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P08306

- COX2_PARDE

UniProt

P08306 - COX2_PARDE

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Protein
Cytochrome c oxidase subunit 2
Gene
ctaC, coiI, ctaB
Organism
Paracoccus denitrificans
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 2 copper A ions per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi210 – 2101Copper A1
Metal bindingi245 – 2451Copper A1
Metal bindingi245 – 2451Copper A2
Metal bindingi247 – 2471Copper A2; via carbonyl oxygen
Metal bindingi249 – 2491Copper A1
Metal bindingi249 – 2491Copper A2
Metal bindingi253 – 2531Copper A2
Metal bindingi256 – 2561Copper A1

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Protein family/group databases

TCDBi3.D.4.6.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene namesi
Name:ctaC
Synonyms:coiI, ctaB
OrganismiParacoccus denitrificans
Taxonomic identifieri266 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 5526Periplasmic
Add
BLAST
Transmembranei56 – 8833Helical
Add
BLAST
Topological domaini89 – 10315Cytoplasmic
Add
BLAST
Transmembranei104 – 13431Helical
Add
BLAST
Topological domaini135 – 280146Periplasmic
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929
Add
BLAST
Chaini30 – 280251Cytochrome c oxidase subunit 2
PRO_0000006059Add
BLAST
Propeptidei281 – 29818C-terminal propeptide
PRO_0000006060Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301Pyrrolidone carboxylic acid

Keywords - PTMi

Pyrrolidone carboxylic acid

Interactioni

Protein-protein interaction databases

DIPiDIP-6089N.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni32 – 354
Beta strandi38 – 403
Helixi55 – 8834
Turni91 – 933
Beta strandi94 – 963
Helixi104 – 13330
Beta strandi140 – 1489
Beta strandi151 – 1566
Turni157 – 1604
Beta strandi161 – 1655
Helixi170 – 1723
Helixi174 – 1763
Helixi180 – 1823
Turni183 – 1853
Beta strandi187 – 1893
Beta strandi191 – 20818
Beta strandi210 – 2145
Helixi215 – 2173
Beta strandi219 – 2235
Beta strandi229 – 2346
Beta strandi236 – 2438
Turni251 – 2544
Beta strandi258 – 2636
Helixi265 – 27814

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AR1X-ray2.70B1-298[»]
1QLEX-ray3.00B30-281[»]
1ZYYmodel-B30-281[»]
3EHBX-ray2.32B1-298[»]
3HB3X-ray2.25B1-298[»]
ProteinModelPortaliP08306.
SMRiP08306. Positions 30-281.

Miscellaneous databases

EvolutionaryTraceiP08306.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08306-1 [UniParc]FASTAAdd to Basket

« Hide

MMAIATKRRG VAAVMSLGVA TMTAVPALAQ DVLGDLPVIG KPVNGGMNFQ    50
PASSPLAHDQ QWLDHFVLYI ITAVTIFVCL LLLICIVRFN RRANPVPARF 100
THNTPIEVIW TLVPVLILVA IGAFSLPILF RSQEMPNDPD LVIKAIGHQW 150
YWSYEYPNDG VAFDALMLEK EALADAGYSE DEYLLATDNP VVVPVGKKVL 200
VQVTATDVIH AWTIPAFAVK QDAVPGRIAQ LWFSVDQEGV YFGQCSELCG 250
INHAYMPIVV KAVSQEKYEA WLAGAKEEFA ADASDYLPAS PVKLASAE 298
Length:298
Mass (Da):32,539
Last modified:August 1, 1988 - v1
Checksum:i918A64A9E3B93366
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1612GV → AF AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X05828 Genomic DNA. Translation: CAA29268.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X05828 Genomic DNA. Translation: CAA29268.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AR1 X-ray 2.70 B 1-298 [» ]
1QLE X-ray 3.00 B 30-281 [» ]
1ZYY model - B 30-281 [» ]
3EHB X-ray 2.32 B 1-298 [» ]
3HB3 X-ray 2.25 B 1-298 [» ]
ProteinModelPortali P08306.
SMRi P08306. Positions 30-281.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-6089N.

Protein family/group databases

TCDBi 3.D.4.6.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P08306.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and analysis of the genes for cytochrome c oxidase in Paracoccus denitrificans."
    Raitio M., Jalli T., Saraste M.
    EMBO J. 6:2825-2833(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S1657.
  2. "Subunit II of cytochrome c oxidase from Paracoccus denitrificans. DNA sequence, gene expression and the protein."
    Steinruecke P., Steffens G.C.M., Panskus G., Buse G., Ludwig B.
    Eur. J. Biochem. 167:431-439(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Strain: ATCC 13543 / NRRL B-3784 / NRC 449.
  3. "Structure at 2.8-A resolution of cytochrome c oxidase from Paracoccus denitrificans."
    Iwata S., Ostermeier C., Ludwig B., Michel H.
    Nature 376:660-669(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  4. "Structure at 2.7-A resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody FV fragment."
    Ostermeier C., Harrenga A., Ermler U., Michel H.
    Proc. Natl. Acad. Sci. U.S.A. 94:10547-10553(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).

Entry informationi

Entry nameiCOX2_PARDE
AccessioniPrimary (citable) accession number: P08306
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 16, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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