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P08267

- FRIH_CHICK

UniProt

P08267 - FRIH_CHICK

Protein

Ferritin heavy chain

Gene

FTH

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney By similarity.By similarity

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi27 – 271Iron 1PROSITE-ProRule annotation
    Metal bindingi62 – 621Iron 1PROSITE-ProRule annotation
    Metal bindingi62 – 621Iron 2PROSITE-ProRule annotation
    Metal bindingi65 – 651Iron 1PROSITE-ProRule annotation
    Metal bindingi107 – 1071Iron 2PROSITE-ProRule annotation
    Metal bindingi141 – 1411Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. immune response Source: UniProtKB
    3. iron ion transport Source: InterPro
    4. negative regulation of cell proliferation Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_198084. Scavenging by Class A Receptors.
    REACT_203318. Iron uptake and transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferritin heavy chain (EC:1.16.3.1)
    Short name:
    Ferritin H subunit
    Gene namesi
    Name:FTH
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 5

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 180179Ferritin heavy chainPRO_0000201057Add
    BLAST

    Proteomic databases

    PaxDbiP08267.
    PRIDEiP08267.

    Interactioni

    Subunit structurei

    Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000038030.

    Structurei

    3D structure databases

    ProteinModelPortaliP08267.
    SMRiP08267. Positions 6-176.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 159150Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1528.
    GeneTreeiENSGT00700000104283.
    HOGENOMiHOG000223383.
    HOVERGENiHBG000410.
    InParanoidiP08267.
    KOiK00522.
    OrthoDBiEOG7DRJ49.
    PhylomeDBiP08267.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00540. FERRITIN_1. 1 hit.
    PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P08267-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATPPSQVRQ NYHQDCEAAI NRQINLELYA SYVYLSMSYY FDRDDVALKN    50
    FAKYFLHQSH EEREHAEKLM KLQNQRGGRI FLQDIKKPDR DDWENGLTAM 100
    ECALHLEKNV NQSLLELHKL ATEKNDPHLC DFIETHYLDE QVKAIKQLGD 150
    HVTNLRKMGA PKYGMAEYLF DKHTLGESDS 180
    Length:180
    Mass (Da):21,092
    Last modified:January 23, 2007 - v2
    Checksum:i0A779C213E5EF35E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16343 Genomic DNA. Translation: AAA48768.1.
    Y14698 mRNA. Translation: CAA75004.1.
    PIRiA26886.
    RefSeqiNP_990417.1. NM_205086.1.
    UniGeneiGga.4390.
    Gga.52366.

    Genome annotation databases

    EnsembliENSGALT00000011687; ENSGALP00000011673; ENSGALG00000007220.
    GeneIDi395970.
    KEGGigga:395970.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16343 Genomic DNA. Translation: AAA48768.1 .
    Y14698 mRNA. Translation: CAA75004.1 .
    PIRi A26886.
    RefSeqi NP_990417.1. NM_205086.1.
    UniGenei Gga.4390.
    Gga.52366.

    3D structure databases

    ProteinModelPortali P08267.
    SMRi P08267. Positions 6-176.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000038030.

    Proteomic databases

    PaxDbi P08267.
    PRIDEi P08267.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000011687 ; ENSGALP00000011673 ; ENSGALG00000007220 .
    GeneIDi 395970.
    KEGGi gga:395970.

    Organism-specific databases

    CTDi 2495.

    Phylogenomic databases

    eggNOGi COG1528.
    GeneTreei ENSGT00700000104283.
    HOGENOMi HOG000223383.
    HOVERGENi HBG000410.
    InParanoidi P08267.
    KOi K00522.
    OrthoDBi EOG7DRJ49.
    PhylomeDBi P08267.

    Enzyme and pathway databases

    Reactomei REACT_198084. Scavenging by Class A Receptors.
    REACT_203318. Iron uptake and transport.

    Miscellaneous databases

    NextBioi 20816035.
    PROi P08267.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00540. FERRITIN_1. 1 hit.
    PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of the chicken ferritin H-subunit gene."
      Stevens P.W., Dodgson J.B., Engel J.D.
      Mol. Cell. Biol. 7:1751-1758(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Mikulits W., Linhartova I., Dolznig H., Propst F., Wiche G., Beug H., Muellner E.W.
      Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiFRIH_CHICK
    AccessioniPrimary (citable) accession number: P08267
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3