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P08362

- HEMA_MEASE

UniProt

P08362 - HEMA_MEASE

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Protein

Hemagglutinin glycoprotein

Gene

H

Organism
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis.1 Publication

GO - Molecular functioni

  1. exo-alpha-sialidase activity Source: InterPro

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin glycoprotein
Gene namesi
Name:H
OrganismiMeasles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
Taxonomic identifieri11235 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeMorbillivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000000833: Genome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737IntravirionSequence AnalysisAdd
BLAST
Transmembranei38 – 5821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini59 – 617559Virion surfaceSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Hemagglutinin glycoproteinPRO_0000142599Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi168 – 1681N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi187 – 1871N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi200 – 2001N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi215 – 2151N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi238 – 2381N-linked (GlcNAc...); by hostSequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with human PVRL4; this interaction allows virus infection of the respiratory epithelium (By similarity). Interacts with human MCP/CD46 antigen and SLAMF1.By similarity2 Publications

Protein-protein interaction databases

DIPiDIP-59049N.

Structurei

Secondary structure

1
617
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi159 – 1635Combined sources
Beta strandi189 – 19810Combined sources
Helixi205 – 2117Combined sources
Beta strandi215 – 22410Combined sources
Beta strandi227 – 23610Combined sources
Beta strandi250 – 26112Combined sources
Beta strandi264 – 2674Combined sources
Beta strandi269 – 27911Combined sources
Beta strandi281 – 2833Combined sources
Beta strandi286 – 2927Combined sources
Beta strandi295 – 30713Combined sources
Beta strandi313 – 3153Combined sources
Beta strandi318 – 32710Combined sources
Beta strandi333 – 3397Combined sources
Beta strandi344 – 3507Combined sources
Beta strandi355 – 3595Combined sources
Beta strandi362 – 37110Combined sources
Helixi374 – 38512Combined sources
Beta strandi387 – 3893Combined sources
Helixi391 – 3955Combined sources
Helixi400 – 4034Combined sources
Beta strandi409 – 41810Combined sources
Turni420 – 4223Combined sources
Beta strandi425 – 4306Combined sources
Beta strandi442 – 4454Combined sources
Beta strandi451 – 4566Combined sources
Turni460 – 4623Combined sources
Beta strandi466 – 4716Combined sources
Beta strandi473 – 4753Combined sources
Beta strandi477 – 48610Combined sources
Beta strandi488 – 4936Combined sources
Beta strandi495 – 4973Combined sources
Turni504 – 5063Combined sources
Beta strandi509 – 5113Combined sources
Beta strandi519 – 5213Combined sources
Beta strandi524 – 5307Combined sources
Beta strandi531 – 5355Combined sources
Beta strandi538 – 5436Combined sources
Beta strandi548 – 5525Combined sources
Beta strandi565 – 5728Combined sources
Beta strandi574 – 58411Combined sources
Turni588 – 5903Combined sources
Beta strandi595 – 60612Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RKCX-ray2.70A156-617[»]
2ZB5X-ray3.00A149-617[»]
2ZB6X-ray2.60A149-617[»]
3ALWX-ray3.55A184-607[»]
3ALXX-ray3.15A/B/C/D184-607[»]
3ALZX-ray4.52A149-617[»]
3INBX-ray3.10A/B179-617[»]
ProteinModelPortaliP08362.
SMRiP08362. Positions 157-607.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08362.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P08362-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPQRDRINA FYKDNPHPKG SRIVINREHL MIDRPYVLLA VLFVMFLSLI
60 70 80 90 100
GLLAIAGIRL HRAAIYTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG
110 120 130 140 150
DEVGLRTPQR FTDLVKFISD KIKFLNPDRE YDFRDLTWCI NPPERIKLDY
160 170 180 190 200
DQYCADVAAE ELMNALVNST LLETRTTNQF LAVSKGNCSG PTTIRGQFSN
210 220 230 240 250
MSLSLLDLYL GRGYNVSSIV TMTSQGMYGG TYLVEKPNLS SKRSELSQLS
260 270 280 290 300
MYRVFEVGVI RNPGLGAPVF HMTNYLEQPV SNDLSNCMVA LGELKLAALC
310 320 330 340 350
HGEDSITIPY QGSGKGVSFQ LVKLGVWKSP TDMQSWVPLS TDDPVIDRLY
360 370 380 390 400
LSSHRGVIAD NQAKWAVPTT RTDDKLRMET CFQQACKGKI QALCENPEWA
410 420 430 440 450
PLKDNRIPSY GVLSVDLSLT VELKIKIASG FGPLITHGSG MDLYKSNHNN
460 470 480 490 500
VYWLTIPPMK NLALGVINTL EWIPRFKVSP YLFNVPIKEA GEDCHAPTYL
510 520 530 540 550
PAEVDGDVKL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY YVYSPSRSFS
560 570 580 590 600
YFYPFRLPIK GVPIELQVEC FTWDQKLWCR HFCVLADSES GGHITHSGME
610
GMGVSCTVTR EDGTNRR
Length:617
Mass (Da):69,250
Last modified:August 1, 1988 - v1
Checksum:i0E5A05AEDA43D9C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14877 Genomic RNA. Translation: AAA46424.1.
K01711 Genomic RNA. Translation: AAA75500.1.
PIRiA27006. HMNZED.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14877 Genomic RNA. Translation: AAA46424.1 .
K01711 Genomic RNA. Translation: AAA75500.1 .
PIRi A27006. HMNZED.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2RKC X-ray 2.70 A 156-617 [» ]
2ZB5 X-ray 3.00 A 149-617 [» ]
2ZB6 X-ray 2.60 A 149-617 [» ]
3ALW X-ray 3.55 A 184-607 [» ]
3ALX X-ray 3.15 A/B/C/D 184-607 [» ]
3ALZ X-ray 4.52 A 149-617 [» ]
3INB X-ray 3.10 A/B 179-617 [» ]
ProteinModelPortali P08362.
SMRi P08362. Positions 157-607.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59049N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P08362.

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The predicted primary structure of the measles virus hemagglutinin."
    Alkhatib G., Briedis D.J.
    Virology 150:479-490(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Mutated and hypermutated genes of persistent measles viruses which caused lethal human brain diseases."
    Cattaneo R., Schmid A., Spielhofer P., Kaelin K., Baczko K., Meulen V., Pardowitz J., Flanagan S., Rima B.K., Udem S.A.
    Virology 173:415-425(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "The human CD46 molecule is a receptor for measles virus (Edmonston strain)."
    Doerig R.E., Marcil A., Chopra A., Richardson C.D.
    Cell 75:295-305(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HUMAN MCP/CD46.
  4. "Morbillivirus downregulation of CD46."
    Galbraith S.E., Tiwari A., Baron M.D., Lund B.T., Barrett T., Cosby S.L.
    J. Virol. 72:10292-10297(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "SLAM (CDw150) is a cellular receptor for measles virus."
    Tatsuo H., Ono N., Tanaka K., Yanagi Y.
    Nature 406:893-897(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HUMAN SLAMF1.

Entry informationi

Entry nameiHEMA_MEASE
AccessioniPrimary (citable) accession number: P08362
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 26, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

Morbiliviruses hemagglutinins have no neuraminidase activity.Curated

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3