P08314 (ATI2_HHV1F) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha trans-inducing factor 78 kDa protein

Alternative name(s):
Tegument protein UL46
Tegument protein VP11/12

Gene names

ORF Names:

UL46

Organism

Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

Taxonomic identifier

10304 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	715 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Abundant tegument protein. Trans-activates the immediate early genes By similarity.
Subunit structure	Interacts with VP16 By similarity.
Subcellular location	Virion tegument By similarity. Host cell membrane; Peripheral membrane protein By similarity.
Post-translational modification	Phosphorylated. The phosphorylation seems to be lymphocyte-specific By similarity.
Sequence similarities	Belongs to the herpesviridae VP11/12 protein family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Host cell membrane Host membrane Membrane Virion Virion tegument
Molecular function	Activator
PTM	Phosphoprotein
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-KW viral tegument Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 715	715	Alpha trans-inducing factor 78 kDa protein		PRO_0000115793
Regions
	Compositional bias	582 – 586	5	Poly-Asp
	Compositional bias	665 – 674	10	Poly-Pro

Sequences

	Sequence		Length	Mass (Da)
	P08314 [UniParc]. Last modified August 1, 1988. Version 1. Checksum: 9490E875ADD88155	FASTA	715	77,357
	10 20 30 40 50 60 MQRRTRGASS LRLARCLTPA NLIRGDNAGV PERRIFGGCL LPTPEGLLSA AVGALRQRSD 70 80 90 100 110 120 DAQPAFLTCT DRSVRLAARQ HNTVPESLIV DGLASDPHYE YIRHYASAAT QALGEVELTG 130 140 150 160 170 180 GQLSRAILTQ YWKYLQTVVP SGLDVPEDPV GDCDPSLHVL LRPTLAPKLL ARTPFKSGAA 190 200 210 220 230 240 AAKYAATVAG LRDALHRIQQ YMFFMRPADP SRPSTDTALR LNELLAYVSV LYRWASWMLW 250 260 270 280 290 300 TTDKHVCHRL SPSNRRFLPL GGSPEAPAET FARHLDRGPS GTTGSMQCMA LRAAVSDVLG 310 320 330 340 350 360 HLTRLANLWQ TGKRSGGTYG TVDTVVSTVE VLSIVHHHAQ YIINATLTGY GVWATDSLNN 370 380 390 400 410 420 EYLRAAVDSQ ERFCRTTAPL FPTMTAPSWA RMELSIKAWF GAALAADLLR SGAPSLHYES 430 440 450 460 470 480 ILRLVASRRT TWSAGPPPDD MARGPGGHRA GGGTVGKRFS GPARQRAPAP PPTSPTLDPR 490 500 510 520 530 540 GHPAVPEAPR GRPAPPLPDA DDPVAEPPGC AAQPATYYTH MGEVPPRLPA RNVAGPDRRP 550 560 570 580 590 600 PAATCPLLVR RASLGSLDRP RGWGPAPEGE PDQMEATYLT ADDDDDARRK ATHAASARER 610 620 630 640 650 660 HAPYEDDESI YETVSEDGGR VYEEIPWMRV YENVCANTAN AAPASPYIEA ENPLYDWGGS 670 680 690 700 710 ALFSPPPRPP PPPPLSPSPV LARHRANALT NDGPTNVAAL SALLTKLKRE GRRSR

References

[1]

"Characterization and nucleotide sequence of two herpes simplex virus 1 genes whose products modulate alpha-trans-inducing factor-dependent activation of alpha genes." McKnight J.L.C., Pellett P.E., Jenkins F.J., Roizman B. J. Virol. 61:992-1001(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M15621 Genomic DNA. Translation: AAA45768.1.
PIR	TNBE77. B26133.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR005051. Herpes_UL46. [Graphical view]
Pfam	PF03387. Herpes_UL46. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATI2_HHV1F

Accession

Primary (citable) accession number: P08314

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program