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Protein

Asialoglycoprotein receptor 2

Gene

Asgr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Miscellaneous

Calcium is required for ligand binding.
Two types of rat hepatic lectin have been identified, RHL-1 and RHL-2/3, having a relative abundance of 4:1. RHL-2 and RHL-3 only differs in their carbohydrate structures.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processEndocytosis
LigandCalcium, Lectin

Enzyme and pathway databases

ReactomeiR-RNO-446203 Asparagine N-linked glycosylation

Names & Taxonomyi

Protein namesi
Recommended name:
Asialoglycoprotein receptor 2
Short name:
ASGP-R 2
Short name:
ASGPR 2
Alternative name(s):
Hepatic lectin R2/3
Short name:
HL-2
Short name:
rHL-2
Gene namesi
Name:Asgr2
Synonyms:Asgr-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2161 Asgr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 58CytoplasmicSequence analysisAdd BLAST58
Transmembranei59 – 79Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini80 – 301ExtracellularSequence analysisAdd BLAST222

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466561 – 301Asialoglycoprotein receptor 2Add BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Lipidationi54S-palmitoyl cysteine1 Publication1
Glycosylationi97N-linked (GlcNAc...) asparagine1
Glycosylationi119N-linked (GlcNAc...) asparagine1
Glycosylationi165N-linked (GlcNAc...) asparagine1
Disulfide bondi170 ↔ 181PROSITE-ProRule annotation
Disulfide bondi198 ↔ 293PROSITE-ProRule annotation
Disulfide bondi271 ↔ 285PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP08290
PRIDEiP08290

PTM databases

iPTMnetiP08290
PhosphoSitePlusiP08290
SwissPalmiP08290

Expressioni

Tissue specificityi

Expressed exclusively in hepatic parenchymal cells.

Gene expression databases

BgeeiENSRNOG00000030726
ExpressionAtlasiP08290 baseline and differential
GenevisibleiP08290 RN

Interactioni

Subunit structurei

Interacts with LASS2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060474

Structurei

3D structure databases

ProteinModelPortaliP08290
SMRiP08290
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 295C-type lectinPROSITE-ProRule annotationAdd BLAST127

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00760000118924
HOGENOMiHOG000034093
HOVERGENiHBG000270
InParanoidiP08290
KOiK10064
OMAiQDLKADH
OrthoDBiEOG091G062T
PhylomeDBiP08290
TreeFamiTF352155

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
IPR005640 Lectin_N
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PF03954 Lectin_N, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P08290-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKDFQDIQQ LDSEENDHQL IGDEEQGSHV QNLRTENPRW GGQPPSRPFP
60 70 80 90 100
QRLCSKFRLS LLALAFNILL LVVICVVSSQ SMQLQKEFWT LKETLSNFST
110 120 130 140 150
TTLMEFKALD SHGGSRNDNL TSWETILEKK QKDIKADHST LLFHLKHFPL
160 170 180 190 200
DLRTLTCQLA FFLSNGTECC PVNWVEFGGS CYWFSRDGLT WAEADQYCQM
210 220 230 240 250
ENAHLLVINS REEQEFVVKH RGAFHIWIGL TDKDGSWKWV DGTEYRSNFK
260 270 280 290 300
NWAFTQPDNW QGHEEGGSED CAEILSDGLW NDNFCQQVNR WACERKRDIT

Y
Length:301
Mass (Da):35,027
Last modified:May 1, 2007 - v4
Checksum:i21832FA713C3433C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153R → A in AAA42038 (PubMed:3600647).Curated1
Sequence conflicti202N → I in AAA42038 (PubMed:3600647).Curated1
Sequence conflicti260W → C in AAA42038 (PubMed:3600647).Curated1
Sequence conflicti260W → C AA sequence (PubMed:6319386).Curated1
Sequence conflicti282 – 283DN → ND AA sequence (PubMed:6319386).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16347 mRNA Translation: AAA42038.1
J02762 mRNA Translation: AAA41522.1
X07636 mRNA Translation: CAA30476.1
BC088099 mRNA Translation: AAH88099.1
PIRiB28462 LNRT2
RefSeqiNP_058885.1, NM_017189.2
XP_006246738.1, XM_006246676.3
UniGeneiRn.9834

Genome annotation databases

EnsembliENSRNOT00000065370; ENSRNOP00000060474; ENSRNOG00000030726
GeneIDi29403
KEGGirno:29403
UCSCiRGD:2161 rat

Similar proteinsi

Entry informationi

Entry nameiASGR2_RAT
AccessioniPrimary (citable) accession number: P08290
Secondary accession number(s): Q5M8C9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 1, 2007
Last modified: April 25, 2018
This is version 140 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health