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Protein

Antitoxin ChpS

Gene

chpS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Antitoxin component of a type II toxin-antitoxin (TA) module. May be involved in the regulation of cell growth. It acts as a suppressor of the endoribonuclease (inhibitory function) of ChpB protein. Both ChpS and ChpB probably bind to the promoter region of the chpS-chpB operon to autoregulate their synthesis.2 Publications

GO - Molecular functioni

GO - Biological processi

  • positive regulation of cell growth Source: EcoCyc
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11250-MONOMER.
ECOL316407:JW5750-MONOMER.
MetaCyc:EG11250-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Antitoxin ChpS
Gene namesi
Name:chpS
Synonyms:chpBI, yjfB
Ordered Locus Names:b4224, JW5750
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11250. chpS.

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8383Antitoxin ChpSPRO_0000089651Add
BLAST

Proteomic databases

PaxDbiP08365.

Expressioni

Inductioni

Part of the chpS-chpB operon.1 Publication

Interactioni

Subunit structurei

Interacts with ChpB, inhibiting its endoribonuclease activity.1 Publication

Protein-protein interaction databases

DIPiDIP-9280N.
IntActiP08365. 1 interaction.
MINTiMINT-1263242.
STRINGi511145.b4224.

Structurei

3D structure databases

ProteinModelPortaliP08365.
SMRiP08365. Positions 1-74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 4846SpoVT-AbrBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PemI family.Curated
Contains 1 SpoVT-AbrB domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41087RY. Bacteria.
ENOG41102J6. LUCA.
HOGENOMiHOG000289070.
KOiK18842.
OMAiLEQMHAS.
PhylomeDBiP08365.

Family and domain databases

InterProiIPR007159. SpoVT-AbrB_dom.
[Graphical view]
PfamiPF04014. MazE_antitoxin. 1 hit.
[Graphical view]
SMARTiSM00966. SpoVT_AbrB. 1 hit.
[Graphical view]
PROSITEiPS51740. SPOVT_ABRB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08365-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRITIKRWGN SAGMVIPNIV MKELNLQPGQ SVEAQVSNNQ LILTPISRRY
60 70 80
SLDELLAQCD MNAAELSEQD VWGKSTPAGD EIW
Length:83
Mass (Da):9,272
Last modified:August 1, 1988 - v1
Checksum:iA680B3BD47985A2D
GO

Sequence cautioni

The sequence AAA24011 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAA97121 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16451 Genomic DNA. Translation: BAA41179.1.
M14018 Genomic DNA. Translation: AAA24011.1. Different initiation.
U14003 Genomic DNA. Translation: AAA97121.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77181.2.
AP009048 Genomic DNA. Translation: BAE78225.1.
PIRiS56450. QQECR8.
RefSeqiNP_418645.2. NC_000913.3.
WP_001223208.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77181; AAC77181; b4224.
BAE78225; BAE78225; BAE78225.
GeneIDi948739.
KEGGiecj:JW5750.
eco:b4224.
PATRICi32124023. VBIEscCol129921_4356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16451 Genomic DNA. Translation: BAA41179.1.
M14018 Genomic DNA. Translation: AAA24011.1. Different initiation.
U14003 Genomic DNA. Translation: AAA97121.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77181.2.
AP009048 Genomic DNA. Translation: BAE78225.1.
PIRiS56450. QQECR8.
RefSeqiNP_418645.2. NC_000913.3.
WP_001223208.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP08365.
SMRiP08365. Positions 1-74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-9280N.
IntActiP08365. 1 interaction.
MINTiMINT-1263242.
STRINGi511145.b4224.

Proteomic databases

PaxDbiP08365.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77181; AAC77181; b4224.
BAE78225; BAE78225; BAE78225.
GeneIDi948739.
KEGGiecj:JW5750.
eco:b4224.
PATRICi32124023. VBIEscCol129921_4356.

Organism-specific databases

EchoBASEiEB1230.
EcoGeneiEG11250. chpS.

Phylogenomic databases

eggNOGiENOG41087RY. Bacteria.
ENOG41102J6. LUCA.
HOGENOMiHOG000289070.
KOiK18842.
OMAiLEQMHAS.
PhylomeDBiP08365.

Enzyme and pathway databases

BioCyciEcoCyc:EG11250-MONOMER.
ECOL316407:JW5750-MONOMER.
MetaCyc:EG11250-MONOMER.

Miscellaneous databases

PROiP08365.

Family and domain databases

InterProiIPR007159. SpoVT-AbrB_dom.
[Graphical view]
PfamiPF04014. MazE_antitoxin. 1 hit.
[Graphical view]
SMARTiSM00966. SpoVT_AbrB. 1 hit.
[Graphical view]
PROSITEiPS51740. SPOVT_ABRB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHPS_ECOLI
AccessioniPrimary (citable) accession number: P08365
Secondary accession number(s): P76803, Q2M681
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.