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P08368

- CREB_ECOLI

UniProt

P08368 - CREB_ECOLI

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Protein
Transcriptional regulatory protein CreB
Gene
creB, yjjE, b4398, JW4361
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system CreC/CreB involved in catabolic regulation.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. identical protein binding Source: IntAct
  3. phosphorelay response regulator activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:CREB-MONOMER.
ECOL316407:JW4361-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein CreB
Gene namesi
Name:creB
Synonyms:yjjE
Ordered Locus Names:b4398, JW4361
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG11218. creB.

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Transcriptional regulatory protein CreB
PRO_0000081082Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 5414-aspartylphosphate By similarity

Post-translational modificationi

Phosphorylated by CreC.1 Publication

Keywords - PTMi

Phosphoprotein

Expressioni

Gene expression databases

GenevestigatoriP08368.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1131567,EBI-1131567

Protein-protein interaction databases

DIPiDIP-9318N.
IntActiP08368. 4 interactions.
STRINGi511145.b4398.

Structurei

3D structure databases

ProteinModelPortaliP08368.
SMRiP08368. Positions 4-224.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 119119Response regulatory
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034819.
KOiK07663.
OMAiAHRVTAG.
OrthoDBiEOG6G4VQG.
PhylomeDBiP08368.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08368-1 [UniParc]FASTAAdd to Basket

« Hide

MQRETVWLVE DEQGIADTLV YMLQQEGFAV EVFERGLPVL DKARKQVPDV    50
MILDVGLPDI SGFELCRQLL ALHPALPVLF LTARSEEVDR LLGLEIGADD 100
YVAKPFSPRE VCARVRTLLR RVKKFSTPSP VIRIGHFELN EPAAQISWFD 150
TPLALTRYEF LLLKTLLKSP GRVWSRQQLM DSVWEDAQDT YDRTVDTHIK 200
TLRAKLRAIN PDLSPINTHR GMGYSLRGL 229
Length:229
Mass (Da):26,125
Last modified:August 1, 1988 - v1
Checksum:iA982C6D832C7607B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13608 Genomic DNA. Translation: AAA24374.1.
U14003 Genomic DNA. Translation: AAA97294.1.
U00096 Genomic DNA. Translation: AAC77351.1.
AP009048 Genomic DNA. Translation: BAE78387.1.
PIRiB25038. QQECFJ.
RefSeqiNP_418815.1. NC_000913.3.
YP_492528.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC77351; AAC77351; b4398.
BAE78387; BAE78387; BAE78387.
GeneIDi12934258.
948922.
KEGGiecj:Y75_p4282.
eco:b4398.
PATRICi32124414. VBIEscCol129921_4547.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13608 Genomic DNA. Translation: AAA24374.1 .
U14003 Genomic DNA. Translation: AAA97294.1 .
U00096 Genomic DNA. Translation: AAC77351.1 .
AP009048 Genomic DNA. Translation: BAE78387.1 .
PIRi B25038. QQECFJ.
RefSeqi NP_418815.1. NC_000913.3.
YP_492528.1. NC_007779.1.

3D structure databases

ProteinModelPortali P08368.
SMRi P08368. Positions 4-224.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-9318N.
IntActi P08368. 4 interactions.
STRINGi 511145.b4398.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC77351 ; AAC77351 ; b4398 .
BAE78387 ; BAE78387 ; BAE78387 .
GeneIDi 12934258.
948922.
KEGGi ecj:Y75_p4282.
eco:b4398.
PATRICi 32124414. VBIEscCol129921_4547.

Organism-specific databases

EchoBASEi EB1201.
EcoGenei EG11218. creB.

Phylogenomic databases

eggNOGi COG0745.
HOGENOMi HOG000034819.
KOi K07663.
OMAi AHRVTAG.
OrthoDBi EOG6G4VQG.
PhylomeDBi P08368.

Enzyme and pathway databases

BioCyci EcoCyc:CREB-MONOMER.
ECOL316407:JW4361-MONOMER.

Miscellaneous databases

PROi P08368.

Gene expression databases

Genevestigatori P08368.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view ]
SMARTi SM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the phoM region of Escherichia coli: four open reading frames may constitute an operon."
    Amemura M., Makino K., Shinagawa H., Nakata A.
    J. Bacteriol. 168:294-302(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
    Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli."
    Yamamoto K., Hirao K., Oshima T., Aiba H., Utsumi R., Ishihama A.
    J. Biol. Chem. 280:1448-1456(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiCREB_ECOLI
AccessioniPrimary (citable) accession number: P08368
Secondary accession number(s): Q2M5R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 14, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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