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P08305

- COX1A_PARDE

UniProt

P08305 - COX1A_PARDE

Protein

Cytochrome c oxidase subunit 1-alpha

Gene

ctaDI

Organism
Paracoccus denitrificans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
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    Functioni

    Subunit I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Binds 1 copper B ion per subunit.
    Binds 2 heme groups per subunit.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi91 – 911Iron (heme A axial ligand)By similarity
    Metal bindingi273 – 2731Copper BBy similarity
    Metal bindingi277 – 2771Copper BBy similarity
    Metal bindingi322 – 3221Copper BBy similarity
    Metal bindingi323 – 3231Copper BBy similarity
    Metal bindingi406 – 4061Iron (heme A3 axial ligand)By similarity
    Metal bindingi408 – 4081Iron (heme A axial ligand)By similarity

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1-alpha (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 1-alpha
    Cytochrome c oxidase polypeptide I-alpha
    Gene namesi
    Name:ctaDI
    Synonyms:coi
    OrganismiParacoccus denitrificans
    Taxonomic identifieri266 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 554554Cytochrome c oxidase subunit 1-alphaPRO_0000183455Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi63 ↔ 77By similarity
    Cross-linki273 ↔ 2771'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliP08305.
    SMRiP08305. Positions 14-540.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 5631HelicalBy similarityAdd
    BLAST
    Transmembranei81 – 11838HelicalBy similarityAdd
    BLAST
    Transmembranei127 – 14822HelicalBy similarityAdd
    BLAST
    Transmembranei175 – 20329HelicalBy similarityAdd
    BLAST
    Transmembranei215 – 24834HelicalBy similarityAdd
    BLAST
    Transmembranei260 – 29536HelicalBy similarityAdd
    BLAST
    Transmembranei301 – 31919HelicalBy similarityAdd
    BLAST
    Transmembranei331 – 35929HelicalBy similarityAdd
    BLAST
    Transmembranei367 – 39024HelicalBy similarityAdd
    BLAST
    Transmembranei399 – 42527HelicalBy similarityAdd
    BLAST
    Transmembranei436 – 46328HelicalBy similarityAdd
    BLAST
    Transmembranei478 – 50831HelicalBy similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08305-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAQISDSIE EKRGFFTRWF MSTNHKDIGV LYLFTAGLAG LISVTLTVYM    50
    RMELQHPGVQ YMCLEGMRLV ADAAAECTPN AHLWNVVVTY HGILMMFFVV 100
    IPALFGGFGN YFMPLHIGAP DMAFPRLNNL SYWLYVCGVS LAIASLLSPG 150
    GSDQPGAGVG WVLYPPLSTT EAGYAMDLAI FAVHVSGATS ILGAINIITT 200
    FLNMRAPGMT LFKVPLFAWA VFITAWMILL SLPVLAGGIT MLLMDRNFGT 250
    QFFDPAGGGD PVLYQHILWF FGHPEVYMLI LPGFGIISHV ISTFARKPIF 300
    GYLPMVLAMA AIAFLGFIVW AHHMYTAGMS LTQQTYFQMA TMTIAVPTGI 350
    KVFSWIATMW GGSIEFKTPM LWALAFLFTV GGVTGVVIAQ GSLDRVYHDT 400
    YYIVAHFHYV MSLGALFAIF AGTYYWIGKM SGRQYPEWAG QLHFWMMFIG 450
    SNLIFFPQHF LGRQGMPRRY IDYPVEFSYW NNISSIGAYI SFASFLFFIG 500
    IVFYTLFAGK PVNVPNYWNE HADTLEWTLP SPPPEHTFET LPKPEDWDRA 550
    QAHR 554
    Length:554
    Mass (Da):62,013
    Last modified:August 1, 1988 - v1
    Checksum:i58AD591FBBDCE794
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X05829 Genomic DNA. Translation: CAA29274.1.
    PIRiS03809.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X05829 Genomic DNA. Translation: CAA29274.1 .
    PIRi S03809.

    3D structure databases

    ProteinModelPortali P08305.
    SMRi P08305. Positions 14-540.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and analysis of the genes for cytochrome c oxidase in Paracoccus denitrificans."
      Raitio M., Jalli T., Saraste M.
      EMBO J. 6:2825-2833(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: S1657.

    Entry informationi

    Entry nameiCOX1A_PARDE
    AccessioniPrimary (citable) accession number: P08305
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3