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P08262

- HEM1_BRADU

UniProt

P08262 - HEM1_BRADU

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Protein
5-aminolevulinate synthase
Gene
hemA, bll1200
Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pyridoxal phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei21 – 211Substrate By similarity
Binding sitei136 – 1361Substrate By similarity
Binding sitei188 – 1881Pyridoxal phosphate By similarity
Binding sitei216 – 2161Pyridoxal phosphate By similarity
Binding sitei244 – 2441Pyridoxal phosphate By similarity
Active sitei247 – 2471 By similarity
Binding sitei276 – 2761Pyridoxal phosphate By similarity
Binding sitei277 – 2771Pyridoxal phosphate By similarity
Binding sitei362 – 3621Substrate By similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-1210-MONOMER.
UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase (EC:2.3.1.37)
Alternative name(s):
5-aminolevulinic acid synthase
Delta-ALA synthase
Delta-aminolevulinate synthase
Gene namesi
Name:hemA
Ordered Locus Names:bll1200
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4094095-aminolevulinate synthase
PRO_0000163825Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei247 – 2471N6-(pyridoxal phosphate)lysine Inferred

Interactioni

Protein-protein interaction databases

STRINGi224911.bll1200.

Structurei

3D structure databases

ProteinModelPortaliP08262.
SMRiP08262. Positions 2-394.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0156.
HOGENOMiHOG000221020.
KOiK00643.
OrthoDBiEOG6Q8HZD.
PhylomeDBiP08262.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08262-1 [UniParc]FASTAAdd to Basket

« Hide

MDYSQFFNSA LDRLHTERRY RVFADLERMA GRFPHAIWHS PKGKRDVVIW    50
CSNDYLGMGQ HPKVVGAMVE TATRVGTGAG GTRNIAGTHH PLVQLEAELA 100
DLHGKEAALL FTSGYVSNQT GIATIAKLIP NCLILSDELN HNSMIEGIRQ 150
SGCERQVFRH NDLADLEALL KAAGANRPKL IACESLYSMD GDVAPLAKIC 200
DLAEKYNAMT YVDEVHAVGM YGPRGGGIAE RDGVMHRIDI LEGTLAKAFG 250
CLGGYIAANG QIIDAVRSYA PGFIFTTALP PAICSAATAA IKHLKTSSWE 300
RERHQDRAAR VKAILNAAGL PVMSSDTHIV PLFIGDAEKC KQASDLLLEE 350
HGIYIQPINY PTVAKGSERL RITPSPYHDD GLIDQLAEAL LQVWDRLGLP 400
LKQKSLAAE 409
Length:409
Mass (Da):44,574
Last modified:February 28, 2003 - v2
Checksum:iB21B011EB9542D66
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti261 – 2611Q → R in AAA26216. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16751 Genomic DNA. Translation: AAA26216.1.
BA000040 Genomic DNA. Translation: BAC46465.1.
PIRiA27478. SYZJAL.
RefSeqiNP_767840.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC46465; BAC46465; BAC46465.
GeneIDi1049580.
KEGGibja:bll1200.
PATRICi21185942. VBIBraJap65052_1241.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16751 Genomic DNA. Translation: AAA26216.1 .
BA000040 Genomic DNA. Translation: BAC46465.1 .
PIRi A27478. SYZJAL.
RefSeqi NP_767840.1. NC_004463.1.

3D structure databases

ProteinModelPortali P08262.
SMRi P08262. Positions 2-394.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224911.bll1200.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC46465 ; BAC46465 ; BAC46465 .
GeneIDi 1049580.
KEGGi bja:bll1200.
PATRICi 21185942. VBIBraJap65052_1241.

Phylogenomic databases

eggNOGi COG0156.
HOGENOMi HOG000221020.
KOi K00643.
OrthoDBi EOG6Q8HZD.
PhylomeDBi P08262.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00375 .
BioCyci BJAP224911:GJEJ-1210-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the Bradyrhizobium japonicum gene hemA encoding 5-aminolevulinic acid synthase."
    McClung C.R., Somerville J.E., Guerinot M.L., Chelm B.K.
    Gene 54:133-139(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Entry informationi

Entry nameiHEM1_BRADU
AccessioniPrimary (citable) accession number: P08262
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 28, 2003
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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