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Protein

Ferritin heavy chain

Gene

FTH

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27Iron 1PROSITE-ProRule annotation1
Metal bindingi62Iron 1PROSITE-ProRule annotation1
Metal bindingi62Iron 2PROSITE-ProRule annotation1
Metal bindingi65Iron 1PROSITE-ProRule annotation1
Metal bindingi107Iron 2PROSITE-ProRule annotation1
Metal bindingi141Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Enzyme and pathway databases

ReactomeiR-GGA-432722 Golgi Associated Vesicle Biogenesis
R-GGA-6798695 Neutrophil degranulation
R-GGA-917937 Iron uptake and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin heavy chain (EC:1.16.3.1)
Short name:
Ferritin H subunit
Gene namesi
Name:FTH
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002010572 – 180Ferritin heavy chainAdd BLAST179

Proteomic databases

PaxDbiP08267

Expressioni

Gene expression databases

BgeeiENSGALG00000007220

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038030

Structurei

3D structure databases

ProteinModelPortaliP08267
SMRiP08267
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 159Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Belongs to the ferritin family.Curated

Phylogenomic databases

eggNOGiKOG2332 Eukaryota
COG1528 LUCA
GeneTreeiENSGT00760000119129
HOGENOMiHOG000223383
HOVERGENiHBG000410
InParanoidiP08267
KOiK00522
OMAiQALHNFA
OrthoDBiEOG091G0J20
PhylomeDBiP08267

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00540 FERRITIN_1, 1 hit
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08267-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPPSQVRQ NYHQDCEAAI NRQINLELYA SYVYLSMSYY FDRDDVALKN
60 70 80 90 100
FAKYFLHQSH EEREHAEKLM KLQNQRGGRI FLQDIKKPDR DDWENGLTAM
110 120 130 140 150
ECALHLEKNV NQSLLELHKL ATEKNDPHLC DFIETHYLDE QVKAIKQLGD
160 170 180
HVTNLRKMGA PKYGMAEYLF DKHTLGESDS
Length:180
Mass (Da):21,092
Last modified:January 23, 2007 - v2
Checksum:i0A779C213E5EF35E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16343 Genomic DNA Translation: AAA48768.1
Y14698 mRNA Translation: CAA75004.1
PIRiA26886
RefSeqiNP_990417.1, NM_205086.1
UniGeneiGga.4390
Gga.52366

Genome annotation databases

EnsembliENSGALT00000011687; ENSGALP00000011673; ENSGALG00000007220
GeneIDi395970
KEGGigga:395970

Similar proteinsi

Entry informationi

Entry nameiFRIH_CHICK
AccessioniPrimary (citable) accession number: P08267
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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