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P08314 (TEG1_HHV1F) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tegument protein UL46
Alternative name(s):
Tegument protein VP11/12
Gene names
ORF Names:UL46
OrganismHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifier10304 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length715 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Abundant tegument protein. Trans-activates the immediate early genes By similarity.

Subunit structure

Interacts with VP16 By similarity.

Subcellular location

Virion tegument By similarity. Host cell membrane; Peripheral membrane protein By similarity.

Post-translational modification

Phosphorylated. The phosphorylation seems to be lymphocyte-specific By similarity.

Sequence similarities

Belongs to the herpesviridae HHV-1 VP11/12 protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 715715Tegument protein UL46
PRO_0000115793

Regions

Compositional bias582 – 5865Poly-Asp
Compositional bias665 – 67410Poly-Pro

Sequences

Sequence LengthMass (Da)Tools
P08314 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: 9490E875ADD88155

FASTA71577,357
        10         20         30         40         50         60 
MQRRTRGASS LRLARCLTPA NLIRGDNAGV PERRIFGGCL LPTPEGLLSA AVGALRQRSD 

        70         80         90        100        110        120 
DAQPAFLTCT DRSVRLAARQ HNTVPESLIV DGLASDPHYE YIRHYASAAT QALGEVELTG 

       130        140        150        160        170        180 
GQLSRAILTQ YWKYLQTVVP SGLDVPEDPV GDCDPSLHVL LRPTLAPKLL ARTPFKSGAA 

       190        200        210        220        230        240 
AAKYAATVAG LRDALHRIQQ YMFFMRPADP SRPSTDTALR LNELLAYVSV LYRWASWMLW 

       250        260        270        280        290        300 
TTDKHVCHRL SPSNRRFLPL GGSPEAPAET FARHLDRGPS GTTGSMQCMA LRAAVSDVLG 

       310        320        330        340        350        360 
HLTRLANLWQ TGKRSGGTYG TVDTVVSTVE VLSIVHHHAQ YIINATLTGY GVWATDSLNN 

       370        380        390        400        410        420 
EYLRAAVDSQ ERFCRTTAPL FPTMTAPSWA RMELSIKAWF GAALAADLLR SGAPSLHYES 

       430        440        450        460        470        480 
ILRLVASRRT TWSAGPPPDD MARGPGGHRA GGGTVGKRFS GPARQRAPAP PPTSPTLDPR 

       490        500        510        520        530        540 
GHPAVPEAPR GRPAPPLPDA DDPVAEPPGC AAQPATYYTH MGEVPPRLPA RNVAGPDRRP 

       550        560        570        580        590        600 
PAATCPLLVR RASLGSLDRP RGWGPAPEGE PDQMEATYLT ADDDDDARRK ATHAASARER 

       610        620        630        640        650        660 
HAPYEDDESI YETVSEDGGR VYEEIPWMRV YENVCANTAN AAPASPYIEA ENPLYDWGGS 

       670        680        690        700        710 
ALFSPPPRPP PPPPLSPSPV LARHRANALT NDGPTNVAAL SALLTKLKRE GRRSR 

« Hide

References

[1]"Characterization and nucleotide sequence of two herpes simplex virus 1 genes whose products modulate alpha-trans-inducing factor-dependent activation of alpha genes."
McKnight J.L.C., Pellett P.E., Jenkins F.J., Roizman B.
J. Virol. 61:992-1001(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M15621 Genomic DNA. Translation: AAA45768.1.
PIRTNBE77. B26133.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR005051. Herpes_UL46.
[Graphical view]
PfamPF03387. Herpes_UL46. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTEG1_HHV1F
AccessionPrimary (citable) accession number: P08314
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: February 19, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families