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Protein

Antitoxin ChpS

Gene

chpS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antitoxin component of a type II toxin-antitoxin (TA) system. May be involved in the regulation of cell growth. It acts as a suppressor of the endoribonuclease (inhibitory function) of ChpB protein. Both ChpS and ChpB probably bind to the promoter region of the chpS-chpB operon to autoregulate their synthesis.2 Publications

GO - Molecular functioni

GO - Biological processi

  • positive regulation of cell growth Source: EcoCyc
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processToxin-antitoxin system, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG11250-MONOMER
MetaCyc:EG11250-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Antitoxin ChpS
Gene namesi
Name:chpS
Synonyms:chpBI, yjfB
Ordered Locus Names:b4224, JW5750
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11250 chpS

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000896511 – 83Antitoxin ChpSAdd BLAST83

Proteomic databases

PaxDbiP08365
PRIDEiP08365

Expressioni

Inductioni

Part of the chpS-chpB operon.1 Publication

Interactioni

Subunit structurei

Interacts with ChpB, inhibiting its endoribonuclease activity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ptaP0A9M83EBI-556499,EBI-555015

Protein-protein interaction databases

DIPiDIP-9280N
IntActiP08365, 1 interactor
STRINGi316385.ECDH10B_4419

Structurei

3D structure databases

ProteinModelPortaliP08365
SMRiP08365
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 48SpoVT-AbrBPROSITE-ProRule annotationAdd BLAST46

Sequence similaritiesi

Belongs to the PemI family.Curated

Phylogenomic databases

eggNOGiENOG41087RY Bacteria
ENOG41102J6 LUCA
HOGENOMiHOG000289070
KOiK18842
OMAiLEQMHAS
PhylomeDBiP08365

Family and domain databases

InterProiView protein in InterPro
IPR007159 SpoVT-AbrB_dom
IPR037914 SpoVT-AbrB_sf
PfamiView protein in Pfam
PF04014 MazE_antitoxin, 1 hit
SMARTiView protein in SMART
SM00966 SpoVT_AbrB, 1 hit
SUPFAMiSSF89447 SSF89447, 1 hit
PROSITEiView protein in PROSITE
PS51740 SPOVT_ABRB, 1 hit

Sequencei

Sequence statusi: Complete.

P08365-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRITIKRWGN SAGMVIPNIV MKELNLQPGQ SVEAQVSNNQ LILTPISRRY
60 70 80
SLDELLAQCD MNAAELSEQD VWGKSTPAGD EIW
Length:83
Mass (Da):9,272
Last modified:August 1, 1988 - v1
Checksum:iA680B3BD47985A2D
GO

Sequence cautioni

The sequence AAA24011 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAA97121 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16451 Genomic DNA Translation: BAA41179.1
M14018 Genomic DNA Translation: AAA24011.1 Different initiation.
U14003 Genomic DNA Translation: AAA97121.1 Different initiation.
U00096 Genomic DNA Translation: AAC77181.2
AP009048 Genomic DNA Translation: BAE78225.1
PIRiS56450 QQECR8
RefSeqiNP_418645.2, NC_000913.3
WP_001223208.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77181; AAC77181; b4224
BAE78225; BAE78225; BAE78225
GeneIDi948739
KEGGiecj:JW5750
eco:b4224
PATRICifig|1411691.4.peg.2477

Similar proteinsi

Entry informationi

Entry nameiCHPS_ECOLI
AccessioniPrimary (citable) accession number: P08365
Secondary accession number(s): P76803, Q2M681
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health