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Protein

Large structural phosphoprotein

Gene

UL32

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the last steps of viral maturation and release. Associates with nuclear capsids prior to DNA encapsidation and later preserves the integrity of nucleocapsids through secondary envelopment at the assembly compartment. Interacts with host CCNA2 and thereby blocks the onset of lytic gene expression to promote establishment of a quiescent state of infection in undifferentiated cells.5 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Large structural phosphoprotein
Alternative name(s):
150 kDa matrix phosphoprotein
150 kDa phosphoprotein
Short name:
pp150
Basic phosphoprotein
Short name:
BPP
Phosphoprotein UL32
Tegument protein UL32
Gene namesi
Name:UL32
OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri10360 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008992 Componenti: Genome
  • UP000008991 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • host cell cytoplasmic vesicle Source: BHF-UCL
  • host cell nucleus Source: UniProtKB-SubCell
  • host cell perinuclear region of cytoplasm Source: BHF-UCL
  • host cell viral assembly compartment Source: BHF-UCL
  • viral tegument Source: UniProtKB-SubCell

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001163021 – 1048Large structural phosphoproteinAdd BLAST1048

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
GlycosylationiCAR_000179921O-linked (GlcNAc) serine; by host1 Publication1
GlycosylationiCAR_000195952O-linked (GlcNAc) serine; by host1 Publication1

Post-translational modificationi

Phosphorylated by host CCNA2.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP08318.

PTM databases

UniCarbKBiP08318.

Interactioni

Subunit structurei

Interacts with host BICD1 and RAB6A. Interacts with small capsid protein UL48A; this interaction links together the capsid and pp150. Interacts with host CCNA2.4 Publications

Structurei

3D structure databases

ProteinModelPortaliP08318.
SMRiP08318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi410 – 413Poly-Pro4
Compositional biasi429 – 437Poly-Asp9
Compositional biasi485 – 488Poly-Gln4
Compositional biasi825 – 888Ser-richAdd BLAST64

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG09000030.

Family and domain databases

InterProiView protein in InterPro
IPR010340. Herpes_UL11/UL32.
PfamiView protein in Pfam
PF06070. Herpes_UL32. 1 hit.

Sequencei

Sequence statusi: Complete.

P08318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQFIGLQR RDVVALVNFL RHLTQKPDVD LEAHPKILKK CGEKRLHRRT
60 70 80 90 100
VLFNELMLWL GYYRELRFHN PDLSSVLEEF EVRCVAVARR GYTYPFGDRG
110 120 130 140 150
KARDHLAVLD RTEFDTDVRH DAEIVERALV SAVILAKMSV RETLVTAIGQ
160 170 180 190 200
TEPIAFVHLK DTEVQRIEEN LEGVRRNMFC VKPLDLNLDR HANTALVNAV
210 220 230 240 250
NKLVYTGRLI MNVRRSWEEL ERKCLARIQE RCKLLVKELR MCLSFDSNYC
260 270 280 290 300
RNILKHAVEN GDSADTLLEL LIEDFDIYVD SFPQSAHTFL GARSPSLEFD
310 320 330 340 350
DDANLLSLGG GSAFSSVPKK HVPTQPLDGW SWIASPWKGH KPFRFEAHGS
360 370 380 390 400
LAPAAEAHAA RSAAVGYYDE EEKRRERQKR VDDEVVQREK QQLKAWEERQ
410 420 430 440 450
QNLQQRQQQP PPPARKPSAS RRLFGSSADE DDDDDDDEKN IFTPIKKPGT
460 470 480 490 500
SGKGAASGGG VSSIFSGLLS SGSQKPTSGP LNIPQQQQRH AAFSLVSPQV
510 520 530 540 550
TKASPGRVRR DSAWDVRPLT ETRGDLFSGD EDSDSSDGYP PNRQDPRFTD
560 570 580 590 600
TLVDITDTET SAKPPVTTAY KFEQPTLTFG AGVNVPAGAG AAILTPTPVN
610 620 630 640 650
PSTAPAPAPT PTFAGTQTPV NGNSPWAPTA PLPGDMNPAN WPRERAWALK
660 670 680 690 700
NPHLAYNPFR MPTTSTASQN TVSTTPRRPS TPRAAVTQTA SRDAADEVWA
710 720 730 740 750
LRDQTAESPV EDSEEEDDDS SDTGSVVSLG HTTPSSDYNN DVISPPSQTP
760 770 780 790 800
EQSTPSRIRK AKLSSPMTTT STSQKPVLGK RVATPHASAR AQTVTSTPVQ
810 820 830 840 850
GRLEKQVSGT PSTVPATLLQ PQPASSKTTS SRNVTSGAGT SSASSARQPS
860 870 880 890 900
ASASVLSPTE DDVVSPATSP LSMLSSASPS PAKSAPPSPV KGRGSRVGVP
910 920 930 940 950
SLKPTLGGKA VVGRPPSVPV SGSAPGRLSG SSRAASTTPT YPAVTTVYPP
960 970 980 990 1000
SSTAKSSVSN APPVASPSIL KPGASAALQS RRSTGTAAVG SPVKSTTGMK
1010 1020 1030 1040
TVAFDLSSPQ KSGTGPQPGS AGMGGAKTPS DAVQNILQKI EKIKNTEE
Length:1,048
Mass (Da):112,688
Last modified:August 1, 1988 - v1
Checksum:i9C4DD60B4F56FF1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16022 Genomic DNA. Translation: AAA45992.1.
X17403 Genomic DNA. Translation: CAA35431.1.
BK000394 Genomic DNA. Translation: DAA00137.1.
PIRiA29533. XPBEA9.

Similar proteinsi

Entry informationi

Entry nameiPP150_HCMVA
AccessioniPrimary (citable) accession number: P08318
Secondary accession number(s): Q7M6Q1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 10, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families