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Protein

Cytochrome c oxidase subunit 1-alpha

Gene

ctaDI

Organism
Paracoccus denitrificans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Subunit I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu2+Note: Binds 1 copper B ion per subunit.
  • hemeNote: Binds 2 heme groups per subunit.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi91 – 911Iron (heme A axial ligand)By similarity
Metal bindingi273 – 2731Copper BBy similarity
Metal bindingi277 – 2771Copper BBy similarity
Metal bindingi322 – 3221Copper BBy similarity
Metal bindingi323 – 3231Copper BBy similarity
Metal bindingi406 – 4061Iron (heme A3 axial ligand)By similarity
Metal bindingi408 – 4081Iron (heme A axial ligand)By similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1-alpha (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1-alpha
Cytochrome c oxidase polypeptide I-alpha
Gene namesi
Name:ctaDI
Synonyms:coi
OrganismiParacoccus denitrificans
Taxonomic identifieri266 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 5631HelicalBy similarityAdd
BLAST
Transmembranei81 – 11838HelicalBy similarityAdd
BLAST
Transmembranei127 – 14822HelicalBy similarityAdd
BLAST
Transmembranei175 – 20329HelicalBy similarityAdd
BLAST
Transmembranei215 – 24834HelicalBy similarityAdd
BLAST
Transmembranei260 – 29536HelicalBy similarityAdd
BLAST
Transmembranei301 – 31919HelicalBy similarityAdd
BLAST
Transmembranei331 – 35929HelicalBy similarityAdd
BLAST
Transmembranei367 – 39024HelicalBy similarityAdd
BLAST
Transmembranei399 – 42527HelicalBy similarityAdd
BLAST
Transmembranei436 – 46328HelicalBy similarityAdd
BLAST
Transmembranei478 – 50831HelicalBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Cytochrome c oxidase subunit 1-alphaPRO_0000183455Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi63 ↔ 77By similarity
Cross-linki273 ↔ 2771'-histidyl-3'-tyrosine (His-Tyr)By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP08305.
SMRiP08305. Positions 14-540.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAQISDSIE EKRGFFTRWF MSTNHKDIGV LYLFTAGLAG LISVTLTVYM
60 70 80 90 100
RMELQHPGVQ YMCLEGMRLV ADAAAECTPN AHLWNVVVTY HGILMMFFVV
110 120 130 140 150
IPALFGGFGN YFMPLHIGAP DMAFPRLNNL SYWLYVCGVS LAIASLLSPG
160 170 180 190 200
GSDQPGAGVG WVLYPPLSTT EAGYAMDLAI FAVHVSGATS ILGAINIITT
210 220 230 240 250
FLNMRAPGMT LFKVPLFAWA VFITAWMILL SLPVLAGGIT MLLMDRNFGT
260 270 280 290 300
QFFDPAGGGD PVLYQHILWF FGHPEVYMLI LPGFGIISHV ISTFARKPIF
310 320 330 340 350
GYLPMVLAMA AIAFLGFIVW AHHMYTAGMS LTQQTYFQMA TMTIAVPTGI
360 370 380 390 400
KVFSWIATMW GGSIEFKTPM LWALAFLFTV GGVTGVVIAQ GSLDRVYHDT
410 420 430 440 450
YYIVAHFHYV MSLGALFAIF AGTYYWIGKM SGRQYPEWAG QLHFWMMFIG
460 470 480 490 500
SNLIFFPQHF LGRQGMPRRY IDYPVEFSYW NNISSIGAYI SFASFLFFIG
510 520 530 540 550
IVFYTLFAGK PVNVPNYWNE HADTLEWTLP SPPPEHTFET LPKPEDWDRA

QAHR
Length:554
Mass (Da):62,013
Last modified:July 31, 1988 - v1
Checksum:i58AD591FBBDCE794
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05829 Genomic DNA. Translation: CAA29274.1.
PIRiS03809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05829 Genomic DNA. Translation: CAA29274.1.
PIRiS03809.

3D structure databases

ProteinModelPortaliP08305.
SMRiP08305. Positions 14-540.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and analysis of the genes for cytochrome c oxidase in Paracoccus denitrificans."
    Raitio M., Jalli T., Saraste M.
    EMBO J. 6:2825-2833(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S1657.

Entry informationi

Entry nameiCOX1A_PARDE
AccessioniPrimary (citable) accession number: P08305
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 31, 1988
Last sequence update: July 31, 1988
Last modified: January 6, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.