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Protein

Sodium/potassium-transporting ATPase subunit beta-1

Gene

ATP1B1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-1
Gene namesi
Name:ATP1B1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535CytoplasmicSequence analysisAdd
BLAST
Transmembranei36 – 6328Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini64 – 305242ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Sodium/potassium-transporting ATPase subunit beta-1PRO_0000219102Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi127 ↔ 150By similarity
Glycosylationi159 – 1591N-linked (GlcNAc...)By similarity
Disulfide bondi160 ↔ 176By similarity
Glycosylationi194 – 1941N-linked (GlcNAc...)By similarity
Disulfide bondi214 ↔ 277By similarity
Glycosylationi266 – 2661N-linked (GlcNAc...)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP08251.
PRIDEiP08251.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Binary interactionsi

WithEntry#Exp.IntActNotes
KCNMA1Q8AYS83EBI-7206371,EBI-1635766
Kcnma1Q084605EBI-7206371,EBI-1633915From a different organism.

Protein-protein interaction databases

DIPiDIP-29N.
IntActiP08251. 2 interactions.
STRINGi9031.ENSGALP00000036140.

Structurei

3D structure databases

ProteinModelPortaliP08251.
SMRiP08251. Positions 29-74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP08251.
KOiK01540.
PhylomeDBiP08251.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
IPR015565. Na/K_ATPase_sub_beta_chordates.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PTHR11523:SF10. PTHR11523:SF10. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08251-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGKANDGD GNWKKFIWNS EKKELLGRTG GSWFKILLFY VIFYGCLAGI
60 70 80 90 100
FIGTIQVMLL TVSEFEPKYQ DRVAPPGLTQ VPQVQKTEIS FTVNDPKSYD
110 120 130 140 150
PYVKNLEGFL NKYSAGEQTD NIVFQDCGDI PTDYKERGPY NDAQGQKKVC
160 170 180 190 200
KFKREWLENC SGLQDNTFGY KDGKPCILVK LNRIIGFKPK APENESLPSD
210 220 230 240 250
LAGKYNPYLI PVHCVAKRDE DADKIGMVEY YGMGGYPGFA LQYYPYYGRL
260 270 280 290 300
LQPQYLQPLV AVQFTNLTYD VEVRVECKEY GQNIQYSDKD RFQGRFDIKF

DIKSS
Length:305
Mass (Da):34,941
Last modified:August 1, 1988 - v1
Checksum:iE56E47E920769252
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02787 mRNA. Translation: AAA48608.1.
PIRiA28491.
RefSeqiNP_990851.1. NM_205520.4.
UniGeneiGga.3301.

Genome annotation databases

GeneIDi396529.
KEGGigga:396529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02787 mRNA. Translation: AAA48608.1.
PIRiA28491.
RefSeqiNP_990851.1. NM_205520.4.
UniGeneiGga.3301.

3D structure databases

ProteinModelPortaliP08251.
SMRiP08251. Positions 29-74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29N.
IntActiP08251. 2 interactions.
STRINGi9031.ENSGALP00000036140.

Proteomic databases

PaxDbiP08251.
PRIDEiP08251.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396529.
KEGGigga:396529.

Organism-specific databases

CTDi481.

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP08251.
KOiK01540.
PhylomeDBiP08251.

Miscellaneous databases

PROiP08251.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
IPR015565. Na/K_ATPase_sub_beta_chordates.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PTHR11523:SF10. PTHR11523:SF10. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of hybrid (Na+ + K+)-ATPase molecules after transfection of mouse Ltk-cells with DNA encoding the beta-subunit of an avian brain sodium pump."
    Takeyasu K., Tamkun M.M., Siegel N.R., Fambrough D.M.
    J. Biol. Chem. 262:10733-10740(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAT1B1_CHICK
AccessioniPrimary (citable) accession number: P08251
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.