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Protein

Interleukin-8

Gene

CXCL8

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils.

GO - Molecular functioni

  • chemokine activity Source: GO_Central
  • CXCR chemokine receptor binding Source: GO_Central
  • cytokine activity Source: AgBase

GO - Biological processi

  • angiogenesis Source: AgBase
  • chemokine-mediated signaling pathway Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • immune response Source: GO_Central
  • inflammatory response Source: GO_Central
  • lymphocyte chemotaxis Source: AgBase
  • macrophage chemotaxis Source: AgBase
  • monocyte chemotaxis Source: AgBase
  • myofibroblast differentiation Source: AgBase
  • negative regulation of fibroblast proliferation Source: AgBase
  • positive regulation of gene expression Source: AgBase
  • positive regulation of neutrophil chemotaxis Source: GO_Central
  • response to lipopolysaccharide Source: GO_Central
  • wound healing Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiR-GGA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-GGA-375276. Peptide ligand-binding receptors.
R-GGA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-8
Short name:
IL-8
Alternative name(s):
9E3
C-X-C motif chemokine 8
CEF-4
Chemokine (C-X-C motif) ligand 8
Embryo fibroblast protein 1
Short name:
EMF-1
Gene namesi
Name:CXCL8
Synonyms:CEF4, EMF1, IL8
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 10387Interleukin-8PRO_0000005138Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 60By similarity
Disulfide bondi35 ↔ 76By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP08317.

Expressioni

Inductioni

By serum. Expressed constitutively in Rous sarcoma virus (RSV) infected cells.

Gene expression databases

ExpressionAtlasiP08317. baseline and differential.

Interactioni

GO - Molecular functioni

  • chemokine activity Source: GO_Central
  • CXCR chemokine receptor binding Source: GO_Central
  • cytokine activity Source: AgBase

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019051.

Structurei

3D structure databases

ProteinModelPortaliP08317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J24U. Eukaryota.
ENOG410Z1BP. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP08317.
KOiK10030.
OMAiCEAAVLT.
PhylomeDBiP08317.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08317-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGKLGAVLA LLLVSAALSQ GRTLVKMGNE LRCQCISTHS KFIHPKSIQD
60 70 80 90 100
VKLTPSGPHC KNVEIIATLK DGREVCLDPT APWVQLIVKA LMAKAQLNSD

APL
Length:103
Mass (Da):11,056
Last modified:August 1, 1988 - v1
Checksum:i28A9802A22349A6F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51L → F in AAA49059 (PubMed:2821543).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16199 mRNA. Translation: AAA48758.1.
J02975 mRNA. Translation: AAA49059.1.
AJ009800 Genomic DNA. Translation: CAB37669.1.
PIRiA26736.
I50417.
RefSeqiNP_990829.1. NM_205498.1.
UniGeneiGga.826.

Genome annotation databases

EnsembliENSGALT00000042745; ENSGALP00000041738; ENSGALG00000026098.
GeneIDi396495.
KEGGigga:396495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16199 mRNA. Translation: AAA48758.1.
J02975 mRNA. Translation: AAA49059.1.
AJ009800 Genomic DNA. Translation: CAB37669.1.
PIRiA26736.
I50417.
RefSeqiNP_990829.1. NM_205498.1.
UniGeneiGga.826.

3D structure databases

ProteinModelPortaliP08317.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019051.

Proteomic databases

PaxDbiP08317.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000042745; ENSGALP00000041738; ENSGALG00000026098.
GeneIDi396495.
KEGGigga:396495.

Organism-specific databases

CTDi396495.

Phylogenomic databases

eggNOGiENOG410J24U. Eukaryota.
ENOG410Z1BP. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP08317.
KOiK10030.
OMAiCEAAVLT.
PhylomeDBiP08317.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiR-GGA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-GGA-375276. Peptide ligand-binding receptors.
R-GGA-418594. G alpha (i) signalling events.

Miscellaneous databases

NextBioi20816534.
PROiP08317.

Gene expression databases

ExpressionAtlasiP08317. baseline and differential.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Transformation by Rous sarcoma virus induces a novel gene with homology to a mitogenic platelet protein."
    Sugano S., Stoeckle M.Y., Hanafusa H.
    Cell 49:321-328(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Constitutive expression of a gene encoding a polypeptide homologous to biologically active human platelet protein in Rous sarcoma virus-transformed fibroblasts."
    Bedard P.-A., Alcorta D., Simmons D., Luk K.-C., Erikson R.L.
    Proc. Natl. Acad. Sci. U.S.A. 84:6715-6719(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The chicken 9E3/CEF4 CXC chemokine is the avian orthologue of IL8 and maps to chicken chromosome 4 syntenic with genes flanking the mammalian chemokine cluster."
    Kaiser P., Hughes S., Bumstead N.
    Immunogenetics 49:673-684(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiIL8_CHICK
AccessioniPrimary (citable) accession number: P08317
Secondary accession number(s): Q546U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: February 17, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.