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P08305

- COX1A_PARDE

UniProt

P08305 - COX1A_PARDE

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Protein
Cytochrome c oxidase subunit 1-alpha
Gene
ctaDI, coi
Organism
Paracoccus denitrificans
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Subunit I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 1 copper B ion per subunit.
Binds 2 heme groups per subunit.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi91 – 911Iron (heme A axial ligand) By similarity
Metal bindingi273 – 2731Copper B By similarity
Metal bindingi277 – 2771Copper B By similarity
Metal bindingi322 – 3221Copper B By similarity
Metal bindingi323 – 3231Copper B By similarity
Metal bindingi406 – 4061Iron (heme A3 axial ligand) By similarity
Metal bindingi408 – 4081Iron (heme A axial ligand) By similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1-alpha (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1-alpha
Cytochrome c oxidase polypeptide I-alpha
Gene namesi
Name:ctaDI
Synonyms:coi
OrganismiParacoccus denitrificans
Taxonomic identifieri266 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 5631Helical; By similarity
Add
BLAST
Transmembranei81 – 11838Helical; By similarity
Add
BLAST
Transmembranei127 – 14822Helical; By similarity
Add
BLAST
Transmembranei175 – 20329Helical; By similarity
Add
BLAST
Transmembranei215 – 24834Helical; By similarity
Add
BLAST
Transmembranei260 – 29536Helical; By similarity
Add
BLAST
Transmembranei301 – 31919Helical; By similarity
Add
BLAST
Transmembranei331 – 35929Helical; By similarity
Add
BLAST
Transmembranei367 – 39024Helical; By similarity
Add
BLAST
Transmembranei399 – 42527Helical; By similarity
Add
BLAST
Transmembranei436 – 46328Helical; By similarity
Add
BLAST
Transmembranei478 – 50831Helical; By similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Cytochrome c oxidase subunit 1-alpha
PRO_0000183455Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi63 ↔ 77 By similarity
Cross-linki273 ↔ 2771'-histidyl-3'-tyrosine (His-Tyr) By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP08305.
SMRiP08305. Positions 14-540.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08305-1 [UniParc]FASTAAdd to Basket

« Hide

MSAQISDSIE EKRGFFTRWF MSTNHKDIGV LYLFTAGLAG LISVTLTVYM    50
RMELQHPGVQ YMCLEGMRLV ADAAAECTPN AHLWNVVVTY HGILMMFFVV 100
IPALFGGFGN YFMPLHIGAP DMAFPRLNNL SYWLYVCGVS LAIASLLSPG 150
GSDQPGAGVG WVLYPPLSTT EAGYAMDLAI FAVHVSGATS ILGAINIITT 200
FLNMRAPGMT LFKVPLFAWA VFITAWMILL SLPVLAGGIT MLLMDRNFGT 250
QFFDPAGGGD PVLYQHILWF FGHPEVYMLI LPGFGIISHV ISTFARKPIF 300
GYLPMVLAMA AIAFLGFIVW AHHMYTAGMS LTQQTYFQMA TMTIAVPTGI 350
KVFSWIATMW GGSIEFKTPM LWALAFLFTV GGVTGVVIAQ GSLDRVYHDT 400
YYIVAHFHYV MSLGALFAIF AGTYYWIGKM SGRQYPEWAG QLHFWMMFIG 450
SNLIFFPQHF LGRQGMPRRY IDYPVEFSYW NNISSIGAYI SFASFLFFIG 500
IVFYTLFAGK PVNVPNYWNE HADTLEWTLP SPPPEHTFET LPKPEDWDRA 550
QAHR 554
Length:554
Mass (Da):62,013
Last modified:August 1, 1988 - v1
Checksum:i58AD591FBBDCE794
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X05829 Genomic DNA. Translation: CAA29274.1.
PIRiS03809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X05829 Genomic DNA. Translation: CAA29274.1 .
PIRi S03809.

3D structure databases

ProteinModelPortali P08305.
SMRi P08305. Positions 14-540.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and analysis of the genes for cytochrome c oxidase in Paracoccus denitrificans."
    Raitio M., Jalli T., Saraste M.
    EMBO J. 6:2825-2833(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S1657.

Entry informationi

Entry nameiCOX1A_PARDE
AccessioniPrimary (citable) accession number: P08305
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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