Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P08368

- CREB_ECOLI

UniProt

P08368 - CREB_ECOLI

Protein

Transcriptional regulatory protein CreB

Gene

creB

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Member of the two-component regulatory system CreC/CreB involved in catabolic regulation.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. identical protein binding Source: IntAct
    3. phosphorelay response regulator activity Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation, Two-component regulatory system

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciEcoCyc:CREB-MONOMER.
    ECOL316407:JW4361-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional regulatory protein CreB
    Gene namesi
    Name:creB
    Synonyms:yjjE
    Ordered Locus Names:b4398, JW4361
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG11218. creB.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 229229Transcriptional regulatory protein CreBPRO_0000081082Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei54 – 5414-aspartylphosphatePROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated by CreC.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Gene expression databases

    GenevestigatoriP08368.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-1131567,EBI-1131567

    Protein-protein interaction databases

    DIPiDIP-9318N.
    IntActiP08368. 4 interactions.
    STRINGi511145.b4398.

    Structurei

    3D structure databases

    ProteinModelPortaliP08368.
    SMRiP08368. Positions 4-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 119119Response regulatoryPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 response regulatory domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0745.
    HOGENOMiHOG000034819.
    KOiK07663.
    OMAiAHRVTAG.
    OrthoDBiEOG6G4VQG.
    PhylomeDBiP08368.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR011006. CheY-like_superfamily.
    IPR001867. Sig_transdc_resp-reg_C.
    IPR016032. Sig_transdc_resp-reg_C-effctor.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00072. Response_reg. 1 hit.
    PF00486. Trans_reg_C. 1 hit.
    [Graphical view]
    SMARTiSM00448. REC. 1 hit.
    SM00862. Trans_reg_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46894. SSF46894. 1 hit.
    SSF52172. SSF52172. 1 hit.
    PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08368-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRETVWLVE DEQGIADTLV YMLQQEGFAV EVFERGLPVL DKARKQVPDV    50
    MILDVGLPDI SGFELCRQLL ALHPALPVLF LTARSEEVDR LLGLEIGADD 100
    YVAKPFSPRE VCARVRTLLR RVKKFSTPSP VIRIGHFELN EPAAQISWFD 150
    TPLALTRYEF LLLKTLLKSP GRVWSRQQLM DSVWEDAQDT YDRTVDTHIK 200
    TLRAKLRAIN PDLSPINTHR GMGYSLRGL 229
    Length:229
    Mass (Da):26,125
    Last modified:August 1, 1988 - v1
    Checksum:iA982C6D832C7607B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13608 Genomic DNA. Translation: AAA24374.1.
    U14003 Genomic DNA. Translation: AAA97294.1.
    U00096 Genomic DNA. Translation: AAC77351.1.
    AP009048 Genomic DNA. Translation: BAE78387.1.
    PIRiB25038. QQECFJ.
    RefSeqiNP_418815.1. NC_000913.3.
    YP_492528.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC77351; AAC77351; b4398.
    BAE78387; BAE78387; BAE78387.
    GeneIDi12934258.
    948922.
    KEGGiecj:Y75_p4282.
    eco:b4398.
    PATRICi32124414. VBIEscCol129921_4547.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13608 Genomic DNA. Translation: AAA24374.1 .
    U14003 Genomic DNA. Translation: AAA97294.1 .
    U00096 Genomic DNA. Translation: AAC77351.1 .
    AP009048 Genomic DNA. Translation: BAE78387.1 .
    PIRi B25038. QQECFJ.
    RefSeqi NP_418815.1. NC_000913.3.
    YP_492528.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P08368.
    SMRi P08368. Positions 4-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-9318N.
    IntActi P08368. 4 interactions.
    STRINGi 511145.b4398.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC77351 ; AAC77351 ; b4398 .
    BAE78387 ; BAE78387 ; BAE78387 .
    GeneIDi 12934258.
    948922.
    KEGGi ecj:Y75_p4282.
    eco:b4398.
    PATRICi 32124414. VBIEscCol129921_4547.

    Organism-specific databases

    EchoBASEi EB1201.
    EcoGenei EG11218. creB.

    Phylogenomic databases

    eggNOGi COG0745.
    HOGENOMi HOG000034819.
    KOi K07663.
    OMAi AHRVTAG.
    OrthoDBi EOG6G4VQG.
    PhylomeDBi P08368.

    Enzyme and pathway databases

    BioCyci EcoCyc:CREB-MONOMER.
    ECOL316407:JW4361-MONOMER.

    Miscellaneous databases

    PROi P08368.

    Gene expression databases

    Genevestigatori P08368.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR011006. CheY-like_superfamily.
    IPR001867. Sig_transdc_resp-reg_C.
    IPR016032. Sig_transdc_resp-reg_C-effctor.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00072. Response_reg. 1 hit.
    PF00486. Trans_reg_C. 1 hit.
    [Graphical view ]
    SMARTi SM00448. REC. 1 hit.
    SM00862. Trans_reg_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46894. SSF46894. 1 hit.
    SSF52172. SSF52172. 1 hit.
    PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the phoM region of Escherichia coli: four open reading frames may constitute an operon."
      Amemura M., Makino K., Shinagawa H., Nakata A.
      J. Bacteriol. 168:294-302(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
      Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
      Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    5. "Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli."
      Yamamoto K., Hirao K., Oshima T., Aiba H., Utsumi R., Ishihama A.
      J. Biol. Chem. 280:1448-1456(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION.
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

    Entry informationi

    Entry nameiCREB_ECOLI
    AccessioniPrimary (citable) accession number: P08368
    Secondary accession number(s): Q2M5R9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3