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Protein

Sodium/potassium-transporting ATPase subunit beta-1

Gene

ATP1B1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.

GO - Biological processi

Keywordsi

Biological processIon transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-1
Gene namesi
Name:ATP1B1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 63Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST28
Topological domaini64 – 305ExtracellularSequence analysisAdd BLAST242

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191021 – 305Sodium/potassium-transporting ATPase subunit beta-1Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi127 ↔ 150By similarity
Glycosylationi159N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi160 ↔ 176By similarity
Glycosylationi194N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi214 ↔ 277By similarity
Glycosylationi266N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP08251
PRIDEiP08251

Interactioni

Subunit structurei

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.Curated

Binary interactionsi

Show more details

Protein-protein interaction databases

DIPiDIP-29N
IntActiP08251, 2 interactors
MINTiP08251
STRINGi9031.ENSGALP00000036140

Structurei

3D structure databases

ProteinModelPortaliP08251
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927 Eukaryota
ENOG411150A LUCA
HOGENOMiHOG000039248
HOVERGENiHBG050603
InParanoidiP08251
KOiK01540
PhylomeDBiP08251

Family and domain databases

Gene3Di2.60.40.1660, 1 hit
InterProiView protein in InterPro
IPR000402 Na/K_ATPase_sub_beta
IPR015565 Na/K_ATPase_sub_beta_chordates
IPR038702 Na/K_ATPase_sub_beta_sf
PANTHERiPTHR11523 PTHR11523, 1 hit
PTHR11523:SF10 PTHR11523:SF10, 1 hit
PfamiView protein in Pfam
PF00287 Na_K-ATPase, 1 hit
TIGRFAMsiTIGR01107 Na_K_ATPase_bet, 1 hit
PROSITEiView protein in PROSITE
PS00390 ATPASE_NA_K_BETA_1, 1 hit
PS00391 ATPASE_NA_K_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P08251-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGKANDGD GNWKKFIWNS EKKELLGRTG GSWFKILLFY VIFYGCLAGI
60 70 80 90 100
FIGTIQVMLL TVSEFEPKYQ DRVAPPGLTQ VPQVQKTEIS FTVNDPKSYD
110 120 130 140 150
PYVKNLEGFL NKYSAGEQTD NIVFQDCGDI PTDYKERGPY NDAQGQKKVC
160 170 180 190 200
KFKREWLENC SGLQDNTFGY KDGKPCILVK LNRIIGFKPK APENESLPSD
210 220 230 240 250
LAGKYNPYLI PVHCVAKRDE DADKIGMVEY YGMGGYPGFA LQYYPYYGRL
260 270 280 290 300
LQPQYLQPLV AVQFTNLTYD VEVRVECKEY GQNIQYSDKD RFQGRFDIKF

DIKSS
Length:305
Mass (Da):34,941
Last modified:August 1, 1988 - v1
Checksum:iE56E47E920769252
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02787 mRNA Translation: AAA48608.1
PIRiA28491
RefSeqiNP_990851.1, NM_205520.4
UniGeneiGga.3301

Genome annotation databases

GeneIDi396529
KEGGigga:396529

Similar proteinsi

Entry informationi

Entry nameiAT1B1_CHICK
AccessioniPrimary (citable) accession number: P08251
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 25, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health