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Protein

Transcriptional regulatory protein CreB

Gene

creB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system CreC/CreB involved in catabolic regulation.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. identical protein binding Source: IntAct

GO - Biological processi

  1. phosphorelay signal transduction system Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:CREB-MONOMER.
ECOL316407:JW4361-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein CreB
Gene namesi
Name:creB
Synonyms:yjjE
Ordered Locus Names:b4398, JW4361
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11218. creB.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Transcriptional regulatory protein CreBPRO_0000081082Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 5414-aspartylphosphatePROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by CreC.1 Publication

Keywords - PTMi

Phosphoprotein

Expressioni

Gene expression databases

GenevestigatoriP08368.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1131567,EBI-1131567

Protein-protein interaction databases

DIPiDIP-9318N.
IntActiP08368. 4 interactions.
STRINGi511145.b4398.

Structurei

3D structure databases

ProteinModelPortaliP08368.
SMRiP08368. Positions 6-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 119119Response regulatoryPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034819.
InParanoidiP08368.
KOiK07663.
OMAiGYMLRPA.
OrthoDBiEOG6G4VQG.
PhylomeDBiP08368.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRETVWLVE DEQGIADTLV YMLQQEGFAV EVFERGLPVL DKARKQVPDV
60 70 80 90 100
MILDVGLPDI SGFELCRQLL ALHPALPVLF LTARSEEVDR LLGLEIGADD
110 120 130 140 150
YVAKPFSPRE VCARVRTLLR RVKKFSTPSP VIRIGHFELN EPAAQISWFD
160 170 180 190 200
TPLALTRYEF LLLKTLLKSP GRVWSRQQLM DSVWEDAQDT YDRTVDTHIK
210 220
TLRAKLRAIN PDLSPINTHR GMGYSLRGL
Length:229
Mass (Da):26,125
Last modified:July 31, 1988 - v1
Checksum:iA982C6D832C7607B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13608 Genomic DNA. Translation: AAA24374.1.
U14003 Genomic DNA. Translation: AAA97294.1.
U00096 Genomic DNA. Translation: AAC77351.1.
AP009048 Genomic DNA. Translation: BAE78387.1.
PIRiB25038. QQECFJ.
RefSeqiNP_418815.1. NC_000913.3.
YP_492528.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC77351; AAC77351; b4398.
BAE78387; BAE78387; BAE78387.
GeneIDi12934258.
948922.
KEGGiecj:Y75_p4282.
eco:b4398.
PATRICi32124414. VBIEscCol129921_4547.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13608 Genomic DNA. Translation: AAA24374.1.
U14003 Genomic DNA. Translation: AAA97294.1.
U00096 Genomic DNA. Translation: AAC77351.1.
AP009048 Genomic DNA. Translation: BAE78387.1.
PIRiB25038. QQECFJ.
RefSeqiNP_418815.1. NC_000913.3.
YP_492528.1. NC_007779.1.

3D structure databases

ProteinModelPortaliP08368.
SMRiP08368. Positions 6-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-9318N.
IntActiP08368. 4 interactions.
STRINGi511145.b4398.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77351; AAC77351; b4398.
BAE78387; BAE78387; BAE78387.
GeneIDi12934258.
948922.
KEGGiecj:Y75_p4282.
eco:b4398.
PATRICi32124414. VBIEscCol129921_4547.

Organism-specific databases

EchoBASEiEB1201.
EcoGeneiEG11218. creB.

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034819.
InParanoidiP08368.
KOiK07663.
OMAiGYMLRPA.
OrthoDBiEOG6G4VQG.
PhylomeDBiP08368.

Enzyme and pathway databases

BioCyciEcoCyc:CREB-MONOMER.
ECOL316407:JW4361-MONOMER.

Miscellaneous databases

PROiP08368.

Gene expression databases

GenevestigatoriP08368.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the phoM region of Escherichia coli: four open reading frames may constitute an operon."
    Amemura M., Makino K., Shinagawa H., Nakata A.
    J. Bacteriol. 168:294-302(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
    Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 23:2105-2119(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli."
    Yamamoto K., Hirao K., Oshima T., Aiba H., Utsumi R., Ishihama A.
    J. Biol. Chem. 280:1448-1456(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiCREB_ECOLI
AccessioniPrimary (citable) accession number: P08368
Secondary accession number(s): Q2M5R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 31, 1988
Last sequence update: July 31, 1988
Last modified: January 6, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.