P08251 (AT1B1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1

Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-1

Gene names

Name:

ATP1B1

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
Subunit structure	Composed of three subunits: alpha (catalytic), beta and gamma.
Subcellular location	Membrane; Single-pass type II membrane protein.
Sequence similarities	Belongs to the X(+)/potassium ATPases subunit beta family.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Sodium transport Sodium/potassium transport Transport
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Potassium Sodium
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sodium:potassium-exchanging ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Sodium/potassium-transporting ATPase subunit beta-1		PRO_0000219102
Regions
	Topological domain	1 – 35	35	Cytoplasmic Potential
	Transmembrane	36 – 63	28	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	64 – 305	242	Extracellular Potential
Amino acid modifications
	Glycosylation	159	1	N-linked (GlcNAc...) By similarity
	Glycosylation	194	1	N-linked (GlcNAc...) By similarity
	Glycosylation	266	1	N-linked (GlcNAc...) By similarity
	Disulfide bond	127 ↔ 150		By similarity
	Disulfide bond	160 ↔ 176		By similarity
	Disulfide bond	214 ↔ 277		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P08251 [UniParc]. Last modified August 1, 1988. Version 1. Checksum: E56E47E920769252	FASTA	305	34,941
	10 20 30 40 50 60 MARGKANDGD GNWKKFIWNS EKKELLGRTG GSWFKILLFY VIFYGCLAGI FIGTIQVMLL 70 80 90 100 110 120 TVSEFEPKYQ DRVAPPGLTQ VPQVQKTEIS FTVNDPKSYD PYVKNLEGFL NKYSAGEQTD 130 140 150 160 170 180 NIVFQDCGDI PTDYKERGPY NDAQGQKKVC KFKREWLENC SGLQDNTFGY KDGKPCILVK 190 200 210 220 230 240 LNRIIGFKPK APENESLPSD LAGKYNPYLI PVHCVAKRDE DADKIGMVEY YGMGGYPGFA 250 260 270 280 290 300 LQYYPYYGRL LQPQYLQPLV AVQFTNLTYD VEVRVECKEY GQNIQYSDKD RFQGRFDIKF DIKSS

References

[1]

"Expression of hybrid (Na+ + K+)-ATPase molecules after transfection of mouse Ltk-cells with DNA encoding the beta-subunit of an avian brain sodium pump." Takeyasu K., Tamkun M.M., Siegel N.R., Fambrough D.M. J. Biol. Chem. 262:10733-10740(1987) [PubMed: 3038895] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	J02787 mRNA. Translation: AAA48608.1.
IPI	IPI00579860.
PIR	A28491.
RefSeq	NP_990851.1. NM_205520.4.
UniGene	Gga.3301.
3D structure databases
ProteinModelPortal	P08251.
SMR	P08251. Positions 29-74.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-29N.
STRING	P08251.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	396529.
KEGG	gga:396529.
Organism-specific databases
CTD	481.
Phylogenomic databases
eggNOG	veNOG07622.
GeneTree	ENSGT00550000074530.
HOGENOM	HBG446583.
HOVERGEN	HBG050603.
InParanoid	P08251.
OrthoDB	EOG4M3998.
Family and domain databases
InterPro	IPR000402. ATPase_P-typ_cation-exchng_bsu. IPR015565. ATPase_P-typ_Na/K-dep_b1su. [Graphical view]
KO	K01540.
PANTHER	PTHR11523. ATPase_H_Na/K_b. 1 hit. PTHR11523:SF10. Na/K_ATPaseBeta1. 1 hit.
Pfam	PF00287. Na_K-ATPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITE	PS00390. ATPASE_NA_K_BETA_1. 1 hit. PS00391. ATPASE_NA_K_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AT1B1_CHICK

Accession

Primary (citable) accession number: P08251

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	November 16, 2011
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program