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P08314

- TEG1_HHV1F

UniProt

P08314 - TEG1_HHV1F

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Protein

Tegument protein UL46

Gene
UL46
Organism
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Abundant tegument protein. Trans-activates the immediate early genes By similarity.

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Tegument protein UL46
Alternative name(s):
Tegument protein VP11/12
Gene namesi
ORF Names:UL46
OrganismiHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10304 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-KW
  3. viral tegument Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 715715Tegument protein UL46PRO_0000115793Add
BLAST

Post-translational modificationi

Phosphorylated. The phosphorylation seems to be lymphocyte-specific By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with VP16 By similarity.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi582 – 5865Poly-Asp
Compositional biasi665 – 67410Poly-Pro

Sequence similaritiesi

Family and domain databases

InterProiIPR005051. Herpes_UL46.
[Graphical view]
PfamiPF03387. Herpes_UL46. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08314-1 [UniParc]FASTAAdd to Basket

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MQRRTRGASS LRLARCLTPA NLIRGDNAGV PERRIFGGCL LPTPEGLLSA    50
AVGALRQRSD DAQPAFLTCT DRSVRLAARQ HNTVPESLIV DGLASDPHYE 100
YIRHYASAAT QALGEVELTG GQLSRAILTQ YWKYLQTVVP SGLDVPEDPV 150
GDCDPSLHVL LRPTLAPKLL ARTPFKSGAA AAKYAATVAG LRDALHRIQQ 200
YMFFMRPADP SRPSTDTALR LNELLAYVSV LYRWASWMLW TTDKHVCHRL 250
SPSNRRFLPL GGSPEAPAET FARHLDRGPS GTTGSMQCMA LRAAVSDVLG 300
HLTRLANLWQ TGKRSGGTYG TVDTVVSTVE VLSIVHHHAQ YIINATLTGY 350
GVWATDSLNN EYLRAAVDSQ ERFCRTTAPL FPTMTAPSWA RMELSIKAWF 400
GAALAADLLR SGAPSLHYES ILRLVASRRT TWSAGPPPDD MARGPGGHRA 450
GGGTVGKRFS GPARQRAPAP PPTSPTLDPR GHPAVPEAPR GRPAPPLPDA 500
DDPVAEPPGC AAQPATYYTH MGEVPPRLPA RNVAGPDRRP PAATCPLLVR 550
RASLGSLDRP RGWGPAPEGE PDQMEATYLT ADDDDDARRK ATHAASARER 600
HAPYEDDESI YETVSEDGGR VYEEIPWMRV YENVCANTAN AAPASPYIEA 650
ENPLYDWGGS ALFSPPPRPP PPPPLSPSPV LARHRANALT NDGPTNVAAL 700
SALLTKLKRE GRRSR 715
Length:715
Mass (Da):77,357
Last modified:August 1, 1988 - v1
Checksum:i9490E875ADD88155
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M15621 Genomic DNA. Translation: AAA45768.1.
PIRiB26133. TNBE77.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M15621 Genomic DNA. Translation: AAA45768.1 .
PIRi B26133. TNBE77.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR005051. Herpes_UL46.
[Graphical view ]
Pfami PF03387. Herpes_UL46. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization and nucleotide sequence of two herpes simplex virus 1 genes whose products modulate alpha-trans-inducing factor-dependent activation of alpha genes."
    McKnight J.L.C., Pellett P.E., Jenkins F.J., Roizman B.
    J. Virol. 61:992-1001(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiTEG1_HHV1F
AccessioniPrimary (citable) accession number: P08314
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: February 19, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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