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Protein

Cytochrome c oxidase subunit 1-alpha

Gene

ctaDI

Organism
Paracoccus denitrificans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Subunit I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu2+Note: Binds 1 copper B ion per subunit.
  • hemeNote: Binds 2 heme groups per subunit.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi91Iron (heme A axial ligand)By similarity1
Metal bindingi273Copper BBy similarity1
Metal bindingi277Copper BBy similarity1
Metal bindingi322Copper BBy similarity1
Metal bindingi323Copper BBy similarity1
Metal bindingi406Iron (heme A3 axial ligand)By similarity1
Metal bindingi408Iron (heme A axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1-alpha (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1-alpha
Cytochrome c oxidase polypeptide I-alpha
Gene namesi
Name:ctaDI
Synonyms:coi
OrganismiParacoccus denitrificans
Taxonomic identifieri266 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 56HelicalBy similarityAdd BLAST31
Transmembranei81 – 118HelicalBy similarityAdd BLAST38
Transmembranei127 – 148HelicalBy similarityAdd BLAST22
Transmembranei175 – 203HelicalBy similarityAdd BLAST29
Transmembranei215 – 248HelicalBy similarityAdd BLAST34
Transmembranei260 – 295HelicalBy similarityAdd BLAST36
Transmembranei301 – 319HelicalBy similarityAdd BLAST19
Transmembranei331 – 359HelicalBy similarityAdd BLAST29
Transmembranei367 – 390HelicalBy similarityAdd BLAST24
Transmembranei399 – 425HelicalBy similarityAdd BLAST27
Transmembranei436 – 463HelicalBy similarityAdd BLAST28
Transmembranei478 – 508HelicalBy similarityAdd BLAST31

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834551 – 554Cytochrome c oxidase subunit 1-alphaAdd BLAST554

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi63 ↔ 77By similarity
Cross-linki273 ↔ 2771'-histidyl-3'-tyrosine (His-Tyr)By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi318586.Pden_3028.

Structurei

3D structure databases

ProteinModelPortaliP08305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAQISDSIE EKRGFFTRWF MSTNHKDIGV LYLFTAGLAG LISVTLTVYM
60 70 80 90 100
RMELQHPGVQ YMCLEGMRLV ADAAAECTPN AHLWNVVVTY HGILMMFFVV
110 120 130 140 150
IPALFGGFGN YFMPLHIGAP DMAFPRLNNL SYWLYVCGVS LAIASLLSPG
160 170 180 190 200
GSDQPGAGVG WVLYPPLSTT EAGYAMDLAI FAVHVSGATS ILGAINIITT
210 220 230 240 250
FLNMRAPGMT LFKVPLFAWA VFITAWMILL SLPVLAGGIT MLLMDRNFGT
260 270 280 290 300
QFFDPAGGGD PVLYQHILWF FGHPEVYMLI LPGFGIISHV ISTFARKPIF
310 320 330 340 350
GYLPMVLAMA AIAFLGFIVW AHHMYTAGMS LTQQTYFQMA TMTIAVPTGI
360 370 380 390 400
KVFSWIATMW GGSIEFKTPM LWALAFLFTV GGVTGVVIAQ GSLDRVYHDT
410 420 430 440 450
YYIVAHFHYV MSLGALFAIF AGTYYWIGKM SGRQYPEWAG QLHFWMMFIG
460 470 480 490 500
SNLIFFPQHF LGRQGMPRRY IDYPVEFSYW NNISSIGAYI SFASFLFFIG
510 520 530 540 550
IVFYTLFAGK PVNVPNYWNE HADTLEWTLP SPPPEHTFET LPKPEDWDRA

QAHR
Length:554
Mass (Da):62,013
Last modified:August 1, 1988 - v1
Checksum:i58AD591FBBDCE794
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05829 Genomic DNA. Translation: CAA29274.1.
PIRiS03809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05829 Genomic DNA. Translation: CAA29274.1.
PIRiS03809.

3D structure databases

ProteinModelPortaliP08305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi318586.Pden_3028.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1A_PARDE
AccessioniPrimary (citable) accession number: P08305
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.