Transcriptional regulatory protein CreB - Escherichia coli (strain K12)

Contribute

Send feedback

Read comments (?) or add your own

P08368 (CREB_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 114. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Transcriptional regulatory protein CreB

Gene names

Name:	creB
Synonyms:	yjjE
Ordered Locus Names:	b4398, JW4361

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Member of the two-component regulatory system CreC/CreB involved in catabolic regulation.
Subcellular location	Cytoplasm Probable.
Post-translational modification	Phosphorylated by CreC. Ref.5
Sequence similarities	Contains 1 response regulatory domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Two-component regulatory system
Cellular component	Cytoplasm
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW phosphorelay response regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 229

229

Transcriptional regulatory protein CreB

PRO_0000081082

Regions

Domain

1 – 119

119

Response regulatory

Amino acid modifications

Modified residue

4-aspartylphosphate By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P08368 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: A982C6D832C7607B
Show »

FASTA

229

26,125

        10         20         30         40         50         60 
MQRETVWLVE DEQGIADTLV YMLQQEGFAV EVFERGLPVL DKARKQVPDV MILDVGLPDI 

        70         80         90        100        110        120 
SGFELCRQLL ALHPALPVLF LTARSEEVDR LLGLEIGADD YVAKPFSPRE VCARVRTLLR 

       130        140        150        160        170        180 
RVKKFSTPSP VIRIGHFELN EPAAQISWFD TPLALTRYEF LLLKTLLKSP GRVWSRQQLM 

       190        200        210        220 
DSVWEDAQDT YDRTVDTHIK TLRAKLRAIN PDLSPINTHR GMGYSLRGL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the phoM region of Escherichia coli: four open reading frames may constitute an operon." Amemura M., Makino K., Shinagawa H., Nakata A. J. Bacteriol. 168:294-302(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R. Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli." Yamamoto K., Hirao K., Oshima T., Aiba H., Utsumi R., Ishihama A. J. Biol. Chem. 280:1448-1456(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M13608 Genomic DNA. Translation: AAA24374.1. U14003 Genomic DNA. Translation: AAA97294.1. U00096 Genomic DNA. Translation: AAC77351.1. AP009048 Genomic DNA. Translation: BAE78387.1.
PIR	QQECFJ. B25038.
RefSeq	NP_418815.1. NC_000913.2. YP_492528.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P08368.
SMR	P08368. Positions 4-227.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-9318N.
IntAct	P08368. 1 interaction.
STRING	511145.b4398.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC77351; AAC77351; b4398. BAE78387; BAE78387; BAE78387.
GeneID	12934258. 948922.
KEGG	ecj:Y75_p4282. eco:b4398.
PATRIC	32124414. VBIEscCol129921_4547.
Organism-specific databases
EchoBASE	EB1201.
EcoGene	EG11218. creB.
Phylogenomic databases
eggNOG	COG0745.
HOGENOM	HOG000034819.
KO	K07663.
OMA	CARVRTI.
ProtClustDB	PRK11083.
Enzyme and pathway databases
BioCyc	EcoCyc:CREB-MONOMER. ECOL316407:JW4361-MONOMER.
Gene expression databases
Genevestigator	P08368.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR011006. CheY-like_superfamily. IPR001867. Sig_transdc_resp-reg_C. IPR001789. Sig_transdc_resp-reg_receiver. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00072. Response_reg. 1 hit. PF00486. Trans_reg_C. 1 hit. [Graphical view]
SMART	SM00448. REC. 1 hit. SM00862. Trans_reg_C. 1 hit. [Graphical view]
SUPFAM	SSF52172. CheY_like. 1 hit.
PROSITE	PS50110. RESPONSE_REGULATORY. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CREB_ECOLI

Accession

Primary (citable) accession number: P08368
Secondary accession number(s): Q2M5R9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	May 1, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents