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Protein

Inner membrane protein CreD

Gene

creD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Mutations of this gene leads to an enhanced transcription of the gene cause tolerance to colicin E2.

Enzyme and pathway databases

BioCyciEcoCyc:EG10145-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane protein CreD
Gene namesi
Name:creD
Synonyms:cet
Ordered Locus Names:b4400, JW4363
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10145 creD

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 297PeriplasmicSequence analysisAdd BLAST270
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 322CytoplasmicSequence analysis4
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 347PeriplasmicSequence analysis4
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 378CytoplasmicSequence analysis10
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400PeriplasmicSequence analysis1
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Topological domaini422 – 450CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793451 – 450Inner membrane protein CreDAdd BLAST450

Proteomic databases

PaxDbiP08369
PRIDEiP08369

Interactioni

Protein-protein interaction databases

BioGridi4262782, 8 interactors
STRINGi316385.ECDH10B_4558

Structurei

3D structure databases

ProteinModelPortaliP08369
SMRiP08369
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CT7 Bacteria
COG4452 LUCA
HOGENOMiHOG000211010
InParanoidiP08369
KOiK06143
OMAiRVHPIQY
PhylomeDBiP08369

Family and domain databases

InterProiView protein in InterPro
IPR010364 Uncharacterised_IM_CreD
PANTHERiPTHR30092 PTHR30092, 1 hit
PfamiView protein in Pfam
PF06123 CreD, 1 hit
PIRSFiPIRSF004548 CreD, 1 hit

Sequencei

Sequence statusi: Complete.

P08369-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKSPLFWKM TSLFGAVLLL LIPIMLIRQV IVERADYRSD VEDAIRQSTS
60 70 80 90 100
GPQKLVGPLI AIPVTELYTV QEEDKTVERK RSFIHFWLPE SLMVDGNQNV
110 120 130 140 150
EERKIGIYTG QVWHSDLTLK ADFDVSRLSE LNAPNITLGK PFIVISVGDA
160 170 180 190 200
RGIGVVKAPE VNGTALTIEP GTGLEQGGQG VHIPLPEGDW RKQNLKLNMA
210 220 230 240 250
LNLSGTGDLS VVPGGRNSEM TLTSNWPHPS FLGDFLPAKR EVSESGFQAH
260 270 280 290 300
WQSSWFANNL GERFASGNDT GWENFPAFSV AVTTPADQYQ LTDRATKYAI
310 320 330 340 350
LLIALTFMAF FVFETLTAQR LHPMQYLLVG LSLVMFYLLL LALSEHTGFT
360 370 380 390 400
VAWIIASLIG AIMNGIYLQA VLKGWCNSML FTLALLLLDG VMWGLLNSAD
410 420 430 440 450
SALLLGTSVL VVALAGMMFV TRNIDWYAFS LPKMKASKEV TTDDELRIWK
Length:450
Mass (Da):49,830
Last modified:August 1, 1988 - v1
Checksum:iB2D9F63197EB1B13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13608 Genomic DNA Translation: AAA24376.1
Y00538 Genomic DNA Translation: CAA68602.1
U14003 Genomic DNA Translation: AAA97296.1
U00096 Genomic DNA Translation: AAC77353.1
AP009048 Genomic DNA Translation: BAE78389.1
PIRiD25038 BVECCT
RefSeqiNP_418817.1, NC_000913.3
WP_000920294.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77353; AAC77353; b4400
BAE78389; BAE78389; BAE78389
GeneIDi948868
KEGGiecj:JW4363
eco:b4400
PATRICifig|1411691.4.peg.2284

Similar proteinsi

Entry informationi

Entry nameiCRED_ECOLI
AccessioniPrimary (citable) accession number: P08369
Secondary accession number(s): Q2M5R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health