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P08362 (HEMA_MEASE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hemagglutinin glycoprotein
Gene names
Name:H
OrganismMeasles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus) [Complete proteome]
Taxonomic identifier11235 [NCBI]
Taxonomic lineageViruses › ssRNA negative-strand viruses › Mononegavirales › Paramyxoviridae › Paramyxovirinae › Morbillivirus ›
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length617 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis. Ref.4

Subunit structure

Interacts with human PVRL4; this interaction allows virus infection of the respiratory epithelium By similarity. Interacts with human MCP/CD46 antigen and SLAMF1. Ref.3 Ref.5

Subcellular location

Virion membrane; Single-pass type II membrane protein Potential. Host cell membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the paramyxoviruses hemagglutinin-neuraminidase family. Non-sialidase subfamily.

Caution

Morbiliviruses hemagglutinins have no neuraminidase activity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 617617Hemagglutinin glycoprotein
PRO_0000142599

Regions

Topological domain1 – 3737Intravirion Potential
Transmembrane38 – 5821Helical; Signal-anchor for type II membrane protein; Potential
Topological domain59 – 617559Virion surface Potential

Amino acid modifications

Glycosylation1681N-linked (GlcNAc...); by host Potential
Glycosylation1871N-linked (GlcNAc...); by host Potential
Glycosylation2001N-linked (GlcNAc...); by host Potential
Glycosylation2151N-linked (GlcNAc...); by host Potential
Glycosylation2381N-linked (GlcNAc...); by host Potential

Secondary structure

1 ...................................................................................... 617
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P08362 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: 0E5A05AEDA43D9C6

FASTA61769,250
        10         20         30         40         50         60 
MSPQRDRINA FYKDNPHPKG SRIVINREHL MIDRPYVLLA VLFVMFLSLI GLLAIAGIRL 

        70         80         90        100        110        120 
HRAAIYTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG DEVGLRTPQR FTDLVKFISD 

       130        140        150        160        170        180 
KIKFLNPDRE YDFRDLTWCI NPPERIKLDY DQYCADVAAE ELMNALVNST LLETRTTNQF 

       190        200        210        220        230        240 
LAVSKGNCSG PTTIRGQFSN MSLSLLDLYL GRGYNVSSIV TMTSQGMYGG TYLVEKPNLS 

       250        260        270        280        290        300 
SKRSELSQLS MYRVFEVGVI RNPGLGAPVF HMTNYLEQPV SNDLSNCMVA LGELKLAALC 

       310        320        330        340        350        360 
HGEDSITIPY QGSGKGVSFQ LVKLGVWKSP TDMQSWVPLS TDDPVIDRLY LSSHRGVIAD 

       370        380        390        400        410        420 
NQAKWAVPTT RTDDKLRMET CFQQACKGKI QALCENPEWA PLKDNRIPSY GVLSVDLSLT 

       430        440        450        460        470        480 
VELKIKIASG FGPLITHGSG MDLYKSNHNN VYWLTIPPMK NLALGVINTL EWIPRFKVSP 

       490        500        510        520        530        540 
YLFNVPIKEA GEDCHAPTYL PAEVDGDVKL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY 

       550        560        570        580        590        600 
YVYSPSRSFS YFYPFRLPIK GVPIELQVEC FTWDQKLWCR HFCVLADSES GGHITHSGME 

       610 
GMGVSCTVTR EDGTNRR

« Hide

References

[1]"The predicted primary structure of the measles virus hemagglutinin."
Alkhatib G., Briedis D.J.
Virology 150:479-490(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Mutated and hypermutated genes of persistent measles viruses which caused lethal human brain diseases."
Cattaneo R., Schmid A., Spielhofer P., Kaelin K., Baczko K., Meulen V., Pardowitz J., Flanagan S., Rima B.K., Udem S.A.
Virology 173:415-425(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[3]"The human CD46 molecule is a receptor for measles virus (Edmonston strain)."
Doerig R.E., Marcil A., Chopra A., Richardson C.D.
Cell 75:295-305(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HUMAN MCP/CD46.
[4]"Morbillivirus downregulation of CD46."
Galbraith S.E., Tiwari A., Baron M.D., Lund B.T., Barrett T., Cosby S.L.
J. Virol. 72:10292-10297(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"SLAM (CDw150) is a cellular receptor for measles virus."
Tatsuo H., Ono N., Tanaka K., Yanagi Y.
Nature 406:893-897(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HUMAN SLAMF1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M14877 Genomic RNA. Translation: AAA46424.1.
K01711 Genomic RNA. Translation: AAA75500.1.
PIRHMNZED. A27006.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2RKCX-ray2.70A156-617[»]
2ZB5X-ray3.00A149-617[»]
2ZB6X-ray2.60A149-617[»]
3ALWX-ray3.55A184-607[»]
3ALXX-ray3.15A/B/C/D184-607[»]
3ALZX-ray4.52A149-617[»]
3INBX-ray3.10A/B179-617[»]
ProteinModelPortalP08362.
SMRP08362. Positions 157-607.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-59049N.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.120.10.10. 1 hit.
InterProIPR000665. Hemagglutn-neuramid.
IPR011040. Sialidases.
[Graphical view]
PfamPF00423. HN. 1 hit.
[Graphical view]
SUPFAMSSF50939. Sialidase. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP08362.

Entry information

Entry nameHEMA_MEASE
AccessionPrimary (citable) accession number: P08362
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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