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P08314

- TEG1_HHV1F

UniProt

P08314 - TEG1_HHV1F

Protein

Tegument protein UL46

Gene

UL46

Organism
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
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    Functioni

    Abundant tegument protein. Trans-activates the immediate early genes By similarity.By similarity

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tegument protein UL46
    Alternative name(s):
    Tegument protein VP11/12
    Gene namesi
    ORF Names:UL46
    OrganismiHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10304 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Virion tegument By similarity. Host cell membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-KW
    3. viral tegument Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Virion, Virion tegument

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 715715Tegument protein UL46PRO_0000115793Add
    BLAST

    Post-translational modificationi

    Phosphorylated. The phosphorylation seems to be lymphocyte-specific By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with VP16.By similarity

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi582 – 5865Poly-Asp
    Compositional biasi665 – 67410Poly-Pro

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR005051. Herpes_UL46.
    [Graphical view]
    PfamiPF03387. Herpes_UL46. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08314-1 [UniParc]FASTAAdd to Basket

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    MQRRTRGASS LRLARCLTPA NLIRGDNAGV PERRIFGGCL LPTPEGLLSA    50
    AVGALRQRSD DAQPAFLTCT DRSVRLAARQ HNTVPESLIV DGLASDPHYE 100
    YIRHYASAAT QALGEVELTG GQLSRAILTQ YWKYLQTVVP SGLDVPEDPV 150
    GDCDPSLHVL LRPTLAPKLL ARTPFKSGAA AAKYAATVAG LRDALHRIQQ 200
    YMFFMRPADP SRPSTDTALR LNELLAYVSV LYRWASWMLW TTDKHVCHRL 250
    SPSNRRFLPL GGSPEAPAET FARHLDRGPS GTTGSMQCMA LRAAVSDVLG 300
    HLTRLANLWQ TGKRSGGTYG TVDTVVSTVE VLSIVHHHAQ YIINATLTGY 350
    GVWATDSLNN EYLRAAVDSQ ERFCRTTAPL FPTMTAPSWA RMELSIKAWF 400
    GAALAADLLR SGAPSLHYES ILRLVASRRT TWSAGPPPDD MARGPGGHRA 450
    GGGTVGKRFS GPARQRAPAP PPTSPTLDPR GHPAVPEAPR GRPAPPLPDA 500
    DDPVAEPPGC AAQPATYYTH MGEVPPRLPA RNVAGPDRRP PAATCPLLVR 550
    RASLGSLDRP RGWGPAPEGE PDQMEATYLT ADDDDDARRK ATHAASARER 600
    HAPYEDDESI YETVSEDGGR VYEEIPWMRV YENVCANTAN AAPASPYIEA 650
    ENPLYDWGGS ALFSPPPRPP PPPPLSPSPV LARHRANALT NDGPTNVAAL 700
    SALLTKLKRE GRRSR 715
    Length:715
    Mass (Da):77,357
    Last modified:August 1, 1988 - v1
    Checksum:i9490E875ADD88155
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15621 Genomic DNA. Translation: AAA45768.1.
    PIRiB26133. TNBE77.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15621 Genomic DNA. Translation: AAA45768.1 .
    PIRi B26133. TNBE77.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR005051. Herpes_UL46.
    [Graphical view ]
    Pfami PF03387. Herpes_UL46. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and nucleotide sequence of two herpes simplex virus 1 genes whose products modulate alpha-trans-inducing factor-dependent activation of alpha genes."
      McKnight J.L.C., Pellett P.E., Jenkins F.J., Roizman B.
      J. Virol. 61:992-1001(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiTEG1_HHV1F
    AccessioniPrimary (citable) accession number: P08314
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3