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Protein

Transcriptional regulatory protein CreB

Gene

creB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system CreC/CreB involved in catabolic regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi129 – 228OmpR/PhoB-typePROSITE-ProRule annotationAdd BLAST100

GO - Molecular functioni

  • bacterial-type proximal promoter sequence-specific DNA binding Source: EcoCyc
  • identical protein binding Source: IntAct

GO - Biological processi

  • phosphorelay signal transduction system Source: UniProtKB-KW
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system

Enzyme and pathway databases

BioCyciEcoCyc:CREB-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein CreB
Gene namesi
Name:creB
Synonyms:yjjE
Ordered Locus Names:b4398, JW4361
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11218 creB

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000810821 – 229Transcriptional regulatory protein CreBAdd BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei544-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by CreC.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP08368
PRIDEiP08368

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1131567,EBI-1131567

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4263252, 1 interactor
DIPiDIP-9318N
IntActiP08368, 4 interactors
STRINGi316385.ECDH10B_4556

Structurei

3D structure databases

ProteinModelPortaliP08368
SMRiP08368
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 119Response regulatoryPROSITE-ProRule annotationAdd BLAST115

Phylogenomic databases

eggNOGiENOG4105E3W Bacteria
COG0745 LUCA
HOGENOMiHOG000034819
InParanoidiP08368
KOiK07663
OMAiAVHIRHI
PhylomeDBiP08368

Family and domain databases

CDDicd00156 REC, 1 hit
cd00383 trans_reg_C, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR001867 OmpR/PhoB-type_DNA-bd
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR001789 Sig_transdc_resp-reg_receiver
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00072 Response_reg, 1 hit
PF00486 Trans_reg_C, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SM00862 Trans_reg_C, 1 hit
SUPFAMiSSF46894 SSF46894, 1 hit
SSF52172 SSF52172, 1 hit
PROSITEiView protein in PROSITE
PS51755 OMPR_PHOB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

P08368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRETVWLVE DEQGIADTLV YMLQQEGFAV EVFERGLPVL DKARKQVPDV
60 70 80 90 100
MILDVGLPDI SGFELCRQLL ALHPALPVLF LTARSEEVDR LLGLEIGADD
110 120 130 140 150
YVAKPFSPRE VCARVRTLLR RVKKFSTPSP VIRIGHFELN EPAAQISWFD
160 170 180 190 200
TPLALTRYEF LLLKTLLKSP GRVWSRQQLM DSVWEDAQDT YDRTVDTHIK
210 220
TLRAKLRAIN PDLSPINTHR GMGYSLRGL
Length:229
Mass (Da):26,125
Last modified:August 1, 1988 - v1
Checksum:iA982C6D832C7607B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13608 Genomic DNA Translation: AAA24374.1
U14003 Genomic DNA Translation: AAA97294.1
U00096 Genomic DNA Translation: AAC77351.1
AP009048 Genomic DNA Translation: BAE78387.1
PIRiB25038 QQECFJ
RefSeqiNP_418815.1, NC_000913.3
WP_001188654.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77351; AAC77351; b4398
BAE78387; BAE78387; BAE78387
GeneIDi948922
KEGGiecj:JW4361
eco:b4398
PATRICifig|1411691.4.peg.2286

Similar proteinsi

Entry informationi

Entry nameiCREB_ECOLI
AccessioniPrimary (citable) accession number: P08368
Secondary accession number(s): Q2M5R9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: March 28, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health