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Protein

Inner membrane protein CreD

Gene

creD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciEcoCyc:EG10145-MONOMER.
ECOL316407:JW4363-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane protein CreD
Gene namesi
Name:creD
Synonyms:cet
Ordered Locus Names:b4400, JW4363
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10145. creD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence analysis
Transmembranei7 – 2721HelicalSequence analysisAdd
BLAST
Topological domaini28 – 297270PeriplasmicSequence analysisAdd
BLAST
Transmembranei298 – 31821HelicalSequence analysisAdd
BLAST
Topological domaini319 – 3224CytoplasmicSequence analysis
Transmembranei323 – 34321HelicalSequence analysisAdd
BLAST
Topological domaini344 – 3474PeriplasmicSequence analysis
Transmembranei348 – 36821HelicalSequence analysisAdd
BLAST
Topological domaini369 – 37810CytoplasmicSequence analysis
Transmembranei379 – 39921HelicalSequence analysisAdd
BLAST
Topological domaini400 – 4001PeriplasmicSequence analysis
Transmembranei401 – 42121HelicalSequence analysisAdd
BLAST
Topological domaini422 – 45029CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Inner membrane protein CreDPRO_0000079345Add
BLAST

Proteomic databases

PaxDbiP08369.

Interactioni

Protein-protein interaction databases

BioGridi4262782. 8 interactions.
STRINGi511145.b4400.

Structurei

3D structure databases

ProteinModelPortaliP08369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CT7. Bacteria.
COG4452. LUCA.
HOGENOMiHOG000211010.
InParanoidiP08369.
KOiK06143.
OMAiPIQYALV.
PhylomeDBiP08369.

Family and domain databases

InterProiIPR010364. Uncharacterised_IM_CreD.
[Graphical view]
PfamiPF06123. CreD. 1 hit.
[Graphical view]
PIRSFiPIRSF004548. CreD. 1 hit.

Sequencei

Sequence statusi: Complete.

P08369-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKSPLFWKM TSLFGAVLLL LIPIMLIRQV IVERADYRSD VEDAIRQSTS
60 70 80 90 100
GPQKLVGPLI AIPVTELYTV QEEDKTVERK RSFIHFWLPE SLMVDGNQNV
110 120 130 140 150
EERKIGIYTG QVWHSDLTLK ADFDVSRLSE LNAPNITLGK PFIVISVGDA
160 170 180 190 200
RGIGVVKAPE VNGTALTIEP GTGLEQGGQG VHIPLPEGDW RKQNLKLNMA
210 220 230 240 250
LNLSGTGDLS VVPGGRNSEM TLTSNWPHPS FLGDFLPAKR EVSESGFQAH
260 270 280 290 300
WQSSWFANNL GERFASGNDT GWENFPAFSV AVTTPADQYQ LTDRATKYAI
310 320 330 340 350
LLIALTFMAF FVFETLTAQR LHPMQYLLVG LSLVMFYLLL LALSEHTGFT
360 370 380 390 400
VAWIIASLIG AIMNGIYLQA VLKGWCNSML FTLALLLLDG VMWGLLNSAD
410 420 430 440 450
SALLLGTSVL VVALAGMMFV TRNIDWYAFS LPKMKASKEV TTDDELRIWK
Length:450
Mass (Da):49,830
Last modified:August 1, 1988 - v1
Checksum:iB2D9F63197EB1B13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13608 Genomic DNA. Translation: AAA24376.1.
Y00538 Genomic DNA. Translation: CAA68602.1.
U14003 Genomic DNA. Translation: AAA97296.1.
U00096 Genomic DNA. Translation: AAC77353.1.
AP009048 Genomic DNA. Translation: BAE78389.1.
PIRiD25038. BVECCT.
RefSeqiNP_418817.1. NC_000913.3.
WP_000920294.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77353; AAC77353; b4400.
BAE78389; BAE78389; BAE78389.
GeneIDi948868.
KEGGiecj:JW4363.
eco:b4400.
PATRICi32124418. VBIEscCol129921_4549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13608 Genomic DNA. Translation: AAA24376.1.
Y00538 Genomic DNA. Translation: CAA68602.1.
U14003 Genomic DNA. Translation: AAA97296.1.
U00096 Genomic DNA. Translation: AAC77353.1.
AP009048 Genomic DNA. Translation: BAE78389.1.
PIRiD25038. BVECCT.
RefSeqiNP_418817.1. NC_000913.3.
WP_000920294.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP08369.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262782. 8 interactions.
STRINGi511145.b4400.

Proteomic databases

PaxDbiP08369.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77353; AAC77353; b4400.
BAE78389; BAE78389; BAE78389.
GeneIDi948868.
KEGGiecj:JW4363.
eco:b4400.
PATRICi32124418. VBIEscCol129921_4549.

Organism-specific databases

EchoBASEiEB0143.
EcoGeneiEG10145. creD.

Phylogenomic databases

eggNOGiENOG4105CT7. Bacteria.
COG4452. LUCA.
HOGENOMiHOG000211010.
InParanoidiP08369.
KOiK06143.
OMAiPIQYALV.
PhylomeDBiP08369.

Enzyme and pathway databases

BioCyciEcoCyc:EG10145-MONOMER.
ECOL316407:JW4363-MONOMER.

Miscellaneous databases

PROiP08369.

Family and domain databases

InterProiIPR010364. Uncharacterised_IM_CreD.
[Graphical view]
PfamiPF06123. CreD. 1 hit.
[Graphical view]
PIRSFiPIRSF004548. CreD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCRED_ECOLI
AccessioniPrimary (citable) accession number: P08369
Secondary accession number(s): Q2M5R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Mutations of this gene leads to an enhanced transcription of the gene cause tolerance to colicin E2.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.