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P08267 (FRIH_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin heavy chain

Short name=Ferritin H subunit
EC=1.16.3.1
Gene names
Name:FTH
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Sequence similarities

Belongs to the ferritin family.

Contains 1 ferritin-like diiron domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 180179Ferritin heavy chain
PRO_0000201057

Regions

Domain10 – 159150Ferritin-like diiron

Sites

Metal binding271Iron 1 By similarity
Metal binding621Iron 1 By similarity
Metal binding621Iron 2 By similarity
Metal binding651Iron 1 By similarity
Metal binding1071Iron 2 By similarity
Metal binding1411Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P08267 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 0A779C213E5EF35E

FASTA18021,092
        10         20         30         40         50         60 
MATPPSQVRQ NYHQDCEAAI NRQINLELYA SYVYLSMSYY FDRDDVALKN FAKYFLHQSH 

        70         80         90        100        110        120 
EEREHAEKLM KLQNQRGGRI FLQDIKKPDR DDWENGLTAM ECALHLEKNV NQSLLELHKL 

       130        140        150        160        170        180 
ATEKNDPHLC DFIETHYLDE QVKAIKQLGD HVTNLRKMGA PKYGMAEYLF DKHTLGESDS 

« Hide

References

[1]"Structure and expression of the chicken ferritin H-subunit gene."
Stevens P.W., Dodgson J.B., Engel J.D.
Mol. Cell. Biol. 7:1751-1758(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mikulits W., Linhartova I., Dolznig H., Propst F., Wiche G., Beug H., Muellner E.W.
Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M16343 Genomic DNA. Translation: AAA48768.1.
Y14698 mRNA. Translation: CAA75004.1.
PIRA26886.
RefSeqNP_990417.1. NM_205086.1.
UniGeneGga.4390.
Gga.52366.

3D structure databases

ProteinModelPortalP08267.
SMRP08267. Positions 6-176.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000038030.

Proteomic databases

PaxDbP08267.
PRIDEP08267.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000011687; ENSGALP00000011673; ENSGALG00000007220.
GeneID395970.
KEGGgga:395970.

Organism-specific databases

CTD2495.

Phylogenomic databases

eggNOGCOG1528.
GeneTreeENSGT00700000104283.
HOGENOMHOG000223383.
HOVERGENHBG000410.
InParanoidP08267.
KOK00522.
OrthoDBEOG7DRJ49.
PhylomeDBP08267.

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816035.
PROP08267.

Entry information

Entry nameFRIH_CHICK
AccessionPrimary (citable) accession number: P08267
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families