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P08267

- FRIH_CHICK

UniProt

P08267 - FRIH_CHICK

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Protein

Ferritin heavy chain

Gene

FTH

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Iron 1PROSITE-ProRule annotation
Metal bindingi62 – 621Iron 1PROSITE-ProRule annotation
Metal bindingi62 – 621Iron 2PROSITE-ProRule annotation
Metal bindingi65 – 651Iron 1PROSITE-ProRule annotation
Metal bindingi107 – 1071Iron 2PROSITE-ProRule annotation
Metal bindingi141 – 1411Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. immune response Source: UniProtKB
  2. intracellular sequestering of iron ion Source: Ensembl
  3. iron ion transport Source: InterPro
  4. negative regulation of cell proliferation Source: UniProtKB
  5. negative regulation of fibroblast proliferation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_198084. Scavenging by Class A Receptors.
REACT_203318. Iron uptake and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin heavy chain (EC:1.16.3.1)
Short name:
Ferritin H subunit
Gene namesi
Name:FTH
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. mitochondrion Source: Ensembl
  3. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 180179Ferritin heavy chainPRO_0000201057Add
BLAST

Proteomic databases

PaxDbiP08267.
PRIDEiP08267.

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038030.

Structurei

3D structure databases

ProteinModelPortaliP08267.
SMRiP08267. Positions 6-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 159150Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1528.
GeneTreeiENSGT00760000119129.
HOGENOMiHOG000223383.
HOVERGENiHBG000410.
InParanoidiP08267.
KOiK00522.
OrthoDBiEOG7DRJ49.
PhylomeDBiP08267.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08267-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATPPSQVRQ NYHQDCEAAI NRQINLELYA SYVYLSMSYY FDRDDVALKN
60 70 80 90 100
FAKYFLHQSH EEREHAEKLM KLQNQRGGRI FLQDIKKPDR DDWENGLTAM
110 120 130 140 150
ECALHLEKNV NQSLLELHKL ATEKNDPHLC DFIETHYLDE QVKAIKQLGD
160 170 180
HVTNLRKMGA PKYGMAEYLF DKHTLGESDS
Length:180
Mass (Da):21,092
Last modified:January 23, 2007 - v2
Checksum:i0A779C213E5EF35E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16343 Genomic DNA. Translation: AAA48768.1.
Y14698 mRNA. Translation: CAA75004.1.
PIRiA26886.
RefSeqiNP_990417.1. NM_205086.1.
UniGeneiGga.4390.
Gga.52366.

Genome annotation databases

EnsembliENSGALT00000011687; ENSGALP00000011673; ENSGALG00000007220.
GeneIDi395970.
KEGGigga:395970.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16343 Genomic DNA. Translation: AAA48768.1 .
Y14698 mRNA. Translation: CAA75004.1 .
PIRi A26886.
RefSeqi NP_990417.1. NM_205086.1.
UniGenei Gga.4390.
Gga.52366.

3D structure databases

ProteinModelPortali P08267.
SMRi P08267. Positions 6-176.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000038030.

Proteomic databases

PaxDbi P08267.
PRIDEi P08267.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000011687 ; ENSGALP00000011673 ; ENSGALG00000007220 .
GeneIDi 395970.
KEGGi gga:395970.

Organism-specific databases

CTDi 2495.

Phylogenomic databases

eggNOGi COG1528.
GeneTreei ENSGT00760000119129.
HOGENOMi HOG000223383.
HOVERGENi HBG000410.
InParanoidi P08267.
KOi K00522.
OrthoDBi EOG7DRJ49.
PhylomeDBi P08267.

Enzyme and pathway databases

Reactomei REACT_198084. Scavenging by Class A Receptors.
REACT_203318. Iron uptake and transport.

Miscellaneous databases

NextBioi 20816035.
PROi P08267.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and expression of the chicken ferritin H-subunit gene."
    Stevens P.W., Dodgson J.B., Engel J.D.
    Mol. Cell. Biol. 7:1751-1758(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Mikulits W., Linhartova I., Dolznig H., Propst F., Wiche G., Beug H., Muellner E.W.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiFRIH_CHICK
AccessioniPrimary (citable) accession number: P08267
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3