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Protein

Interleukin-8

Gene

CXCL8

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils.

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: AgBase
  • chemokine-mediated signaling pathway Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • hemopoiesis Source: AgBase
  • immune response Source: GO_Central
  • leukocyte activation involved in inflammatory response Source: AgBase
  • leukocyte chemotaxis Source: AgBase
  • leukocyte chemotaxis involved in inflammatory response Source: AgBase
  • lymphocyte chemotaxis Source: AgBase
  • macrophage chemotaxis Source: AgBase
  • monocyte chemotaxis Source: AgBase
  • myofibroblast differentiation Source: AgBase
  • negative regulation of fibroblast proliferation Source: AgBase
  • neutrophil activation Source: InterPro
  • neutrophil chemotaxis Source: InterPro
  • positive regulation of gene expression Source: AgBase
  • positive regulation of inflammatory response Source: AgBase
  • positive regulation of neutrophil chemotaxis Source: GO_Central
  • response to lipopolysaccharide Source: GO_Central
  • wound healing Source: AgBase

Keywordsi

Molecular functionCytokine, Growth factor
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-8
Short name:
IL-8
Alternative name(s):
9E3
C-X-C motif chemokine 8
CEF-4
Chemokine (C-X-C motif) ligand 8
Embryo fibroblast protein 1
Short name:
EMF-1
Gene namesi
Name:CXCL8
Synonyms:CEF4, EMF1, IL8
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000000513817 – 103Interleukin-8Add BLAST87

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 60By similarity
Disulfide bondi35 ↔ 76By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP08317

Expressioni

Inductioni

By serum. Expressed constitutively in Rous sarcoma virus (RSV) infected cells.

Gene expression databases

BgeeiENSGALG00000026098
ExpressionAtlasiP08317 differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019051

Structurei

3D structure databases

ProteinModelPortaliP08317
SMRiP08317
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J24U Eukaryota
ENOG410Z1BP LUCA
GeneTreeiENSGT00530000062901
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP08317
KOiK10030
OMAiPTAPWVQ
OrthoDBiEOG091G0YLH
PhylomeDBiP08317
TreeFamiTF333433

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR028469 Interleukin-8
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PTHR10179:SF68 PTHR10179:SF68, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08317-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGKLGAVLA LLLVSAALSQ GRTLVKMGNE LRCQCISTHS KFIHPKSIQD
60 70 80 90 100
VKLTPSGPHC KNVEIIATLK DGREVCLDPT APWVQLIVKA LMAKAQLNSD

APL
Length:103
Mass (Da):11,056
Last modified:August 1, 1988 - v1
Checksum:i28A9802A22349A6F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5L → F in AAA49059 (PubMed:2821543).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16199 mRNA Translation: AAA48758.1
J02975 mRNA Translation: AAA49059.1
AJ009800 Genomic DNA Translation: CAB37669.1
PIRiA26736
I50417
RefSeqiNP_990829.1, NM_205498.1
UniGeneiGga.826

Genome annotation databases

EnsembliENSGALT00000042745; ENSGALP00000041738; ENSGALG00000026098
GeneIDi396495
KEGGigga:396495

Similar proteinsi

Entry informationi

Entry nameiIL8_CHICK
AccessioniPrimary (citable) accession number: P08317
Secondary accession number(s): Q546U2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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