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P08368 (CREB_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional regulatory protein CreB
Gene names
Name:creB
Synonyms:yjjE
Ordered Locus Names:b4398, JW4361
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Member of the two-component regulatory system CreC/CreB involved in catabolic regulation.

Subcellular location

Cytoplasm Probable.

Post-translational modification

Phosphorylated by CreC. Ref.5

Sequence similarities

Contains 1 response regulatory domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself2EBI-1131567,EBI-1131567

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229Transcriptional regulatory protein CreB
PRO_0000081082

Regions

Domain1 – 119119Response regulatory

Amino acid modifications

Modified residue5414-aspartylphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
P08368 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: A982C6D832C7607B

FASTA22926,125
        10         20         30         40         50         60 
MQRETVWLVE DEQGIADTLV YMLQQEGFAV EVFERGLPVL DKARKQVPDV MILDVGLPDI 

        70         80         90        100        110        120 
SGFELCRQLL ALHPALPVLF LTARSEEVDR LLGLEIGADD YVAKPFSPRE VCARVRTLLR 

       130        140        150        160        170        180 
RVKKFSTPSP VIRIGHFELN EPAAQISWFD TPLALTRYEF LLLKTLLKSP GRVWSRQQLM 

       190        200        210        220 
DSVWEDAQDT YDRTVDTHIK TLRAKLRAIN PDLSPINTHR GMGYSLRGL 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the phoM region of Escherichia coli: four open reading frames may constitute an operon."
Amemura M., Makino K., Shinagawa H., Nakata A.
J. Bacteriol. 168:294-302(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli."
Yamamoto K., Hirao K., Oshima T., Aiba H., Utsumi R., Ishihama A.
J. Biol. Chem. 280:1448-1456(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION.
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M13608 Genomic DNA. Translation: AAA24374.1.
U14003 Genomic DNA. Translation: AAA97294.1.
U00096 Genomic DNA. Translation: AAC77351.1.
AP009048 Genomic DNA. Translation: BAE78387.1.
PIRQQECFJ. B25038.
RefSeqNP_418815.1. NC_000913.3.
YP_492528.1. NC_007779.1.

3D structure databases

ProteinModelPortalP08368.
SMRP08368. Positions 4-224.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-9318N.
IntActP08368. 4 interactions.
STRING511145.b4398.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC77351; AAC77351; b4398.
BAE78387; BAE78387; BAE78387.
GeneID12934258.
948922.
KEGGecj:Y75_p4282.
eco:b4398.
PATRIC32124414. VBIEscCol129921_4547.

Organism-specific databases

EchoBASEEB1201.
EcoGeneEG11218. creB.

Phylogenomic databases

eggNOGCOG0745.
HOGENOMHOG000034819.
KOK07663.
OMAAQETFER.
OrthoDBEOG6G4VQG.
PhylomeDBP08368.
ProtClustDBPRK11083.

Enzyme and pathway databases

BioCycEcoCyc:CREB-MONOMER.
ECOL316407:JW4361-MONOMER.

Gene expression databases

GenevestigatorP08368.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP08368.

Entry information

Entry nameCREB_ECOLI
AccessionPrimary (citable) accession number: P08368
Secondary accession number(s): Q2M5R9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 16, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene