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P08306 (COX2_PARDE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene names
Name:ctaC
Synonyms:coiI, ctaB
OrganismParacoccus denitrificans
Taxonomic identifier266 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Binds 2 copper A ions per subunit.

Subcellular location

Cell inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929
Chain30 – 280251Cytochrome c oxidase subunit 2
PRO_0000006059
Propeptide281 – 29818C-terminal propeptide
PRO_0000006060

Regions

Topological domain30 – 5526Periplasmic
Transmembrane56 – 8833Helical
Topological domain89 – 10315Cytoplasmic
Transmembrane104 – 13431Helical
Topological domain135 – 280146Periplasmic

Sites

Metal binding2101Copper A1
Metal binding2451Copper A1
Metal binding2451Copper A2
Metal binding2471Copper A2; via carbonyl oxygen
Metal binding2491Copper A1
Metal binding2491Copper A2
Metal binding2531Copper A2
Metal binding2561Copper A1

Amino acid modifications

Modified residue301Pyrrolidone carboxylic acid

Experimental info

Sequence conflict160 – 1612GV → AF AA sequence Ref.2

Secondary structure

............................................ 298
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P08306 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: 918A64A9E3B93366

FASTA29832,539
        10         20         30         40         50         60 
MMAIATKRRG VAAVMSLGVA TMTAVPALAQ DVLGDLPVIG KPVNGGMNFQ PASSPLAHDQ 

        70         80         90        100        110        120 
QWLDHFVLYI ITAVTIFVCL LLLICIVRFN RRANPVPARF THNTPIEVIW TLVPVLILVA 

       130        140        150        160        170        180 
IGAFSLPILF RSQEMPNDPD LVIKAIGHQW YWSYEYPNDG VAFDALMLEK EALADAGYSE 

       190        200        210        220        230        240 
DEYLLATDNP VVVPVGKKVL VQVTATDVIH AWTIPAFAVK QDAVPGRIAQ LWFSVDQEGV 

       250        260        270        280        290 
YFGQCSELCG INHAYMPIVV KAVSQEKYEA WLAGAKEEFA ADASDYLPAS PVKLASAE 

« Hide

References

[1]"Isolation and analysis of the genes for cytochrome c oxidase in Paracoccus denitrificans."
Raitio M., Jalli T., Saraste M.
EMBO J. 6:2825-2833(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: S1657.
[2]"Subunit II of cytochrome c oxidase from Paracoccus denitrificans. DNA sequence, gene expression and the protein."
Steinruecke P., Steffens G.C.M., Panskus G., Buse G., Ludwig B.
Eur. J. Biochem. 167:431-439(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
Strain: ATCC 13543 / NRRL B-3784 / NRC 449.
[3]"Structure at 2.8-A resolution of cytochrome c oxidase from Paracoccus denitrificans."
Iwata S., Ostermeier C., Ludwig B., Michel H.
Nature 376:660-669(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[4]"Structure at 2.7-A resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody FV fragment."
Ostermeier C., Harrenga A., Ermler U., Michel H.
Proc. Natl. Acad. Sci. U.S.A. 94:10547-10553(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X05828 Genomic DNA. Translation: CAA29268.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1AR1X-ray2.70B1-298[»]
1QLEX-ray3.00B30-281[»]
1ZYYmodel-B30-281[»]
3EHBX-ray2.32B1-298[»]
3HB3X-ray2.25B1-298[»]
ProteinModelPortalP08306.
SMRP08306. Positions 30-281.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-6089N.

Protein family/group databases

TCDB3.D.4.6.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP08306.

Entry information

Entry nameCOX2_PARDE
AccessionPrimary (citable) accession number: P08306
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 16, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references