genomic DNA. Translation: BAA16176.1. M15541 Genomic DNA. Translation: AAA24311.1. M15542 Genomic DNA. Translation: AAA24312.1. M29962 Genomic DNA. Translation: AAA24309.1.
PIR	QQECH3. A23792.
RefSeq	AP_002919.1. NP_416822.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:11095N.
IntAct	P08390. 16 interactions.
Genome annotation databases
GeneID	946797.
GenomeReviews	Gene locus JW2316 in contig AP009048_GR. Gene locus b2319 in contig U00096_GR.
KEGG	ecj:JW2316. eco:b2319.
Organism-specific databases
EchoBASE	EB1052.
EcoGene	EG11059. usg.
CMR	Search...
Phylogenomic databases
HOGENOM	P08390.
OMA	P08390. LELWLCG.
Enzyme and pathway databases
BioCyc	EcoCyc:EG11059-MON.
Family and domain databases
InterPro	IPR012080. Asp_semialdehyde_DH. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
PIRSF	PIRSF000148. ASA_dh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

USG_ECOLI

Accession

Primary (citable) accession number: P08390

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	June 16, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)