ID   CREB_ECOLI              Reviewed;         229 AA.
AC   P08368; Q2M5R9;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   27-MAR-2024, entry version 173.
DE   RecName: Full=Transcriptional regulatory protein CreB;
GN   Name=creB; Synonyms=yjjE; OrderedLocusNames=b4398, JW4361;
OS   Escherichia coli (strain K12).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3531171; DOI=10.1128/jb.168.1.294-302.1986;
RA   Amemura M., Makino K., Shinagawa H., Nakata A.;
RT   "Nucleotide sequence of the phoM region of Escherichia coli: four open
RT   reading frames may constitute an operon.";
RL   J. Bacteriol. 168:294-302(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA   Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT   "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT   from 92.8 through 100 minutes.";
RL   Nucleic Acids Res. 23:2105-2119(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   PHOSPHORYLATION.
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=15522865; DOI=10.1074/jbc.m410104200;
RA   Yamamoto K., Hirao K., Oshima T., Aiba H., Utsumi R., Ishihama A.;
RT   "Functional characterization in vitro of all two-component signal
RT   transduction systems from Escherichia coli.";
RL   J. Biol. Chem. 280:1448-1456(2005).
CC   -!- FUNCTION: Member of the two-component regulatory system CreC/CreB
CC       involved in catabolic regulation.
CC   -!- INTERACTION:
CC       P08368; P08368: creB; NbExp=2; IntAct=EBI-1131567, EBI-1131567;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by CreC. {ECO:0000269|PubMed:15522865}.
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DR   EMBL; M13608; AAA24374.1; -; Genomic_DNA.
DR   EMBL; U14003; AAA97294.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC77351.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE78387.1; -; Genomic_DNA.
DR   PIR; B25038; QQECFJ.
DR   RefSeq; NP_418815.1; NC_000913.3.
DR   RefSeq; WP_001188654.1; NZ_LN832404.1.
DR   AlphaFoldDB; P08368; -.
DR   SMR; P08368; -.
DR   BioGRID; 4263252; 86.
DR   BioGRID; 853198; 4.
DR   DIP; DIP-9318N; -.
DR   IntAct; P08368; 4.
DR   STRING; 511145.b4398; -.
DR   PaxDb; 511145-b4398; -.
DR   EnsemblBacteria; AAC77351; AAC77351; b4398.
DR   GeneID; 948922; -.
DR   KEGG; ecj:JW4361; -.
DR   KEGG; eco:b4398; -.
DR   PATRIC; fig|1411691.4.peg.2286; -.
DR   EchoBASE; EB1201; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_000445_30_4_6; -.
DR   InParanoid; P08368; -.
DR   OMA; QIISEVW; -.
DR   OrthoDB; 9802426at2; -.
DR   PhylomeDB; P08368; -.
DR   BioCyc; EcoCyc:CREB-MONOMER; -.
DR   PRO; PR:P08368; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR   GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:EcoCyc.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IMP:EcoCyc.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   CDD; cd17574; REC_OmpR; 1.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   Gene3D; 6.10.250.690; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; REGULATOR OF RPOS; 1.
DR   PANTHER; PTHR48111:SF6; TRANSCRIPTIONAL REGULATORY PROTEIN CREB; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF52172; CheY-like; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..229
FT                   /note="Transcriptional regulatory protein CreB"
FT                   /id="PRO_0000081082"
FT   DOMAIN          5..119
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        129..228
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         54
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   229 AA;  26125 MW;  A982C6D832C7607B CRC64;
     MQRETVWLVE DEQGIADTLV YMLQQEGFAV EVFERGLPVL DKARKQVPDV MILDVGLPDI
     SGFELCRQLL ALHPALPVLF LTARSEEVDR LLGLEIGADD YVAKPFSPRE VCARVRTLLR
     RVKKFSTPSP VIRIGHFELN EPAAQISWFD TPLALTRYEF LLLKTLLKSP GRVWSRQQLM
     DSVWEDAQDT YDRTVDTHIK TLRAKLRAIN PDLSPINTHR GMGYSLRGL
//