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Protein

Hemagglutinin glycoprotein

Gene

H

Organism
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin glycoprotein
Gene namesi
Name:H
OrganismiMeasles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
Taxonomic identifieri11235 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeMorbillivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000833 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37IntravirionSequence analysisAdd BLAST37
Transmembranei38 – 58Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini59 – 617Virion surfaceSequence analysisAdd BLAST559

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001425991 – 617Hemagglutinin glycoproteinAdd BLAST617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi168N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi187N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi200N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi215N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi238N-linked (GlcNAc...); by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with human NECTIN4; this interaction allows virus infection of the respiratory epithelium (By similarity). Interacts with human MCP/CD46 antigen and SLAMF1.By similarity2 Publications

Protein-protein interaction databases

DIPiDIP-59049N.

Structurei

Secondary structure

1617
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi159 – 163Combined sources5
Beta strandi189 – 198Combined sources10
Helixi205 – 211Combined sources7
Beta strandi215 – 224Combined sources10
Beta strandi227 – 236Combined sources10
Turni238 – 240Combined sources3
Beta strandi250 – 261Combined sources12
Beta strandi264 – 267Combined sources4
Beta strandi269 – 279Combined sources11
Beta strandi281 – 283Combined sources3
Beta strandi286 – 292Combined sources7
Beta strandi295 – 307Combined sources13
Beta strandi313 – 315Combined sources3
Beta strandi318 – 327Combined sources10
Beta strandi333 – 339Combined sources7
Beta strandi344 – 350Combined sources7
Beta strandi355 – 359Combined sources5
Beta strandi362 – 371Combined sources10
Helixi374 – 385Combined sources12
Beta strandi387 – 389Combined sources3
Helixi391 – 395Combined sources5
Helixi400 – 403Combined sources4
Beta strandi409 – 418Combined sources10
Turni420 – 422Combined sources3
Beta strandi425 – 430Combined sources6
Beta strandi442 – 445Combined sources4
Beta strandi451 – 456Combined sources6
Turni460 – 462Combined sources3
Beta strandi466 – 471Combined sources6
Beta strandi473 – 475Combined sources3
Beta strandi477 – 486Combined sources10
Beta strandi488 – 493Combined sources6
Beta strandi495 – 497Combined sources3
Turni504 – 506Combined sources3
Beta strandi509 – 511Combined sources3
Beta strandi519 – 521Combined sources3
Beta strandi524 – 530Combined sources7
Beta strandi531 – 535Combined sources5
Beta strandi538 – 543Combined sources6
Beta strandi548 – 552Combined sources5
Beta strandi565 – 572Combined sources8
Beta strandi574 – 584Combined sources11
Turni588 – 590Combined sources3
Beta strandi595 – 606Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RKCX-ray2.70A156-617[»]
2ZB5X-ray3.00A149-617[»]
2ZB6X-ray2.60A149-617[»]
3ALWX-ray3.55A184-607[»]
3ALXX-ray3.15A/B/C/D184-607[»]
3ALZX-ray4.52A149-617[»]
3INBX-ray3.10A/B179-617[»]
ProteinModelPortaliP08362.
SMRiP08362.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08362.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn/HN.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P08362-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPQRDRINA FYKDNPHPKG SRIVINREHL MIDRPYVLLA VLFVMFLSLI
60 70 80 90 100
GLLAIAGIRL HRAAIYTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG
110 120 130 140 150
DEVGLRTPQR FTDLVKFISD KIKFLNPDRE YDFRDLTWCI NPPERIKLDY
160 170 180 190 200
DQYCADVAAE ELMNALVNST LLETRTTNQF LAVSKGNCSG PTTIRGQFSN
210 220 230 240 250
MSLSLLDLYL GRGYNVSSIV TMTSQGMYGG TYLVEKPNLS SKRSELSQLS
260 270 280 290 300
MYRVFEVGVI RNPGLGAPVF HMTNYLEQPV SNDLSNCMVA LGELKLAALC
310 320 330 340 350
HGEDSITIPY QGSGKGVSFQ LVKLGVWKSP TDMQSWVPLS TDDPVIDRLY
360 370 380 390 400
LSSHRGVIAD NQAKWAVPTT RTDDKLRMET CFQQACKGKI QALCENPEWA
410 420 430 440 450
PLKDNRIPSY GVLSVDLSLT VELKIKIASG FGPLITHGSG MDLYKSNHNN
460 470 480 490 500
VYWLTIPPMK NLALGVINTL EWIPRFKVSP YLFNVPIKEA GEDCHAPTYL
510 520 530 540 550
PAEVDGDVKL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY YVYSPSRSFS
560 570 580 590 600
YFYPFRLPIK GVPIELQVEC FTWDQKLWCR HFCVLADSES GGHITHSGME
610
GMGVSCTVTR EDGTNRR
Length:617
Mass (Da):69,250
Last modified:August 1, 1988 - v1
Checksum:i0E5A05AEDA43D9C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14877 Genomic RNA. Translation: AAA46424.1.
K01711 Genomic RNA. Translation: AAA75500.1.
PIRiA27006. HMNZED.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14877 Genomic RNA. Translation: AAA46424.1.
K01711 Genomic RNA. Translation: AAA75500.1.
PIRiA27006. HMNZED.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RKCX-ray2.70A156-617[»]
2ZB5X-ray3.00A149-617[»]
2ZB6X-ray2.60A149-617[»]
3ALWX-ray3.55A184-607[»]
3ALXX-ray3.15A/B/C/D184-607[»]
3ALZX-ray4.52A149-617[»]
3INBX-ray3.10A/B179-617[»]
ProteinModelPortaliP08362.
SMRiP08362.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59049N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP08362.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn/HN.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHEMA_MEASE
AccessioniPrimary (citable) accession number: P08362
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

Morbiliviruses hemagglutinins have no neuraminidase activity.Curated

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.