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P08267

- FRIH_CHICK

UniProt

P08267 - FRIH_CHICK

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Protein
Ferritin heavy chain
Gene
FTH
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Iron 1 By similarity
Metal bindingi62 – 621Iron 1 By similarity
Metal bindingi62 – 621Iron 2 By similarity
Metal bindingi65 – 651Iron 1 By similarity
Metal bindingi107 – 1071Iron 2 By similarity
Metal bindingi141 – 1411Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. immune response Source: UniProtKB
  3. iron ion transport Source: InterPro
  4. negative regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_198084. Scavenging by Class A Receptors.
REACT_203318. Iron uptake and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin heavy chain (EC:1.16.3.1)
Short name:
Ferritin H subunit
Gene namesi
Name:FTH
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 5

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 180179Ferritin heavy chain
PRO_0000201057Add
BLAST

Proteomic databases

PaxDbiP08267.
PRIDEiP08267.

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038030.

Structurei

3D structure databases

ProteinModelPortaliP08267.
SMRiP08267. Positions 6-176.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 159150Ferritin-like diiron
Add
BLAST

Sequence similaritiesi

Belongs to the ferritin family.

Phylogenomic databases

eggNOGiCOG1528.
GeneTreeiENSGT00700000104283.
HOGENOMiHOG000223383.
HOVERGENiHBG000410.
InParanoidiP08267.
KOiK00522.
OrthoDBiEOG7DRJ49.
PhylomeDBiP08267.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08267-1 [UniParc]FASTAAdd to Basket

« Hide

MATPPSQVRQ NYHQDCEAAI NRQINLELYA SYVYLSMSYY FDRDDVALKN    50
FAKYFLHQSH EEREHAEKLM KLQNQRGGRI FLQDIKKPDR DDWENGLTAM 100
ECALHLEKNV NQSLLELHKL ATEKNDPHLC DFIETHYLDE QVKAIKQLGD 150
HVTNLRKMGA PKYGMAEYLF DKHTLGESDS 180
Length:180
Mass (Da):21,092
Last modified:January 23, 2007 - v2
Checksum:i0A779C213E5EF35E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16343 Genomic DNA. Translation: AAA48768.1.
Y14698 mRNA. Translation: CAA75004.1.
PIRiA26886.
RefSeqiNP_990417.1. NM_205086.1.
UniGeneiGga.4390.
Gga.52366.

Genome annotation databases

EnsembliENSGALT00000011687; ENSGALP00000011673; ENSGALG00000007220.
GeneIDi395970.
KEGGigga:395970.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16343 Genomic DNA. Translation: AAA48768.1 .
Y14698 mRNA. Translation: CAA75004.1 .
PIRi A26886.
RefSeqi NP_990417.1. NM_205086.1.
UniGenei Gga.4390.
Gga.52366.

3D structure databases

ProteinModelPortali P08267.
SMRi P08267. Positions 6-176.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000038030.

Proteomic databases

PaxDbi P08267.
PRIDEi P08267.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000011687 ; ENSGALP00000011673 ; ENSGALG00000007220 .
GeneIDi 395970.
KEGGi gga:395970.

Organism-specific databases

CTDi 2495.

Phylogenomic databases

eggNOGi COG1528.
GeneTreei ENSGT00700000104283.
HOGENOMi HOG000223383.
HOVERGENi HBG000410.
InParanoidi P08267.
KOi K00522.
OrthoDBi EOG7DRJ49.
PhylomeDBi P08267.

Enzyme and pathway databases

Reactomei REACT_198084. Scavenging by Class A Receptors.
REACT_203318. Iron uptake and transport.

Miscellaneous databases

NextBioi 20816035.
PROi P08267.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and expression of the chicken ferritin H-subunit gene."
    Stevens P.W., Dodgson J.B., Engel J.D.
    Mol. Cell. Biol. 7:1751-1758(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Mikulits W., Linhartova I., Dolznig H., Propst F., Wiche G., Beug H., Muellner E.W.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiFRIH_CHICK
AccessioniPrimary (citable) accession number: P08267
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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