ID   ATI2_HHV1F              Reviewed;         715 AA.
AC   P08314;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   24-NOV-2009, entry version 39.
DE   RecName: Full=Alpha trans-inducing factor 78 kDa protein;
DE   AltName: Full=Tegument protein VP11/12;
DE   AltName: Full=Tegument protein UL46;
GN   ORFNames=UL46;
OS   Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
OC   Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10304;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=87141362; PubMed=3029433;
RA   McKnight J.L.C., Pellett P.E., Jenkins F.J., Roizman B.;
RT   "Characterization and nucleotide sequence of two herpes simplex virus
RT   1 genes whose products modulate alpha-trans-inducing factor-dependent
RT   activation of alpha genes.";
RL   J. Virol. 61:992-1001(1987).
CC   -!- FUNCTION: Abundant tegument protein. Trans-activates the immediate
CC       early genes (By similarity).
CC   -!- SUBUNIT: Interacts with VP16 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Virion tegument (By similarity). Host cell
CC       membrane; Peripheral membrane protein (By similarity).
CC   -!- PTM: Phosphorylated. The phosphorylation seems to be lymphocyte-
CC       specific (By similarity).
CC   -!- SIMILARITY: Belongs to the herpesviridae VP11/12 protein family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; M15621; AAA45768.1; -; Genomic_DNA.
DR   PIR; B26133; TNBE77.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR005051; Herpes_UL46.
DR   Pfam; PF03387; Herpes_UL46; 1.
PE   3: Inferred from homology;
KW   Activator; Host cell membrane; Host membrane; Membrane;
KW   Phosphoprotein; Transcription; Transcription regulation; Virion;
KW   Virion tegument.
FT   CHAIN         1    715       Alpha trans-inducing factor 78 kDa
FT                                protein.
FT                                /FTId=PRO_0000115793.
FT   COMPBIAS    582    586       Poly-Asp.
FT   COMPBIAS    665    674       Poly-Pro.
SQ   SEQUENCE   715 AA;  77357 MW;  9490E875ADD88155 CRC64;
     MQRRTRGASS LRLARCLTPA NLIRGDNAGV PERRIFGGCL LPTPEGLLSA AVGALRQRSD
     DAQPAFLTCT DRSVRLAARQ HNTVPESLIV DGLASDPHYE YIRHYASAAT QALGEVELTG
     GQLSRAILTQ YWKYLQTVVP SGLDVPEDPV GDCDPSLHVL LRPTLAPKLL ARTPFKSGAA
     AAKYAATVAG LRDALHRIQQ YMFFMRPADP SRPSTDTALR LNELLAYVSV LYRWASWMLW
     TTDKHVCHRL SPSNRRFLPL GGSPEAPAET FARHLDRGPS GTTGSMQCMA LRAAVSDVLG
     HLTRLANLWQ TGKRSGGTYG TVDTVVSTVE VLSIVHHHAQ YIINATLTGY GVWATDSLNN
     EYLRAAVDSQ ERFCRTTAPL FPTMTAPSWA RMELSIKAWF GAALAADLLR SGAPSLHYES
     ILRLVASRRT TWSAGPPPDD MARGPGGHRA GGGTVGKRFS GPARQRAPAP PPTSPTLDPR
     GHPAVPEAPR GRPAPPLPDA DDPVAEPPGC AAQPATYYTH MGEVPPRLPA RNVAGPDRRP
     PAATCPLLVR RASLGSLDRP RGWGPAPEGE PDQMEATYLT ADDDDDARRK ATHAASARER
     HAPYEDDESI YETVSEDGGR VYEEIPWMRV YENVCANTAN AAPASPYIEA ENPLYDWGGS
     ALFSPPPRPP PPPPLSPSPV LARHRANALT NDGPTNVAAL SALLTKLKRE GRRSR
//